Search Results - "WEIDONG LE"

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases by Tang, Yu, Le, Weidong

“…One of the most striking hallmarks shared by various neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease (AD), and amyotrophic…”
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Recent advances and perspectives of metabolomics-based investigations in Parkinson's disease by Shao, Yaping, Le, Weidong

“…Parkinson's disease (PD) is the second most prevalent neurodegenerative disease of the central nervous system (CNS), which affects mostly older adults. In…”
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Autophagy in neurodegenerative diseases: pathogenesis and therapy by Guo, Fang, Liu, Xinyao, Cai, Huaibin, Le, Weidong

“…The most prevalent pathological features of many neurodegenerative diseases are the aggregation of misfolded proteins and the loss of certain neuronal…”
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Genetics of amyotrophic lateral sclerosis: an update by Chen, Sheng, Sayana, Pavani, Zhang, Xiaojie, Le, Weidong

“…Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving both upper motor neurons (UMN) and lower motor neurons (LMN)…”
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Role of iron in UPS impairment model of Parkinson's disease by Le, Weidong

“…Summary Iron homeostasis requires the regulation of iron influx, iron efflux and iron storage, which are all essential to the execution of the multiple…”
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Pathological role of hypoxia in Alzheimer's disease by Zhang, Xin, Le, Weidong

“…The majority cases of Alzheimer's disease (AD) are sporadic late-onset form not being linked to APP and PS1 gene mutations. It is believed that the…”
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Editorial: Viral infection and brain diseases by Li, Song, Le, Weidong

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Role of autophagy in the pathogenesis of multiple sclerosis by Liang, Peizhou, Le, Weidong

“…Autophagy plays an important role in maintaining the cellular homeostasis. One of its functions is to degrade unnecessary organelles and proteins for energy…”
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Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms by Wei, Min, Li, Song, Le, Weidong

“…Stem cells are unspecialized cells that have the potential for self-renewal and differentiation into more specialized cell types. The chemical and physical…”
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Neurogranin: A Potential Biomarker of Neurological and Mental Diseases by Xiang, Yang, Xin, Jiayan, Le, Weidong, Yang, Yongjian

“…Neurogranin (Ng) is a small protein usually expressed in granule-like structures in pyramidal cells of the hippocampus and cortex. However, its clinical value…”
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Molecular network of neuronal autophagy in the pathophysiology and treatment of depression by Jia, Jack, Le, Weidong

“…Major depressive disorder （MDD） is a complicated multifactorial induced disease, characterized by depressed mood, anhedonia, fatigue, and altered cognitive…”
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MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis by Zhang, Xiaojie, Chen, Sheng, Song, Lin, Tang, Yu, Shen, Yufei, Jia, Li, Le, Weidong

“…Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder caused by selective motor neuron degeneration. Abnormal protein aggregation and…”
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Modeling neurodegenerative diseases in Caenorhabditis elegans by Li, Jia, Le, Weidong

“…Neurodegenerative diseases which include Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington disease (HD), and…”
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Iron dysregulation in movement disorders by Dusek, Petr, Jankovic, Joseph, Le, Weidong

“…Abstract Iron is an essential element necessary for energy production, DNA and neurotransmitter synthesis, myelination and phospholipid metabolism…”
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Olfactory dysfunction and neurotransmitter disturbance in olfactory bulb of transgenic mice expressing human A53T mutant α-synuclein by Zhang, Sufang, Xiao, Qian, Le, Weidong

“…Parkinson disease is a multi-system neurodegenerative disease characterized by both motor and non-motor symptoms. Hyposmia is one of the early non-motor…”
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Comprehensive metabolic profiling of Parkinson's disease by liquid chromatography-mass spectrometry by Shao, Yaping, Li, Tianbai, Liu, Zheyi, Wang, Xiaolin, Xu, Xiaojiao, Li, Song, Xu, Guowang, Le, Weidong

“…Parkinson's disease (PD) is a prevalent neurological disease in the elderly with increasing morbidity and mortality. Despite enormous efforts, rapid and…”
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Autophagy Dysregulation in Amyotrophic Lateral Sclerosis by Chen, Sheng, Zhang, Xiaojie, Song, Lin, Le, Weidong

“…Autophagy is an intracellular lysosomal degradation process, which plays an important role in cell growth and development, and keeping cellular homeostasis in…”
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Profiling Non-motor Symptoms in Monogenic Parkinson’s Disease by Liu, Xinyao, Le, Weidong

“…Parkinson's disease (PD) is the second most common neurodegenerative disease in elder population, pathologically characterized by the progressive loss of…”
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The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease by Pan, Tianhong, Kondo, Seiji, Le, Weidong, Jankovic, Joseph

“…The ubiquitin-proteasome system (UPS) and autophagy-lysosome pathway (ALP) are the two most important mechanisms that normally repair or remove abnormal…”
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PM2.5 exposure triggers cell death through lysosomal membrane permeabilization and leads to ferroptosis insensitivity via the autophagy dysfunction/p62-KEAP1-NRF2 activation in neuronal cells by Wei, Min, Bao, Guangming, Li, Song, Yang, Zhaofei, Cheng, Cheng, Le, Weidong

“…PM2.5 exposure can be associated with the onset of neurodegenerative diseases, with oxidative stress-induced cellular homeostasis disruption and cell death as…”
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