Search Results - "WAXMAN, Amanda R"

Differential expressions of the alternatively spliced variant mRNAs of the µ opioid receptor gene, OPRM1, in brain regions of four inbred mouse strains by Xu, Jin, Lu, Zhigang, Xu, Mingming, Rossi, Grace C, Kest, Benjamin, Waxman, Amanda R, Pasternak, Gavril W, Pan, Ying-Xian

“…The µ opioid receptor gene, OPRM1, undergoes extensive alternative pre-mRNA splicing in rodents and humans, with dozens of alternatively spliced variants of…”
Get full text

Sex-specific Mediation of Opioid-induced Hyperalgesia by the Melanocortin-1 Receptor by JUNI, Aaron, MINYING CAI, STANKOVA, Magda, WAXMAN, Amanda R, AROUT, Caroline, KLEIN, Gad, DAHAN, Albert, HRUBY, Victor J, MOGIL, Jeffrey S, KEST, Benjamin

“…N-Methyl-D-aspartate receptor antagonists reverse hyperalgesia during morphine infusion in male mice only. Because the melanocortin-1 receptor can act as a…”
Get full text

Sex-Specific Responses to Opiates : Animal and Human Studies by DAHAN, Albert, KEST, Benjamin, WAXMAN, Amanda R, SARTON, Elise

Get full text

Morphine-6β-glucuronide Rapidly Increases Pain Sensitivity Independently of Opioid Receptor Activity in Mice and Humans by VAN DORP, Eveline L. A, KEST, Benjamin, KOWALCZYK, William J, MORARIU, Aurora M, WAXMAN, Amanda R, AROUT, Caroline A, DAHAN, Albert, SARTON, Elise Y

Get full text

Sex-Specific Responses to Opiates: Animal and Human Studies by Dahan, Albert, Kest, Benjamin, Waxman, Amanda R., Sarton, Elise

“…It is widely reported that analgesic drugs acting at μ, κ, and δ opioid-receptors display quantitative and qualitative differences in effect in males and…”
Get full text

Mice lacking ghrelin receptors resist the development of diet-induced obesity by Zigman, Jeffrey M, Nakano, Yoshihide, Coppari, Roberto, Balthasar, Nina, Marcus, Jacob N, Lee, Charlotte E, Jones, Juli E, Deysher, Amy E, Waxman, Amanda R, White, Ryan D, Williams, Todd D, Lachey, Jennifer L, Seeley, Randy J, Lowell, Bradford B, Elmquist, Joel K

“…Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor (GHSR; ghrelin receptor). Since its discovery, accumulating evidence has…”
Get full text

Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice by Waxman, Amanda R., Arout, Caroline, Caldwell, Megan, Dahan, Albert, Kest, Benjamin

“…Although μ-receptor opioids are clinically important analgesics, they can also paradoxically cause hyperalgesia independently of opioid receptor activity,…”
Get full text

Morphine induces hyperalgesia without involvement of μ-opioid receptor or morphine-3-glucuronide by Swartjes, Maarten, Mooren, René A G, Waxman, Amanda R, Arout, Caroline, van de Wetering, Koen, den Hartigh, Jan, Beijnen, Jos H, Kest, Benjamin, Dahan, Albert

“…Opioid-induced hyperalgesia (OIH) is a paradoxical increase in pain perception that may manifest during opioid treatment. For morphine, the metabolite…”
Get full text

Illness-specific anxiety: Implications for functioning and utilization of medical services in adolescents with inflammatory bowel disease by Reigada, Laura C., Bruzzese, Jean-Marie, Benkov, Keith J., Levy, Joseph, Waxman, Amanda R., Petkova, Eva, Warner, Carrie Masia

“…Purpose.  Adolescents with inflammatory bowel disease (IBD) may be at heightened risk for developing anxiety and depression. This cross‐sectional pilot study…”
Get full text

Progesterone rapidly recruits female-typical opioid-induced hyperalgesic mechanisms by Waxman, Amanda R, Juni, Aaron, Kowalczyk, William, Arout, Caroline, Sternberg, Wendy F, Kest, Benjamin

“…Abstract Continuous morphine treatment can paradoxically increase nociception (i.e. hyperalgesia) in male and female mice, but sex differences have been…”
Get full text

The contribution of MOR-1 exons 1–4 to morphine and heroin analgesia and dependence by Klein, Gad, Rossi, Grace C., Waxman, Amanda R., Arout, Carolne, Juni, Aaron, Inturrisi, Charles E., Kest, Benjamin

“…Although morphine and heroin analgesia is mediated by μ-opioid receptors encoded by the MOR-1 gene, distinct isoforms are involved. Both opioids also induce…”
Get full text

Acute and chronic heroin dependence in mice: Contribution of opioid and excitatory amino acid receptors by Klein, Gad, Juni, Aaron, Arout, Caroline A., Waxman, Amanda R., Inturrisi, Charles E., Kest, Benjamin

“…Opioid and excitatory amino acid receptors contribute to morphine dependence, but there are no studies of their role in heroin dependence. Thus, mice injected…”
Get full text

A survey of acute and chronic heroin dependence in ten inbred mouse strains: Evidence of genetic correlation with morphine dependence by Klein, Gad, Juni, Aaron, Waxman, Amanda R., Arout, Caroline A., Inturrisi, Charles E., Kest, Benjamin

“…Heroin and morphine exposure can cause physical dependence, with symptoms manifesting during their withdrawal. Inter-individual differences in symptom…”
Get full text

Differential Expressions of the Alternatively Spliced Variant mRNAs of the [micro] Opioid Receptor Gene, OPRM1, in Brain Regions of Four Inbred Mouse Strains by Xu, Jin, Lu, Zhigang, Xu, Mingming, Rossi, Grace C, Kest, Benjamin, Waxman, Amanda R, Pasternak, Gavril W, Pan, Ying-Xian

“…The [micro] opioid receptor gene, OPRM1, undergoes extensive alternative pre-mRNA splicing in rodents and humans, with dozens of alternatively spliced variants…”
Get full text

Differential Expressions of the Alternatively Spliced Variant mRNAs of the mu Opioid Receptor Gene, OPRM1, in Brain Regions of Four Inbred Mouse Strains: e111267 by Xu, Jin, Lu, Zhigang, Xu, Mingming, Rossi, Grace C, Kest, Benjamin, Waxman, Amanda R, Pasternak, Gavril W, Pan, Ying-Xian

“…The mu opioid receptor gene, OPRM1, undergoes extensive alternative pre-mRNA splicing in rodents and humans, with dozens of alternatively spliced variants of…”
Get full text

Acute morphine hyperalgesia: A pharmacological and pharmacogenetic analysis by Waxman, Amanda R

“…Opioids such as morphine remain the most efficacious and widely used analgesics for moderate to severe pain. However, the clinical use of these opioids is…”
Get full text

Illness-specific anxiety: Implications for functioning and utilization of medical services in adolescents with inflammatory bowel disease: Illness-Specific Anxiety: Implications for Functioning and Utilization of Medical Services in Adolescents With IBD by Reigada, Laura C., Bruzzese, Jean-Marie, Benkov, Keith J., Levy, Joseph, Waxman, Amanda R., Petkova, Eva, Warner, Carrie Masia

Get full text

Morphine-6beta-glucuronide rapidly increases pain sensitivity independently of opioid receptor activity in mice and humans by van Dorp, Eveline L A, Kest, Benjamin, Kowalczyk, William J, Morariu, Aurora M, Waxman, Amanda R, Arout, Caroline A, Dahan, Albert, Sarton, Elise Y

“…Previous data indicate that morphine-6beta-glucuronide (M6G), a morphine metabolite with analgesic properties, can paradoxically increase pain sensitivity in…”
Get full text