Search Results - "WEBB, DAVID"

Endothelins in cardiovascular biology and therapeutics by Dhaun, Neeraj, Webb, David J.

“…Cardiovascular disease is a major contributor to global morbidity and mortality and is the common end point of many chronic diseases. The endothelins comprise…”
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Type 2 diabetes by Ahmad, Ehtasham, Lim, Soo, Lamptey, Roberta, Webb, David R, Davies, Melanie J

“…Type 2 diabetes accounts for nearly 90% of the approximately 537 million cases of diabetes worldwide. The number affected is increasing rapidly with alarming…”
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Zilebesiran, a ribonucleic acid interference agent targeting angiotensinogen, proves a promising approach in hypertension by Webb, David J

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Streamer-blowout Coronal Mass Ejections: Their Properties and Relation to the Coronal Magnetic Field Structure by Vourlidas, Angelos, Webb, David F.

“…We present a comprehensive analysis of a particular class of coronal mass ejection (CME) event called streamer-blowout CMEs (SBOs). The events are…”
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Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective by Zaccardi, Francesco, Webb, David R, Yates, Thomas, Davies, Melanie J

“…Diabetes mellitus is a complex metabolic disorder associated with an increased risk of microvascular and macrovascular disease; its main clinical…”
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Efficacy and safety of glucagon‐like peptide‐1 receptor agonists in type 2 diabetes: A systematic review and mixed‐treatment comparison analysis by Htike, Zin Z., Zaccardi, Francesco, Papamargaritis, Dimitris, Webb, David R., Khunti, Kamlesh, Davies, Melanie J.

“…Aims To compare efficacy and safety of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) in people with type 2 diabetes. Materials and methods We…”
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Animal models of human disease: Inflammation by Webb, David R.

“…Animals have been used as models to study inflammation and autoimmunity for more than 80 years. During that time it has been understood that although the use…”
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Established and emerging therapeutic uses of PDE type 5 inhibitors in cardiovascular disease by Tzoumas, Nikolaos, Farrah, Tariq E., Dhaun, Neeraj, Webb, David J.

“…PDE type 5 inhibitors (PDE5Is), such as sildenafil, tadalafil and vardenafil, are a class of drugs used to prolong the physiological effects of NO/cGMP…”
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Small interfering RNA: Discovery, pharmacology and clinical development—An introductory review by Ranasinghe, Priyanga, Addison, Melisande L., Dear, James W., Webb, David J.

“…Post‐transcriptional gene silencing targets and degrades mRNA transcripts, silencing the expression of specific genes. RNA interference technology, using…”
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Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial by Williams, Bryan, Prof, MacDonald, Thomas M, Prof, Morant, Steve, PhD, Webb, David J, Prof, Sever, Peter, Prof, McInnes, Gordon, Prof, Ford, Ian, Prof, Cruickshank, J Kennedy, Prof, Caulfield, Mark J, Prof, Salsbury, Jackie, Prof, Mackenzie, Isla, FRCP, Padmanabhan, Sandosh, FRCP, Brown, Morris J, Prof

“…Summary Background Optimal drug treatment for patients with resistant hypertension is undefined. We aimed to test the hypotheses that resistant hypertension is…”
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Results of a randomized trial in children with Acute Myeloid Leukaemia: Medical Research Council AML12 trial by Gibson, Brenda E. S., Webb, David K. H., Howman, Andrew J., De Graaf, Siebold S. N., Harrison, Christine J., Wheatley, Keith

“…Summary The Medical Research Council Acute Myeloid Leukaemia 12 (MRC AML12) trial (children) addressed the optimal anthracenedione/anthracycline in induction…”
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Epilepsy, suicidality, and psychiatric disorders: A bidirectional association by Hesdorffer, Dale C., Ishihara, Lianna, Mynepalli, Lakshmi, Webb, David J., Weil, John, Hauser, W. Allen

“…Objective: A study was undertaken to determine whether psychiatric disorders associated with suicide are more common in incident epilepsy than in matched…”
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Identification and proteomic profiling of exosomes in human cerebrospinal fluid by Street, Jonathan M, Barran, Perdita E, Mackay, C Logan, Weidt, Stefan, Balmforth, Craig, Walsh, Tim S, Chalmers, Rod T A, Webb, David J, Dear, James W

“…Exosomes are released from multiple cell types, contain protein and RNA species, and have been exploited as a novel reservoir for disease biomarker discovery…”
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The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons by Farrah, Tariq E, Dhillon, Baljean, Keane, Pearse A, Webb, David J, Dhaun, Neeraj

“…Chronic kidney disease (CKD) is common, with hypertension and diabetes mellitus acting as major risk factors for its development. Cardiovascular disease is the…”
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LASCO White-Light Observations of Eruptive Current Sheets Trailing CMEs by Webb, David F., Vourlidas, Angelos

“…Many models of eruptive flares or coronal mass ejections (CMEs) involve formation of a current sheet connecting the ejecting CME flux rope with a magnetic loop…”
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A high-fat meal induces low-grade endotoxemia : evidence of a novel mechanism of postprandial inflammation by ERRIDGE, Clett, ATTINA, Teresa, SPICKETT, Corinne M, WEBB, David J

“…Bacterial endotoxin is a potently inflammatory antigen that is abundant in the human gut. Endotoxin circulates at low concentrations in the blood of all…”
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Novel Pharmacological Approaches in the Treatment of Hypertension: A Focus on RNA-Based Therapeutics by Addison, Melisande L., Ranasinghe, Priyanga, Webb, David J.

“…Hypertension remains the leading cause of cardiovascular disease and premature death globally, affecting half of US adults. A high proportion of hypertensive…”
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Cytogenetics of Childhood Acute Myeloid Leukemia: United Kingdom Medical Research Council Treatment Trials AML 10 and 12 by HARRISON, Christine J, HILLS, Robert K, GIBSON, Brenda E. S, MOORMAN, Anthony V, GRIMWADE, David J, HANN, Ian, WEBB, David K. H, WHEATLEY, Keith, DE GRAAF, Siebold S. N, VAN DEN BERG, Eva, BURNETT, Alan K

“…Karyotype is an independent indicator of prognosis in acute myeloid leukemia (AML) that is widely applied to risk-adapted therapy. Because AML is rare in…”
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Endothelin by Davenport, Anthony P, Hyndman, Kelly A, Dhaun, Neeraj, Southan, Christopher, Kohan, Donald E, Pollock, Jennifer S, Pollock, David M, Webb, David J, Maguire, Janet J

“…The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1 and -2 activate two G-protein coupled receptors, ETA and ETB, with…”
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Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension by Desai, Akshay S., Webb, David J., Taubel, Jorg, Casey, Sarah, Cheng, Yansong, Robbie, Gabriel J., Foster, Don, Huang, Stephen A., Rhyee, Sean, Sweetser, Marianne T., Bakris, George L.

“…In this phase 1 study involving persons with hypertension, zilebesiran (an RNA interference therapeutic agent) was associated with decreases in angiotensin…”
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