Search Results - "WATSON, JOSEPH B"

Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging by Zeng, Yan, Tan, Miao, Kohyama, Jun, Sneddon, Marissa, Watson, Joseph B, Sun, Yi E, Xie, Cui-Wei

“…Aging-related cognitive declines are well documented in humans and animal models. Yet the synaptic and molecular mechanisms responsible for cognitive aging are…”
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Impairment of mitochondria in adult mouse brain overexpressing predominantly full-length, N-terminally acetylated human α-synuclein by Sarafian, Theodore A, Ryan, Christopher M, Souda, Puneet, Masliah, Eliezer, Kar, Upendra K, Vinters, Harry V, Mathern, Gary W, Faull, Kym F, Whitelegge, Julian P, Watson, Joseph B

“…While most forms of Parkinson's Disease (PD) are sporadic in nature, a small percentage of PD have genetic causes as first described for dominant, single base…”
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Does social media pay for music artists? Quantitative evidence on the co-evolution of social media, streaming and live music by Watson, Allan, Watson, Joseph B., Tompkins, Lou

“…Recent commentaries on the music industry have emphasised the importance of social media in creating a monetisable fan base. However, no quantitative evidence…”
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Project brainstorm: using neuroscience to connect college students with local schools by Romero-Calderón, Rafael, O'Hare, Elizabeth D, Suthana, Nanthia A, Scott-Van Zeeland, Ashley A, Rizk-Jackson, Angela, Attar, Aida, Madsen, Sarah K, Ghiani, Cristina A, Evans, Christopher J, Watson, Joseph B

“…[...]this radical shift in teaching science has percolated down the education pipeline to include schools in the kindergarten to 12th grade levels (K-12)…”
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Mechanisms underlying the enhancement of γ‐aminobutyric acid responses in the external globus pallidus of R6/2 Huntington’s disease model mice by Barry, Joshua, Sarafian, Theodore A., Watson, Joseph B., Cepeda, Carlos, Levine, Michael S.

“…In Huntington's disease (HD), the output of striatal indirect pathway medium‐sized spiny neurons (MSNs) is altered in its target region, the external globus…”
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Enhanced mitochondrial inhibition by 3,4‐dihydroxyphenyl‐acetaldehyde (DOPAL)‐oligomerized α‐synuclein by Sarafian, Theodore A., Yacoub, Amneh, Kunz, Anastasia, Aranki, Burkan, Serobyan, Grigor, Cohn, Whitaker, Whitelegge, Julian P., Watson, Joseph B.

“…Oligomeric forms of α‐synuclein are believed to cause mitochondrial injury, which may contribute to neurotoxicity in Parkinson's disease (PD). Here oligomers…”
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Multiple sources of striatal inhibition are differentially affected in Huntington's disease mouse models by Cepeda, Carlos, Galvan, Laurie, Holley, Sandra M, Rao, Shilpa P, André, Véronique M, Botelho, Elian P, Chen, Jane Y, Watson, Joseph B, Deisseroth, Karl, Levine, Michael S

“…In Huntington's disease (HD) mouse models, spontaneous inhibitory synaptic activity is enhanced in a subpopulation of medium-sized spiny neurons (MSNs), which…”
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Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α‐synuclein by Sarafian, Theodore A., Littlejohn, Kaitlyn, Yuan, Sarah, Fernandez, Charlene, Cilluffo, Marianne, Koo, Bon‐Kyung, Whitelegge, Julian P., Watson, Joseph B.

“…The α‐synuclein protein exists in vivo in a variety of covalently modified and aggregated forms associated with Parkinson's disease (PD) pathology. However,…”
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Adenylyl Cyclase Activation Modulates Activity-Dependent Changes in Synaptic Strength and Ca2+/Calmodulin-Dependent Kinase II Autophosphorylation by Makhinson, Michael, Chotiner, Jennifer K, Watson, Joseph B, O'Dell, Thomas J

“…Activation of the Ca2+- and calmodulin-dependent protein kinase II (CaMKII) and its conversion into a persistently activated form by autophosphorylation are…”
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Amyloid beta prevents activation of calcium/calmodulin-dependent protein kinase II and AMPA receptor phosphorylation during hippocampal long-term potentiation by Zhao, Danyun, Watson, Joseph B, Xie, Cui-Wei

“…Accumulation of amyloid beta-peptides (Abeta) in the brain has been linked with memory loss in Alzheimer's disease and its animal models. However, the synaptic…”
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A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington's disease by Cummings, Damian M, Alaghband, Yasaman, Hickey, Miriam A, Joshi, Prasad R, Hong, S Candice, Zhu, Chunni, Ando, Timothy K, André, Véronique M, Cepeda, Carlos, Watson, Joseph B, Levine, Michael S

“…The R6/2 mouse is the most frequently used model for experimental and preclinical drug trials in Huntington's disease (HD). When the R6/2 mouse was first…”
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Synaptoneurosome micromethod for fractionation of mouse and human brain, and primary neuronal cultures by Chang, Julia W., Arnold, Monica M., Rozenbaum, Anna, Caputo, Anna, Schweizer, Felix E., Huynh, My, Mathern, Gary W., Sarafian, Theodore A., Watson, Joseph B.

“…[Display omitted] ► Easy step-by-step protocol for preparing synaptoneurosomes (SNs) from small amounts of mammalian brain tissue. ► Novel SN applications…”
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Rescuing the Corticostriatal Synaptic Disconnection in the R6/2 Mouse Model of Huntington's Disease: Exercise, Adenosine Receptors and Ampakines by Cepeda, Carlos, Cummings, Damian M, Hickey, Miriam A, Kleiman-Weiner, Max, Chen, Jane Y, Watson, Joseph B, Levine, Michael S

“…In the R6/2 mouse model of Huntington's disease (HD) we examined the effects of a number of behavioral and pharmacological manipulations aimed at rescuing the…”
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Histone acetylation enhances neurotrophin expression and synaptic plasticity in aging brain by XIE, Cui-Wei, Yin, Xiao Feng, Zeng, Yan, Watson, Joseph B

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Effects of repeated amphetamine treatment on the locomotor activity of the dopamine D1A-deficient mouse by Crawford, Cynthia A, Drago, John, Watson, Joseph B, Levine, Michael S

“…THE role of dopamine D1A receptors in mediating amphetamine-induced sensitization was investigated using the D1A-deficient mouse. During the drug pre-exposure…”
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Effects of repeated methylphenidate treatment in the young rat: sensitization of both locomotor activity and stereotyped sniffing by McDougall, S A, Collins, R L, Karper, P E, Watson, J B, Crawford, C A

“…The behavioral effects of repeated methylphenidate (MPH) treatment were assessed in young rats. In 4 experiments, rats (starting at Postnatal Day 10 or 16)…”
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Mechanisms Underlying the Enhancement of GABA Responses in the External Globus Pallidus of R6/2 Huntington’s Disease Model Mice by Barry, Joshua, Sarafian, Theodore A., Watson, Joseph B., Cepeda, Carlos, Levine, Michael S.

“…In Huntington’s Disease (HD), the output of striatal indirect pathway medium-sized spiny neurons (MSNs) is altered in its target region, the external globus…”
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Isolation and characterization of synaptoneurosomes from single rat hippocampal slices by Johnson, Michael W, Chotiner, Jennifer K, Watson, Joseph B

“…A technique for recovering functional synaptoneurosomes containing vesicularized elements of the presynapse and postsynapse into an enriched fraction has been…”
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Localization of the Protein Kinase C Phosphorylation/Calmodulin-Binding Substrate RC3 in Dendritic Spines of Neostriatal Neurons by Watson, Joseph B., Sutcliffe, J. Gregor, Fisher, Robin S.

“…The rodent protein RC3 is expressed mainly by forebrain neurons during postnatal development and maturity. RC3 and its bovine homolog neurogranin/B-50…”
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Dendritic Translocation of RC3/Neurogranin mRNA in Normal Aging, Alzheimer Disease and Fronto-Temporal Dementia by CHANG, JULIA W, SCHUMACHER, ERIC, COULTER, PHILLIP M, VINTERS, HARRY V, WATSON, JOSEPH B

“…RC3/neurogranin is a postsynaptic protein kinase C (PKC)-/calmodulin-binding substrate implicated in long-term potentiation (LTP) forms of synaptic plasticity…”
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