Search Results - "WEI PENG YONG"

PD‐L1 expression is mainly regulated by interferon gamma associated with JAK‐STAT pathway in gastric cancer by Mimura, Kousaku, Teh, Jun Liang, Okayama, Hirokazu, Shiraishi, Kensuke, Kua, Ley‐Fang, Koh, Vivien, Smoot, Duane T., Ashktorab, Hassan, Oike, Takahiro, Suzuki, Yoshiyuki, Fazreen, Zul, Asuncion, Bernadette R., Shabbir, Asim, Yong, Wei‐Peng, So, Jimmy, Soong, Richie, Kono, Koji

“…Despite multidisciplinary treatment for patients with advanced gastric cancer, their prognosis remains poor. Therefore, the development of novel therapeutic…”
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Combined inhibition of PD-1/PD-L1, Lag-3, and Tim-3 axes augments antitumor immunity in gastric cancer–T cell coculture models by Mimura, Kosaku, Kua, Ley-Fang, Xiao, Jin-Fen, Asuncion, Bernadette Reyna, Nakayama, Yuko, Syn, Nicholas, Fazreen, Zul, Soong, Richie, Kono, Koji, Yong, Wei-Peng

“…Background Immunotherapy targeting PD-1 provides a limited survival benefit in patients with unresectable advanced or recurrent gastric cancer (GC). Beside…”
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Bevacizumab in Combination With Chemotherapy As First-Line Therapy in Advanced Gastric Cancer: A Biomarker Evaluation From the AVAGAST Randomized Phase III Trial by VAN CUTSEM, Eric, DE HAAS, S. Anne, SHAH, Manish A, KANG, Yoon-Koo, OHTSU, Atsushi, TEBBUTT, Niall C, JIAN MING XU, WEI PENG YONG, LANGER, Bernd, DELMAR, Paul, SCHERER, Stefan J

“…The AVAGAST study showed that adding bevacizumab to chemotherapy in patients with advanced gastric cancer improves progression-free survival and tumor response…”
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Choice of PD-L1 immunohistochemistry assay influences clinical eligibility for gastric cancer immunotherapy by Yeong, Joe, Lum, Huey Yew Jeffrey, Teo, Chong Boon, Tan, Benjamin Kye Jyn, Chan, Yiong Huak, Tay, Ryan Yong Kiat, Choo, Joan Rou-En, Jeyasekharan, Anand D., Miow, Qing Hao, Loo, Lit-Hsin, Yong, Wei Peng, Sundar, Raghav

“…Background Immune checkpoint inhibitors (ICI) are now standard-of-care treatment for patients with metastatic gastric cancer (GC). To guide patient selection…”
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Report of a Multicenter Phase II Trial Testing a Combination of Biweekly Bevacizumab and Daily Erlotinib in Patients With Unresectable Biliary Cancer: A Phase II Consortium Study by LUBNER, Sam J, MAHONEY, Michelle R, VAN HAZEL, Guy, ERLICHMAN, Charles E, HOLEN, Kyle D, KOLESAR, Jill L, LOCONTE, Noelle K, KIM, George P, PITOT, Henry C, PHILIP, Philip A, PICUS, Joel, YONG, Wei-Peng, HORVATH, Lisa

“…Biliary cancers overexpress epidermal growth factor receptor (EGFR), and angiogenesis has been correlated with poor outcome. Erlotinib, an EGFR tyrosine kinase…”
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Therapeutic potential of highly cytotoxic natural killer cells for gastric cancer by Mimura, Kousaku, Kamiya, Takahiro, Shiraishi, Kensuke, Kua, Ley‐Fang, Shabbir, Asim, So, Jimmy, Yong, Wei‐Peng, Suzuki, Yoshiyuki, Yoshimoto, Yuya, Nakano, Takashi, Fujii, Hideki, Campana, Dario, Kono, Koji

“…To develop more effective therapies for patients with advanced gastric cancer, we examined the potential of ex vivo expanded natural killer (NK) cells. We…”
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Inhibition of mitogen‐activated protein kinase pathway can induce upregulation of human leukocyte antigen class I without PD‐L1‐upregulation in contrast to interferon‐γ treatment by Mimura, Kousaku, Kua, Ley‐Fang, Shiraishi, Kensuke, Kee Siang, Lim, Shabbir, Asim, Komachi, Mayumi, Suzuki, Yoshiyuki, Nakano, Takashi, Yong, Wei‐Peng, So, Jimmy, Kono, Koji

“…Recently, we reported that human leukocyte antigen (HLA) class I expression is predominantly regulated by the mitogen‐activated protein kinase (MAPK) pathway…”
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Clinical pharmacology and pharmacogenetics of gemcitabine by Wong, Andrea, Soo, Ross A., Yong, Wei-Peng, Innocenti, Federico

“…Gemcitabine is a cytotoxic nucleoside analog, which is widely used in the treatment of malignancies. Interindividual differences in gemcitabine…”
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The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer by Mimura, Kousaku, Shiraishi, Kensuke, Mueller, Anja, Izawa, Shinichiro, Kua, Ley-Fang, So, Jimmy, Yong, Wei-Peng, Fujii, Hideki, Seliger, Barbara, Kiessling, Rolf, Kono, Koji

“…Downregulation of HLA class I expression may contribute to a poor prognosis in cancer patients. There is limited information about epigenetic and oncogenic…”
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Pembrolizumab in Asian patients with microsatellite‐instability‐high/mismatch‐repair‐deficient colorectal cancer by Yoshino, Takayuki, Andre, Thierry, Kim, Tae Won, Yong, Wei Peng, Shiu, Kai‐Keen, Jensen, Benny Vittrup, Jensen, Lars Henrik, Punt, Cornelis J. A., Smith, Denis, Garcia‐Carbonero, Rocio, Alcaide‐Garcia, Julia, Gibbs, Peter, Fouchardiere, Christelle, Rivera, Fernando, Elez, Elena, Le, Dung T., Adachi, Noriaki, Fogelman, David, Marinello, Patricia, Diaz, Luis A.

“…The phase 3 KEYNOTE‐177 study evaluated pembrolizumab versus chemotherapy with or without bevacizumab or cetuximab in patients with newly diagnosed,…”
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miR-204 Inhibits Epithelial to Mesenchymal Transition by Targeting Slug in Intrahepatic Cholangiocarcinoma Cells by Qiu, Ying-he, Wei, Yong-peng, Shen, Ning-jia, Wang, Zhou-chong, Kan, Tong, Yu, Wen-long, Yi, Bin, Zhang, Yong-jie

“…Background/Aims: MicroRNAs (miRNAs) play critical roles during carcinogenesis and cancer progression. Down-regulation of miR-204 has been frequently observed…”
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Clinical translation of patient-derived tumour organoids- bottlenecks and strategies by Foo, Malia Alexandra, You, Mingliang, Chan, Shing Leng, Sethi, Gautam, Bonney, Glenn K, Yong, Wei-Peng, Chow, Edward Kai-Hua, Fong, Eliza Li Shan, Wang, Lingzhi, Goh, Boon-Cher

“…Multiple three-dimensional (3D) tumour organoid models assisted by multi-omics and Artificial Intelligence (AI) have contributed greatly to preclinical drug…”
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Inhibition of MMP activity can restore NKG2D ligand expression in gastric cancer, leading to improved NK cell susceptibility by Shiraishi, Kensuke, Mimura, Kousaku, Kua, Ley-Fang, Koh, Vivien, Siang, Lim Kee, Nakajima, Shotaro, Fujii, Hideki, Shabbir, Asim, Yong, Wei-Peng, So, Jimmy, Takenoshita, Seiichi, Kono, Koji

“…Background and methods Natural killer (NK) cells can react with tumor cells through the balance of inhibitory and stimulatory signals between NK cell surface…”
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Krüppel‐like factor 8 promotes cancer stem cell‐like traits in hepatocellular carcinoma through Wnt/β‐catenin signaling by Shen, Yi‐Nan, He, Hai‐Guan, Shi, Yang, Cao, Jian, Yuan, Jian‐Yong, Wang, Zhou‐Chong, Shi, Chun‐Feng, Zhu, Nan, Wei, Yong‐Peng, Liu, Fang, Huang, Jia‐Li, Yang, Guang‐Shun, Lu, Jun‐Hua

“…Krüppel‐like factor 8 (KLF8) is highly expressed in hepatocellular carcinoma (HCC) and contributes to tumor initiation and progression by promoting HCC cell…”
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Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression by Wong, Foong Ying, Liem, Natalia, Xie, Chen, Yan, Fui Leng, Wong, Wing Cheong, Wang, Lingzhi, Yong, Wei-Peng

“…Although gemcitabine is highly active in several cancer types, intrinsic and acquired drug resistance remains a major challenge. Overexpression of Bcl-2 has…”
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FAM3C in circulating tumor-derived extracellular vesicles promotes non-small cell lung cancer growth in secondary sites by Thuya, Win Lwin, Kong, Li Ren, Syn, Nicholas L, Ding, Ling-Wen, Cheow, Esther Sok Hwee, Wong, Regina Tong Xin, Wang, Tingting, Goh, Robby Miguel Wen-Jing, Song, Hongyan, Jayasinghe, Migara K, Le, Minh Tn, Hu, Jian Cheng, Yong, Wei-Peng, Lee, Soo-Chin, Wong, Andrea Li-Ann, Sethi, Gautam, Hung, Huynh The, Ho, Paul Chi-Lui, Thiery, Jean-Paul, Sze, Siu Kwan, Guo, Tiannan, Soo, Ross A, Yang, Henry, Lim, Yaw Chyn, Wang, Lingzhi, Goh, Boon-Cher

“…: Metastasis is a complex process with a molecular underpinning that remains unclear. We hypothesize that cargo proteins conducted by extracellular vesicles…”
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Impact of Surveillance in Chronic Hepatitis B Patients on Long-Term Outcomes After Curative Liver Resection for Hepatocellular Carcinoma by Li, Zhen-Li, Wu, Han, Wei, Yong-Peng, Zhong, Qian, Song, Jin-Chao, Yu, Jiong-Jie, Li, Chao, Wang, Ming-Da, Xu, Xin-Fei, Li, Ju-Dong, Han, Jun, Xing, Hao, Lau, Wan Yee, Wu, Meng-Chao, Shen, Feng, Yang, Tian

“…Background Clinical guidelines recommend surveillance in high-risk population to early detect hepatocellular carcinoma (HCC), when curative treatment such as…”
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Dose modifications in Asian cancer patients with hepatic dysfunction receiving weekly docetaxel: A prospective pharmacokinetic and safety study by Syn, Nicholas Li‐Xun, Wang, Lingzhi, Wong, Andrea Li‐Ann, Soe, Mu‐Yar, Chuah, Benjamin, Chan, Daniel, Tan, Sing‐Huang, Soo, Ross Andrew, Lee, Soo‐Chin, Goh, Boon‐Cher, Yong, Wei‐Peng

“…Hepatic dysfunction may modify the safety profile and pharmacokinetics of docetaxel in cancer patients, but no validated guideline exists to guide dose…”
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Phenotyping of UGT1A1 Activity Using Raltegravir Predicts Pharmacokinetics and Toxicity of Irinotecan in FOLFIRI by Lee, Lawrence Soon-U, Seng, Kok-Yong, Wang, Ling-Zhi, Yong, Wei-Peng, Hee, Kim-Hor, Soh, Thomas I, Wong, Andrea, Cheong, Pei F, Soong, Richie, Sapari, Nur S, Soo, Ross, Fan, Lu, Lee, Soo-Chin, Goh, Boon C

“…Irinotecan toxicity correlates with UGT1A1 activity. We explored whether phenotyping UGT1A1 using a probe approach works better than current genotyping…”
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UGT1A6 polymorphisms modulated lung cancer risk in a Chinese population by Kua, Ley-Fang, Ross, Soo, Lee, Soo-Chin, Mimura, Kousaku, Kono, Koji, Goh, Boon-Cher, Yong, Wei-Peng

“…Uridine diphosphoglucuronosyltransferases (UGTs) 1A6 is the only UGT1A isoform expressed in lung tissue. It is responsible for the detoxification of…”
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