Search Results - "WEGGEN, Sascha"

Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier by Storck, Steffen E., Meister, Sabrina, Nahrath, Julius, Meißner, Julius N., Schubert, Nils, Di Spiezio, Alessandro, Baches, Sandra, Vandenbroucke, Roosmarijn E., Bouter, Yvonne, Prikulis, Ingrid, Korth, Carsten, Weggen, Sascha, Heimann, Axel, Schwaninger, Markus, Bayer, Thomas A., Pietrzik, Claus U.

“…According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor–related protein-1 (LRP1) in brain capillaries of the blood-brain…”
Get full text

The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM by Storck, Steffen E., Hartz, Anika M.S., Bernard, Jessica, Wolf, Andrea, Kachlmeier, André, Mahringer, Anne, Weggen, Sascha, Pahnke, Jens, Pietrzik, Claus U.

“…Schematic representation of Aβ trafficking across the brain capillary endothelium. PICALM directs the abluminal Aβ-LRP1 complex to Rab11-positive sorting…”
Get full text

Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis by Stazi, Martina, Lehmann, Sandra, Sakib, M. Sadman, Pena-Centeno, Tonatiuh, Büschgens, Luca, Fischer, Andre, Weggen, Sascha, Wirths, Oliver

“…Epidemiological studies indicate that the consumption of caffeine, the most commonly ingested psychoactive substance found in coffee, tea or soft drinks,…”
Get full text

PCSK9 acts as a key regulator of Aβ clearance across the blood–brain barrier by Mazura, Alexander D., Ohler, Anke, Storck, Steffen E., Kurtyka, Magdalena, Scharfenberg, Franka, Weggen, Sascha, Becker-Pauly, Christoph, Pietrzik, Claus U.

“…Despite the neurodegenerative disorder Alzheimer’s disease (AD) is the most common form of dementia in late adult life, there is currently no therapy available…”
Get full text

DOGS: reaction-driven de novo design of bioactive compounds by Hartenfeller, Markus, Zettl, Heiko, Walter, Miriam, Rupp, Matthias, Reisen, Felix, Proschak, Ewgenij, Weggen, Sascha, Stark, Holger, Schneider, Gisbert

“…We present a computational method for the reaction-based de novo design of drug-like molecules. The software DOGS (Design of Genuine Structures) features a…”
Get full text

Limited Effects of Prolonged Environmental Enrichment on the Pathology of 5XFAD Mice by Hüttenrauch, Melanie, Walter, Susanne, Kaufmann, Margie, Weggen, Sascha, Wirths, Oliver

“…The environmental enrichment (EE) paradigm is regarded as a useful tool to create a physical and intellectual stimulation for laboratory rodents and has been…”
Get full text

NSAIDs: small molecules for prevention of Alzheimer's disease or precursors for future drug development? by Weggen, Sascha, Rogers, Mark, Eriksen, Jason

“…Non-steroidal anti-inflammatory drugs (NSAIDs) have been considered for treatment and prevention of Alzheimer's disease (AD) for more than two decades…”
Get full text

Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer’s disease by Marengo, Liana, Armbrust, Fred, Schoenherr, Caroline, Storck, Steffen E., Schmitt, Ulrich, Zampar, Silvia, Wirths, Oliver, Altmeppen, Hermann, Glatzel, Markus, Kaether, Christoph, Weggen, Sascha, Becker-Pauly, Christoph, Pietrzik, Claus U.

“…β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is the major described β-secretase to generate Aβ peptides in Alzheimer’s disease (AD)…”
Get full text

Neprilysin deficiency alters the neuropathological and behavioral phenotype in the 5XFAD mouse model of Alzheimer's disease by Hüttenrauch, Melanie, Baches, Sandra, Gerth, Janina, Bayer, Thomas A, Weggen, Sascha, Wirths, Oliver

“…The deposition of amyloid-β (Aβ) is one of the major neuropathological hallmarks of Alzheimer's disease (AD). In the case of sporadic AD, an imbalance in Aβ in…”
Get more information

The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease by Walter, Susanne, Jumpertz, Thorsten, Hüttenrauch, Melanie, Ogorek, Isabella, Gerber, Hermeto, Storck, Steffen E., Zampar, Silvia, Dimitrov, Mitko, Lehmann, Sandra, Lepka, Klaudia, Berndt, Carsten, Wiltfang, Jens, Becker-Pauly, Christoph, Beher, Dirk, Pietrzik, Claus U., Fraering, Patrick C., Wirths, Oliver, Weggen, Sascha

“…Brain accumulation and aggregation of amyloid-β (Aβ) peptides is a critical step in the pathogenesis of Alzheimer’s disease (AD). Full-length Aβ peptides…”
Get full text

Blood platelets in the progression of Alzheimer's disease by Gowert, Nina S, Donner, Lili, Chatterjee, Madhumita, Eisele, Yvonne S, Towhid, Seyda T, Münzer, Patrick, Walker, Britta, Ogorek, Isabella, Borst, Oliver, Grandoch, Maria, Schaller, Martin, Fischer, Jens W, Gawaz, Meinrad, Weggen, Sascha, Lang, Florian, Jucker, Mathias, Elvers, Margitta

“…Alzheimer's disease (AD) is characterized by neurotoxic amyloid-ß plaque formation in brain parenchyma and cerebral blood vessels known as cerebral amyloid…”
Get full text

Truncated mini LRP1 transports cargo from luminal to basolateral side across the blood brain barrier by Fritzen, Laura, Wienken, Katharina, Wagner, Lelia, Kurtyka, Magdalena, Vogel, Katharina, Körbelin, Jakob, Weggen, Sascha, Fricker, Gert, Pietrzik, Claus U

“…The most crucial area to focus on when thinking of novel pathways for drug delivery into the CNS is the blood brain barrier (BBB). A number of nanoparticulate…”
Get full text

Evaluation of cerebrospinal fluid glycoprotein NMB (GPNMB) as a potential biomarker for Alzheimer's disease by Aichholzer, Freyja, Klafki, Hans-Wolfgang, Ogorek, Isabella, Vogelgsang, Jonathan, Wiltfang, Jens, Scherbaum, Norbert, Weggen, Sascha, Wirths, Oliver

“…Alzheimer's disease (AD) is a neurodegenerative disorder associated with extracellular amyloid-β peptide deposition and progressive neuron loss. Strong…”
Get full text

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Aβ42 production by Golde, Todd E, Kukar, Thomas, Murphy, Michael Paul, Eriksen, Jason L, Sagi, Sarah A, Weggen, Sascha, Smith, Tawnya E, Ladd, Thomas, Khan, Murad A, Kache, Rajashaker, Beard, Jenny, Dodson, Mark, Merit, Sami, Ozols, Victor V, Anastasiadis, Panos Z, Das, Pritam, Fauq, Abdul, Koo, Edward H

“…Increased Aβ42 production has been linked to the development of Alzheimer disease. We now identify a number of compounds that raise Aβ42. Among the more potent…”
Get full text

Amyloid beta 42 peptide (Aβ42)-lowering compounds directly bind to Aβ and interfere with amyloid precursor protein (APP) transmembrane dimerization by Richter, Luise, Munter, Lisa-Marie, Ness, Julia, Hildebrand, Peter W, Dasari, Muralidhar, Unterreitmeier, Stephanie, Bulic, Bruno, Beyermann, Michael, Gust, Ronald, Reif, Bernd, Weggen, Sascha, Langosch, Dieter, Multhaup, Gerd

“…Following ectodomain shedding by β-secretase, successive proteolytic cleavages within the transmembrane sequence (TMS) of the amyloid precursor protein (APP)…”
Get full text

A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity by Koo, Edward H, Weggen, Sascha, Eriksen, Jason L, Das, Pritam, Sagi, Sarah A, Wang, Rong, Pietrzik, Claus U, Findlay, Kirk A, Smith, Tawnya E, Murphy, Michael P, Bulter, Thomas, Kang, David E, Marquez-Sterling, Numa, Golde, Todd E

“…Epidemiological studies have documented a reduced prevalence of Alzheimer's disease among users of nonsteroidal anti-inflammatory drugs (NSAIDs). It has been…”
Get full text

Presenilin is the molecular target of acidic γ-secretase modulators in living cells by Jumpertz, Thorsten, Rennhack, Andreas, Ness, Julia, Baches, Sandra, Pietrzik, Claus U, Bulic, Bruno, Weggen, Sascha

“…The intramembrane-cleaving protease γ-secretase catalyzes the last step in the generation of toxic amyloid-β (Aβ) peptides and is a principal therapeutic…”
Get full text

Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice by Bader, Angelika Sabine, Gnädig, Marius-Uwe, Fricke, Merle, Büschgens, Luca, Berger, Lena Josefine, Klafki, Hans-Wolfgang, Meyer, Thomas, Jahn, Olaf, Weggen, Sascha, Wirths, Oliver

“…Senile plaques consisting of amyloid-beta (Aβ) peptides are a major pathological hallmark of Alzheimer's disease (AD). Aβ peptides are heterogeneous regarding…”
Get full text

N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models by Wirths, Oliver, Walter, Susanne, Kraus, Inga, Klafki, Hans W., Stazi, Martina, Oberstein, Timo J., Ghiso, Jorge, Wiltfang, Jens, Bayer, Thomas A., Weggen, Sascha

“…BACKGROUNDThe deposition of neurotoxic amyloid-β (Aβ) peptides in plaques in the brain parenchyma and in cerebral blood vessels is considered to be a key event…”
Get full text

APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms by Isbert, Simone, Wagner, Katja, Eggert, Simone, Schweitzer, Andrea, Multhaup, Gerd, Weggen, Sascha, Kins, Stefan, Pietrzik, Claus U.

“…The amyloid precursor protein (APP) is part of a larger gene family, which has been found to form homo- or heterotypic complexes with its homologues, whereby…”
Get full text