Search Results - "WEI MENG, X"

Characterization of an alternative BAK-binding site for BH3 peptides by Ye, Kaiqin, Meng, Wei X., Sun, Hongbin, Wu, Bo, Chen, Meng, Pang, Yuan-Ping, Gao, Jia, Wang, Hongzhi, Wang, Junfeng, Kaufmann, Scott H., Dai, Haiming

“…Many cellular stresses are transduced into apoptotic signals through modification or up-regulation of the BH3-only subfamily of BCL2 proteins. Through direct…”
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Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells by Schroeder, Barbara, Vander Steen, Travis, Espinoza, Ingrid, Venkatapoorna, Chandra M. Kurapaty, Hu, Zeng, Silva, Fernando Martín, Regan, Kevin, Cuyàs, Elisabet, Meng, X. Wei, Verdura, Sara, Arbusà, Aina, Schneider, Paula A., Flatten, Karen S., Kemble, George, Montero, Joan, Kaufmann, Scott H., Menendez, Javier A., Lupu, Ruth

“…Inhibitors of the lipogenic enzyme fatty acid synthase (FASN) have attracted much attention in the last decade as potential targeted cancer therapies. However,…”
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Contribution of Bcl-2 Phosphorylation to Bak Binding and Drug Resistance by HAIMING DAI, HUSHENG DING, WEI MENG, X, LEE, Sun-Hee, SCHNEIDER, Paula A, KAUFMANN, Scott H

“…Bcl-2 is phosphorylated on Ser(70) after treatment of cells with spindle poisons. On the basis of effects observed in cells overexpressing Bcl-2 S70E or S70A…”
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Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization by Dai, Haiming, Smith, Alyson, Meng, X Wei, Schneider, Paula A, Pang, Yuan-Ping, Kaufmann, Scott H

“…The mechanism by which the proapoptotic Bcl-2 family members Bax and Bak release cytochrome c from mitochondria is incompletely understood. In this paper, we…”
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ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance by O’Sullivan, Julia, Kothari, Charu, Caron, Marie-Christine, Gagné, Jean-Philippe, Jin, Zhigang, Nonfoux, Louis, Beneyton, Adèle, Coulombe, Yan, Thomas, Mélissa, Atalay, Nurgul, Meng, X Wei, Milano, Larissa, Jean, Dominique, Boisvert, François-Michel, Kaufmann, Scott H, Hendzel, Michael J, Masson, Jean-Yves, Poirier, Guy G

“…Abstract Zinc finger (ZNF) motifs are some of the most frequently occurring domains in the human genome. It was only recently that ZNF proteins emerged as key…”
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Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells by Dai, Haiming, Ding, Husheng, Meng, X Wei, Peterson, Kevin L, Schneider, Paula A, Karp, Judith E, Kaufmann, Scott H

“…Mitochondrial outer membrane permeabilization (MOMP), a key step in the intrinsic apoptotic pathway, is incompletely understood. Current models emphasize the…”
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CDK2-Mediated Upregulation of TNFα as a Mechanism of Selective Cytotoxicity in Acute Leukemia by Ding, Husheng, Vincelette, Nicole D, McGehee, Cordelia D, Kohorst, Mira A, Koh, Brian D, Venkatachalam, Annapoorna, Meng, X Wei, Schneider, Paula A, Flatten, Karen S, Peterson, Kevin L, Correia, Cristina, Lee, Sun-Hee, Patnaik, Mrinal, Webster, Jonathan A, Ghiaur, Gabriel, Smith, B Douglas, Karp, Judith E, Pratz, Keith W, Li, Hu, Karnitz, Larry M, Kaufmann, Scott H

“…Although inhibitors of the kinases CHK1, ATR, and WEE1 are undergoing clinical testing, it remains unclear how these three classes of agents kill susceptible…”
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Death Receptor 5 Signaling Promotes Hepatocyte Lipoapoptosis by Cazanave, Sophie C., Mott, Justin L., Bronk, Steven F., Werneburg, Nathan W., Fingas, Christian D., Meng, X. Wei, Finnberg, Niklas, El-Deiry, Wafik S., Kaufmann, Scott H., Gores, Gregory J.

“…Nonalcoholic steatohepatitis is characterized by hepatic steatosis, elevated levels of circulating free fatty acids (FFA), endoplasmic reticulum (ER) stress,…”
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Proapoptotic activity of JNK-sensitive BH3-only proteins underpins ovarian cancer response to replication checkpoint inhibitors by Venkatachalam, Annapoorna, Correia, Cristina, Peterson, Kevin L, Hou, Xianon, Schneider, Paula A, Strathman, Annabella R, Flatten, Karen S, Sine, Chance C, Balczewski, Emily A, McGehee, Cordelia D, Larson, Melissa C, Duffield, Laura N, Meng, X Wei, Vincelette, Nicole D, Ding, Husheng, Oberg, Ann L, Couch, Fergus J, Swisher, Elizabeth M, Li, Hu, Weroha, S John, Kaufmann, Scott H

“…Recent studies indicate that replication checkpoint modulators (RCMs) such as inhibitors of CHK1, ATR, and WEE1 have promising monotherapy activity in solid…”
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Mitochondrial apoptosis and BH3 mimetics [version 1; peer review: 3 approved] by Dai, Haiming, Meng, X. Wei, Kaufmann, Scott H

“…The BCL2-selective BH3 mimetic venetoclax was recently approved for the treatment of relapsed, chromosome 17p-deleted chronic lymphocytic leukemia (CLL) and is…”
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Cytotoxicity of farnesyltransferase inhibitors in lymphoid cells mediated by MAPK pathway inhibition and Bim up-regulation by Ding, Husheng, Hackbarth, Jennifer, Schneider, Paula A., Peterson, Kevin L., Meng, X. Wei, Dai, Haiming, Witzig, Thomas E., Kaufmann, Scott H.

“…The mechanism of cytotoxicity of farnesyltransferase inhibitors is incompletely understood and seems to vary depending on the cell type. To identify potential…”
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Characterization of a RAD51C -silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance by Hurley, Rachel M, McGehee, Cordelia D, Nesic, Ksenija, Correia, Cristina, Weiskittel, Taylor M, Kelly, Rebecca L, Venkatachalam, Annapoorna, Hou, Xiaonan, Pathoulas, Nicholas M, Meng, X Wei, Kondrashova, Olga, Radke, Marc R, Schneider, Paula A, Flatten, Karen S, Peterson, Kevin L, Becker, Marc A, Wong, Ee Ming, Southey, Melissa S, Dobrovic, Alexander, Lin, Kevin K, Harding, Thomas C, McNeish, Iain, Ross, Christian A, Wagner, Jill M, Wakefield, Matthew J, Scott, Clare L, Haluska, Paul, Wahner Hendrickson, Andrea E, Karnitz, Larry M, Swisher, Elizabeth M, Li, Hu, Weroha, S John, Kaufmann, Scott H

“…Acquired PARP inhibitor (PARPi) resistance in - or -mutant ovarian cancer often results from secondary mutations that restore expression of functional protein…”
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Context-dependent Bcl-2/Bak Interactions Regulate Lymphoid Cell Apoptosis by Dai, Haiming, Meng, X. Wei, Lee, Sun-Hee, Schneider, Paula A., Kaufmann, Scott H.

“…The release of cytochrome c from mitochondria, which leads to activation of the intrinsic apoptotic pathway, is regulated by interactions of Bax and Bak with…”
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Selective Inhibition of BFL1: It's All about Finding the Right Partner by Dai, Haiming, Meng, X Wei, Kaufmann, Scott H

“…In this issue of Cell Chemical Biology, Harvey et al. (2020) identify 4E14, a sulfhydryl-containing N-acetyltryptophan analog that selectively disrupts binding…”
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A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C by Dai, Haiming, Peterson, Kevin L., Flatten, Karen S., Meng, X. Wei, Venkatachalam, Annapoorna, Correia, Cristina, Ramirez-Alvarado, Marina, Pang, Yuan-Ping, Kaufmann, Scott H.

“…How BAK and BAX induce mitochondrial outer membrane (MOM) permeabilization (MOMP) during apoptosis is incompletely understood. Here we have used molecular…”
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BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma by Correia, Cristina, Schneider, Paula A., Dai, Haiming, Dogan, Ahmet, Maurer, Matthew J., Church, Amy K., Novak, Anne J., Feldman, Andrew L., Wu, Xiaosheng, Ding, Husheng, Meng, X. Wei, Cerhan, James R., Slager, Susan L., Macon, William R., Habermann, Thomas M., Karp, Judith E., Gore, Steven D., Kay, Neil E., Jelinek, Diane F., Witzig, Thomas E., Nowakowski, Grzegorz S., Kaufmann, Scott H.

“…Follicular lymphoma (FL), an indolent neoplasm caused by a t(14;18) chromosomal translocation that juxtaposes the BCL2 gene and immunoglobulin locus, has a…”
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53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer by Hurley, Rachel M., Wahner Hendrickson, Andrea E., Visscher, Daniel W., Ansell, Peter, Harrell, Maria I., Wagner, Jill M., Negron, Vivian, Goergen, Krista M., Maurer, Matthew J., Oberg, Ann L., Meng, X. Wei, Flatten, Karen S., De Jonge, Maja J.A., Van Herpen, Carla D., Gietema, Jourik A., Koornstra, Rutger H.T., Jager, Agnes, den Hollander, Martha W., Dudley, Matthew, Shepherd, Stacie P., Swisher, Elizabeth M., Kaufmann, Scott H.

“…Poly(ADP-ribose) polymerase (PARP) inhibitors have shown substantial activity in homologous recombination- (HR-) deficient ovarian cancer and are undergoing…”
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Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells by Ding, Husheng, McDonald, Jennifer S, Yun, Seongseok, Schneider, Paula A, Peterson, Kevin L, Flatten, Karen S, Loegering, David A, Oberg, Ann L, Riska, Shaun M, Huang, Shengbing, Sinicrope, Frank A, Adjei, Alex A, Karp, Judith E, Meng, X Wei, Kaufmann, Scott H

“…Although farnesyltransferase inhibitors have shown promising activity in relapsed lymphoma and sporadic activity in acute myelogenous leukemia, their mechanism…”
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AMPK inhibition sensitizes acute leukemia cells to BH3 mimetic-induced cell death by Jia, Jia, Ji, Wenbo, Saliba, Antoine N., Csizmar, Clifford M., Ye, Kaiqin, Hu, Lei, Peterson, Kevin L., Schneider, Paula A., Meng, X. Wei, Venkatachalam, Annapoorna, Patnaik, Mrinal M., Webster, Jonathan A., Smith, B. Douglas, Ghiaur, Gabriel, Wu, Xinyan, Zhong, Jun, Pandey, Akhilesh, Flatten, Karen S., Deng, Qingmei, Wang, Hongzhi, Kaufmann, Scott H., Dai, Haiming

“…BH3 mimetics, including the BCL2/BCLX L /BCLw inhibitor navitoclax and MCL1 inhibitors S64315 and tapotoclax, have undergone clinical testing for a variety of…”
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Measurement of BH3-only protein tolerance by Dai, Haiming, Ding, Husheng, Peterson, Kevin L, Meng, X Wei, Schneider, Paula A, Knorr, Katherine L B, Kaufmann, Scott H

“…The BCL2 family of proteins regulates cellular life and death decisions. Among BCL2 family members, BH3-only proteins have critical roles by neutralizing…”
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