Search Results - "WEINA, Peter J"

Topical paromomycin for New World cutaneous leishmaniasis by Sosa, Néstor, Pascale, Juan Miguel, Jiménez, Ana I, Norwood, Jeanne A, Kreishman-Detrick, Mara, Weina, Peter J, Lawrence, Kendra, McCarthy, William F, Adams, Ryan C, Scott, Charles, Ransom, Janet, Tang, Douglas, Grogl, Max

“…Paromomycin-based topical treatments were shown to be effective in curing cutaneous leishmaniasis (CL) lesions caused by Leishmania major in Tunisia. Cure…”
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Real World Impact of Remdesivir and Dexamethasone on Clinical Outcomes of Severe Coronavirus Disease 2019 in a Community Hospital by Larson, Derek T, Ewers, Evan C, Gallagher, Kia M, Mahoney, Alexandra M, Paul, Madison L, Weina, Peter J

“…ABSTRACT Background Evidence has emerged showing potential benefit of Remdesivir and dexamethasone in severe coronavirus disease 2019 (COVID-19) but results…”
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Severe embryotoxicity of artemisinin derivatives in experimental animals, but possibly safe in pregnant women by Li, Qigui, Weina, Peter J

“…Preclinical studies in rodents have demonstrated that artemisinins, especially injectable artesunate, can induce fetal death and congenital malformations at a…”
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Old World Leishmaniasis: An Emerging Infection among Deployed US Military and Civilian Workers by Weina, Peter J., Neafie, Ronald C., Wortmann, Glenn, Polhemus, Mark, Aronson, Naomi E., Strausbaugh, Larry J.

“…Many veterans of Operation Iraqi Freedom are now returning to the United States after potential exposure to leishmaniasis. In the past year, large numbers of…”
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Pre-clinical drug-drug interactions (DDIs) of gefitinib with/without losartan and selective serotonin reuptake inhibitors (SSRIs): citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, and venlafaxine by Luong, Thu-Lan T., Powers, Chelsea N., Reinhardt, Brian J., Weina, Peter J.

“…To evaluate drug-drug interactions (DDIs) between gefitinib with/without losartan and selective serotonin reuptake inhibitors (SSRIs). In vitro supersomes were…”
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Pre-clinical drug-drug interaction (DDI) of gefitinib or erlotinib with Cytochrome P450 (CYP) inhibiting drugs, fluoxetine and/or losartan by Luong, Thu-Lan T., McAnulty, Michael J., Evers, David L., Reinhardt, Brian J., Weina, Peter J.

“…[Display omitted] •In vitro drug-drug interactions (DDIs) can predict drug combination outcomes.•Cytochrome (CYP) P450 and hepatocytes are able to confirm…”
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Pharmacokinetic profiles of artesunate following multiple intravenous doses of 2, 4, and 8 mg/kg in healthy volunteers: phase 1b study by Miller, Robert Scott, Li, Qigui, Cantilena, Louis R, Leary, Kevin J, Saviolakis, George A, Melendez, Victor, Smith, Bryan, Weina, Peter J

“…Severe malaria results in over a million deaths every year, most of them in children aged less than five years and living in sub-Saharan Africa. Injectable…”
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United States military tropical medicine: extraordinary legacy, uncertain future by Beaumier, Coreen M, Gomez-Rubio, Ana Maria, Hotez, Peter J, Weina, Peter J

“…Throughout the 20th century and into this new millennium, American troops in combat have been devastated by tropical infections. In response, the United States…”
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Pharmacokinetics, tissue distribution and mass balance of radiolabeled dihydroartemisinin in male rats by Xie, Lisa H, Li, Qigui, Zhang, Jing, Weina, Peter J

“…Dihydroartemisinin (DHA), a powerful anti-malarial drug, has been used as monotherapy and artemisinin-based combination therapy (ACT) for more than decades. So…”
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A simplified liquid chromatography-mass spectrometry assay for artesunate and dihydroartemisinin, its metabolite, in human plasma by Teja-Isavadharm, Paktiya, Siriyanonda, Duangsuda, Siripokasupkul, Raveewan, Apinan, Roongnapa, Chanarat, Nitima, Lim, Apassorn, Wannaying, Srisombat, Saunders, David, Fukuda, Mark M, Miller, Robert S, Weina, Peter J, Meléndez, Victor

“…Artesunate (AS) is a potent antimalarial that is used worldwide for the treatment of malaria. A simple method with a total run time of 12 min was developed and…”
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Clinical Outcomes of Coronavirus Disease 2019 With Evidence-based Supportive Care by Larson, Derek T, Sherner, John H, Gallagher, Kia M, Judy, Cynthia L, Paul, Madison B, Mahoney, Alexandra M, Weina, Peter J

“…Abstract Calls for adherence to evidence-based medicine have emerged during the initial wave of the COVID-19 pandemic but reports of outcomes are lacking. This…”
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Military Medicine Regulatory "Delays" ... Not as Bad as Advertised by Weina, Peter J.

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A simple empirical algorithm to distinguish among Leishmania braziliensis, major, and tropica species by MALDI-TOF mass spectrometry by Evers, David L., Frye, Franz A., Weina, Peter J.

“…This work developed a simple empirical algorithm to distinguish three Leishmania species using MALDI-TOF mass spectrometry. It suggests that complicated…”
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Toxicokinetics and Hydrolysis of Artelinate and Artesunate in Malaria-Infected Rats by Li, Qigui, Xie, Lisa H., Si, Yuanzheng, Wong, Elaine, Upadhyay, Ravi, Yanez, Danielle, Weina, Peter J.

“…Comparative toxicokinetic (TK) and hydrolysis studies of intravenously administered two new antimalarial agents, artelinate (AL) and artesunate (AS), were…”
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Fatal neurotoxicity of arteether and artemether by Brewer, T G, Grate, S J, Peggins, J O, Weina, P J, Petras, J M, Levine, B S, Heiffer, M H, Schuster, B G

“…Artemisinin (qinghaosu) and several derivatives have been developed and are in use as antimalarial drugs but scant information is available regarding animal or…”
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Letter to the editor regarding the article "The use of Psychiatric Electroencephalography Evaluations Registry (PEER) to personalize pharmacotherapy" by Weina, Peter J, Brooks, Sanjur

“…Peter J Weina,1 Sanjur Brooks2 1Department of Research Programs, Infectious Diseases Physician, WRNMMC and FBCH, Medicine and Preventive Medicine, USUHS,…”
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Significance of infectious agents in colorectal cancer development by Antonic, Vlado, Stojadinovic, Alexander, Kester, Kent E, Weina, Peter J, Brücher, Björn Ldm, Protic, Mladjan, Avital, Itzhak, Izadjoo, Mina

“…Colorectal cancer (CRC) is a major burden to healthcare systems worldwide accounting for approximately one million of new cancer cases worldwide. Even though,…”
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Texting away malaria: a new alternative to directly observed therapy by Scott, William, Weina, Peter J

“…Operation Onward Liberty is the current U.S. military mentorship program working with the Armed Forces of Liberia, training their national army. Throughout…”
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The Botanical Solution for Malaria by Milhous, Wilbur K., Weina, Peter J.

“…Improved breeding of a plant that produces a major antimalarial compound is now possible based on knowledge of its genetic map. For thousands of years, Chinese…”
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Comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated Plasmodium coatneyi-infected rhesus monkey model by Teja-Isavadharm, Paktiya, Siriyanonda, Duangsuda, Rasameesoraj, Maneerat, Limsalakpeth, Amporn, Chanarat, Nitima, Komcharoen, Natthasorn, Weina, Peter J, Saunders, David L, Gettayacamin, Montip, Scott Miller, R

“…The US Army designed artelinate/lysine salt (AL) to overcome the instability of sodium artesunate in aqueous solution (AS). To select the most efficacious…”
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