Search Results - "WEGENER, G"

Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder by Mørk, A, Pehrson, A, Brennum, L T, Nielsen, S Møller, Zhong, H, Lassen, A B, Miller, S, Westrich, L, Boyle, N J, Sánchez, C, Fischer, C W, Liebenberg, N, Wegener, G, Bundgaard, C, Hogg, S, Bang-Andersen, B, Stensbøl, T Bryan

“…1-[2-(2,4-Dimethylphenyl-sulfanyl)-phenyl]-piperazine (Lu AA21004) is a human (h) serotonin (5-HT)(3A) receptor antagonist (K(i) = 3.7 nM), h5-HT(7) receptor…”
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Stress and corticosterone increase the readily releasable pool of glutamate vesicles in synaptic terminals of prefrontal and frontal cortex by Treccani, G, Musazzi, L, Perego, C, Milanese, M, Nava, N, Bonifacino, T, Lamanna, J, Malgaroli, A, Drago, F, Racagni, G, Nyengaard, J R, Wegener, G, Bonanno, G, Popoli, M

“…Stress and glucocorticoids alter glutamatergic transmission, and the outcome of stress may range from plasticity enhancing effects to noxious, maladaptive…”
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Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene by Wei, Yabin, Melas, Philippe A, Wegener, Gregers, Mathé, Aleksander A, Lavebratt, Catharina

“…Epigenetic drugs like sodium butyrate (NaB) show antidepressant-like effects in preclinical studies, but the exact molecular mechanisms of the antidepressant…”
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Phylogenetic and functional diverse ANME-1 thrive in Arctic hydrothermal vents by Vulcano, F, Hahn, C J, Roerdink, D, Dahle, H, Reeves, E P, Wegener, G, Steen, I H, Stokke, R

“…Abstract The methane-rich areas, the Loki's Castle vent field and the Jan Mayen vent field at the Arctic Mid Ocean Ridge (AMOR), host abundant niches for…”
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The antidepressant action of imipramine and venlafaxine involves suppression of nitric oxide synthesis by Krass, M., Wegener, G., Vasar, E., Volke, V.

“…▶ We studied whether l-arginine pretreatment modifies the effects of antidepressants. ▶l-arg counteracted the effect of imipramine, venlafaxine and bupropion…”
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Co-administration of cannabidiol and ketamine induces antidepressant-like effects devoid of hyperlocomotor side-effects by Sartim, A.G., Marques, J., Silveira, K.M., Gobira, P.H., Guimarães, F.S., Wegener, G., Joca, S.R.

“…Although useful as a rapid-acting antidepressant drug, ketamine is known to induce psychotomimetic effects, which may interfere with its therapeutic use…”
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Telomerase Dysregulation in the Hippocampus of a Rat Model of Depression: Normalization by Lithium by Wei, Ya Bin, Backlund, Lena, Wegener, Gregers, Mathé, Aleksander A, Lavebratt, Catharina

“…Background: Telomeres are protective DNA-protein complexes at the ends of each chromosome, maintained primarily by the enzyme telomerase. Shortening of the…”
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Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner by Dudele, A, Hougaard, K S, Kjølby, M, Hokland, M, Winther, G, Elfving, B, Wegener, G, Nielsen, A L, Larsen, A, Nøhr, M K, Pedersen, S B, Wang, T, Lund, S

“…Background/Objectives: The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes…”
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Effect of fishing effort on catch rate and catchability of largemouth bass in small impoundments by Wegener, M. G., Schramm, H. L., Neal, J. W., Gerard, P. D.

“…Largemouth bass Micropterus salmoides (Lacepède) catch rates decline with sustained fishing effort, even without harvest. It is unclear why declines in catch…”
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Hemisphere-dependent endocannabinoid system activity in prefrontal cortex and hippocampus of the Flinders Sensitive Line rodent model of depression by Kirkedal, C., Elfving, B., Müller, H.K., Moreira, F.A., Bindila, L., Lutz, B., Wegener, G., Liebenberg, N.

“…Altered endocannabinoid (eCB) signalling is suggested as an important contributor to the pathophysiology of depression. To further elucidate this, we conducted…”
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Saturated CO2 inhibits microbial processes in CO2-vented deep-sea sediments by de Beer, D, Haeckel, M, Neumann, J, Wegener, G, Inagaki, F, Boetius, A

“…This study focused on biogeochemical processes and microbial activity in sediments of a natural deep-sea CO2 seepage area (Yonaguni Knoll IV hydrothermal…”
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Ketamine is effective in an animal model of treatment-resistant depression by Pereira, V, Joca, S, Wegener, G

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Animal models of depression and anxiety: What do they tell us about human condition? by Neumann, I.D., Wegener, G., Homberg, J.R., Cohen, H., Slattery, D.A., Zohar, J., Olivier, J.D.A., Mathé, A.A.

“…While modern neurobiology methods are necessary they are not sufficient to elucidate etiology and pathophysiology of affective disorders and develop new…”
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An experimental study on short-term changes in the anaerobic oxidation of methane in response to varying methane and sulfate fluxes by Wegener, G., Boetius, A.

“…A major role in regulation of global methane fluxes has been attributed to the process of anaerobic oxidation of methane (AOM), which is performed by consortia…”
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Affectivity during social behaviour in a schizophrenic-like rat by Kai, L, Gill, D, Wegener, G, Tasker, A

“…Introduction Rats are social animals that produce high-frequency whistles said to reflect their underlying affective state. Injecting rats with a glutamate…”
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P.1.h.014 Time dependent sensitisation exaggerates depressive-like symptoms in Flinders sensitive line (FSL) rats, a genetic animal model of depression by Brand, S, Wegener, G, Harvey, B

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Astroglial Control of the Antidepressant-Like Effects of Prefrontal Cortex Deep Brain Stimulation by Etiévant, A., Oosterhof, C., Bétry, C., Abrial, E., Novo-Perez, M., Rovera, R., Scarna, H., Devader, C., Mazella, J., Wegener, G., Sánchez, C., Dkhissi-Benyahya, O., Gronfier, C., Coizet, V., Beaulieu, J.M., Blier, P., Lucas, G., Haddjeri, N.

“…Although deep brain stimulation (DBS) shows promising efficacy as a therapy for intractable depression, the neurobiological bases underlying its therapeutic…”
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Intratumoral expression of programmed death ligand 1 (PD-L1) in patients with clear cell renal cell carcinoma (ccRCC) by Abbas, M., Steffens, S., Bellut, M., Eggers, H., Großhennig, A., Becker, J. U., Wegener, G., Schrader, A. J., Grünwald, V., Ivanyi, P.

“…The immunological checkpoints of programmed death 1 and its ligand (PD-L1) are currently in focus as novel therapeutic targets in renal cell carcinoma (RCC)…”
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Elevation of Il6 is associated with disturbed let-7 biogenesis in a genetic model of depression by Wei, Y B, Liu, J J, Villaescusa, J C, Åberg, E, Brené, S, Wegener, G, Mathé, A A, Lavebratt, C

“…Elevation of the proinflammatory cytokine IL-6 has been implicated in depression; however, the mechanisms remain elusive. MicroRNAs (miRNAs) are small…”
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103. Maternal perinatal high-fat diet increases anxiety-like behavior in male offspring by Winther, G, Lund, S, Müller, H.K, Wegener, G

“…Background: Maternal obesity during gestation represents a significant health risk for the offspring, becoming evident later in life and includes metabolic…”
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