Search Results - "WATKINS, J"

An Engineered Monovalent Anti–TNF-α Antibody with pH-Sensitive Binding Abrogates Immunogenicity in Mice following a Single Intravenous Dose by Watkins, J. Monty, Watkins, Jeffry D.

“…Abstract Therapeutic Abs directed toward TNF-α display significant immunogenicity in humans, frequently leading to lower serum concentrations of the Ab that…”
Get full text

The influence of seminal plasma on offspring development and health by Morgan, Hannah L., Watkins, Adam J.

“…The concept that a father’s wellbeing at the time of conception influences the development and long-term health of his offspring is now well established…”
Get full text

Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice by Watkins, Adam J., Dias, Irundika, Tsuro, Heather, Allen, Danielle, Emes, Richard D., Moreton, Joanna, Wilson, Ray, Ingram, Richard J. M., Sinclair, Kevin D.

“…The association between poor paternal diet, perturbed embryonic development, and adult offspring ill health represents a new focus for the Developmental…”
Get full text

The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress by Sloan, Katherine E., Bohnsack, Markus T., Watkins, Nicholas J.

“…Several proto-oncogenes and tumor suppressors regulate the production of ribosomes. Ribosome biogenesis is a major consumer of cellular energy, and defects…”
Get full text

Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice by Watkins, Adam J, Sinclair, Kevin D

“…Although the association between maternal periconceptional diet and adult offspring health is well characterised, our understanding of the impact of paternal…”
Get more information

Origins of lifetime health around the time of conception: causes and consequences by Fleming, Tom P, Watkins, Adam J, Velazquez, Miguel A, Mathers, John C, Prentice, Andrew M, Stephenson, Judith, Barker, Mary, Saffery, Richard, Yajnik, Chittaranjan S, Eckert, Judith J, Hanson, Mark A, Forrester, Terrence, Gluckman, Peter D, Godfrey, Keith M

“…Parental environmental factors, including diet, body composition, metabolism, and stress, affect the health and chronic disease risk of people throughout their…”
Get full text

The box C/D and H/ACA snoRNPs: key players in the modification, processing and the dynamic folding of ribosomal RNA by Watkins, Nicholas J., Bohnsack, Markus T.

“…Box C/D and H/ACA RNPs are essential ribonucleoprotein particles that are found throughout both eukaryotes [small nucleolar RNPs (snoRNPs)] and archaea…”
Get full text

A closer look at mammalian antiviral condensates by Watkins, J Monty, Burke, James M

“…Several biomolecular condensates assemble in mammalian cells in response to viral infection. The most studied of these are stress granules (SGs), which have…”
Get more information

The importance of ribosome production, and the 5S RNP-MDM2 pathway, in health and disease by Pelava, Andria, Schneider, Claudia, Watkins, Nicholas J

“…Ribosomes are abundant, large RNA-protein complexes that are the source of all protein synthesis in the cell. The production of ribosomes is an extremely…”
Get more information

Periconceptional environment and the developmental origins of disease by Velazquez, Miguel A, Fleming, Tom P, Watkins, Adam J

“…The concept emerging from Professor David Barker’s seminal research on the developmental origins of later-life disease has progressed in many directions since…”
Get full text

Classification of crystallization outcomes using deep convolutional neural networks by Bruno, Andrew E, Charbonneau, Patrick, Newman, Janet, Snell, Edward H, So, David R, Vanhoucke, Vincent, Watkins, Christopher J, Williams, Shawn, Wilson, Julie

“…The Machine Recognition of Crystallization Outcomes (MARCO) initiative has assembled roughly half a million annotated images of macromolecular crystallization…”
Get full text

RNase L-induced bodies sequester subgenomic flavivirus RNAs to promote viral RNA decay by Watkins, J. Monty, Burke, James M.

“…Subgenomic flavivirus RNAs (sfRNAs) are structured RNAs encoded by flaviviruses that promote viral infection by inhibiting cellular RNA decay machinery…”
Get full text

Search for Neutrinoless Double- β Decay with the Complete EXO-200 Dataset by Anton, G., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Daniels, T., Danilov, M., Darroch, L., Daugherty, S. J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Echevers, J., Fairbank, W., Fairbank, D., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fudenberg, D., Gautam, P., Gornea, R., Gratta, G., Hall, C., Hansen, E. V., Hoessl, J., Hufschmidt, P., Hughes, M., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Johnson, A., Karelin, A., Kaufman, L. J., Koffas, T., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Lenardo, B. G., Leonard, D. S., Li, G. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., McElroy, T., Michel, T., Mong, B., Moore, D. C., Murray, K., Njoya, O., Nusair, O., Odian, A., Ostrovskiy, I., Piepke, A., Pocar, A., Retière, F., Robinson, A. L., Rowson, P. C., Ruddell, D., Runge, J., Schmidt, S., Sinclair, D., Soma, A. K., Stekhanov, V., Tarka, M., Todd, J., Tolba, T., Totev, T. I., Veenstra, B., Veeraraghavan, V., Vogel, P., Vuilleumier, J.-L., Wagenpfeil, M., Watkins, J., Weber, M., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Xia, Q., Yahne, D. R., Yang, L., Yen, Y.-R.

“…A search for neutrinoless double-β decay (0νββ) in Xe136 is performed with the full EXO-200 dataset using a deep neural network to discriminate between 0νββ…”
Get full text

Public health and economic responses to COVID-19: finding the tipping point by Watkins, J., Maruthappu, M.

Get full text

Maternal blood metal and metalloid concentrations in association with birth outcomes in Northern Puerto Rico by Ashrap, Pahriya, Watkins, Deborah J., Mukherjee, Bhramar, Boss, Jonathan, Richards, Michael J., Rosario, Zaira, Vélez-Vega, Carmen M., Alshawabkeh, Akram, Cordero, José F., Meeker, John D.

“…•First study to assess maternal metals in relation to birth outcomes in Puerto Rico.•Highlights the importance of assessing the effects of mixtures on health…”
Get full text

H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro by Watkins, Sarah J, Borthwick, Gillian M, Arthur, Helen M

“…Cardiac hypertrophy is a major risk factor for heart failure and associated patient morbidity and mortality. Research investigating the aberrant molecular…”
Get full text

Proton superfluidity and charge radii in proton-rich calcium isotopes by Miller, A. J., Minamisono, K., Klose, A., Garand, D., Kujawa, C., Lantis, J. D., Liu, Y., Maaß, B., Mantica, P. F., Nazarewicz, W., Nörtershäuser, W., Pineda, S. V., Reinhard, P.-G., Rossi, D. M., Sommer, F., Sumithrarachchi, C., Teigelhöfer, A., Watkins, J.

“…One of the most important global properties of the atomic nucleus is its size. Experimentally determined nuclear charge radii carry unique information on the…”
Get full text

Elevated concentrations of urinary triclocarban, phenol and paraben among pregnant women in Northern Puerto Rico: Predictors and trends by Ashrap, Pahriya, Watkins, Deborah J., Calafat, Antonia M., Ye, Xiaoyun, Rosario, Zaira, Brown, Phil, Vélez-Vega, Carmen M., Alshawabkeh, Akram, Cordero, José F., Meeker, John D.

“…Understanding important sources and pathways of exposure to common chemicals known or suspected to impact human health is critical to eliminate or reduce the…”
Get full text

Diabetes, oxidative stress, and antioxidants: A review by Maritim, A. C., Sanders, R. A., Watkins III, J. B.

“…Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of both types of diabetes…”
Get full text

Characterization of Four Alkyl-branched Fatty Acids as Methyl, Ethyl, Propyl, and Butyl Esters Using Gas Chromatography–Quadrupole Time of Flight Mass Spectrometry by WATKINS, Peter J.

“…Branched fatty chain fatty acids (BCFAs) are associated with the “mutton flavor” found with the aroma resulting from cooked older sheep meat with three BCFAs,…”
Get full text