Search Results - "WEIR, GORDON C."

Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates by Veiseh, Omid, Doloff, Joshua C., Ma, Minglin, Vegas, Arturo J., Tam, Hok Hei, Bader, Andrew R., Li, Jie, Langan, Erin, Wyckoff, Jeffrey, Loo, Whitney S., Jhunjhunwala, Siddharth, Chiu, Alan, Siebert, Sean, Tang, Katherine, Hollister-Lock, Jennifer, Aresta-Dasilva, Stephanie, Bochenek, Matthew, Mendoza-Elias, Joshua, Wang, Yong, Qi, Merigeng, Lavin, Danya M., Chen, Michael, Dholakia, Nimit, Thakrar, Raj, Lacík, Igor, Weir, Gordon C., Oberholzer, Jose, Greiner, Dale L., Langer, Robert, Anderson, Daniel G.

“…The efficacy of implanted biomedical devices is often compromised by host recognition and subsequent foreign body responses. Here, we demonstrate the role of…”
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Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice by Vegas, Arturo J, Veiseh, Omid, Gürtler, Mads, Millman, Jeffrey R, Pagliuca, Felicia W, Bader, Andrew R, Doloff, Joshua C, Li, Jie, Chen, Michael, Olejnik, Karsten, Tam, Hok Hei, Jhunjhunwala, Siddharth, Langan, Erin, Aresta-Dasilva, Stephanie, Gandham, Srujan, McGarrigle, James J, Bochenek, Matthew A, Hollister-Lock, Jennifer, Oberholzer, Jose, Greiner, Dale L, Weir, Gordon C, Melton, Douglas A, Langer, Robert, Anderson, Daniel G

“…When encapsulated with alginate derivatives that resist the foreign-body response, human embryonic stem cell–derived beta cells restore long-term normoglycemia…”
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Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations by Farah, Shady, Doloff, Joshua C., Müller, Peter, Sadraei, Atieh, Han, Hye Jung, Olafson, Katy, Vyas, Keval, Tam, Hok Hei, Hollister-Lock, Jennifer, Kowalski, Piotr S., Griffin, Marissa, Meng, Ashley, McAvoy, Malia, Graham, Adam C., McGarrigle, James, Oberholzer, Jose, Weir, Gordon C., Greiner, Dale L., Langer, Robert, Anderson, Daniel G.

“…Implantable medical devices have revolutionized modern medicine. However, immune-mediated foreign body response (FBR) to the materials of these devices can…”
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Five Stages of Evolving Beta-Cell Dysfunction During Progression to Diabetes by Weir, Gordon C., Bonner-Weir, Susan

“…This article proposes five stages in the progression of diabetes, each of which is characterized by different changes in beta-cell mass, phenotype, and…”
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Induction of remission in diabetes by lowering blood glucose by Weir, Gordon C, Bonner-Weir, Susan

“…As diabetes continues to grow as major health problem, there has been great progress in understanding the important role of pancreatic beta-cells in its…”
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Transplantation of Macroencapsulated Insulin-Producing Cells by Hwa, Albert J., Weir, Gordon C.

“…Purpose of Review There is considerable interest in using macroencapsulation devices as a delivery strategy for transplanting insulin-producing cells. This…”
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Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes by Marselli, Lorella, Thorne, Jeffrey, Dahiya, Sonika, Sgroi, Dennis C, Sharma, Arun, Bonner-Weir, Susan, Marchetti, Piero, Weir, Gordon C

“…Changes in gene expression in pancreatic beta-cells from type 2 diabetes (T2D) should provide insights into their abnormal insulin secretion and turnover…”
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Glucolipotoxicity, β-Cells, and Diabetes: The Emperor Has No Clothes by Weir, Gordon C

“…Reduction of β-cell mass and function is central to the pathogenesis of type 2 diabetes. The terms glucotoxicity, lipotoxicity, and glucolipotoxicity are used…”
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Beta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability by Ebrahimi, Aref G., Hollister-Lock, Jennifer, Sullivan, Brooke A., Tsuchida, Ryohei, Bonner-Weir, Susan, Weir, Gordon C.

“…As diabetes develops, marked reductions of insulin secretion are associated with very modest elevations of glucose. We wondered if these glucose changes…”
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A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells by Bose, Suman, Volpatti, Lisa R., Thiono, Devina, Yesilyurt, Volkan, McGladrigan, Collin, Tang, Yaoyu, Facklam, Amanda, Wang, Amy, Jhunjhunwala, Siddharth, Veiseh, Omid, Hollister-Lock, Jennifer, Bhattacharya, Chandrabali, Weir, Gordon C., Greiner, Dale L., Langer, Robert, Anderson, Daniel G.

“…The long-term function of transplanted therapeutic cells typically requires systemic immune suppression. Here, we show that a retrievable implant comprising a…”
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Long-term viability and function of transplanted islets macroencapsulated at high density are achieved by enhanced oxygen supply by Evron, Yoav, Colton, Clark K., Ludwig, Barbara, Weir, Gordon C., Zimermann, Baruch, Maimon, Shiri, Neufeld, Tova, Shalev, Nurit, Goldman, Tali, Leon, Assaf, Yavriyants, Karina, Shabtay, Noa, Rozenshtein, Tania, Azarov, Dimitri, DiIenno, Amanda R., Steffen, Anja, de Vos, Paul, Bornstein, Stefan R., Barkai, Uriel, Rotem, Avi

“…Transplantation of encapsulated islets can cure diabetes without immunosuppression, but oxygen supply limitations can cause failure. We investigated a…”
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Enhanced oxygen supply improves islet viability in a new bioartificial pancreas by Barkai, Uriel, Weir, Gordon C, Colton, Clark K, Ludwig, Barbara, Bornstein, Stefan R, Brendel, Mathias D, Neufeld, Tova, Bremer, Chezi, Leon, Assaf, Evron, Yoav, Yavriyants, Karina, Azarov, Dimitri, Zimermann, Baruch, Maimon, Shiri, Shabtay, Noa, Balyura, Maria, Rozenshtein, Tania, Vardi, Pnina, Bloch, Konstantin, de Vos, Paul, Rotem, Avi

“…The current epidemic of diabetes with its overwhelming burden on our healthcare system requires better therapeutic strategies. Here we present a promising…”
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Enhancement of Subcutaneous Islet Transplant Performance by Collagen 1 Gel by French, Anna, Hollister-Lock, Jennifer, Sullivan, Brooke A, Stas, Eline, Hwa, Albert J, Weir, Gordon C, Bonner-Weir, Susan

“…Human islets can be transplanted into the portal vein for T1 diabetes, and a similar procedure is being used in a clinical trial for stem cell-derived…”
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Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist by Ludwig, Barbara, Rotem, Avi, Schmid, Janine, Weir, Gordon C, Colton, Clark K, Brendel, Mathias D, Neufeld, Tova, Block, Norman L, Yavriyants, Karina, Steffen, Anja, Ludwig, Stefan, Chavakis, Triantafyllos, Reichel, Andreas, Azarov, Dimitri, Zimermann, Baruch, Maimon, Shiri, Balyura, Mariya, Rozenshtein, Tania, Shabtay, Noa, Vardi, Pnina, Bloch, Konstantin, de Vos, Paul, Schally, Andrew V, Bornstein, Stefan R, Barkai, Uriel

“…Islet transplantation is a feasible therapeutic alternative for metabolically labile patients with type 1 diabetes. The primary therapeutic target is stable…”
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Quantitative analysis of cell composition and purity of human pancreatic islet preparations by Pisania, Anna, Weir, Gordon C, O'Neil, John J, Omer, Abdulkadir, Tchipashvili, Vaja, Lei, Ji, Colton, Clark K, Bonner-Weir, Susan

“…Despite improvements in outcomes for human islet transplantation, characterization of islet preparations remains poorly defined. This study used both light…”
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Dynamic development of the pancreas from birth to adulthood by Bonner-Weir, Susan, Aguayo-Mazzucato, Cristina, Weir, Gordon C.

“…After birth the endocrine pancreas continues its development, a complex process that involves both the maturation of islet cells and a marked expansion of…”
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The efficacy of an immunoisolating membrane system for islet xenotransplantation in minipigs by Neufeld, Tova, Ludwig, Barbara, Barkai, Uriel, Weir, Gordon C, Colton, Clark K, Evron, Yoav, Balyura, Maria, Yavriyants, Karina, Zimermann, Baruch, Azarov, Dmitri, Maimon, Shiri, Shabtay, Noa, Rozenshtein, Tania, Lorber, Dana, Steffen, Anja, Willenz, Udi, Bloch, Konstantine, Vardi, Pnina, Taube, Ran, de Vos, Paul, Lewis, Eli C, Bornstein, Stefan R, Rotem, Avi

“…Developing a device that protects xenogeneic islets to allow treatment and potentially cure of diabetes in large mammals has been a major challenge in the past…”
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Islet Oxygen Consumption Rate (OCR) Dose Predicts Insulin Independence in Clinical Islet Autotransplantation by Papas, Klearchos K, Bellin, Melena D, Sutherland, David E R, Suszynski, Thomas M, Kitzmann, Jennifer P, Avgoustiniatos, Efstathios S, Gruessner, Angelika C, Mueller, Kathryn R, Beilman, Gregory J, Balamurugan, Appakalai N, Loganathan, Gopalakrishnan, Colton, Clark K, Koulmanda, Maria, Weir, Gordon C, Wilhelm, Josh J, Qian, Dajun, Niland, Joyce C, Hering, Bernhard J

“…Reliable in vitro islet quality assessment assays that can be performed routinely, prospectively, and are able to predict clinical transplant outcomes are…”
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Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates by Veiseh, Omid, Doloff, Joshua C., Ma, Minglin, Vegas, Arturo J., Tam, Hok Hei, Bader, Andrew R., Li, Jie, Langan, Erin, Wyckoff, Jeffrey, Loo, Whitney S., Jhunjhunwala, Siddharth, Chiu, Alan, Siebert, Sean, Tang, Katherine, Hollister-Lock, Jennifer, Aresta-Dasilva, Stephanie, Bochenek, Matthew, Mendoza-Elias, Joshua, Wang, Yong, Qi, Merigeng, Lavin, Danya M., Chen, Michael, Dholakia, Nimit, Thakrar, Raj, Lacík, Igor, Weir, Gordon C., Oberholzer, Jose, Greiner, Dale L., Langer, Robert, Anderson, Daniel G.

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Differentiation of Affinity-Purified Human Pancreatic Duct Cells to β-Cells by YATOH, Shigeru, DODGE, Rikke, AKASHI, Tomoyuki, OMER, Abdulkadir, SHARMA, Arun, WEIR, Gordon C, BONNER-WEIR, Susan

“…Differentiation of Affinity-Purified Human Pancreatic Duct Cells to β-Cells Shigeru Yatoh , Rikke Dodge , Tomoyuki Akashi , Abdulkadir Omer , Arun Sharma ,…”
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