Young Malaysian children with lower respiratory tract infections show low incidence of chlamydial infection

Objective: The incidence of Chlamydia pneumoniae and Chlamydia trachomatis infection was studied among infants and young children admitted to hospital for the management of lower respiratory tract infections, over a 12 month period. Methodology: Respiratory secretions were examined for chlamydiae by...

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Bibliographic Details
Published in:	Journal of paediatrics and child health Vol. 33; no. 5; pp. 422 - 425
Main Authors:	NGEOW, YF, WEIL, AF, KHAIRULLAH, NS, YUSOF, MY MOHD, LUAM, L, GAYDOS, C, QUINN, TC
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-10-1997 Blackwell
Subjects:	Bacterial diseases Bacterial diseases of the respiratory system Biological and medical sciences Child, Preschool children chlamydia Chlamydia Infections - epidemiology Chlamydia trachomatis Chlamydia trachomatis - isolation & purification Chlamydophila pneumoniae - isolation & purification Community-Acquired Infections - epidemiology Community-Acquired Infections - microbiology Community-Acquired Infections - virology Enzyme-Linked Immunosorbent Assay Human bacterial diseases Humans Incidence Infant Infants Infectious diseases Malaysia Medical sciences Polymerase Chain Reaction Population Relationship Respiratory diseases respiratory infection Respiratory Tract Infections - microbiology Respiratory Tract Infections - virology Asia Malaysia Human Preschool age Lung disease Respiratory disease Infant Haemophilus influenzae Infection Pasteurellaceae Etiology Streptococcal infection Viral disease Bacteriosis Bacteria Chlamydiosis Child Pneumococcal infection Pneumopathy Measurement Age Factors Respiratory Infections Infections Malaysia Laboratory Procedures Research Methodology Incidence Chlamydia Population Characteristics Reproductive Tract Infections Population Research Report Retrospective Studies Demographic Factors Laboratory Examinations And Diagnoses Youth Examinations And Diagnoses Diseases Studies Sexually Transmitted Diseases Asia Southeastern Asia Developing Countries
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Summary:	Objective: The incidence of Chlamydia pneumoniae and Chlamydia trachomatis infection was studied among infants and young children admitted to hospital for the management of lower respiratory tract infections, over a 12 month period. Methodology: Respiratory secretions were examined for chlamydiae by cell culture, enzyme‐linked immunosorbent assay and polymerase chain reaction‐enzyme immunoassay. Sera were tested by micro‐immunofluorescence for chlamydial IgG, IgM and IgA. Other bacterial and viral pathogens were also looked for by standard cultural and serological methods. Results: Of 87 patients aged 2 months‐3 years, an aetiologic diagnosis was made in 41 (47.1%). C. pneumoniae and C. trachomatis were each detected in 1 (1.2%) of the patients. Among common bacterial pathogens, Haemophilus influenzae (13.8%) and Streptococcus pneumoniae (8.1%) were the most frequently identified. Respiratory viruses and elevated Mycoplasma pneumoniae antibodies were found in 10.3% and 9.1% of patients, respectively. Conclusion: Chlamydiae are infrequent causes of community‐acquired acute lower respiratory tract infections in infants and very young children in Malaysia.
Bibliography:	ark:/67375/WNG-021BV7DK-5 ArticleID:JPC422 istex:25A58FF3CF2F567127106A1F5B78813C84E312F9 YF Ngeow, FRCPath, Professor of Medical Microbiology. AF Weil, MSc, Research Assistant. NS Khairullah, MRCPath, Virologist. MY Mohd Yusof, MBBS, MSc, Microbiologist. L Lum, MRCP, Paediatrician. C Gaydos, DrPH, Assistant Professor. TC Quinn, MD, Professor of Medicine. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1034-4810 1440-1754
DOI:	10.1111/j.1440-1754.1997.tb01633.x