Search Results - "WEIG, B"

SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors by Fawzi, A B, Macdonald, D, Benbow, L L, Smith-Torhan, A, Zhang, H, Weig, B C, Ho, G, Tulshian, D, Linder, M E, Graziano, M P

“…A novel thiadiazole compound, SCH-202676 (N-(2,3-diphenyl-1,2, 4-thiadiazol-5-(2H)-ylidene)methanamine), has been identified as an inhibitor of both agonist…”
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Binding of leptin to the soluble ectodomain of recombinant leptin receptor: a kinetic analysis by surface plasmon resonance by Rock, F L, Peterson, D, Weig, B C, Kastelein, R A, Bazan, J F

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Discovery of Orally Efficacious Melanin-Concentrating Hormone Receptor-1 Antagonists as Antiobesity Agents. Synthesis, SAR, and Biological Evaluation of Bicyclo[3.1.0]hexyl Ureas by McBriar, Mark D, Guzik, Henry, Shapiro, Sherry, Paruchova, Jaroslava, Xu, Ruo, Palani, Anandan, Clader, John W, Cox, Kathleen, Greenlee, William J, Hawes, Brian E, Kowalski, Timothy J, O'Neill, Kim, Spar, Brian D, Weig, Blair, Weston, Daniel J, Farley, Constance, Cook, John

“…Melanin-concentrating hormone (MCH) is a cyclic, nonadecapeptide expressed in the CNS of all vertebrates that regulates feeding behavior and energy homeostasis…”
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Discovery of Bicycloalkyl Urea Melanin Concentrating Hormone Receptor Antagonists:  Orally Efficacious Antiobesity Therapeutics by McBriar, Mark D, Guzik, Henry, Xu, Ruo, Paruchova, Jaroslava, Li, Shengjian, Palani, Anandan, Clader, John W, Greenlee, William J, Hawes, Brian E, Kowalski, Timothy J, O'Neill, Kim, Spar, Brian, Weig, Blair

“…Melanin concentrating hormone (MCH) is involved in regulation of food intake and energy homeostasis. Antagonists of the MCH receptor are expected to affect…”
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Biaryl Ureas as Potent and Orally Efficacious Melanin Concentrating Hormone Receptor 1 Antagonists for the Treatment of Obesity by Palani, Anandan, Shapiro, Sherry, McBriar, Mark D, Clader, John W, Greenlee, William J, Spar, Brian, Kowalski, Timothy J, Farley, Constance, Cook, John, van Heek, Margaret, Weig, Blair, O'Neill, Kim, Graziano, Michael, Hawes, Brian

“…Herein, we report a small molecule MCH-R1 antagonist which demonstrates oral efficacy in chronic rodent models. Substituted phenyl biaryl urea derivatives were…”
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Identification and Pharmacological Characterization of a Novel Human Melanin-concentrating Hormone Receptor, MCH-R2 by Wang, Suke, Behan, Jiang, O'Neill, Kim, Weig, Blair, Fried, Steven, Laz, Thomas, Bayne, Marvin, Gustafson, Eric, Hawes, Brian E.

“…Melanin-concentrating hormone (MCH) is a neuropeptide highly expressed in the brain that regulates several physiological functions mediated by receptors in the…”
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Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice by Kowalski, Timothy J., Spar, Brian D., Weig, Blair, Farley, Constance, Cook, John, Ghibaudi, Lorraine, Fried, Steve, O'Neill, Kim, Del Vecchio, Robert A., McBriar, Mark, Guzik, Henry, Clader, John, Hawes, Brian E., Hwa, Joyce

“…Melanin concentrating hormone (MCH) is a cyclic neuropeptide expressed in the lateral hypothalamus that plays an important role in energy homeostasis. To…”
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Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists by Xu, Ruo, Li, Shengjian, Paruchova, Jaroslava, McBriar, Mark D., Guzik, Henry, Palani, Anandan, Clader, John W., Cox, Kathleen, Greenlee, William J., Hawes, Brian E., Kowalski, Timothy J., O’Neill, Kim, Spar, Brian D., Weig, Blair, Weston, Daniel J.

“…Bicyclic[4.1.0]heptanes were discovered as replacements for the middle phenyl ring of the biphenylamine moiety in order to eliminate its potential mutagenic…”
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Fossil Soft-Shelled Turtles (Family Trionychidae) of the Lake Turkana Basin, Africa by Meylan, Peter A., Weig, Blair S., Wood, Roger C.

“…Fossil soft-shelled turtles (family Trionychidae) are described from three localities in the Lake Turkana Basin, Kenya. Data on trionychid specimens from these…”
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Nociceptin activation of the human ORL1 receptor expressed in Chinese hamster ovary cells : Functional homology with opioid receptors by FAWZI, A. B, ZHANG, H, WEIG, B, HAWES, B, GRAZIANO, M. P

“…Opioid receptor-like 1 (ORL1) receptor, a member of the superfamily of G-protein-coupled receptors has significant primary sequence homology to the mu-, delta-…”
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Nociceptin (ORL-1) and mu -opioid receptors mediate mitogen-activated protein kinase activation in CHO cells through a G sub(i)-coupled signaling pathway: Evidence for distinct mechanisms of agonist-mediated desensitization by Hawes, B E, Fried, S, Yao, Xiaorui, Weig, B, Graziano, M P

“…The recently identified 17-amino acid peptide nociceptin (orphanin FQ) is the endogenous ligand for the opioid receptor-like-1 (ORL-1) receptor. A physiologic…”
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Nociceptin (ORL‐1) and μ‐Opioid Receptors Mediate Mitogen‐Activated Protein Kinase Activation in CHO Cells Through a Gi‐Coupled Signaling Pathway: Evidence for Distinct Mechanisms of Agonist‐Mediated Desensitization by Hawes, Brian E., Fried, Steven, Yao, Xiaorui, Weig, Blair, Graziano, Michael P.

“…: The recently identified 17‐amino acid peptide nociceptin (orphanin FQ) is the endogenous ligand for the opioid receptor‐like‐1 (ORL‐1) receptor. A…”
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Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461 by Salisbury, Brian G, Davis, Harry R, Burrier, Robert E, Burnett, Duane A, Boykow, George, Caplen, Mary Ann, Clemmons, Anthony L, Compton, Douglas S, Hoos, Lizbeth M, McGregor, Daniel G, Schnitzer-Polokoff, Robin, Smith, April A, Weig, Blair C, Zilli, Deborah L, Clader, John W, Sybertz, Edmund J

“…The amount of cholesterol that circulates in the plasma as lipoproteins can be affected by the balance of cholesterol metabolism within and between the…”
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