Search Results - "WAUN KI HONG"
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Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models
Published in Molecular cancer therapeutics (01-12-2011)“…Tumor cell proliferation requires both growth signals and sufficient cellular bioenergetics. The AMP-activated protein kinase (AMPK) pathway seems dominant…”
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Implication of the Insulin-like Growth Factor-IR Pathway in the Resistance of Non–small Cell Lung Cancer Cells to Treatment with Gefitinib
Published in Clinical cancer research (01-05-2007)“…Purpose: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have been found to be effective against lung cancer in vitro , but clinical…”
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3
HER Family Receptor Abnormalities in Lung Cancer Brain Metastases and Corresponding Primary Tumors
Published in Clinical cancer research (01-08-2009)“…Purpose: To compare the characteristics of deregulation of HER receptors and their ligands between primary tumor and corresponding brain metastases of…”
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4
Podoplanin: A Novel Marker for Oral Cancer Risk in Patients With Oral Premalignancy
Published in Journal of clinical oncology (20-01-2008)“…Oral leukoplakia (OPL) is a heterogeneous oral lesion with an increased oral cancer risk. Current clinical parameters cannot predict the potential of malignant…”
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5
Gene expression profiling predicts the development of oral cancer
Published in Cancer prevention research (Philadelphia, Pa.) (01-02-2011)“…Patients with oral premalignant lesion (OPL) have a high risk of developing oral cancer. Although certain risk factors, such as smoking status and histology,…”
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Immunohistochemical Expression of Basic Fibroblast Growth Factor and Fibroblast Growth Factor Receptors 1 and 2 in the Pathogenesis of Lung Cancer
Published in Clinical cancer research (01-10-2008)“…Purpose: To identify the patterns of protein expression of basic fibroblast growth factor (bFGF) and FGF receptors 1 and 2 in non-small cell lung carcinoma…”
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Implication of AMP-Activated Protein Kinase and Akt-Regulated Survivin in Lung Cancer Chemopreventive Activities of Deguelin
Published in Cancer research (Chicago, Ill.) (15-12-2007)“…Survivin plays important roles in maintaining cell proliferation and survival and promoting tumorigenesis. The present study was conducted to determine the…”
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Inhibition of c-Src expression and activation in malignant pleural mesothelioma tissues leads to apoptosis, cell cycle arrest, and decreased migration and invasion
Published in Molecular cancer therapeutics (01-07-2007)“…Malignant pleural mesothelioma (MPM) is a deadly disease with few systemic treatment options. One potential therapeutic target, the non–receptor tyrosine…”
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CXCR2 Expression in Tumor Cells is a Poor Prognostic Factor and Promotes Invasion and Metastasis in Lung Adenocarcinoma
Published in Cancer research (Chicago, Ill.) (15-01-2013)“…CXCR2 in non-small cell lung cancer (NSCLC) has been studied mainly in stromal cells and is known to increase tumor inflammation and angiogenesis. Here, we…”
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10
Randomized Trial of 13-cis Retinoic Acid Compared With Retinyl Palmitate With or Without Beta-Carotene in Oral Premalignancy
Published in Journal of clinical oncology (01-02-2009)“…To investigate whether retinyl palmitate (RP) alone or plus beta-carotene (BC) would be as effective and less toxic than low-dose 13-cis retinoic acid (13cRA)…”
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Elevated Epithelial Insulin-like Growth Factor Expression Is a Risk Factor for Lung Cancer Development
Published in Cancer research (Chicago, Ill.) (15-09-2009)“…Insulin-like growth factor (IGF)-I receptor (IGF-IR) signaling has been implicated in several human neoplasms. However, the role of serum levels of IGFs in…”
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12
Nuclear factor‐κB (nf‐κB) is frequently expressed in lung cancer and preneoplastic lesions
Published in Cancer (01-12-2006)“…BACKGROUND. Nuclear factor‐κB (NF‐κB), a key transcription factor thought to play a major role in carcinogenesis, regulates many important signaling pathways…”
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13
Development of an Orthotopic Model to Study the Biology and Therapy of Primary Human Lung Cancer in Nude Mice
Published in Clinical cancer research (15-11-2003)“…Purpose: This study was conducted to develop biologically relevant animal models of human lung cancer that are reproducible, inexpensive, and easy to perform…”
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14
Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia‐inducible factor‐1 alpha
Published in International journal of cancer (01-01-2008)“…Hypoxia‐inducible factor 1 (HIF‐1) plays an essential role in tumor angiogenesis and growth by regulating the transcription of several genes in response to…”
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Expression of Interleukin-1 Receptor–Associated Kinase-1 in Non–Small Cell Lung Carcinoma and Preneoplastic Lesions
Published in Clinical cancer research (01-01-2010)“…Purpose: To identify the pattern of interleukin-1 receptor–associated kinase (IRAK-1) protein expression in non–small cell lung carcinoma (NSCLC) and…”
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Expression of Hepatoma-Derived Growth Factor Is a Strong Prognostic Predictor for Patients With Early-Stage Non–Small-Cell Lung Cancer
Published in Journal of clinical oncology (15-08-2004)“…Hepatoma-derived growth factor (HDGF), which is unrelated to hepatocyte growth factor, can stimulate DNA synthesis and cell proliferation on entering the…”
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Correlation between Insulin-like Growth Factor-binding Protein-3 Promoter Methylation and Prognosis of Patients with Stage I Non-Small Cell Lung Cancer
Published in Clinical cancer research (01-12-2002)“…Purpose: The activities of insulin-like growth factors (IGFs) in regulating cell proliferation,differentiation, and apoptosis are modulated by a family of…”
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18
Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing
Published in Science (American Association for the Advancement of Science) (10-10-2014)“…Cancers are composed of populations of cells with distinct molecular and phenotypic features, a phenomenon termed intratumor heterogeneity (ITH). ITH in lung…”
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Durable Long-Term Remission With Chemotherapy Alone for Stage II to IV Laryngeal Cancer
Published in Journal of clinical oncology (20-04-2009)“…For patients with stage II to IV laryngeal cancer, radiation therapy (RT) either alone or with concurrent chemotherapy provides the highest rate of organ…”
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Differential Impacts of Insulin-Like Growth Factor-Binding Protein-3 (IGFBP-3) in Epithelial IGF-Induced Lung Cancer Development
Published in Endocrinology (Philadelphia) (01-06-2011)“…IGFBP-3 has dual impact for the lung cancer development. The IGF axis has been implicated in the risk of various cancers. We previously reported a potential…”
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