Search Results - "WEICHSELBAUM, R. R"

Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy by He, Chunbai, Duan, Xiaopin, Guo, Nining, Chan, Christina, Poon, Christopher, Weichselbaum, Ralph R., Lin, Wenbin

“…Advanced colorectal cancer is one of the deadliest cancers, with a 5-year survival rate of only 12% for patients with the metastatic disease. Checkpoint…”
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Oligometastases revisited by Weichselbaum, Ralph R, Hellman, Samuel

“…This Perspectives article expands on the previously proposed clinical state of metastasis termed 'oligometastases' that refers to restricted tumor metastatic…”
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Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice by Deng, Liufu, Liang, Hua, Burnette, Byron, Beckett, Michael, Darga, Thomas, Weichselbaum, Ralph R, Fu, Yang-Xin

“…High-dose ionizing irradiation (IR) results in direct tumor cell death and augments tumor-specific immunity, which enhances tumor control both locally and…”
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Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors by Duan, Xiaopin, Chan, Christina, Han, Wenbo, Guo, Nining, Weichselbaum, Ralph R., Lin, Wenbin

“…Nanoparticles can potentially stimulate tumour microenvironments to elicit antitumour immunity. Herein, we demonstrate effective immunotherapy of colorectal…”
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STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors by Deng, Liufu, Liang, Hua, Xu, Meng, Yang, Xuanming, Burnette, Byron, Arina, Ainhoa, Li, Xiao-Dong, Mauceri, Helena, Beckett, Michael, Darga, Thomas, Huang, Xiaona, Gajewski, Thomas F., Chen, Zhijian J., Fu, Yang-Xin, Weichselbaum, Ralph R.

“…Ionizing radiation-mediated tumor regression depends on type I interferon (IFN) and the adaptive immune response, but several pathways control I IFN induction…”
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Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling by Shi, Yaoyao, Zheng, Wenxin, Yang, Kaiting, Harris, Katharine G, Ni, Kaiyuan, Xue, Lai, Lin, Wenbin, Chang, Eugene B, Weichselbaum, Ralph R, Fu, Yang-Xin

“…Most studies focus on how intestinal microbiota influence cancer immunotherapy through activating gut immunity. However, immunotherapies related to innate…”
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Integration of radiotherapy and immunotherapy for treatment of oligometastases by Pitroda, Sean P, MD, Chmura, Steven J, MD, Weichselbaum, Ralph R, Prof

“…SummaryMetastasis is the leading cause of cancer-related mortality and remains one of the prevailing challenges in cancer treatment. Most patients with…”
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Host STING-dependent MDSC mobilization drives extrinsic radiation resistance by Liang, Hua, Deng, Liufu, Hou, Yuzhu, Meng, Xiangjiao, Huang, Xiaona, Rao, Enyu, Zheng, Wenxin, Mauceri, Helena, Mack, Matthias, Xu, Meng, Fu, Yang-Xin, Weichselbaum, Ralph R.

“…Radiotherapy induces and promotes innate and adaptive immunity in which host STING plays an important role. However, radioresistance in irradiated tumors can…”
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Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy by Ni, Kaiyuan, Lan, Guangxu, Chan, Christina, Quigley, Bryan, Lu, Kuangda, Aung, Theint, Guo, Nining, La Riviere, Patrick, Weichselbaum, Ralph R., Lin, Wenbin

“…Checkpoint blockade immunotherapy enhances systemic antitumor immune response by targeting T cell inhibitory pathways; however, inadequate T cell infiltration…”
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Oligometastatic prostate cancer: Reality or figment of imagination? by Foster, Corey C., Weichselbaum, Ralph R., Pitroda, Sean P.

“…The term “oligometastatic prostate cancer” refers to a heterogeneous group of disease states currently defined solely on the basis of clinical features…”
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Integrated molecular and clinical staging defines the spectrum of metastatic cancer by Pitroda, Sean P., Weichselbaum, Ralph R.

“…The elimination of metastases remains one of the major challenges in the curative treatment of patients with cancer. Therefore, most patients with metastatic…”
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Tumor-reprogrammed resident T cells resist radiation to control tumors by Arina, Ainhoa, Beckett, Michael, Fernandez, Christian, Zheng, Wenxin, Pitroda, Sean, Chmura, Steven J., Luke, Jason J., Forde, Martin, Hou, Yuzhu, Burnette, Byron, Mauceri, Helena, Lowy, Israel, Sims, Tasha, Khodarev, Nikolai, Fu, Yang-Xin, Weichselbaum, Ralph R.

“…Successful combinations of radiotherapy and immunotherapy depend on the presence of live T cells within the tumor; however, radiotherapy is believed to damage…”
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New paradigms and future challenges in radiation oncology: an update of biological targets and technology by Liauw, Stanley L, Connell, Philip P, Weichselbaum, Ralph R

“…Radiation oncology exploits the biological interaction of radiation within tissue to promote tumor death while minimizing damage to surrounding normal tissue…”
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The Efficacy of Radiotherapy Relies upon Induction of Type I Interferon-Dependent Innate and Adaptive Immunity by BURNETTE, Byron C, HUA LIANG, LEE, Youjin, CHLEWICKI, Lukasz, KHODAREV, Nikolai N, WEICHSELBAUM, Ralph R, FU, Yang-Xin, AUH, Sogyong L

“…The most widely held explanation for the efficacy of local radiotherapy (RT) is based on direct cytotoxicity to cancer cells through the induction of lethal…”
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Targeting the Tumor Microenvironment with Interferon-β Bridges Innate and Adaptive Immune Responses by Yang, Xuanming, Zhang, Xunmin, Fu, May Lynne, Weichselbaum, Ralph R., Gajewski, Thomas F., Guo, Yajun, Fu, Yang-Xin

“…Antibodies (Abs) that preferentially target oncogenic receptors have been increasingly used for cancer therapy, but tumors often acquire intrinsic Ab…”
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Molecular Pathways: Interferon/Stat1 Pathway: Role in the Tumor Resistance to Genotoxic Stress and Aggressive Growth by KHODAREV, Nikolai N, ROIZMAN, Bernard, WEICHSELBAUM, Ralph R

“…STAT1 is activated by IFNs and other cell signals. Following activation, STAT1 is translocated to the nuclei and activates transcription of IFN-stimulated…”
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Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas by Seiwert, Tanguy Y, Zuo, Zhixiang, Keck, Michaela K, Khattri, Arun, Pedamallu, Chandra S, Stricker, Thomas, Brown, Christopher, Pugh, Trevor J, Stojanov, Petar, Cho, Juok, Lawrence, Michael S, Getz, Gad, Brägelmann, Johannes, DeBoer, Rebecca, Weichselbaum, Ralph R, Langerman, Alexander, Portugal, Louis, Blair, Elizabeth, Stenson, Kerstin, Lingen, Mark W, Cohen, Ezra E W, Vokes, Everett E, White, Kevin P, Hammerman, Peter S

“…The genetic differences between human papilloma virus (HPV)-positive and -negative head and neck squamous cell carcinomas (HNSCC) remain largely unknown. To…”
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Low-dose X-ray radiotherapy–radiodynamic therapy via nanoscale metal–organic frameworks enhances checkpoint blockade immunotherapy by Lu, Kuangda, He, Chunbai, Guo, Nining, Chan, Christina, Ni, Kaiyuan, Lan, Guangxu, Tang, Haidong, Pelizzari, Charles, Fu, Yang-Xin, Spiotto, Michael T., Weichselbaum, Ralph R., Lin, Wenbin

“…Checkpoint blockade immunotherapy relies on energized cytotoxic T cells attacking tumour tissue systemically. However, for many cancers, the reliance on T cell…”
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Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis by Pitroda, Sean P., Khodarev, Nikolai N., Huang, Lei, Uppal, Abhineet, Wightman, Sean C., Ganai, Sabha, Joseph, Nora, Pitt, Jason, Brown, Miguel, Forde, Martin, Mangold, Kathy, Xue, Lai, Weber, Christopher, Segal, Jeremy P., Kadri, Sabah, Stack, Melinda E., Khan, Sajid, Paty, Philip, Kaul, Karen, Andrade, Jorge, White, Kevin P., Talamonti, Mark, Posner, Mitchell C., Hellman, Samuel, Weichselbaum, Ralph R.

“…The oligometastasis hypothesis suggests a spectrum of metastatic virulence where some metastases are limited in extent and curable with focal therapies. A…”
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Radiation as an Immune Modulator by Burnette, Byron, PhD, Weichselbaum, Ralph R., MD

“…Radiation therapy is currently one of the most widely utilized treatment strategies in the clinical management of cancer. Classically, radiation therapy was…”
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