Search Results - "WEINHOUSE, Michael I"

Solvent-Controlled, Site-Selective N‑Alkylation Reactions of Azolo-Fused Ring Heterocycles at N1‑, N2‑, and N3-Positions, Including Pyrazolo[3,4‑d]pyrimidines, Purines, [1,2,3]Triazolo[4,5]pyridines, and Related Deaza-Compounds by Bookser, Brett C, Weinhouse, Michael I, Burns, Aaron C, Valiere, Andrew N, Valdez, Lino J, Stanczak, Pawel, Na, Jim, Rheingold, Arnold L, Moore, Curtis E, Dyck, Brian

“…Alkylation of 4-methoxy-1H-pyrazolo­[3,4-d]­pyrimidine (1b) with iodomethane in THF using NaHMDS as base selectively provided N2-methyl product…”
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Antimalarial Activities of Novel Synthetic Cysteine Protease Inhibitors by LEE, Belinda J, SINGH, Ajay, CHIANG, Peggy, KEMP, Scott J, GOLDMAN, Erick A, WEINHOUSE, Michael I, VLASUK, George P, ROSENTHAL, Philip J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A new family of H3 receptor antagonists based on the natural product Conessine by SANTORA, Vincent J, COVEL, Jonathan A, WEBB, Robert R, SAGE, Carleton, REN, Albert, PEREIRA, Guilherme, KNUDSEN, Jens, EDWARDS, Jeffrey E, SUAREZ, Marissa, FRAZER, John, THOMSEN, William, HAUSER, Erin, HAYASHI, Rena, WHELAN, Kevin, GROTTICK, Andrew J, HOFILENA, Brian J, IBARRA, Jason B, PULLEY, Michelle D, WEINHOUSE, Michael I, SENGUPTA, Dipanjan, DUFFIELD, Jonathan J, SEMPLE, Graeme

“…A new family of Histamine H(3) receptor antagonists (5a-t) has been prepared based on the structure of the natural product Conessine, a known H(3) antagonist…”
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Design and evaluation of novel biphenyl sulfonamide derivatives with potent histamine H(3) receptor inverse agonist activity by Covel, Jonathan A, Santora, Vincent J, Smith, Jeffrey M, Hayashi, Rena, Gallardo, Charlemagne, Weinhouse, Michael I, Ibarra, Jason B, Schultz, Jeffrey A, Park, Douglas M, Estrada, Scott A, Hofilena, Brian J, Pulley, Michelle D, Smith, Brian M, Ren, Albert, Suarez, Marissa, Frazer, John, Edwards, Jeffrey, Hauser, Erin K, Lorea, Jodie, Semple, Graeme, Grottick, Andrew J

“…Antagonism of the histamine-H(3) receptor is one tactic being explored to increase wakefulness for the treatment of disorders such as excessive daytime…”
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Design and Evaluation of Novel Biphenyl Sulfonamide Derivatives with Potent Histamine H3 Receptor Inverse Agonist Activity by Covel, Jonathan A., Santora, Vincent J., Smith, Jeffrey M., Hayashi, Rena, Gallardo, Charlemagne, Weinhouse, Michael I., Ibarra, Jason B., Schultz, Jeffrey A., Park, Douglas M., Estrada, Scott A., Hofilena, Brian J., Pulley, Michelle D., Smith, Brian M., Ren, Albert, Suarez, Marissa, Frazer, John, Edwards, Jeffrey, Hauser, Erin K., Lorea, Jodie, Semple, Graeme, Grottick, Andrew J.

“…Antagonism of the histamine-H3 receptor is one tactic being explored to increase wakefulness for the treatment of disorders such as excessive daytime…”
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Immobilized catalytic antibodies in aqueous and organic solvents by Janda, Kim D, Ashley, Jon A, Jones, Teresa M, McLeod, Donald A, Schloeder, Diane M, Weinhouse, Michael I

“…We describe the first report of immobilized catalytic antibodies and their behavior in aqueous as well as organic solvents. The results indicate that under…”
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Novel H3 receptor antagonists with improved pharmacokinetic profiles by SANTORA, Vincent J, COVEL, Jonathan A, EDWARDS, Jeffrey E, SUAREZ, Marissa, FRAZER, John, THOMSEN, William, HAUSER, Erin, LOREA, Jodie, GROTTICK, Andrew J, HAYASHI, Rena, HOFILENA, Brian J, IBARRA, Jason B, PULLEY, Michelle D, WEINHOUSE, Michael I, SEMPLE, Graeme, REN, Albert, PEREIRA, Guilherme

“…A new series of H(3) antagonists derived from the natural product Conessine are presented. Several compounds from these new series retain the potency and…”
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Asymmetric induction via a catalytic antibody by Ikeda, Shoji, Weinhouse, Michael I, Janda, Kim D, Lerner, Richard A, Danishefsky, Samuel J

“…Recently it was shown that racemic phosphonate haptens can induce catalytic antibodies with either R or S substrate specificity, thereby accomplishing kinetic…”
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Synthesis and biological activity of peptidyl aldehyde urokinase inhibitors by Tamura, S Y, Weinhouse, M I, Roberts, C A, Goldman, E A, Masukawa, K, Anderson, S M, Cohen, C R, Bradbury, A E, Bernardino, V T, Dixon, S A, Ma, M G, Nolan, T G, Brunck, T K

“…Solid- and solution-phase synthesis of peptidomimetic inhibitors of urokinase-type plasminogen activator based on the sequence dSerAlaArg-al are described. The…”
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Bait and switch strategy for obtaining catalytic antibodies with acyl-transfer capabilities by Janda, Kim D, Weinhouse, Michael I, Schloeder, Diane M, Lerner, Richard A, Benkovic, Stephen J

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Antibody bait and switch catalysis: a survey of antigens capable of inducing abzymes with acyl-transfer properties by Janda, Kim D, Weinhouse, Michael I, Danon, Tami, Pacelli, Karen A, Schloeder, Diane M

“…Antibodies have been shown to catalyze acyl-transfer reactions. Various antigens have been applied to these hydrolytic reactions, but typically all encompass…”
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Catalytic antibodies with acyl-transfer capabilities: mechanistic and kinetic investigations by Janda, Kim D, Ashley, Jon A, Jones, Teresa M, McLeod, Donald A, Schloeder, Diane M, Weinhouse, Michael I, Lerner, Richard A, Gibbs, Richard A, Benkovic, Patricia A

“…Antibodies have been shown to catalyze acyl-transfer reactions. The processes by which they perform such tasks have often been postulated but largely remain…”
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Metalloselective anti-porphyrin monoclonal antibodies by Schwabacher, Alan W, Weinhouse, Michael I, Auditor, Maria Teresa M, Lerner, Richard A

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A new family of H 3 receptor antagonists based on the natural product Conessine by Santora, Vincent J., Covel, Jonathan A., Hayashi, Rena, Hofilena, Brian J., Ibarra, Jason B., Pulley, Michelle D., Weinhouse, Michael I., Sengupta, Dipanjan, Duffield, Jonathan J., Semple, Graeme, Webb, Robert R., Sage, Carleton, Ren, Albert, Pereira, Guilherme, Knudsen, Jens, Edwards, Jeffrey E., Suarez, Marissa, Frazer, John, Thomsen, William, Hauser, Erin, Whelan, Kevin, Grottick, Andrew J.

“…A new family of Histamine H 3 receptor antagonists ( 5a– t) has been prepared based on the structure of the natural product Conessine, a known H 3 antagonist…”
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Design and Evaluation of Novel Biphenyl Sulfonamide Derivatives with Potent Histamine H 3 Receptor Inverse Agonist Activity by Covel, Jonathan A., Santora, Vincent J., Smith, Jeffrey M., Hayashi, Rena, Gallardo, Charlemagne, Weinhouse, Michael I., Ibarra, Jason B., Schultz, Jeffrey A., Park, Douglas M., Estrada, Scott A., Hofilena, Brian J., Pulley, Michelle D., Smith, Brian M., Ren, Albert, Suarez, Marissa, Frazer, John, Edwards, Jeffrey, Hauser, Erin K., Lorea, Jodie, Semple, Graeme, Grottick, Andrew J.

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Novel H 3 receptor antagonists with improved pharmacokinetic profiles by Santora, Vincent J., Covel, Jonathan A., Hayashi, Rena, Hofilena, Brian J., Ibarra, Jason B., Pulley, Michelle D., Weinhouse, Michael I., Semple, Graeme, Ren, Albert, Pereira, Guilherme, Edwards, Jeffrey E., Suarez, Marissa, Frazer, John, Thomsen, William, Hauser, Erin, Lorea, Jodie, Grottick, Andrew J.

“…A new series of H 3 antagonists derived from the natural product Conessine are presented. Several compounds from these new series retain the potency and…”
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Novel H sub(3) receptor antagonists with improved pharmacokinetic profiles by Santora, Vincent J, Covel, Jonathan A, Hayashi, Rena, Hofilena, Brian J, Ibarra, Jason B, Pulley, Michelle D, Weinhouse, Michael I, Semple, Graeme, Ren, Albert, Pereira, Guilherme, Edwards, Jeffrey E, Suarez, Marissa, Frazer, John, Thomsen, William, Hauser, Erin, Lorea, Jodie, Grottick, Andrew J

“…A new series of H sub(3) antagonists derived from the natural product Conessine are presented. Several compounds from these new series retain the potency and…”
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A new family of H sub(3) receptor antagonists based on the natural product Conessine by Santora, Vincent J, Covel, Jonathan A, Hayashi, Rena, Hofilena, Brian J, Ibarra, Jason B, Pulley, Michelle D, Weinhouse, Michael I, Sengupta, Dipanjan, Duffield, Jonathan J, Semple, Graeme, Webb, Robert R, Sage, Carleton, Ren, Albert, Pereira, Guilherme, Knudsen, Jens, Edwards, Jeffrey E, Suarez, Marissa, Frazer, John, Thomsen, William, Hauser, Erin, Whelan, Kevin, Grottick, Andrew J

“…A new family of Histamine H sub(3) receptor antagonists ( 5a- t) has been prepared based on the structure of the natural product Conessine, a known H sub(3)…”
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Antimalarial Activities of Novel SyntheticCysteine ProteaseInhibitors by Lee, Belinda J., Singh, Ajay, Chiang, Peggy, Kemp, Scott J., Goldman, Erick A., Weinhouse, Michael I., Vlasuk, George P., Rosenthal, Philip J.

“…ABSTRACT Among promising new targets for antimalarial chemotherapy are the cysteine protease hemoglobinases falcipain-2 and falcipain-3. We evaluated the…”
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Novel and general method for the preparation of peptidyl argininals by Tamura, Susan Y., Edward Semple, J., Ardecky, Robert J., Leon, Pamela, Carpenter, Steven H., Ge, Yu, Shamblin, Brian M., Weinhouse, Michael I., Ripka, William C., Nutt, Ruth F.

“…A general method for the synthesis of peptidyl argininals was developed which utilizes the novel building block N g-nitro-L-argininal ethyl aminal·HCl. The…”
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