Search Results - "WEBSTER, Kylie E"

Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells by Vazquez-Lombardi, Rodrigo, Loetsch, Claudia, Zinkl, Daniela, Jackson, Jennifer, Schofield, Peter, Deenick, Elissa K., King, Cecile, Phan, Tri Giang, Webster, Kylie E., Sprent, Jonathan, Christ, Daniel

“…Interleukin-2 (IL-2) is an established therapeutic agent used for cancer immunotherapy. Since treatment efficacy is mediated by CD8 + and NK cell activity at…”
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Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models by MCGUIRE, Helen M, WALTERS, Stacey, VOGELZANG, Alexis, LEE, Carol M. Y, WEBSTER, Kylie E, SPRENT, Jonathan, CHRIST, Daniel, GREY, Shane, KING, Cecile

“…Type 1 diabetes is an incurable chronic autoimmune disease. Although transplantation of pancreatic islets may serve as a surrogate source of insulin,…”
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Meiotic and Epigenetic Defects in Dnmt3L-Knockout Mouse Spermatogenesis by Webster, Kylie E., O'Bryan, Moira K., Fletcher, Stephen, Crewther, Pauline E., Aapola, Ulla, Craig, Jeff, Harrison, Dion K., Aung, Hnin, Phutikanit, Nawapen, Lyle, Robert, Meachem, Sarah J., Antonarakis, Stylianos E., de Kretser, David M., Hedger, Mark P., Peterson, Pärt, Carroll, Bernard J., Scott, Hamish S., Cory, Suzanne

“…The production of mature germ cells capable of generating totipotent zygotes is a highly specialized and sexually dimorphic process. The transition from…”
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DNA methylation signatures of the AIRE promoter in thymic epithelial cells, thymomas and normal tissues by Kont, Vivian, Murumägi, Astrid, Tykocinski, Lars-Oliver, Kinkel, Sarah A., Webster, Kylie E., Kisand, Kai, Tserel, Liina, Pihlap, Maire, Ströbel, Philipp, Scott, Hamish S., Marx, Alexander, Kyewski, Bruno, Peterson, Pärt

“…► AIRE is a key molecule in thymic tolerance to peripheral tissue-specific antigens. ► We studied the CpG methylation and histone modifications in AIRE gene in…”
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A role for intrathymic B cells in the generation of natural regulatory T cells by Walters, Stacey N, Webster, Kylie E, Daley, Stephen, Grey, Shane T

“…B cells inhabit the normal human thymus, suggesting a role in T cell selection. In this study, we report that B cells can modulate thymic production of CD4+…”
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In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression by Webster, Kylie E, Walters, Stacey, Kohler, Rachel E, Mrkvan, Tomas, Boyman, Onur, Surh, Charles D, Grey, Shane T, Sprent, Jonathan

“…Via a transcription factor, Foxp3, immunoregulatory CD4(+)CD25(+) T cells (T reg cells) play an important role in suppressing the function of other T cells…”
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Treg-mediated prolonged survival of skin allografts without immunosuppression by Pilat, Nina, Wiletel, Mario, Weijler, Anna M., Steiner, Romy, Mahr, Benedikt, Warren, Joanna, Corpuz, Theresa M., Wekerle, Thomas, Webster, Kylie E., Sprent, Jonathan

“…Injection of Interleukin-2 (IL-2) complexed with a particular anti–IL-2 monoclonal antibody (mab) JES6-1 has been shown to selectively expand CD4⁺Foxp3⁺ T…”
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IL-2 Shapes the Survival and Plasticity of IL-17-Producing γδ T Cells by Corpuz, Theresa M, Vazquez-Lombardi, Rodrigo, Luong, Jason K, Warren, Joanna, Stolp, Jessica, Christ, Daniel, King, Cecile, Brink, Robert, Sprent, Jonathan, Webster, Kylie E

“…IL-17-producing γδ T (γδT-17) cells have proved to be an important early source of IL-17 in many inflammatory settings and are emerging as an important…”
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The majority of murine γδ T cells at the maternal–fetal interface in pregnancy produce IL‐17 by Pinget, Gabriela V, Corpuz, Theresa M, Stolp, Jessica, Lousberg, Erin L, Diener, Kerrilyn R, Robertson, Sarah A, Sprent, Jonathan, Webster, Kylie E

“…Compared with lymphoid tissues, the immune cell compartment at mucosal sites is enriched with T cells bearing the γδ T‐cell receptor (TCR). The female…”
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Differential Responsiveness of Innate-like IL-17- and IFN-γ-Producing γδ T Cells to Homeostatic Cytokines by Corpuz, Theresa M, Stolp, Jessica, Kim, Hee-Ok, Pinget, Gabriela V, Gray, Daniel H D, Cho, Jae-Ho, Sprent, Jonathan, Webster, Kylie E

“…γδ T cells respond to molecules upregulated following infection or cellular stress using both TCR and non-TCR molecules. The importance of innate signals…”
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Increased CD4+Foxp3+ T Cells in BAFF-Transgenic Mice Suppress T Cell Effector Responses by Walters, Stacey, Webster, Kylie E, Sutherland, Andrew, Gardam, Sandra, Groom, Joanna, Liuwantara, David, Marino, Eliana, Thaxton, Jessica, Weinberg, Anita, Mackay, Fabienne, Brink, Robert, Sprent, Jonathon, Grey, Shane T

“…The cytokine B cell activation factor of the TNF family (BAFF) is considered to perform a proinflammatory function. This paradigm is particularly true for B…”
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IL-2/IL-2Ab Complexes Induce Regulatory T Cell Expansion and Protect against Proteinuric CKD by POLHILL, Tania, GEOFF YU ZHANG, SPRENT, Jonathan, HARRIS, David C. H, ALEXANDER, Stephen I, YUAN MIN WANG, MIN HU, SAWYER, Andrew, JIMMY JIANHENG ZHOU, SAITO, Mitsuru, WEBSTER, Kylie E, YA WANG, YIPING WANG, GREY, Shane T

“…Regulatory T cells (Tregs) help protect against autoimmune renal injury. The use of agonist antibodies and antibody/cytokine combinations to expand Tregs in…”
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Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity by Liston, Adrian, Gray, Daniel H D, Lesage, Sylvie, Fletcher, Anne L, Wilson, Judith, Webster, Kylie E, Scott, Hamish S, Boyd, Richard L, Peltonen, Leena, Goodnow, Christopher C

“…Inactivation of the autoimmune regulator (Aire) gene causes a rare recessive disorder, autoimmune polyendocrine syndrome 1 (APS1), but it is not known if…”
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Aire-Deficient C57BL/6 Mice Mimicking the Common Human 13-Base Pair Deletion Mutation Present with Only a Mild Autoimmune Phenotype by Hubert, Francois-Xavier, Kinkel, Sarah A, Crewther, Pauline E, Cannon, Ping Z. F, Webster, Kylie E, Link, Maire, Uibo, Raivo, O'Bryan, Moira K, Meager, Anthony, Forehan, Simon P, Smyth, Gordon K, Mittaz, Laureane, Antonarakis, Stylianos E, Peterson, Part, Heath, William R, Scott, Hamish S

“…Autoimmune regulator (AIRE) is an important transcription regulator that mediates a role in central tolerance via promoting the "promiscuous" expression of…”
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Localization of Idd11 Is Not Associated With Thymus and NKT Cell Abnormalities in NOD Mice by BRODNICKI, Thomas C, FLETCHER, Anne L, MORAHAN, Grant, PELLICCI, Daniel G, BERZINS, Stuart P, MCCLIVE, Peter, QUIRK, Fiona, WEBSTER, Kylie E, SCOTT, Hamish S, BOYD, Richard L, GODFREY, Dale I

“…Localization of Idd11 Is Not Associated With Thymus and NKT Cell Abnormalities in NOD Mice Thomas C. Brodnicki 1 , Anne L. Fletcher 2 , Daniel G. Pellicci 3 ,…”
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A Specific Anti-Aire Antibody Reveals Aire Expression Is Restricted to Medullary Thymic Epithelial Cells and Not Expressed in Periphery by Hubert, Francois-Xavier, Kinkel, Sarah A, Webster, Kylie E, Cannon, Ping, Crewther, Pauline E, Proeitto, Anna I, Wu, Li, Heath, William R, Scott, Hamish S

“…Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy is an autoimmune disorder caused by mutations in the autoimmune regulator gene AIRE. We examined…”
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Choose your own T‐cell fate: creation of a narrative‐based, decision‐making activity to engage students in immunology by Ritchie, Helen E, Denyer, Gareth, Webster, Kylie E

“…Undergraduate courses in immunology are content‐heavy and combined with a new, complex vocabulary, can be an overwhelming subject for students. In‐class active…”
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Identification of missense, nonsense, and deletion mutations in the GRHPR gene in patients with primary hyperoxaluria type II (PH2) by WEBSTER, Kylie E, FERREE, Patrick M, HOLMES, Ross P, CRAMER, Scott D

“…Primary hyperoxaluria type II (PH2) is a rare disease characterized by the absence of an enzyme with glyoxylate reductase, hydroxypyruvate reductase, and…”
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The majority of murine [gamma][delta] T cells at the maternal-fetal interface in pregnancy produce IL-17 by Pinget, Gabriela V, Corpuz, Theresa M, Stolp, Jessica, Lousberg, Erin L, Diener, Kerrilyn R, Robertson, Sarah A, Sprent, Jonathan, Webster, Kylie E

“…Compared with lymphoid tissues, the immune cell compartment at mucosal sites is enriched with T cells bearing the γδ T-cell receptor (TCR). The female…”
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The majority of murine gamma delta T cells at the maternal-fetal interface in pregnancy produce IL-17 by Pinget, Gabriela V, Corpuz, Theresa M, Stolp, Jessica, Lousberg, Erin L, Diener, Kerrilyn R, Robertson, Sarah A, Sprent, Jonathan, Webster, Kylie E

“…Compared with lymphoid tissues, the immune cell compartment at mucosal sites is enriched with T cells bearing the gamma delta T-cell receptor (TCR). The female…”
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