Search Results - "WEIDE, Benjamin"

Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients by Romano, Emanuela, Kusio-Kobialka, Monika, Foukas, Periklis G., Baumgaertner, Petra, Meyer, Christiane, Ballabeni, Pierluigi, Michielin, Olivier, Weide, Benjamin, Romero, Pedro, Speiser, Daniel E.

“…Significance mAbs directed to inhibitory immune receptors represent a very promising class of immunotherapeutics. This study suggests a potential mechanism of…”
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Genomic correlates of response to CTLA-4 blockade in metastatic melanoma by Van Allen, Eliezer M., Miao, Diana, Schilling, Bastian, Shukla, Sachet A., Blank, Christian, Zimmer, Lisa, Sucker, Antje, Hillen, Uwe, Foppen, Marnix H. Geukes, Goldinger, Simone M., Utikal, Jochen, Hassel, Jessica C., Weide, Benjamin, Kaehler, Katharina C., Loquai, Carmen, Mohr, Peter, Gutzmer, Ralf, Dummer, Reinhard, Gabriel, Stacey, Wu, Catherine J., Schadendorf, Dirk, Garraway, Levi A.

“…Monoclonal antibodies directed against cytotoxic T lymphocyte–associated antigen-4 (CTLA-4), such as ipilimumab, yield considerable clinical benefit for…”
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Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions by Sucker, Antje, Zhao, Fang, Pieper, Natalia, Heeke, Christina, Maltaner, Raffaela, Stadtler, Nadine, Real, Birgit, Bielefeld, Nicola, Howe, Sebastian, Weide, Benjamin, Gutzmer, Ralf, Utikal, Jochen, Loquai, Carmen, Gogas, Helen, Klein-Hitpass, Ludger, Zeschnigk, Michael, Westendorf, Astrid M., Trilling, Mirko, Horn, Susanne, Schilling, Bastian, Schadendorf, Dirk, Griewank, Klaus G., Paschen, Annette

“…Melanoma treatment has been revolutionized by antibody-based immunotherapies. IFNγ secretion by CD8 + T cells is critical for therapy efficacy having…”
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The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma by Van Allen, Eliezer M, Wagle, Nikhil, Sucker, Antje, Treacy, Daniel J, Johannessen, Cory M, Goetz, Eva M, Place, Chelsea S, Taylor-Weiner, Amaro, Whittaker, Steven, Kryukov, Gregory V, Hodis, Eran, Rosenberg, Mara, McKenna, Aaron, Cibulskis, Kristian, Farlow, Deborah, Zimmer, Lisa, Hillen, Uwe, Gutzmer, Ralf, Goldinger, Simone M, Ugurel, Selma, Gogas, Helen J, Egberts, Friederike, Berking, Carola, Trefzer, Uwe, Loquai, Carmen, Weide, Benjamin, Hassel, Jessica C, Gabriel, Stacey B, Carter, Scott L, Getz, Gad, Garraway, Levi A, Schadendorf, Dirk

“…Most patients with BRAF(V600)-mutant metastatic melanoma develop resistance to selective RAF kinase inhibitors. The spectrum of clinical genetic resistance…”
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Vemurafenib reverses immunosuppression by myeloid derived suppressor cells by Schilling, Bastian, Sucker, Antje, Griewank, Klaus, Zhao, Fang, Weide, Benjamin, Görgens, André, Giebel, Bernd, Schadendorf, Dirk, Paschen, Annette

“…Myeloid derived suppressor cells (MDSCs) suppress innate and adaptive immunity, thereby limiting anti‐tumor immune responses in cancer patients. In patients…”
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The Generation of CAR-Transfected Natural Killer T Cells for the Immunotherapy of Melanoma by Simon, Bianca, Wiesinger, Manuel, März, Johannes, Wistuba-Hamprecht, Kilian, Weide, Benjamin, Schuler-Thurner, Beatrice, Schuler, Gerold, Dörrie, Jan, Uslu, Ugur

“…Natural killer T (NKT) cells represent a cell subpopulation that combines characteristics of natural killer (NK) cells and T cells. Through their endogenous…”
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Immune Signatures and Survival of Patients With Metastatic Melanoma, Renal Cancer, and Breast Cancer by Wistuba-Hamprecht, Kilian, Gouttefangeas, Cécile, Weide, Benjamin, Pawelec, Graham

“…Despite remarkable recent progress in treating solid cancers, especially the success of immunomodulatory antibody therapies for numerous different cancer…”
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Peripheral PD-1+CD56+ T-cell frequencies correlate with outcome in stage IV melanoma under PD-1 blockade by Bochem, Jonas, Zelba, Henning, Amaral, Teresa, Spreuer, Janine, Soffel, Daniel, Eigentler, Thomas, Wagner, Nikolaus Benjamin, Uslu, Ugur, Terheyden, Patrick, Meier, Friedegund, Garbe, Claus, Pawelec, Graham, Weide, Benjamin, Wistuba-Hamprecht, Kilian

“…Immune checkpoint blockade with anti-PD-1 antibodies is showing great promise for patients with metastatic melanoma and other malignancies, but despite good…”
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Distribution and prognostic relevance of tumor-infiltrating lymphocytes (TILs) and PD-1/PD-L1 immune checkpoints in human brain metastases by Harter, Patrick N, Bernatz, Simon, Scholz, Alexander, Zeiner, Pia S, Zinke, Jenny, Kiyose, Makoto, Blasel, Stella, Beschorner, Rudi, Senft, Christian, Bender, Benjamin, Ronellenfitsch, Michael W, Wikman, Harriet, Glatzel, Markus, Meinhardt, Matthias, Juratli, Tareq A, Steinbach, Joachim P, Plate, Karl H, Wischhusen, Jörg, Weide, Benjamin, Mittelbronn, Michel

“…The activation of immune cells by targeting checkpoint inhibitors showed promising results with increased patient survival in distinct primary cancers. Since…”
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Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients by WEIDE, Benjamin, PASCOLO, Steve, SCHEEL, Birgit, DERHOVANESSIAN, Evelyna, PFLUGFELDER, Annette, EIGENTLER, Thomas K, PAWELEC, Graham, HOERR, Ingmar, RAMMENSEE, Hans-Georg, GARBE, Claus

“…In mice, injection of messenger RNA (mRNA) coding for tumor-associated antigens can induce antitumor immune responses and therefore offers a broadly applicable…”
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Tumor microenvironment-derived S100A8/A9 is a novel prognostic biomarker for advanced melanoma patients and during immunotherapy with anti-PD-1 antibodies by Wagner, Nikolaus B., Weide, Benjamin, Gries, Mirko, Reith, Maike, Tarnanidis, Kathrin, Schuermans, Valerie, Kemper, Charlotte, Kehrel, Coretta, Funder, Anne, Lichtenberger, Ramtin, Sucker, Antje, Herpel, Esther, Holland-Letz, Tim, Schadendorf, Dirk, Garbe, Claus, Umansky, Viktor, Utikal, Jochen, Gebhardt, Christoffer

“…BackgroundPredicting metastasis in melanoma patients is important for disease management and could help to identify those who might benefit from adjuvant…”
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Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma by Jacquelot, Nicolas, Enot, David P, Flament, Caroline, Vimond, Nadège, Blattner, Carolin, Pitt, Jonathan M, Yamazaki, Takahiro, Roberti, María Paula, Daillère, Romain, Vétizou, Marie, Poirier-Colame, Vichnou, Semeraro, Michaëla, Caignard, Anne, Slingluff, Jr, Craig L, Sallusto, Federica, Rusakiewicz, Sylvie, Weide, Benjamin, Marabelle, Aurélien, Kohrt, Holbrook, Dalle, Stéphane, Cavalcanti, Andréa, Kroemer, Guido, Di Giacomo, Anna Maria, Maio, Michele, Wong, Phillip, Yuan, Jianda, Wolchok, Jedd, Umansky, Viktor, Eggermont, Alexander, Zitvogel, Laurence

“…Melanoma prognosis is dictated by tumor-infiltrating lymphocytes, the migratory and functional behavior of which is guided by chemokine or cytokine gradients…”
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Functional T Cells Targeting NY-ESO-1 or Melan-A Are Predictive for Survival of Patients With Distant Melanoma Metastasis by WEIDE, Benjamin, ZELBA, Henning, SCHADENDORF, Dirk, BIITTNER, Petra, GARBE, Claus, PAWELEC, Graham, DERHOVANESSIAN, Evelyna, PFLUGFELDER, Annette, EIGENTLER, Thomas K, DI GIACOMO, Anna Maria, MAIO, Michele, AARNTZEN, Erik H. J. G, DE VRIES, I. Jolanda M, SUCKER, Antje

“…To analyze the prognostic relevance of circulating T cells responding to NY-ESO-1, Melan-A, MAGE-3, and survivin in patients with melanoma with distant…”
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Establishing High Dimensional Immune Signatures from Peripheral Blood via Mass Cytometry in a Discovery Cohort of Stage IV Melanoma Patients by Wistuba-Hamprecht, Kilian, Martens, Alexander, Weide, Benjamin, Teng, Karen Wei Weng, Zelba, Henning, Guffart, Elena, Chen, Jinmiao, Garbe, Claus, Newell, Evan William, Larbi, Anis, Pawelec, Graham

“…The identification of blood-borne biomarkers correlating with melanoma patient survival remains elusive. Novel techniques such as mass cytometry could help to…”
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Serum S100B, lactate dehydrogenase and brain metastasis are prognostic factors in patients with distant melanoma metastasis and systemic therapy by Weide, Benjamin, Richter, Sabina, Büttner, Petra, Leiter, Ulrike, Forschner, Andrea, Bauer, Jürgen, Held, Laura, Eigentler, Thomas Kurt, Meier, Friedegund, Garbe, Claus

“…Prognostic factors of melanoma with distant metastasis and systemic treatment are only poorly established. This study aimed to analyse the impact of S100B,…”
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Putative Cancer Stem Cell Markers are Frequently Expressed by Melanoma Cells in Vitro and in Situ but are also Present in Benign Differentiated Cells by Speigl, Lisa, Janssen, Nicole, Weide, Benjamin, Sinnberg, Tobias, Pawelec, Graham, Shipp, Christopher

“…Background: Currently, there remains an incomplete view of cancer stem cells (CSCs) in solid tumours. Methods: We studied a panel of putative CSC surface…”
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Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells by Beck, Daniela, Niessner, Heike, Smalley, Keiran S M, Flaherty, Keith, Paraiso, Kim H T, Busch, Christian, Sinnberg, Tobias, Vasseur, Sophie, Iovanna, Juan Lucio, Drießen, Stefan, Stork, Björn, Wesselborg, Sebastian, Schaller, Martin, Biedermann, Tilo, Bauer, Jürgen, Lasithiotakis, Konstantinos, Weide, Benjamin, Eberle, Jürgen, Schittek, Birgit, Schadendorf, Dirk, Garbe, Claus, Kulms, Dagmar, Meier, Friedegund

“…The V600E mutation in the kinase BRAF is frequently detected in melanomas and results in constitutive activation of BRAF, which then promotes cell…”
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Survival according to BRAF-V600 tumor mutations--an analysis of 437 patients with primary melanoma by Meckbach, Diana, Bauer, Jürgen, Pflugfelder, Annette, Meier, Friedegund, Busch, Christian, Eigentler, Thomas K, Capper, David, von Deimling, Andreas, Mittelbronn, Michel, Perner, Sven, Ikenberg, Kristian, Hantschke, Markus, Büttner, Petra, Garbe, Claus, Weide, Benjamin

“…The prognostic impact of BRAF-V600 tumor mutations in stage I/II melanoma patients has not yet been analyzed in detail. We investigated primary tumors of 437…”
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Serum CD73 is a prognostic factor in patients with metastatic melanoma and is associated with response to anti-PD-1 therapy by Turiello, Roberta, Capone, Mariaelena, Giannarelli, Diana, Morretta, Elva, Monti, Maria Chiara, Madonna, Gabriele, Mallardo, Domenico, Festino, Lucia, Azzaro, Rosa, Levesque, Mitchell P, Imhof, Laurence, Weide, Benjamin, Amaral, Teresa, Chevrier, Marc, Sucker, Antje, Rutkowski, Piotr, Schadendorf, Dirk, Lebbe, Celeste, Luke, Jason John, Wistuba-Hamprecht, Kilian, Dummer, Reinhard, Pinto, Aldo, Morello, Silvana, Ascierto, Paolo A

“…BackgroundInhibitors of immune checkpoint programmed cell death protein 1 (PD-1) receptor on T cells have shown remarkable clinical outcomes in metastatic…”
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Early decrease of blood myeloid-derived suppressor cells during checkpoint inhibition is a favorable biomarker in metastatic melanoma by Gaißler, Andrea, Bochem, Jonas, Spreuer, Janine, Ottmann, Shannon, Martens, Alexander, Amaral, Teresa, Wagner, Nikolaus Benjamin, Claassen, Manfred, Meier, Friedegund, Terheyden, Patrick, Garbe, Claus, Eigentler, Thomas, Weide, Benjamin, Pawelec, Graham, Wistuba-Hamprecht, Kilian

“…BackgroundThe need for reliable clinical biomarkers to predict which patients with melanoma will benefit from immune checkpoint blockade (ICB) remains unmet…”
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