Search Results - "WEIL, Dominique"

P-Bodies: Cytosolic Droplets for Coordinated mRNA Storage by Standart, Nancy, Weil, Dominique

“…P-bodies (PBs) are cytosolic RNP granules that are conserved among eukaryotic organisms. In the past few years, major progress has been made in understanding…”
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P-Body Purification Reveals the Condensation of Repressed mRNA Regulons by Hubstenberger, Arnaud, Courel, Maïté, Bénard, Marianne, Souquere, Sylvie, Ernoult-Lange, Michèle, Chouaib, Racha, Yi, Zhou, Morlot, Jean-Baptiste, Munier, Annie, Fradet, Magali, Daunesse, Maëlle, Bertrand, Edouard, Pierron, Gérard, Mozziconacci, Julien, Kress, Michel, Weil, Dominique

“…Within cells, soluble RNPs can switch states to coassemble and condense into liquid or solid bodies. Although these phase transitions have been reconstituted…”
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RNA is a critical element for the sizing and the composition of phase-separated RNA–protein condensates by Garcia-Jove Navarro, Marina, Kashida, Shunnichi, Chouaib, Racha, Souquere, Sylvie, Pierron, Gérard, Weil, Dominique, Gueroui, Zoher

“…Liquid–liquid phase separation is thought to be a key organizing principle in eukaryotic cells to generate highly concentrated dynamic assemblies, such as the…”
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P-body assembly requires DDX6 repression complexes rather than decay or Ataxin2/2L complexes by Ayache, Jessica, Bénard, Marianne, Ernoult-Lange, Michèle, Minshall, Nicola, Standart, Nancy, Kress, Michel, Weil, Dominique

“…P-bodies are cytoplasmic ribonucleoprotein granules involved in posttranscriptional regulation. DDX6 is a key component of their assembly in human cells. This…”
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Translationally repressed mRNA transiently cycles through stress granules during stress by Mollet, Stephanie, Cougot, Nicolas, Wilczynska, Ania, Dautry, François, Kress, Michel, Bertrand, Edouard, Weil, Dominique

“…In mammals, repression of translation during stress is associated with the assembly of stress granules in the cytoplasm, which contain a fraction of arrested…”
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The DDX6-4E-T interaction mediates translational repression and P-body assembly by Kamenska, Anastasiia, Simpson, Clare, Vindry, Caroline, Broomhead, Helen, Bénard, Marianne, Ernoult-Lange, Michèle, Lee, Benjamin P, Harries, Lorna W, Weil, Dominique, Standart, Nancy

“…4E-Transporter binds eIF4E via its consensus sequence YXXXXLΦ, shared with eIF4G, and is a nucleocytoplasmic shuttling protein found enriched in P-(rocessing)…”
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GC content shapes mRNA storage and decay in human cells by Courel, Maïté, Clément, Yves, Bossevain, Clémentine, Foretek, Dominika, Vidal Cruchez, Olivia, Yi, Zhou, Bénard, Marianne, Benassy, Marie-Noëlle, Kress, Michel, Vindry, Caroline, Ernoult-Lange, Michèle, Antoniewski, Christophe, Morillon, Antonin, Brest, Patrick, Hubstenberger, Arnaud, Roest Crollius, Hugues, Standart, Nancy, Weil, Dominique

“…mRNA translation and decay appear often intimately linked although the rules of this interplay are poorly understood. In this study, we combined our recent…”
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Rare De Novo Missense Variants in RNA Helicase DDX6 Cause Intellectual Disability and Dysmorphic Features and Lead to P-Body Defects and RNA Dysregulation by Balak, Chris, Benard, Marianne, Schaefer, Elise, Iqbal, Sumaiya, Ramsey, Keri, Ernoult-Lange, Michèle, Mattioli, Francesca, Llaci, Lorida, Geoffroy, Véronique, Courel, Maité, Naymik, Marcus, Bachman, Kristine K., Pfundt, Rolph, Rump, Patrick, ter Beest, Johanna, Wentzensen, Ingrid M., Monaghan, Kristin G., McWalter, Kirsty, Richholt, Ryan, Le Béchec, Antony, Jepsen, Wayne, De Both, Matt, Belnap, Newell, Boland, Anne, Piras, Ignazio S., Deleuze, Jean-François, Szelinger, Szabolcs, Dollfus, Hélène, Chelly, Jamel, Muller, Jean, Campbell, Arthur, Lal, Dennis, Rangasamy, Sampathkumar, Mandel, Jean-Louis, Narayanan, Vinodh, Huentelman, Matt, Weil, Dominique, Piton, Amélie

“…The human RNA helicase DDX6 is an essential component of membrane-less organelles called processing bodies (PBs). PBs are involved in mRNA metabolic processes…”
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CPEB Interacts with an Ovary-specific eIF4E and 4E-T in Early Xenopus Oocytes by Minshall, Nicola, Reiter, Marie Helene, Weil, Dominique, Standart, Nancy

“…CPEB (cytoplasmic polyadenylation element-binding protein) is an important regulator of translation in oocytes and neurons. Although previous studies of CPEB…”
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Localization of Usher 1 proteins to the photoreceptor calyceal processes, which are absent from mice by Sahly, Iman, Dufour, Eric, Schietroma, Cataldo, Michel, Vincent, Bahloul, Amel, Perfettini, Isabelle, Pepermans, Elise, Estivalet, Amrit, Carette, Diane, Aghaie, Asadollah, Ebermann, Inga, Lelli, Andrea, Iribarne, Maria, Hardelin, Jean-Pierre, Weil, Dominique, Sahel, José-Alain, El-Amraoui, Aziz, Petit, Christine

“…The mechanisms underlying retinal dystrophy in Usher syndrome type I (USH1) remain unknown because mutant mice lacking any of the USH1 proteins-myosin VIIa,…”
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Multiple binding of repressed mRNAs by the P-body protein Rck/p54 by Ernoult-Lange, Michèle, Baconnais, Sonia, Harper, Maryannick, Minshall, Nicola, Souquere, Sylvie, Boudier, Thomas, Bénard, Marianne, Andrey, Philippe, Pierron, Gérard, Kress, Michel, Standart, Nancy, le Cam, Eric, Weil, Dominique

“…Translational repression is achieved by protein complexes that typically bind 3' UTR mRNA motifs and interfere with the formation of the cap-dependent…”
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Role of p54 RNA helicase activity and its C-terminal domain in translational repression, P-body localization and assembly by Minshall, Nicola, Kress, Michel, Weil, Dominique, Standart, Nancy

“…The RNA helicase p54 (DDX6, Dhh1, Me31B, Cgh-1, RCK) is a prototypic component of P-(rocessing) bodies in cells ranging from yeast to human. Previously, we…”
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Cytoplasmic organelles on the road to mRNA decay by Weil, Dominique, Hollien, Julie

“…Localization of both mRNAs and mRNA decay factors to internal membranes of eukaryotic cells provides a means of coordinately regulating mRNAs with common…”
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Defect in the gene encoding the EAR/EPTP domain-containing protein TSPEAR causes DFNB98 profound deafness by DELMAGHANI, Sedigheh, AGHAIE, Asadollah, MICHALSKI, Nicolas, BONNET, Crystel, WEIL, Dominique, PETIT, Christine

“…We report a consanguineous Iranian family affected by congenital profound sensorineural deafness segregating in an autosomal recessive mode. Auditory tests…”
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RNA-related nuclear functions of human Pat1b, the P-body mRNA decay factor by Marnef, Aline, Weil, Dominique, Standart, Nancy

“…The evolutionarily conserved Pat1 proteins are P-body components recently shown to play important roles in cytoplasmic gene expression control. Using human…”
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A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth by Lefèvre, Gaelle, Michel, Vincent, Weil, Dominique, Lepelletier, Léa, Bizard, Emilie, Wolfrum, Uwe, Hardelin, Jean-Pierre, Petit, Christine

“…The planar polarity and staircase-like pattern of the hair bundle are essential to the mechanoelectrical transduction function of inner ear sensory cells…”
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Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane by Verpy, Elisabeth, Leibovici, Michel, Michalski, Nicolas, Goodyear, Richard J., Houdon, Carine, Weil, Dominique, Richardson, Guy P., Petit, Christine

“…Stereocilin is defective in a recessive form of deafness, DFNB16. We studied the distribution of stereocilin in the developing and mature mouse inner ear and…”
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Dual RNA Processing Roles of Pat1b via Cytoplasmic Lsm1-7 and Nuclear Lsm2-8 Complexes by Vindry, Caroline, Marnef, Aline, Broomhead, Helen, Twyffels, Laure, Ozgur, Sevim, Stoecklin, Georg, Llorian, Miriam, Smith, Christopher W., Mata, Juan, Weil, Dominique, Standart, Nancy

“…Pat1 RNA-binding proteins, enriched in processing bodies (P bodies), are key players in cytoplasmic 5′ to 3′ mRNA decay, activating decapping of mRNA in…”
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Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia by Caberlotto, Elisa, Michel, Vincent, Foucher, Isabelle, Bahloul, Amel, Goodyear, Richard J, Pepermans, Elise, Michalski, Nicolas, Perfettini, Isabelle, Alegria-Prévot, Olinda, Chardenoux, Sébastien, Do Cruzeiro, Marcio, Hardelin, Jean-Pierre, Richardson, Guy P, Avan, Paul, Weil, Dominique, Petit, Christine

“…The mechanotransducer channels of auditory hair cells are gated by tip-links, oblique filaments that interconnect the stereocilia of the hair bundle. Tip-links…”
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Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy by Lathrop, Mark, Van Camp, Guy, Michel, Vincent, del Castillo, Francisco J, Leibovici, Michel, Delmaghani, Sedigheh, Ron, Uri, Petit, Christine, Langa, Francina, Weil, Dominique, Ben-Tal, Nir, Aghaie, Asadollah, Van Laer, Lut, Avan, Paul

“…Auditory neuropathy is a particular type of hearing impairment in which neural transmission of the auditory signal is impaired, while cochlear outer hair cells…”
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