Search Results - "WECHSELBERGER, RAINER"

Elucidation of Lignin Structure by Quantitative 2D NMR by Sette, Marco, Wechselberger, Rainer, Crestini, Claudia

“…Quick quantitative HSQC (QQ‐HSQC) was applied to quantitative evaluation of different inter‐unit linkages in an array of milled softwood and hardwood and…”
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R Shiny App for the Automated Deconvolution of NMR Spectra to Quantify the Solid-State Forms of Pharmaceutical Mixtures by Prostko, Piotr, Pikkemaat, Jeroen, Selter, Philipp, Lukaschek, Michail, Wechselberger, Rainer, Khamiakova, Tatsiana, Valkenborg, Dirk

“…Bioavailability and chemical stability are important characteristics of drug products that are strongly affected by the solid-state structure of the active…”
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Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihydrofolate reductase of Escherichia coli by Oyen, David, Wechselberger, Rainer, Srinivasan, Vasundara, Steyaert, Jan, Barlow, John N.

“…Although allosteric effector antibodies are used widely as modulators of receptors and enzymes, experimental analysis of their mechanism remains highly…”
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Structural Dynamics in the Activation of Epac by Harper, Shannon M., Wienk, Hans, Wechselberger, Rainer W., Bos, Johannes L., Boelens, Rolf, Rehmann, Holger

“…Epac1 is a cAMP-responsive exchange factor for the small G-protein Rap. It consists of a regulatory region containing a cyclic nucleotide binding (CNB) domain…”
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NMR studies on structure and dynamics of the monomeric derivative of BS-RNase: new insights for 3D domain swapping by Spadaccini, Roberta, Ercole, Carmine, Gentile, Maria A, Sanfelice, Domenico, Boelens, Rolf, Wechselberger, Rainer, Batta, Gyula, Bernini, Andrea, Niccolai, Neri, Picone, Delia

“…Three-dimensional domain swapping is a common phenomenon in pancreatic-like ribonucleases. In the aggregated state, these proteins acquire new biological…”
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Structural Properties of the Promiscuous VP16 Activation Domain by Jonker, Hendrik R. A, Wechselberger, Rainer W, Boelens, Rolf, Folkers, Gert E, Kaptein, Rob

“…Herpes simplex virion protein 16 (VP16) contains two strong activation regions that can independently and cooperatively activate transcription in vivo. We have…”
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The Tandem Zinc-Finger Region of Human ZHX Adopts a Novel C2H2 Zinc Finger Structure with a C-Terminal Extension by Wienk, Hans, Lammers, Ivonne, Hotze, Anna, Wu, Jin, Wechselberger, Rainer W, Owens, Ray, Stammers, David K, Stuart, David, Kaptein, Robert, Folkers, Gert E

“…Binding of the nuclear factor-Y complex (NF-Y) to the inverted CCAAT-box interferes with transcription activation through nucleosome reorganization. The three…”
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Gradual phosphorylation regulates PC4 coactivator function by Jonker, Hendrik R. A., Wechselberger, Rainer W., Pinkse, Martijn, Kaptein, Robert, Folkers, Gert E.

“…The unstructured N‐terminal domain of the transcriptional cofactor PC4 contains multiple phosphorylation sites that regulate activity. The phosphorylation…”
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Structure and function of a unique pore-forming protein from a pathogenic acanthamoeba by Michalek, Matthias, Sönnichsen, Frank D, Wechselberger, Rainer, Dingley, Andrew J, Hung, Chien-Wen, Kopp, Annika, Wienk, Hans, Simanski, Maren, Herbst, Rosa, Lorenzen, Inken, Marciano-Cabral, Francine, Gelhaus, Christoph, Gutsmann, Thomas, Tholey, Andreas, Grötzinger, Joachim, Leippe, Matthias

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The Intrinsically Unstructured Domain of PC4 Modulates the Activity of the Structured Core through Inter- and Intramolecular Interactions by Jonker, Hendrik R. A, Wechselberger, Rainer W, Boelens, Rolf, Kaptein, Rob, Folkers, Gert E

“…Proteins frequently contain unstructured regions apart from a functionally important and well-conserved structured domain. Functional and structural aspects…”
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Lack of Negative Charge in the E46Q Mutant of Photoactive Yellow Protein Prevents Partial Unfolding of the Blue-Shifted Intermediate by Derix, Nocky M, Wechselberger, Rainer W, van der Horst, Michael A, Hellingwerf, Klaas J, Boelens, Rolf, Kaptein, Rob, van Nuland, Nico A. J

“…The long-lived light-induced intermediate (pB) of the E46Q mutant (glutamic acid is replaced by glutamine at position 46) of photoactive yellow protein (PYP)…”
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Structure, Dynamics, and Insertion of a Chloroplast Targeting Peptide in Mixed Micelles by Wienk, Hans L. J, Wechselberger, Rainer W, Czisch, Michael, de Kruijff, Ben

“…Nuclear-encoded, chloroplast-destined proteins are synthesized with transit sequences that contain all information to get them inside the organelle. Different…”
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Structural Characterization of the PIT-1/ETS-1 Interaction: PIT-1 Phosphorylation Regulates PIT-1/ETS-1 Binding by Augustijn, Kevin D., Duval, Dawn L., Wechselberger, Rainer, Kaptein, Rob, Gutierrez-Hartmann, Arthur, van der Vliet, Peter C.

“…The POU-domain transcription factor Pit-1 and Ets-1, a member of the ETS family of transcription factors, can associate in solution and synergistically…”
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An alternate conformation of the hyperthermostable HU protein from Thermotoga maritima has unexpectedly high flexibility by Durney, Michael A, Wechselberger, Rainer W, Kalodimos, Charalampos G, Kaptein, Robert, Vorgias, Constantinos E, Boelens, Rolf

“…The homodimeric HU protein from the hyperthermophile Thermotoga maritima (HU Tmar) is a model system which can yield insights into the molecular determinants…”
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Characterization of In Vitro G-Quadruplex Formation of Imetelstat Telomerase Inhibitor by Carloni, Laure-Elie, Wechselberger, Rainer, De Vijlder, Thomas

“…Imetelstat (GRN163L) is a potent and specific telomerase inhibitor currently in clinical development for the treatment of hematological malignancies such as…”
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Identification of the Single-stranded DNA Binding Surface of the Transcriptional Coactivator PC4 by NMR by Werten, Sebastiaan, Wechselberger, Rainer, Boelens, Rolf, van der Vliet, Peter C., Kaptein, Robert

“…The C-terminal domain of the eukaryotic transcriptional cofactor PC4 (PC4CTD) is known to bind with nanomolar affinity to single-stranded (ss)DNA. Here, NMR is…”
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GM3, GM2 and GM1 mimics designed for biosensing: chemoenzymatic synthesis, target affinities and 900MHz NMR analysis by Pukin, Aliaksei V., Weijers, Carel A.G.M., van Lagen, Barend, Wechselberger, Rainer, Sun, Bin, Gilbert, Michel, Karwaski, Marie-France, Florack, Dion E.A., Jacobs, Bart C., Tio-Gillen, Anne P., van Belkum, Alex, Endtz, Hubert P., Visser, Gerben M., Zuilhof, Han

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Mechanism of 3D domain swapping in bovine seminal ribonuclease by Spadaccini, Roberta, Ercole, Carmine, Graziano, Giuseppe, Wechselberger, Rainer, Boelens, Rolf, Picone, Delia

“…3D domain swapping (3D‐DS) is a complex protein aggregation process for which no unique mechanism exists. We report an analysis of 3D‐DS in bovine seminal…”
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Mechanism of 3 D domain swapping in bovine seminal ribonuclease by Spadaccini, Roberta, Ercole, Carmine, Graziano, Giuseppe, Wechselberger, Rainer, Boelens, Rolf, Picone, Delia

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Structure and function of a unique pore-forming protein from a pathogenic acanthamoeba by Michalek, Matthias, Sönnichsen, Frank D, Wechselberger, Rainer, Dingley, Andrew J, Hung, Chien-Wen, Kopp, Annika, Wienk, Hans, Simanski, Maren, Herbst, Rosa, Lorenzen, Inken, Marciano-Cabral, Francine, Gelhaus, Christoph, Gutsmann, Thomas, Tholey, Andreas, Grötzinger, Joachim, Leippe, Matthias

“…Acanthaporin is identified as a pore-forming protein from the infectious Acanthamoeba culbertsoni with a previously unknown structure. The newly identified…”
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