Search Results - "WEGNER, Craig"

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival by Morgan, Paul, Van Der Graaf, Piet H., Arrowsmith, John, Feltner, Doug E., Drummond, Kira S., Wegner, Craig D., Street, Steve D.A.

“…In an effort to uncover systematic learnings that can be applied to improve compound survival, an analysis was performed on data from Phase II decisions for 44…”
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Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses by MITCHEM, Jonathan B, BRENNAN, Donal J, HEWITT, Stephen, MALLYA UDUPI, Girish, GALLAGHER, William M, WEGNER, Craig, WEST, Brian L, WANG-GILLAM, Andrea, GOEDEGEBUURE, Peter, LINEHAN, David C, DENARDO, David G, KNOLHOFF, Brett L, BELT, Brian A, YU ZHU, SANFORD, Dominic E, BELAYGOROD, Larisa, CARPENTER, Danielle, COLLINS, Lynne, PIWNICA-WORMS, David

“…Tumor-infiltrating immune cells can promote chemoresistance and metastatic spread in aggressive tumors. Consequently, the type and quality of immune responses…”
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Pioneering government-sponsored drug repositioning collaborations: progress and learning by Frail, Donald E., Brady, Madeleine, Escott, K. Jane, Holt, Alison, Sanganee, Hitesh J., Pangalos, Menelas N., Watkins, Chris, Wegner, Craig D.

“…A new model for translational research and drug repositioning has recently been established based on three-way partnerships between public funders, the…”
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A public–private collaboration model for clinical innovation by Wegner, Craig D., Mount, Bobbie Ann, Colvis, Christine M.

“…Launched in May 2012 as part of the New Therapeutic Uses program, the National Center for Advancing Translational Sciences (NCATS)’ National Institutes of…”
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Effects of an Oral CRTh2 Antagonist (AZD1981) on Eosinophil Activity and Symptoms in Chronic Spontaneous Urticaria by Oliver, Eric Tyrell, Chichester, Kris, Devine, Kelly, Sterba, Patricia Meghan, Wegner, Craig, Vonakis, Becky Marie, Saini, Sarbjit Singh

“…Approximately 50% of patients with chronic spontaneous urticaria (CSU) experience symptoms that are not fully controlled by antihistamines, indicating an unmet…”
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Why Do Promising Therapies Stall in Development and How Can We Move Them Forward? by Wegner, Craig D., Goodwin, Andrew, Cook, Jon C., Allamneni, Krishna, Sohn, Jane, McVean, Maralee

“…There are many reasons that molecules fail to progress to market and various principles of risk–benefit decisions that can help drive the molecule through…”
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A Trial of an Oral CRTH2 Antagonist in Antihistamine-Refractory Chronic Spontaneous Urticaria by Oliver, Eric, Dr, Chichester, Kristin, Ms, Devine, Kelly, Ms, Sterba, Patricia M., Ms, Wegner, Craig, Dr, Vonakis, Becky, Dr, Saini, Sarbjit S., Dr

“…AZD1981 treatment led to reductions in patient reported itch, reduced PGD2-induced eosinophil shape change, increased basophil CRTh2 expression, and increased…”
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Functional Expression of CRTH2 on Blood Eosinophils from Chronic Idiopathic Urticaria Subjects by Sterba, Patricia M., MS, Oliver, Eric, MD, Devine, Kelly, RN, Vonakis, Becky M., PhD, FAAAAI, Wegner, Craig, PhD, Saini, Sarbjit S., MD, FAAAAI

“…CRTH2/DP2 are receptors for Prostaglandin D2 (PGD2) expressed on infiltrating cells and induce chemotaxis and activation. Since activated skin MC release PGD2,…”
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Effect of Colchicine on Clostridium Difficile Infection Incidence, Recurrence, and Severity by Young-Xu, Yinong, Kakkar, Rahul, Mills, Peter, Wegner, Craig D

“…OBJECTIVEThe objective of this study was to determine the impact of colchicine use on the incidence, recurrence, and severity of Clostridium difficile…”
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The Canine Purkinje Fiber: An In Vitro Model System for Acquired Long QT Syndrome and Drug-Induced Arrhythmogenesis by Gintant, Gary A, Limberis, James T, McDermott, Jeff S, Wegner, Craig D, Cox, Bryan F

“…Torsade de pointes is a rare but potentially fatal ventricular arrhythmia associated with drug-induced delayed repolarization and prolongation of the QT…”
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Intercellular Adhesion Molecule-1 (ICAM-1) in the Pathogenesis of Asthma by Wesgner, Craig D., Gundel, Robert H., Reilly, Patricia, Haynes, Nancy, Letts, L. Gordon, Rothlein, Robert

“…Airway eosinophilia, epithelial desquamation, and hyperresponsiveness are characteristics of the airway inflammation underlying bronchial asthma. The…”
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Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats by Lubbers, Nathan L, Polakowski, James S, Wegner, Craig D, Burke, Sandra E, Diaz, Gilbert J, Daniell, Katina M, Cox, Bryan F

“…Bimoclomol has been shown to increase an inducible member of the heat shock protein 70 family (HSP70) and cytoprotect in vitro. Here, we addressed whether oral…”
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Nonpeptide Luteinizing Hormone-Releasing Hormone Antagonists Derived from Erythromycin A:  Design, Synthesis, and Biological Activity of Cladinose Replacement Analogues by Randolph, John T, Waid, Philip, Nichols, Charles, Sauer, Daryl, Haviv, Fortuna, Diaz, Gilbert, Bammert, Gary, Besecke, Leslie M, Segreti, Jason A, Mohning, Kurt M, Bush, Eugene N, Wegner, Craig D, Greer, Jonathan

“…The design and synthesis of a series of 11,12-cyclic carbamate derivatives of 6-O-methylerythromycin A that are novel, nonpeptide LHRH antagonists, is…”
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Neointimal Formation After Balloon-Induced Vascular Injury in Yucatan Minipigs is Reduced by Oral Rapamycin by Burke, Sandra E, Lubbers, Nathan L, Chen, Yung-Wu, Hsieh, Gin C, Mollison, Karl W, Luly, Jay R, Wegner, Craig D

“…Rapamycin, a macrolide antibiotic known to prevent allograft rejection, is a potent inhibitor of cell proliferation. Therefore we studied the effects of orally…”
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Transforming Growth Factor β Mimetics: Discovery of 7-[4-(4-Cyanophenyl) phenoxy]-Heptanohydroxamic Acid, a Biaryl Hydroxamate Inhibitor of Histone Deacetylase by Glaser, Keith B, Li, Junling, Aakre, Mary E, Morgan, Douglas W, Sheppard, George, Stewart, Kent D, Pollock, Jennifer, Lee, Paul, O'Connor, Chad Z, Anderson, Steven N, Mussatto, Donna J, Wegner, Craig W, Moses, Harold L

“…Transforming growth factor β (TGF-β) is a multifunctional protein that has been shown to possess potent growth-inhibitory activity. To identify small molecular…”
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Evaluation of tissue perfusion in a rat model of hind-limb muscle ischemia using dynamic contrast-enhanced magnetic resonance imaging by Luo, Yanping, Mohning, Kurt M., Hradil, Vincent P., Wessale, Jerry L., Segreti, Jason A., Nuss, Merrill E., Wegner, Craig D., Burke, Sandra E., Cox, Bryan F.

“…Purpose To evaluate the feasibility of using dynamic contrast‐enhanced magnetic resonance imaging (MRI) for assessment of muscle perfusion in a rat model of…”
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Bimoclomol elevates heat shock protein 70 and cytoprotects rat neonatal cardiomyocytes by Polakowski, James S, Wegner, Craig D, Cox, Bryan F

“…Bimoclomol is a new compound that improves cell survival under experimental stress conditions partly by increasing intracellular heat shock proteins (HSPs)…”
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Neutrophils enhance clearance of necrotic epithelial cells in ozone-induced lung injury in rhesus monkeys by Hyde, D M, Miller, L A, McDonald, R J, Stovall, M Y, Wong, V, Pinkerton, K E, Wegner, C D, Rothlein, R, Plopper, C G

“…To test the hypothesis that neutrophil influx is important for the removal of necrotic airway epithelial cells, rhesus monkeys were treated with a…”
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Inhibition of 11β‐Hydroxysteroid dehydrogenase‐1 with AZD4017 in patients with nonalcoholic steatohepatitis or nonalcoholic fatty liver disease: A randomized, double‐blind, placebo‐controlled, phase II study by Yadav, Yogesh, Dunagan, Kelly, Khot, Rachita, Venkatesh, Sudhakar K., Port, John, Galderisi, Alfonso, Cobelli, Claudio, Wegner, Craig, Basu, Ananda, Carter, Rickey, Basu, Rita

“…Aim To evaluate whether short‐term treatment with a selective 11β‐Hydroxysteroid dehydrogenase‐1 (11β‐HSD1) inhibitor, AZD4017, would block hepatic cortisol…”
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Preischemic and Postischemic Administration of AEOL10113 Reduces Infarct Size in a Rat Model of Myocardial Ischemia and Reperfusion by Lubbers, Nathan L, Polakowski, James S, Crapo, James D, Wegner, Craig D, Cox, Bryan F

“…Reactive oxygen species (ROS) have been implicated as important mediators of cellular damage during ischemia/reperfusion. AEOL10113 is a low-molecular-weight…”
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