Search Results - "WEBB, Robert R"

A calcineurin antifungal strategy with analogs of FK506 by Nambu, Mitchell, Covel, Jonathan A., Kapoor, Mili, Li, Xiaoming, Moloney, Molly K., Numa, Mehdi M., Soltow, Quinlyn A., Trzoss, Michael, Webb, Peter, Webb, Robert R., Mutz, Mitchell

“…[Display omitted] A novel antifungal strategy targeting the inhibition of calcineurin is described. To develop a calcineurin based inhibitor of pathogenic…”
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Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity by SMITH, Brian M, SMITH, Jeffrey M, DIPANJAN SENGUPTA, THOMSEN, William J, SALDANA, Hazel R, WHELAN, Kevin T, MENZAGHI, Frederique, WEBB, Robert R, BEELEY, Nigel R. A, TSAI, James H, SCHULTZ, Jeffrey A, GILSON, Charles A, ESTRADA, Scott A, CHEN, Rita R, PARK, Douglas M, PRIETO, Emily B, GALLARDO, Charlemagne S

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A new family of H3 receptor antagonists based on the natural product Conessine by SANTORA, Vincent J, COVEL, Jonathan A, WEBB, Robert R, SAGE, Carleton, REN, Albert, PEREIRA, Guilherme, KNUDSEN, Jens, EDWARDS, Jeffrey E, SUAREZ, Marissa, FRAZER, John, THOMSEN, William, HAUSER, Erin, HAYASHI, Rena, WHELAN, Kevin, GROTTICK, Andrew J, HOFILENA, Brian J, IBARRA, Jason B, PULLEY, Michelle D, WEINHOUSE, Michael I, SENGUPTA, Dipanjan, DUFFIELD, Jonathan J, SEMPLE, Graeme

“…A new family of Histamine H(3) receptor antagonists (5a-t) has been prepared based on the structure of the natural product Conessine, a known H(3) antagonist…”
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Discovery and Structure−Activity Relationship of (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT2C Receptor Agonist for the Treatment of Obesity by Smith, Brian M, Smith, Jeffrey M, Tsai, James H, Schultz, Jeffrey A, Gilson, Charles A, Estrada, Scott A, Chen, Rita R, Park, Douglas M, Prieto, Emily B, Gallardo, Charlemagne S, Sengupta, Dipanjan, Dosa, Peter I, Covel, Jon A, Ren, Albert, Webb, Robert R, Beeley, Nigel R. A, Martin, Michael, Morgan, Michael, Espitia, Stephen, Saldana, Hazel R, Bjenning, Christina, Whelan, Kevin T, Grottick, Andrew J, Menzaghi, Frederique, Thomsen, William J

“…The synthesis and SAR of a novel 3-benzazepine series of 5-HT2C agonists is described. Compound 7d (lorcaserin, APD356) was identified as one of the more…”
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Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1 by FOLKES, Adrian, BROWN, S. David, LEAHY, James W, MACH, Morrison, MATTHEWS, David, PRISBYLLA, Michael P, SANDERSON, Jason, SIMON, Reyna J, TESFAI, Zerom, VICKER, Nigel, WANG, Shouming, WEBB, Robert R, CANNE, Lynne E, CHARLTON, Peter, CHAN, Jocelyn, ENGELHARDT, Erin, EPSHTEYN, Sergey, FAINT, Richard, GOLEC, Julian, HANEL, Art, KEARNEY, Patrick

“…We have synthesized and evaluated a series of tetramic acid-based and hydroxyquinolinone-based inhibitors of plasminogen activator inhibitor-1 (PAI-1). These…”
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Discovery and Structure−Activity Relationship of 3-Methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): A Highly Selective 5-Hydroxytryptamine2A Receptor Inverse Agonist for the Treatment of Arterial Thrombosis by Xiong, Yifeng, Teegarden, Bradley R, Choi, Jin-Sun Karoline, Strah-Pleynet, Sonja, Decaire, Marc, Jayakumar, Honnappa, Dosa, Peter I, Casper, Martin D, Pham, Lan, Feichtinger, Konrad, Ullman, Brett, Adams, John, Yuskin, Diane, Frazer, John, Morgan, Michael, Sadeque, Abu, Chen, Weichao, Webb, Robert R, Connolly, Daniel T, Semple, Graeme, Al-Shamma, Hussien

“…Serotonin, which is stored in platelets and is released during thrombosis, activates platelets via the 5-HT2A receptor. 5-HT2A receptor inverse agonists thus…”
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Solubilized phenyl-pyrazole ureas as potent, selective 5-HT2A inverse-agonists and their application as antiplatelet agents by DOSA, Peter I, STRAH-PLEYNET, Sonja, WEBB, Robert R, ADAMS, John W, RAMIREZ, Juan, RICHMAN, Jeremy G, THOMSEN, William, SEMPLE, Graeme, TEEGARDEN, Bradley R, JAYAKUMAR, Honnappa, CASPER, Martin, DECAIRE, Marc, YIFENG XIONG, LEHMANN, Juerg, CHOI, Karoline, ELWELL, Katie, WONG, Amy

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Synthesis of a tetramethyl analog of teleocidin by Webb, Robert R, Venuti, Michael C, Eigenbrot, Charles

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Alkaloid synthesis via intramolecular ene reactions. 1. Application to (.+-.)-crinane by Keck, Gary E, Webb, Robert R

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Synthesis of 1-(aminooxy)-4-[(3-nitro-2-pyridyl)dithio]butane and 1-(aminooxy)-4-[(3-nitro-2-pyridyl)dithio]-2-butene, novel heterobifunctional crosslinking reagents by Webb, Robert R, Kaneko, Takushi

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Alkaloid synthesis via intramolecular ene reaction. 2. Application to dl-mesembrine and dl-dihydromaritidine by Keck, Gary E, Webb, Robert R

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Discovery of 1-[3-(4-Bromo-2-methyl-2 H -pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin) and Related 5-Hydroxytryptamine 2A Inverse Agonists for the Treatment of Insomnia by Teegarden, Bradley R., Li, Hongmei, Jayakumar, Honnappa, Strah-Pleynet, Sonja, Dosa, Peter I., Selaya, Susan D., Kato, Naomi, Elwell, Katie H., Davidson, Jarrod, Cheng, Karen, Saldana, Hazel, Frazer, John M., Whelan, Kevin, Foster, Jonathan, Espitia, Stephan, Webb, Robert R., Beeley, Nigel R. A., Thomsen, William, Morairty, Stephen R., Kilduff, Thomas S., Al-Shamma, Hussien A.

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Discovery and SAR of new benzazepines as potent and selective 5-HT 2C receptor agonists for the treatment of obesity by Smith, Brian M., Smith, Jeffrey M., Tsai, James H., Schultz, Jeffrey A., Gilson, Charles A., Estrada, Scott A., Chen, Rita R., Park, Douglas M., Prieto, Emily B., Gallardo, Charlemagne S., Sengupta, Dipanjan, Thomsen, William J., Saldana, Hazel R., Whelan, Kevin T., Menzaghi, Frederique, Webb, Robert R., Beeley, Nigel R.A.

“…The synthesis and SAR of a 3-benzazepine series of selective 5-HT 2C agonists is described. We report on the synthesis, biological evaluation and…”
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A new family of H 3 receptor antagonists based on the natural product Conessine by Santora, Vincent J., Covel, Jonathan A., Hayashi, Rena, Hofilena, Brian J., Ibarra, Jason B., Pulley, Michelle D., Weinhouse, Michael I., Sengupta, Dipanjan, Duffield, Jonathan J., Semple, Graeme, Webb, Robert R., Sage, Carleton, Ren, Albert, Pereira, Guilherme, Knudsen, Jens, Edwards, Jeffrey E., Suarez, Marissa, Frazer, John, Thomsen, William, Hauser, Erin, Whelan, Kevin, Grottick, Andrew J.

“…A new family of Histamine H 3 receptor antagonists ( 5a– t) has been prepared based on the structure of the natural product Conessine, a known H 3 antagonist…”
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Lewis acid catalyzed cyclocondensations of formaldehyde with activated dienes. A direct route to pyranosidal pentoses by Danishefsky, Samuel, Webb, Robert R

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Synthesis and antiviral activity of the nucleotide analog (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cystosine by Bronson, Joanne J, Ghazzouli, Ismail, Hitchcock, Michael J. M, Webb, Robert R, Martin, John C

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Resource ReviewsMastering the Instructional Design Process: A Systematic Approach, (2nd Ed.), by RothwellWilliam J.KazanasH. C.San Francisco, CA: Jossey-Bass, 1998. 425 pages, hard cover by Webb, Robert R.

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Discovery and Structure−Activity Relationship of 3-Methoxy- N -(3-(1-methyl-1 H -pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): A Highly Selective 5-Hydroxytryptamine 2A Receptor Inverse Agonist for the Treatment of Arterial Thrombosis by Xiong, Yifeng, Teegarden, Bradley R., Choi, Jin-Sun Karoline, Strah-Pleynet, Sonja, Decaire, Marc, Jayakumar, Honnappa, Dosa, Peter I., Casper, Martin D., Pham, Lan, Feichtinger, Konrad, Ullman, Brett, Adams, John, Yuskin, Diane, Frazer, John, Morgan, Michael, Sadeque, Abu, Chen, Weichao, Webb, Robert R., Connolly, Daniel T., Semple, Graeme, Al-Shamma, Hussien

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Discovery of 1-[3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin) and Related 5-Hydroxytryptamine2A Inverse Agonists for the Treatment of Insomnia by Teegarden, Bradley R, Li, Hongmei, Jayakumar, Honnappa, Strah-Pleynet, Sonja, Dosa, Peter I, Selaya, Susan D, Kato, Naomi, Elwell, Katie H, Davidson, Jarrod, Cheng, Karen, Saldana, Hazel, Frazer, John M, Whelan, Kevin, Foster, Jonathan, Espitia, Stephan, Webb, Robert R, Beeley, Nigel R. A, Thomsen, William, Morairty, Stephen R, Kilduff, Thomas S, Al-Shamma, Hussien A

“…Insomnia affects a growing portion of the adult population in the U.S. Most current therapeutic approaches to insomnia primarily address sleep onset latency…”
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Solubilized phenyl-pyrazole ureas as potent, selective 5-HT sub(2A) inverse-agonists and their application as antiplatelet agents by Dosa, Peter I, Strah-Pleynet, Sonja, Jayakumar, Honnappa, Casper, Martin, Decaire, Marc, Xiong, Yifeng, Lehmann, Juerg, Choi, Karoline, Elwell, Katie, Wong, Amy, Webb, Robert R, Adams, John W, Ramirez, Juan, Richman, Jeremy G, Thomsen, William, Semple, Graeme, Teegarden, Bradley R

“…Potent 5-HT sub(2A) inverse-agonists containing phenyl-pyrazole ureas with an amino side chain were identified. Optimization of this series resulted in…”
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