Lys-plasminogen as an adjunct to local intra-arterial fibrinolysis for carotid territory stroke : laboratory and clinical findings

To improve the efficacy of local intraarterial fibrinolysis (LIF), we compared different fibrinolytic drugs in a cerebral circulation model in the laboratory. The technical efficacy of fibrinolysis, defined as the clot volume lysed per unit time, was found to be optimal with r-tissue plasminogen act...

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Bibliographic Details
Published in:	Neuroradiology Vol. 38; no. 2; pp. 181 - 185
Main Authors:	FREITAG, H. J, BECKER, V. U, THIE, A, TILSNER, V, PHILAPITSCH, A, SCHWARZ, H. P, WEBHOF, U, MÜLLER, A, ZEUMER, H
Format:	Conference Proceeding Journal Article
Language:	English
Published:	Berlin Springer 01-02-1996
Subjects:	Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Carotid Artery Thrombosis - diagnostic imaging Carotid Artery Thrombosis - drug therapy Cerebral Angiography Dose-Response Relationship, Drug Drug Administration Schedule Humans Infusions, Intra-Arterial Intracranial Embolism and Thrombosis - diagnostic imaging Intracranial Embolism and Thrombosis - drug therapy Medical sciences Models, Cardiovascular Peptide Fragments - administration & dosage Pharmacology. Drug treatments Plasminogen - administration & dosage Recombinant Proteins - administration & dosage Thrombolytic Therapy - methods Tissue Plasminogen Activator - administration & dosage Treatment Outcome Urokinase-Type Plasminogen Activator - administration & dosage Nervous system diseases Stroke u-Plasminogen activator Serine endopeptidases Enzyme Cardiovascular disease Fibrinolysis Plasmin Cerebral disorder Vascular disease Treatment Carotid Central nervous system disease Hydrolases Models Intraarterial administration Proteinases Cerebrovascular disease Fibrinolytic Comparative study
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Summary:	To improve the efficacy of local intraarterial fibrinolysis (LIF), we compared different fibrinolytic drugs in a cerebral circulation model in the laboratory. The technical efficacy of fibrinolysis, defined as the clot volume lysed per unit time, was found to be optimal with r-tissue plasminogen activator (TPA) activated lys-plasminogen (= plasmin). Subsequently, 20 patients with stroke due to carotid artery territory occlusion were treated by local intraarterial fibrinolysis using the plasmin regimen. The angiographic data and clinical outcome of these patients were compared with those of 40 patients who received plasminogen activators (urokinase or r-TPA) only. Laboratory and clinical data confirmed that plasmin lysis is superior to treatment using only plasminogen activators.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0028-3940 1432-1920
DOI:	10.1007/BF00604816