Search Results - "WEIJER, Charles"

Response to Merz by Al, Pepijn, Brehaut, Jamie, Weijer, Charles

“…Jon Merz raises two objections to our article on the ethics of behavioral influences in trial recruitment. In this response, we defend our article against…”
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Heterogeneity in pragmatic randomised trials: sources and management by Giraudeau, Bruno, Caille, Agnès, Eldridge, Sandra M, Weijer, Charles, Zwarenstein, Merrick, Taljaard, Monica

“…Pragmatic trials aim to generate evidence to directly inform patient, caregiver and health-system manager policies and decisions. Heterogeneity in patient…”
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Uses of equipoise in discussions of the ethics of randomized controlled trials of COVID-19 therapies by Nix, Hayden P, Weijer, Charles

“…Early in the COVID-19 pandemic, the urgent need to discover effective therapies for COVID-19 prompted questions about the ethical problem of randomization…”
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The Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials by Weijer, Charles, Grimshaw, Jeremy M, Eccles, Martin P, McRae, Andrew D, White, Angela, Brehaut, Jamie C, Taljaard, Monica

“…[...]of the unique design of CRTs, the interpretation of existing research ethics guidelines is complicated. * The Ottawa Statement on the Ethical Design and…”
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A Scoping Review of Empirical Research Relating to Quality and Effectiveness of Research Ethics Review by Nicholls, Stuart G, Hayes, Tavis P, Brehaut, Jamie C, McDonald, Michael, Weijer, Charles, Saginur, Raphael, Fergusson, Dean

“…To date there is no established consensus of assessment criteria for evaluating research ethics review. We conducted a scoping review of empirical research…”
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Changing patient preferences toward better trial recruitment: an ethical analysis by Al, Pepijn, Hey, Spencer, Weijer, Charles, Gillies, Katie, McCleary, Nicola, Yee, Mei-Lin, Inglis, Juliette, Presseau, Justin, Brehaut, Jamie

“…While randomized controlled trials are essential to health research, many of these trials fail to recruit enough participants. Approaching recruitment through…”
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Risk, diagnostic error, and the clinical science of consciousness by Peterson, Andrew, Cruse, Damian, Naci, Lorina, Weijer, Charles, Owen, Adrian M

“…In recent years, a number of new neuroimaging techniques have detected covert awareness in some patients previously thought to be in a vegetative…”
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Reporting of and explanations for under-recruitment and over-recruitment in pragmatic trials: a secondary analysis of a database of primary trial reports published from 2014 to 2019 by Nevins, Pascale, Nicholls, Stuart G, Ouyang, Yongdong, Carroll, Kelly, Hemming, Karla, Weijer, Charles, Taljaard, Monica

“…To describe the extent to which pragmatic trials underachieved or overachieved their target sample sizes, examine explanations and identify characteristics…”
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COVID-19 human challenge trials and randomized controlled trials: lessons for the next pandemic by Weijer, Charles

“…The COVID-19 pandemic touched off an unprecedented search for vaccines and treatments. Without question, the development of vaccines to prevent COVID-19 was an…”
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Ethical issues in the design and conduct of stepped-wedge cluster randomized trials in low-resource settings by Joag, Kaustubh, Ambrosio, Guillermo, Kestler, Edgar, Weijer, Charles, Hemming, Karla, Van der Graaf, Rieke

“…Stepped-wedge cluster randomized trials (SW-CRTs) are increasingly popular in health-related research in both high- and low-resource settings. There may be…”
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How can behavioural science help us design better trials? by Gillies, Katie, Brehaut, Jamie, Coffey, Taylor, Duncan, Eilidh M, Francis, Jill J, Hey, Spencer P, Presseau, Justin, Weijer, Charles, Campbell, Marion K

“…[...]failure to recognise the behavioural influences (and change them where appropriate) could contribute to the failure of the trial. [...]insofar as…”
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Caregiver reactions to neuroimaging evidence of covert consciousness in patients with severe brain injury: a qualitative interview study by Peterson, Andrew, Webster, Fiona, Gonzalez-Lara, Laura Elizabeth, Munce, Sarah, Owen, Adrian M, Weijer, Charles

“…Severe brain injury is a leading cause of death and disability. Diagnosis and prognostication are difficult, and errors occur often. Novel neuroimaging methods…”
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Ethical issues in pragmatic randomized controlled trials: a review of the recent literature identifies gaps in ethical argumentation by Goldstein, Cory E, Weijer, Charles, Brehaut, Jamie C, Fergusson, Dean A, Grimshaw, Jeremy M, Horn, Austin R, Taljaard, Monica

“…Pragmatic randomized controlled trials (RCTs) are designed to evaluate the effectiveness of interventions in real-world clinical conditions. However, these…”
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Systematic scoping review of cluster randomised trials conducted exclusively in low-income and middle-income countries between 2017 and 2022 by Goldstein, Cory E, Marouf, Yacine, Johri, Mira, Shaw, Julia F, Sergeant, Anand, Nicholls, Stuart G, Althabe, Fernando, Ferrand, Rashida A, van der Graaf, Rieke, Hemming, Karla, Mbuagbaw, Lawrence, Treweek, Shaun, Welch, Vivian A, Weijer, Charles, Taljaard, Monica

“…ObjectiveCluster randomised trials (CRTs) are used for evaluating health-related interventions in low-income and middle-income countries (LMICs) but raise…”
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The ethical challenges raised in the design and conduct of pragmatic trials: an interview study with key stakeholders by Nicholls, Stuart G, Carroll, Kelly, Zwarenstein, Merrick, Brehaut, Jamie C, Weijer, Charles, Hey, Spencer P, Goldstein, Cory E, Graham, Ian D, Grimshaw, Jeremy M, McKenzie, Joanne E, Fergusson, Dean A, Taljaard, Monica

“…There is a concern that the apparent effectiveness of interventions tested in clinical trials may not be an accurate reflection of their actual effectiveness…”
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Placebo comparator group selection and use in surgical trials: the ASPIRE project including expert workshop by Beard, David J, Campbell, Marion K, Blazeby, Jane M, Carr, Andrew J, Weijer, Charles, Cuthbertson, Brian H, Buchbinder, Rachelle, Pinkney, Thomas, Bishop, Felicity L, Pugh, Jonathan, Cousins, Sian, Harris, Ian, Lohmander, L Stefan, Blencowe, Natalie, Gillies, Katie, Probst, Pascal, Brennan, Carol, Cook, Andrew, Farrar-Hockley, Dair, Savulescu, Julian, Huxtable, Richard, Rangan, Amar, Tracey, Irene, Brocklehurst, Peter, Ferreira, Manuela L, Nicholl, Jon, Reeves, Barnaby C, Hamdy, Freddie, Rowley, Samuel Cs, Lee, Naomi, Cook, Jonathan A

“…The use of placebo comparisons for randomised trials assessing the efficacy of surgical interventions is increasingly being considered. However, a placebo…”
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Protocol for a qualitative pilot study to explore ethical issues and stakeholder trust in the use of normothermic regional perfusion in organ donation in Canada by Murphy, Nicholas, Lingard, Lorelei, Blackstock, Laurie, Ott, Mary, Slessarev, Marat, Basmaji, John, Brahmania, Mayur, Healey, Andrew, Shemie, Sam, Skaro, Anton, Wilson, Lindsay, Weijer, Charles

“…IntroductionThe process of controlled organ donation after circulatory determination of death (cDCDD) results in ischaemic injury to organs and leads to poorer…”
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Ethical issues in cluster randomized trials conducted in low- and middle-income countries: an analysis of two case studies by Choko, Augustine T, Roshandel, Gholamreza, Conserve, Donaldson F, Corbett, Elizabeth L, Fielding, Katherine, Hemming, Karla, Malekzadeh, Reza, Weijer, Charles

“…Cluster randomized trials are common in health research in low- and middle-income countries raising issues that challenge interpretation of standard ethical…”
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Neurologic Physiology after Removal of Therapy (NeuPaRT) study: study protocol of a multicentre, prospective, observational, pilot feasibility study of neurophysiology after withdrawal of life-sustaining measures by Gofton, Teneille, Dhanani, Sonny, Meade, Maureen, Boyd, John Gordon, Chamberlain, Erika, Chandler, Jennifer, Chassé, Michaël, Scales, Nathan B, Choi, Yun-Hee, D'Aragon, Frédérick, Debicki, Derek, English, Shane, Fantaneanu, Tadeu A, Kramer, Andreas H, Kromm, Julie, Murphy, Nicholas, Norton, Loretta, Singh, Jeffrey, Smith, Maxwell J, Weijer, Charles, Shemie, Sam, Bentall, Tracey C, Campbell, Eileen, Slessarev, Marat

“…IntroductionIn donation after circulatory determination of death, death is declared 5 min after circulatory arrest. This practice assumes, but does not…”
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FLUID trial: a hospital-wide open-label cluster cross-over pragmatic comparative effectiveness randomised pilot trial comparing normal saline to Ringer’s lactate by McIntyre, Lauralyn Ann, Fergusson, Dean A, McArdle, Tracy, Fox-Robichaud, Alison, English, Shane W, Martin, Claudio, Marshall, John, Cook, Deborah J, Graham, Ian D, Hawken, Steven, McCartney, Colin, Menon, Kusum, Saginur, Raphael, Seely, Andrew, Stiell, Ian, Thavorn, Kednapa, Weijer, Charles, Iyengar, Akshai, Muscedere, John, Forster, Alan J, Taljaard, Monica

“…ObjectivesNormal saline (NS) and Ringer’s lactate (RL) are the most common crystalloids used for fluid therapy. Despite evidence of possible harm associated…”
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