Search Results - "WEDDERBURN, L."

Juvenile Dermatomyositis: what comes next? Long-term outcomes in childhood myositis from a patient perspective by Boros, C., McCann, L., Simou, S., Cancemi, D., Ambrose, N., Pilkington, C. A., Cortina-Borja, M., Wedderburn, L. R

“…BACKGROUNDTo describe long-term outcomes in JDM using patient questionnaires and link to longitudinal, prospectively collected data for each patient within the…”
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Expression of myxovirus‐resistance protein A: a possible marker of muscle disease activity and autoantibody specificities in juvenile dermatomyositis by Soponkanaporn, S., Deakin, C. T., Schutz, P. W., Marshall, L. R., Yasin, S. A., Johnson, C. M., Sag, E., Tansley, S. L., McHugh, N. J., Wedderburn, L. R., Jacques, T. S.

“…Aims To evaluate the relationship between expression of myxovirus‐resistance protein A (MxA) protein on muscle biopsies by immunohistochemistry and disease…”
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Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases by Hinks, A, Bowes, J, Cobb, J, Ainsworth, H C, Marion, M C, Comeau, M E, Sudman, M, Han, B, Becker, M L, Bohnsack, J F, de Bakker, P I W, Haas, J P, Hazen, M, Lovell, D J, Nigrovic, P A, Nordal, E, Punnaro, M, Rosenberg, A M, Rygg, M, Smith, S L, Wise, C A, Videm, V, Wedderburn, L R, Yarwood, A, Yeung, R S M, Prahalad, S, Langefeld, C D, Raychaudhuri, S, Thompson, S D, Thomson, W

“…Juvenile idiopathic arthritis (JIA) is a heterogeneous group of diseases, comprising seven categories. Genetic data could potentially be used to help redefine…”
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The Juvenile Dermatomyositis National Registry and Repository (UK and Ireland) : clinical characteristics of children recruited within the first 5 yr by MCCANN, L. J, JUGGINS, A. D, MAILLARD, S. M, WEDDERBURN, L. R, DAVIDSON, J. E, MURRAY, K. J, PILKINGTON, C. A

“…To identify epidemiological, clinical and laboratory characteristics of juvenile dermatomyositis (JDM) in a national multi-centre cohort of patients, and to…”
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Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes by Miller, F W, Chen, W, O'Hanlon, T P, Cooper, R G, Vencovsky, J, Rider, L G, Danko, K, Wedderburn, L R, Lundberg, I E, Pachman, L M, Reed, A M, Ytterberg, S R, Padyukov, L, Selva-O'Callaghan, A, Radstake, T R, Isenberg, D A, Chinoy, H, Ollier, W E R, Scheet, P, Peng, B, Lee, A, Byun, J, Lamb, J A, Gregersen, P K, Amos, C I

“…Autoimmune muscle diseases (myositis) comprise a group of complex phenotypes influenced by genetic and environmental factors. To identify genetic risk factors…”
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Clinical associations of autoantibodies to a p155/140 kDa doublet protein in juvenile dermatomyositis by Gunawardena, H., Wedderburn, L. R., North, J., Betteridge, Z., Dunphy, J., Chinoy, H., Davidson, J. E., Cooper, R. G., McHugh, N. J.

“…Objectives. Myositis-specific autoantibodies (MSAs) may define homogeneous clinical subsets of adult patients with dermatomyositis (DM). Recently, there have…”
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Development and External Validation of a Model Predicting New‐Onset Chronic Uveitis at Different Disease Durations in Juvenile Idiopathic Arthritis by Straalen, Joeri W., Kearsley‐Fleet, Lianne, Klotsche, Jens, Roock, Sytze, Minden, Kirsten, Heiligenhaus, Arnd, Hyrich, Kimme L., Boer, Joke H., Lamot, Lovro, Olivieri, Alma N., Gallizzi, Romina, Smolewska, Elzbieta, Faugier, Enrique, Pastore, Serena, Hashkes, Philip J., Herrera, Cristina N., Emminger, Wolfgang, Consolini, Rita, Wulffraat, Nico M., Ruperto, Nicolino, Swart, Joost F., Cleary, G, Baildam, E, Wedderburn, L, Davidson, J, Chieng, A, McErlane, F, Foster, H, Ciurtin, C, Ioannou, Y, Thomson, W, Hyrich, K, Kallinich, Tilmann, Dressler, Frank, Deschner, Jasmin Kümmerle, Weller‐Heinemann, Frank, Horneff, Gerd, Hospach, Anton, Mönkemöller, Kirsten, Haas, Johannes Peter, Windschall, Daniel, Foeldvari, Ivan, Foell, Dirk

“…Objective To develop and externally validate a prediction model for new‐onset chronic uveitis in children with juvenile idiopathic arthritis (JIA) for clinical…”
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Comparison of children with onset of juvenile dermatomyositis symptoms before or after their fifth birthday in a UK and Ireland juvenile dermatomyositis cohort study by Martin, N., Krol, P., Smith, S., Beard, L., Pilkington, C. A., Davidson, J., Wedderburn, L. R.

“…Objective To compare 2 groups of children with juvenile dermatomyositis (DM), those with onset of symptoms before their fifth birthday versus those whose…”
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You give me a name that I can't say, but I have to explain what it is every day: the power of poetry to share stories from young people with a rare disease by Livermore, P., Wedderburn, L. R., Gibson, F.

“…Qualitative research is about people's lives; their stories, their thoughts, their feelings, and their experiences. Researchers continue to reflect on the best…”
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Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity by de Kleer, I M, Brinkman, D M C, Ferster, A, Abinun, M, Quartier, P, van der Net, J, ten Cate, R, Wedderburn, L R, Horneff, G, Oppermann, J, Zintl, F, Foster, H E, Prieur, A M, Fasth, A, van Rossum, M A J, Kuis, W, Wulffraat, N M

“…Objective: To evaluate the safety and efficacy of autologous stem cell transplantation (ASCT) for refractory juvenile idiopathic arthritis (JIA). Design:…”
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Quantitative assessment of MRI T2 relaxation time of thigh muscles in juvenile dermatomyositis by Maillard, S. M., Jones, R., Owens, C., Pilkington, C., Woo, P., Wedderburn, L. R., Murray, K. J.

“…Objective. The aim of the study was to examine the validity and reliability of a quantifiable measure of inflammation using magnetic resonance imaging (MRI) in…”
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The lived experience of juvenile idiopathic arthritis in young people receiving etanercept by Livermore, P, Eleftheriou, D, Wedderburn, L R

“…This study explores young people's daily experiences of living with Juvenile Idiopathic Arthritis (JIA) and their thoughts, beliefs and feelings related to the…”
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Genotyping of immune-related genetic variants identifies TYK2 as a novel associated locus for idiopathic inflammatory myopathies by Jani, M, Massey, J, Wedderburn, L R, Vencovský, J, Danko, K, Lundberg, I E, Padyukov, L, Selva-O'Callaghan, A, Radstake, T, Platt, H, Warren, R B, Griffiths, C E, Lee, A, Gregersen, P K, Miller, F W, Ollier, W E, Cooper, R G, Chinoy, H, Lamb, J A

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HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis–scleroderma overlap by Wedderburn, L. R., McHugh, N. J., Chinoy, H., Cooper, R. G., Salway, F., Ollier, W. E. R., McCann, L. J., Varsani, H., Dunphy, J., North, J., Davidson, J. E.

“…Objectives. To investigate a large cohort of children with juvenile dermatomyositis (JDM), and those with JDM–scleroderma (JDM–SSc) overlap, using detailed…”
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Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases by Cobb, J, Cule, E, Moncrieffe, H, Hinks, A, Ursu, S, Patrick, F, Kassoumeri, L, Flynn, E, Bulatović, M, Wulffraat, N, van Zelst, B, de Jonge, R, Bohm, M, Dolezalova, P, Hirani, S, Newman, S, Whitworth, P, Southwood, T R, De Iorio, M, Wedderburn, L R, Thomson, W

“…Clinical response to methotrexate (MTX) treatment for children with juvenile idiopathic arthritis (JIA) displays considerable heterogeneity. Currently, there…”
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Intravenous cyclophosphamide pulse therapy in juvenile dermatomyositis. A review of efficacy and safety by Riley, P., Maillard, S. M., Wedderburn, L. R., Woo, P., Murray, K. J., Pilkington, C. A.

“…Objectives. To assess the efficacy and safety of intravenous cyclophosphamide (CYP) used in severe and refractory juvenile dermatomyositis (JDM). Methods…”
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Effective induction therapy for anti-SRP associated myositis in childhood: A small case series and review of the literature by Binns, E L, Moraitis, E, Maillard, S, Tansley, S, McHugh, N, Jacques, T S, Wedderburn, L R, Pilkington, C, Yasin, S A, Nistala, K

“…Anti-Signal Recognition Particle associated myopathy is a clinically and histopathologically distinct subgroup of Juvenile Idiopathic Inflammatory Myositis,…”
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Association between duration of symptoms and severity of disease at first presentation to paediatric rheumatology: results from the Childhood Arthritis Prospective Study by Adib, N., Hyrich, K., Thornton, J., Lunt, M., Davidson, J., Gardner-Medwin, J., Foster, H., Baildam, E., Wedderburn, L., Thomson, W.

“…Objectives. To study the association between disease severity at first presentation to paediatric rheumatology (PRh) and length of time since symptom onset in…”
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How do tissue infiltrating B cells correlate with other inflammatory features in muscle tissue from patients with JDM and their clinical parameters? by Sag, E, Yasin, S, Arnold, K, Holton, J, Jacques, T, Wedderburn, L

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Age-dependent inhibition of ectopic calcification: a possible role for fetuin-A and osteopontin in patients with juvenile dermatomyositis with calcinosis by Marhaug, G., Shah, V., Shroff, R., Varsani, H., Wedderburn, L. R., Pilkington, C. A., Brogan, P. A.

“…Objectives. To assess if age and/or age-dependent variations in the levels of two major calcification regulatory proteins, fetuin-A and osteopontin, could be…”
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