Search Results - "WEEDA, G"

Rolling contact fatigue and wear behaviour of the infrastar two-material rail by Franklin, F.J., Weeda, G.-J., Kapoor, A., Hiensch, E.J.M.

“…Rolling contact fatigue (RCF) is currently one of the principal limitations of railway infrastructure productivity. Head checks in particular are prevalent in…”
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Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence by Weeda, G., Donker, I., de Wit, J., Morreau, H., Janssens, R., Vissers, C.J., Nigg, A., van Steeg, H., Bootsma, D., Hoeijmakers, J.H.J.

“…Background: The structure-specific ERCC1/XPF endonuclease complex that contains the ERCC1 and XPF subunits is implicated in the repair of two distinct types of…”
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p53 modulation of TFIIH-associated nucleotide excision repair activity by Wang, X.W, Yeh, H, Schaeffer, L, Roy, R, Moncollin, V, Egly, J.-M, Wang, Z, Friedberg, E.C, Evans, M.K, Taffe, B.G, Bohr, V.A, Weeda, G, Hoeijmakers, J.H.J, Forrester, K, Harris, C.C

“…p53 has pleiotropic functions including control of genomic plasticity and integrity. Here we report that p53 can bind to several transcription factor…”
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The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor by Schaeffer, L., Moncollin, V., Roy, R., Staub, A., Mezzina, M., Sarasin, A., Weeda, G., Hoeijmakers, J.H., Egly, J.M.

“…ERCC2 is involved in the DNA repair syndrome xeroderma pigmentosum (XP) group D and was found to copurify with the RNA polymerase II (B) transcription factor…”
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The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage by Van Sloun, Petra P. H., Jansen, Jacob G., Weeda, Geert, Mullenders, Leon H. F., van Zeeland, Albert A., Lohman, Paul H. M., Vrieling, Harry

“…In this study the role of nucleotide excision repair (NER) in protecting mouse embryonic stem (ES) cells against the genotoxic effects of UV-photolesions was…”
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A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy by WEEDA, G, EVENO, E, DONKER, I, VERMEULEN, W, CHEVALLIER-LAGENTE, O, TAÏEB, A, STARY, A, HOEIJMAKERS, J. H. J, MEZZINA, M, SARASIN, A

“…Trichothiodystrophy (TTD) is a rare, autosomal recessive disorder characterized by sulfur-deficient brittle hair and nails, mental retardation, impaired sexual…”
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Prevention of RCF damage in curved track through development of the INFRA-STAR two-material rail by HIENSCH, E. J. M., FRANKLIN, F. J., NIELSEN, J. C. O., RINGSBERG, J. W., WEEDA, G. J., KAPOOR, A., JOSEFSON, B. L.

“…ABSTRACT Results from the European 5th frame research project ‘INFRA‐STAR’ are presented. The goal of the project is to prevent rolling contact fatigue (RCF)…”
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RAD25 (SSL2), the Yeast Homolog of the Human Xeroderma Pigmentosum Group B DNA Repair Gene, is Essential for Viability by Park, Eun, Guzder, Sami N., Marcel H. M. Koken, Jaspers-Dekker, Iris, Weeda, Geert, Jan H. J. Hoeijmakers, Prakash, Satya, Prakash, Louise

“…Xeroderma pigmentosum (XP) patients are extremely sensitive to ultraviolet (UV) light and suffer from a high incidence of skin cancers, due to a defect in…”
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The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor by Weeda, G., Rossignol, M., Fraser, R. A., Winkler, G. S., Vermeulen, W., van't Veer, L. J., Ma, L., Hoeijmakers, J. H. J., Egly, J.-M.

“…Mutations in the basal transcription initiation/DNA repair factor TFIIH are responsible for three human disorders: xeroderma pigmentosum (XP), Cockayne…”
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Clinical heterogeneity within xeroderma pigmentosum associated with mutations in the DNA repair and transcription gene ERCC3 by VERMEULEN, W, SCOTT, R. J, RODGERS, S, MÜLLER, H. J, COLE, J, ARLETT, C. F, KLEIJER, W. J, BOOTSMA, D, HOEIJMAKERS, J. H. J, WEEDA, G

“…The human DNA excision repair gene ERCC3 specifically corrects the nucleotide excision repair (NER) defect of xeroderma pigmentosum (XP) complementation group…”
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The DNA-dependent ATPase activity associated with the class II basic transcription factor BTF2/TFIIH by ROY, R, SCHAEFFER, L, HUMBERT, S, VERMEULEN, W, WEEDA, G, EGLY, J.-M

“…BTF2/TFIIH from human, delta from rat, and factor b from yeast are multisubunit basal transcription factors that have been shown to be closely associated with…”
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Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH) by Vuuren, A.J., Vermeulen, W., Ma, L., Weeda, G., Appeldoorn, E., Jaspers, N.G., Eb, A.J., Bootsma, D., Hoeijmakers, J.H., Humbert, S.

“…ERCC3 was initially identified as a gene correcting the nucleotide excision repair (NER) defect of xeroderma pigmentosum complementation group B (XP‐B). The…”
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A new nucleotide-excision-repair gene associated with the disorder trichothiodystrophy by STEFANINI, M, VERMEULEN, W, LEHMANN, A. R, WEEDA, G, GILIANI, S, NARDO, T, MEZZINA, M, SARASIN, A, HARPER, J. I, ARLETT, C. F, HOEIJMAKERS, J. H. J

“…The sun-sensitive, cancer-prone genetic disorder xeroderma pigmentosum (XP) is associated in most cases with a defect in the ability to carry out excision…”
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Three unusual repair deficiencies associated with transcription factor BTF2(TFIIH): evidence for the existence of a transcription syndrome by Vermeulen, W, van Vuuren, A J, Chipoulet, M, Schaeffer, L, Appeldoorn, E, Weeda, G, Jaspers, N G, Priestley, A, Arlett, C F, Lehmann, A R

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Molecular cloning and biological characterization of the human excision repair gene ERCC-3 by WEEDA, G, VAN HAM, R. C. A, MASUREL, R, WESTERVELD, A, ODIJK, H, DE WIT, J, BOOTSMA, D, VAN DER EB, A. J, HOEIJMAKERS, J. H. J

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Adenosine deaminase: characterization and expression of a gene with a remarkable promoter by Valerio, D., Duyvesteyn, M.G., Dekker, B.M., Weeda, G., Berkvens, T.M., Voorn, L., Ormondt, H., Eb, A.J.

“…Cosmid clones containing the gene for human adenosine deaminase (ADA) were isolated. The gene is 32 kb long and split into 12 exons. The exact sizes and…”
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Mutational analysis of ERCC3, which is involved in DNA repair and transcription initiation: identification of domains essential for the DNA repair function by MA, L, WESTBROEK, A, JOCHEMSEN, A. G, WEEDA, G, BOSCH, A, BOOTSMA, D, HOEIJMAKERS, J. H. J, VAN DER EB, A. J

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The workload of trainees in general practice by Weeda, G, Hutter, A W, Groenier, K H, Schuling, J

“…SUMMARY During their first training period in general practice the authors felt that they did not encounter the balanced workload which is the foundation for…”
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Mammalian nucleotide excision repair and syndromes by Vermeulen, W, de Boer, J, Citterio, E, van Gool, A J, van der Horst, G T, Jaspers, N G, de Laat, W L, Sijbers, A M, van der Spek, P J, Sugasawa, K, Weeda, G, Winkler, G S, Bootsma, D, Egly, J M, Hoeijmakers, J H

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Premature Aging in Mice Deficient in DNA Repair and Transcription by de Boer, Jan, Andressoo, Jaan Olle, de Wit, Jan, Huijmans, Jan, Beems, Rudolph B., van Steeg, Harry, Weeda, Geert, Gijsbertus T. J. van der Horst, van Leeuwen, Wibeke, Axel P. N. Themmen, Meradji, Morteza, Jan H. J. Hoeijmakers

“…One of the factors postulated to drive the aging process is the accumulation of DNA damage. Here, we provide strong support for this hypothesis by describing…”
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