Search Results - "WAY, James M"

Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120) by Sparks, Steven M., Chen, Grace, Collins, Jon L., Danger, Dana, Dock, Steven T., Jayawickreme, Channa, Jenkinson, Stephen, Laudeman, Christopher, Leesnitzer, M. Anthony, Liang, Xi, Maloney, Patrick, McCoy, David C., Moncol, David, Rash, Vincent, Rimele, Thomas, Vulimiri, Padmaja, Way, James M., Ross, Sean

“…The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described. This work led to the identification of…”
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The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids by Briscoe, Celia P, Tadayyon, Mohammad, Andrews, John L, Benson, William G, Chambers, Jon K, Eilert, Michelle M, Ellis, Catherine, Elshourbagy, Nabil A, Goetz, Aaron S, Minnick, Dana T, Murdock, Paul R, Sauls, Jr, Howard R, Shabon, Usman, Spinage, Lisa D, Strum, Jay C, Szekeres, Philip G, Tan, Kong B, Way, James M, Ignar, Diane M, Wilson, Shelagh, Muir, Alison I

“…GPR40 is a member of a subfamily of homologous G protein-coupled receptors that include GPR41 and GPR43 and that have no current function or ligand ascribed…”
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Peroxisome Proliferator-Activated Receptor-α Regulates Fatty Acid Utilization in Primary Human Skeletal Muscle Cells by MUOIO, Deborah M, WAY, James M, TANNER, Charles J, WINEGAR, Deborah A, KLIEWER, Steven A, HOUMARD, Joseph A, KRAUS, William E, DOHM, G. Lynis

“…Peroxisome Proliferator-Activated Receptor-α Regulates Fatty Acid Utilization in Primary Human Skeletal Muscle Cells Deborah M. Muoio 1 2 , James M. Way 3 ,…”
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Effects of fenofibrate on lipid parameters in obese rhesus monkeys by Winegar, D A, Brown, P J, Wilkison, W O, Lewis, M C, Ott, R J, Tong, W Q, Brown, H R, Lehmann, J M, Kliewer, S A, Plunket, K D, Way, J M, Bodkin, N L, Hansen, B C

“…Fenofibrate is a member of the fibrate class of hypolipidemic agents used clinically to treat hypertriglyceridemia and mixed hyperlipidemia. The fibrates were…”
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Identification and Characterization of a Selective Peroxisome Proliferator-Activated Receptor β/δ (NR1C2) Antagonist by Shearer, Barry G, Steger, David J, Way, James M, Stanley, Thomas B, Lobe, David C, Grillot, Didier A, Iannone, Marie A, Lazar, Mitchell A, Willson, Timothy M, Billin, Andrew N

“…The identification of small molecule ligands for the peroxisome proliferator-activated receptors (PPARs) has been instrumental in elucidating their biological…”
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Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta by Muoio, Deborah M, MacLean, Paul S, Lang, David B, Li, Shi, Houmard, Joseph A, Way, James M, Winegar, Deborah A, Corton, J Christopher, Dohm, G Lynis, Kraus, William E

“…Ablation of peroxisome proliferator activated receptor (PPAR) alpha, a lipid-activated transcription factor that regulates expression of beta-oxidative genes,…”
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Loss of Bombesin-Induced Feeding Suppression in Gastrin-Releasing Peptide Receptor-Deficient Mice by Hampton, Lori L., Ladenheim, Ellen E., Akeson, Mark, Way, James M., Weber, H. Christian, Sutliff, Vince E., Jensen, Robert T., Wine, Lara J., Arnheiter, Heinz, Battey, James F.

“…The gastrin-releasing peptide receptor (GRP-R) is one of three members of the mammalian bombesin subfamily of seven-transmembrane G protein-coupled receptors…”
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Identification and Characterization of 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) Antagonist by Shearer, Barry G, Wiethe, Robert W, Ashe, Adam, Billin, Andrew N, Way, James M, Stanley, Thomas B, Wagner, Craig D, Xu, Robert X, Leesnitzer, Lisa M, Merrihew, Raymond V, Shearer, Todd W, Jeune, Michael R, Ulrich, John C, Willson, Timothy M

“…4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide 3 (GSK3787) was identified as a potent and selective ligand for PPARδ with good…”
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Comprehensive Messenger Ribonucleic Acid Profiling Reveals That Peroxisome Proliferator-Activated Receptor γ Activation Has Coordinate Effects on Gene Expression in Multiple Insulin-Sensitive Tissues by Way, James M, Harrington, W. Wallace, Brown, Kathleen K, Gottschalk, William K, Sundseth, Scott S, Mansfield, Traci A, Ramachandran, Ravi K, Willson, Timothy M, Kliewer, Steven A

“…Peroxisome proliferator-activated receptor γ (PPARγ) agonists, including the glitazone class of drugs, are insulin sensitizers that reduce glucose and lipid…”
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Gastrointestinal weight-loss surgery: glimpses at the molecular level by Freudenberg, Johannes M., Rajpal, Neetu, Way, James M., Magid-Slav, Michal, Rajpal, Deepak K.

“…► Molecular data analysis of gastro-intestinal weight-loss surgery. ► Integrated informatics strategy with pre- and post- weight-loss surgery datasets. ►…”
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ERRγ Regulates Cardiac, Gastric, and Renal Potassium Homeostasis by Alaynick, William A, Way, James M, Wilson, Stephanie A, Benson, William G, Pei, Liming, Downes, Michael, Yu, Ruth, Jonker, Johan W, Holt, Jason A, Rajpal, Deepak K, Li, Hao, Stuart, Joan, McPherson, Ruth, Remlinger, Katja S, Chang, Ching-Yi, McDonnell, Donald P, Evans, Ronald M, Billin, Andrew N

“…Energy production by oxidative metabolism in kidney, stomach, and heart, is primarily expended in establishing ion gradients to drive renal electrolyte…”
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Discovery of 6,7-Dihydro‑5H‑pyrrolo[2,3‑a]pyrimidines as Orally Available G Protein-Coupled Receptor 119 Agonists by Katamreddy, Subba R, Carpenter, Andrew J, Ammala, Carina E, Boros, Eric E, Brashear, Ron L, Briscoe, Celia P, Bullard, Sarah R, Caldwell, Richard D, Conlee, Christopher R, Croom, Dallas K, Hart, Shane M, Heyer, Dennis O, Johnson, Paul R, Kashatus, Jennifer A, Minick, Doug J, Peckham, Gregory E, Ross, Sean A, Roller, Shane G, Samano, Vicente A, Sauls, Howard R, Tadepalli, Sarva M, Thompson, James B, Xu, Yun, Way, James M

“…GPR119 is a 7-transmembrane receptor that is expressed in the enteroendocrine cells in the intestine and in the islets of Langerhans in the pancreas. Indolines…”
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Discovery of a novel class of PPARδ partial agonists by Shearer, Barry G., Patel, Hari S., Billin, Andrew N., Way, James M., Winegar, Deborah A., Lambert, Millard H., Xu, Robert X., Leesnitzer, Lisa M., Merrihew, Raymond V., Huet, Stephane, Willson, Timothy M.

“…The discovery and evaluation of a novel anthranilic acid class of PPARδ partial agonists is described. Anthranilic acid GW9371 was identified as a novel class…”
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Phenoxyacetic acids as PPARδ partial agonists: Synthesis, optimization, and in vivo efficacy by Evans, Karen A., Shearer, Barry G., Wisnoski, David D., Shi, Dongchuan, Sparks, Steven M., Sternbach, Daniel D., Winegar, Deborah A., Billin, Andrew N., Britt, Christy, Way, James M., Epperly, Andrea H., Leesnitzer, Lisa M., Merrihew, Raymond V., Xu, Robert X., Lambert, Millard H., Jin, Jian

“…A series of phenoxyacetic acids as subtype selective and potent hPPARδ partial agonists is described. Many analogues were readily accessible via a single…”
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ERRγ Regulates Cardiac, Gastric, and Renal Potassium Homeostasis by Alaynick, William A, Way, James M, Wilson, Stephanie A, Benson, William G, Pei, Liming, Downes, Michael, Yu, Ruth, Jonker, Johan W, Holt, Jason A, Rajpal, Deepak K, Li, Hao, Stuart, Joan, McPherson, Ruth, Remlinger, Katja S, Yi-Chang, Ching, McDonnell, Donald P, Evans, Ronald M, Billin, Andrew N

“…Energy production by oxidative metabolism in kidney, stomach and heart, is primarily expended in establishing ion gradients to drive renal electrolyte…”
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Adipose Tissue Resistin Expression Is Severely Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor γ Agonists by Way, James M., Görgün, Cem Z., Tong, Qiang, Uysal, K. Teoman, Brown, Kathleen K., Harrington, W. Wallace, Oliver, William R., Willson, Timothy M., Kliewer, Steven A., Hotamisligil, Gökhan S.

“…Elevated levels of the hormone resistin, which is secreted by fat cells, are proposed to cause insulin resistance and to serve as a link between obesity and…”
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Discovery of 6,7-Dihydro-5 H -pyrrolo[2,3- a ]pyrimidines as Orally Available G Protein-Coupled Receptor 119 Agonists by Katamreddy, Subba R., Carpenter, Andrew J., Ammala, Carina E., Boros, Eric E., Brashear, Ron L., Briscoe, Celia P., Bullard, Sarah R., Caldwell, Richard D., Conlee, Christopher R., Croom, Dallas K., Hart, Shane M., Heyer, Dennis O., Johnson, Paul R., Kashatus, Jennifer A., Minick, Doug J., Peckham, Gregory E., Ross, Sean A., Roller, Shane G., Samano, Vicente A., Sauls, Howard R., Tadepalli, Sarva M., Thompson, James B., Xu, Yun, Way, James M.

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Phenoxyacetic acids as PPAR[delta] partial agonists: Synthesis, optimization, and in vivo efficacy by Evans, Karen A, Shearer, Barry G, Wisnoski, David D, Shi, Dongchuan, Sparks, Steven M, Sternbach, Daniel D, Winegar, Deborah A, Billin, Andrew N, Britt, Christy, Way, James M, Epperly, Andrea H, Leesnitzer, Lisa M, Merrihew, Raymond V, Xu, Robert X, Lambert, Millard H, Jin, Jian

“…A series of phenoxyacetic acids as subtype selective and potent hPPAR[delta] partial agonists is described. Many analogues were readily accessible via a single…”
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Identification and Characterization of 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethylbenzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) Antagonist by SHEARER, Barry G, WIETHE, Robert W, SHEARER, Todd W, JEUNE, Michael R, ULRICH, John C, WILLSON, Timothy M, ASHE, Adam, BILLIN, Andrew N, WAY, James M, STANLEY, Thomas B, WAGNER, Craig D, XU, Robert X, LEESNITZER, Lisa M, MERRIHEW, Raymond V

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ERRγ Regulates Cardiac, Gastric, and Renal Potassium Homeostasis by Alaynick, William A., Way, James M., Wilson, Stephanie A., Benson, William G., Pei, Liming, Downes, Michael, Yu, Ruth, Jonker, Johan W., Holt, Jason A., Rajpal, Deepak K., Li, Hao, Stuart, Joan, McPherson, Ruth, Remlinger, Katja S., Yi-Chang, Ching, McDonnell, Donald P., Evans, Ronald M., Billin, Andrew N.

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