Search Results - "WEIR, D. G"

Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease by Quinlivan, EP, McPartlin, J, McNulty, H, Ward, M, Strain, JJ, Weir, DG, Scott, JM

“…Fortification of food with folic acid to prevent neural-tube defects in babies also lowers plasma total homocysteine, which is a risk factor for vascular…”
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Endocinch therapy for gastro-oesophageal reflux disease: a one year prospective follow up by Mahmood, Z, McMahon, B P, Arfin, Q, Byrne, P J, Reynolds, J V, Murphy, E M, Weir, D G

“…Background: Gastro-oesophageal reflux disease (GORD) is, in the main, treated with either proton pump inhibitor (PPI) drugs or a Nissen fundoplication…”
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Increased incidence of non-Hodgkin's lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low by Farrell, R J, Ang, Y, Kileen, P, O'Briain, D S, Kelleher, D, Keeling, P W N, Weir, D G

“…BACKGROUND There is concern that the incidence of non-Hodgkin's lymphoma (NHL) will rise with increasing use of immunosuppressive therapy. AIMS Our aim was to…”
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Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements by Kelly, P, McPartlin, J, Goggins, M, Weir, DG, Scott, JM

“…Periconceptual consumption of folic acid has been shown to decrease the incidence of neural tube defects. The strategy of universal fortification of staple…”
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The history of folic acid by Hoffbrand, A. V., Weir, D. G.

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Homocysteine metabolism in pregnancies complicated by neural-tube defects by Mills, J L, McPartlin, J M, Kirke, P N, Lee, Y J, Conley, M R, Weir, D G, Scott, J M

“…Folic acid taken around the time of conception can prevent many neural-tube defects. Women with low-normal vitamin B12 values may also be at increased risk. We…”
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Increased prevalence of methylenetetrahydrofolate reductase C677T variant in patients with inflammatory bowel disease, and its clinical implications by Mahmud, N, Molloy, A, McPartlin, J, Corbally, R, Whitehead, A S, Scott, J M, Weir, D G

“…BACKGROUND Inflammatory bowel disease (IBD) is associated with an increased incidence of thromboembolic disease. Hyperhomocysteinaemia (hyper-tHcy), a…”
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High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy by Farrell, Richard J., Murphy, Ann, Long, Aideen, Donnelly, Suzanne, Cherikuri, Anil, O'Toole, Dermot, Mahmud, Nasir, Keeling, Paul W.N., Weir, Donald G., Kelleher, Dermot

“…Background & Aims: The multidrug resistance (MDR) gene codes for a drug efflux pump P-glycoprotein 170 (Pgp-170) expressed on the surface of lymphocytes and…”
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A prospective study of circulating mutant KRAS2 in the serum of patients with colorectal neoplasia: strong prognostic indicator in postoperative follow up by Ryan, B M, Lefort, F, McManus, R, Daly, J, Keeling, P W N, Weir, D G, Kelleher, D

“…Background and aims: Mutant tumour derived DNA has been detected in the sera of colorectal cancer patients. We investigated if mutant serum KRAS2 was…”
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Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid by WARD, M, MCNULTY, H, MCPARTLIN, J, STRAIN, J. J, WEIR, D. G, SCOTT, J. M

“…Elevated plasma homocysteine, an independent risk factor for cardiovascular disease (CVD) can be lowered by administration of pharmacological doses of folic…”
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Symptomatic gastro-oesophageal reflux disease: double blind controlled study of intermittent treatment with omeprazole or ranitidine by Bardhan, K D, Müller-Lissner, S, Bigard, M A, Porro, G Bianchi, Ponce, J, Hosie, J, Scott, Mairi, Weir, D G, Gillon, K R W, Peacock, R A, Fulton, Claire

“…Abstract Objective: To assess intermittent treatment over 12 months in patients with symptomatic gastro-oesophageal reflux disease. Design: Randomised,…”
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Brain function in the elderly: role of vitamin B12 and folate by Weir, Donald G, Scott, John M

“…Vitamin B12 (cobalamin) deficiency associated neuropathy, originally called sub-acute combined degeneration, is particularly common in the elderly. The…”
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Absence of oats toxicity in adult coeliac disease by Srinivasan, Usha, Leonard, Niamh, Jones, Eileen, Kasarda, Donald D, Weir, Donald G, O'Farrelly, Cliona, Feighery, Conleth

“…The conventional gluten-free diet used to treat coeliac disease proscribes oats cereal as well as wheat, barley, and rye. 1 However, the issue of oats toxicity…”
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The “Thermolabile” Variant of Methylenetetrahydrofolate Reductase and Neural Tube Defects: An Evaluation of Genetic Risk and the Relative Importance of the Genotypes of the Embryo and the Mother by Shields, Denis C., Kirke, Peadar N., Mills, James L., Ramsbottom, Dorothy, Molloy, Anne M., Burke, Helen, Weir, Donald G., Scott, John M., Whitehead, Alexander S.

“…Recent reports have implicated the “thermolabile” (T) variant of methylenetetrahydrofolate reductase (MTHFR) in the causation of folate-dependent neural tube…”
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Olsalazine is not superior to placebo in maintaining remission of inactive Crohn's colitis and ileocolitis: a double blind, parallel, randomised, multicentre study by Mahmud, N, Kamm, M A, Dupas, J L, Jewell, D P, O'Morain, C A, Weir, D G, Kelleher, D

“…BACKGROUND AND AIMS The benefit of 5-aminosalicylic acid therapy for maintenance of remission in Crohn's disease is controversial. The primary aim of this…”
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Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations by Molloy, A M, Daly, S, Mills, J L, Kirke, P N, Whitehead, A S, Ramsbottom, D, Conley, M R, Weir, D G, Scott, J M

“…The dietary reference values for folate, as for other nutrients, are targeted to the general and supposedly normal population, not people with special needs,…”
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Evaluation of renal function following treatment with 5‐aminosalicylic acid derivatives in patients with ulcerative colitis by Mahmud, N., O'Toole, D., O'Hare, N., Freyne, P. J., Weir, D. G., Kelleher, D.

“…Background: A number of cases of nephrotoxicity have been reported in patients with inflammatory bowel disease taking oral 5‐aminosalicylic acid (5‐ASA). Aim:…”
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Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete by MCKINLEY, Michelle C, MCNULTY, Helene, MCPARTLIN, Joseph, STRAIN, J. J, PENTIEVA, Kristina, WARD, Mary, WEIR, Donald G, SCOTT, John M

“…Current data suggest that physiologic doses of vitamin B-6 have no significant homocysteine-lowering effect. It is possible that an effect of vitamin B-6 was…”
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Minimum effective dose of folic acid for food fortification to prevent neural-tube defects by Daly, S, Mills, J L, Molloy, A M, Conley, M, Lee, Y J, Kirke, P N, Weir, D G, Scott, J M

“…Although a daily supplement of 400 micrograms folic acid has been shown to prevent neural-tube defects (NTD), most women do not take the recommended…”
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Epithelial cell folate depletion occurs in neoplastic but not adjacent normal colon mucosa by Meenan, J, O'Hallinan, E, Scott, J, Weir, DG

“…BACKGROUND & AIMS: Restricted folate supply is associated with the development of carcinoma, and folate supplements have a protective effect in colorectal…”
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