Search Results - "WAX, MARTIN B"

Role of tumor necrosis factor receptor-1 in the death of retinal ganglion cells following optic nerve crush injury in mice by Tezel, Gülgün, Yang, Xiangjun, Yang, Junjie, Wax, Martin B.

“…To assess the specific role of tumor necrosis factor (TNF) death receptor signaling in the induction of retinal ganglion cell (RGC) death, optic nerves of mice…”
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Immunohistochemical Assessment of the Glial Mitogen-Activated Protein Kinase Activation in Glaucoma by Tezel, Gulgun, Chauhan, Balwantray C, LeBlanc, Raymond P, Wax, Martin B

“…To determine whether retinal glial cells exhibit an activated phenotype in glaucomatous human eyes and whether the mitogen-activated protein kinases (MAPKs)…”
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Rapid Identification of Novel Inhibitors of the Human Aquaporin-1 Water Channel by Patil, Rajkumar V., Xu, Shouxi, van Hoek, Alfred N., Rusinko, Andrew, Feng, Zixia, May, Jesse, Hellberg, Mark, Sharif, Najam A., Wax, Martin B., Irigoyen, Macarena, Carr, Grant, Brittain, Tom, Brown, Peter, Colbert, Damon, Kumari, Sindhu, Varadaraj, Kulandaiappan, Mitra, Alok K.

“…Aquaporins (AQPs) are a family of membrane proteins that function as channels facilitating water transport in response to osmotic gradients. These play…”
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The Mechanisms of hsp27 Antibody-Mediated Apoptosis in Retinal Neuronal Cells by Tezel, Gulgun, Wax, Martin B

“…Although elevated titers of serum antibodies to hsp27 accompany human diseases such as cancer and glaucoma, evidence of their pathogenic effects is lacking…”
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Introduction of Paul Kaufman as the 2017 Jonas S. Friedenwald Awardee by Wax, Martin B

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The case for autoimmunity in glaucoma by Wax, Martin B.

“…Although the majority of patients with glaucoma have elevated intraocular pressure as the presumed etiology for their resultant neuropathy, it is well known…”
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Immunoregulation of retinal ganglion cell fate in glaucoma by Wax, Martin B., Tezel, Gülgün

“…Glaucomatous neurodegeneration has been associated with the activation of multiple pathogenic mechanisms that can result in RGC death and axonal degeneration…”
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Interleukin-10 Receptor Signaling through STAT-3 Regulates the Apoptosis of Retinal Ganglion Cells in Response to Stress by Boyd, Zachary S, Kriatchko, Aleksie, Yang, Junjie, Agarwal, Neeraj, Wax, Martin B, Patil, Rajkumar V

“…Interleukin (IL)-10 has recently been shown to promote survival of neurons and glia. The purpose of this report is to investigate whether IL-10 has any role in…”
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Glial Modulation of Retinal Ganglion Cell Death in Glaucoma by Tezel, Gülgün, Wax, Martin B

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In vitro evaluation of reactive astrocyte migration, a component of tissue remodeling in glaucomatous optic nerve head by Tezel, Gülgün, Hernandez, M. Rosario, Wax, Martin B.

“…In order to improve understanding of remodeling events in the glaucomatous optic nerve head, the migration of optic nerve head astrocytes was studied in vitro…”
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Induced Autoimmunity to Heat Shock Proteins Elicits Glaucomatous Loss of Retinal Ganglion Cell Neurons via Activated T-Cell-Derived Fas-Ligand by Wax, Martin B, Tezel, Gulgun, Yang, Junjie, Peng, Guanghua, Patil, Rajkumar V, Agarwal, Neeraj, Sappington, Rebecca M, Calkins, David J

“…Glaucomatous optic neuropathy causes blindness through the degeneration of retinal ganglion cells (RGCs) and their axons, which comprise the optic nerve…”
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Introducing David Epstein, the 2013 recipient of the Weisenfeld award by Wax, Martin B

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Administration of Menadione, Vitamin K3, Ameliorates Off-Target Effects on Corneal Epithelial Wound Healing Due to Receptor Tyrosine Kinase Inhibition by Rush, Jamie S, Bingaman, David P, Chaney, Paul G, Wax, Martin B, Ceresa, Brian P

“…The antiangiogenic receptor tyrosine kinase inhibitor (RTKi), 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-[[[4-(1-pyrrolidinyl) butyl] amino]…”
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Increased Production of Tumor Necrosis Factor-alpha by Glial Cells Exposed to Simulated Ischemia or Elevated Hydrostatic Pressure Induces Apoptosis in Cocultured Retinal Ganglion Cells by Tezel, Gulgun, Wax, Martin B

“…Although glial cells in the optic nerve head undergo a reactivation process in glaucoma, the role of glial cells during glaucomatous neurodegeneration of…”
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Noninvasive Measurement of Rodent Intraocular Pressure with a Rebound Tonometer by Wang, Wan-Heng, Millar, J. Cameron, Pang, Iok-Hou, Wax, Martin B, Clark, Abbot F

“…The present study evaluated the applicability of a rebound tonometer in measuring intraocular pressure (IOP) in rats and mice. The accuracy of the TonoLab…”
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The immune system and glaucoma by Tezel, Gülgün, Wax, Martin B

“…PURPOSE OF REVIEWCompelling evidence obtained from studies over the last decade strongly suggests the involvement of immune system regulation in cell fate…”
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Quantitative ex vivo detection of rodent retinal ganglion cells by immunolabeling Brn-3b by Leahy, Kathleen M, Ornberg, Richard L, Wang, Yu, Zhu, Yanli, Gidday, Jeffrey M, Connor, Jane R, Wax, Martin B

“…To evaluate the neuroprotective potential of drug candidates to treat human glaucoma, a short-term rodent model of retinal ganglion cell death was employed…”
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Complex Antibody Profile Changes in an Experimental Autoimmune Glaucoma Animal Model by Joachim, Stephanie C, Grus, Franz H, Kraft, Daniela, White-Farrar, Kisha, Barnes, George, Barbeck, Mike, Ghanaati, Shahram, Cao, Shutong, Li, Byron, Wax, Martin B

“…Increased serum antibodies against heat shock protein 27 (HSP27) have been identified in patients with glaucoma. Immunization with HSP27 caused retinal…”
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Upregulation of antibody response to heat shock proteins and tissue antigens in an ocular ischemia model by Joachim, Stephanie C, Wax, Martin B, Boehm, Nils, Dirk, Desiree R, Pfeiffer, Norbert, Grus, Franz H

“…The aim of this study was to characterize the serum antibody reactivities occurring after ocular ischemia reperfusion. The time course of serum antibody…”
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Serum autoantibodies to α-fodrin are present in glaucoma patients from Germany and the United States by GRUS, Franz H, JOACHIM, Stephanie C, BRUNS, Kai, LACKNER, Karl J, PFEIFFER, Norbert, WAX, Martin B

“…Glaucoma is characterized by a progressive loss of retinal ganglion cells that results in a characteristic optic neuropathy associated with visual field loss…”
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