Search Results - "WATKINS, H"

2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC) by Elliott, Perry M, Anastasakis, Aris, Borger, Michael A, Borggrefe, Martin, Cecchi, Franco, Charron, Philippe, Hagege, Albert Alain, Lafont, Antoine, Limongelli, Giuseppe, Mahrholdt, Heiko, McKenna, William J, Mogensen, Jens, Nihoyannopoulos, Petros, Nistri, Stefano, Pieper, Petronella G, Pieske, Burkert, Rapezzi, Claudio, Rutten, Frans H, Tillmanns, Christoph, Watkins, Hugh

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Genetically Determined Height and Coronary Artery Disease by Nelson, Christopher P, Hamby, Stephen E, Saleheen, Danish, Hopewell, Jenna C, Zeng, Lingyao, Assimes, Themistocles L, Kanoni, Stavroula, Willenborg, Christina, Burgess, Stephen, Amouyel, Phillipe, Anand, Sonia, Blankenberg, Stefan, Boehm, Bernhard O, Clarke, Robert J, Collins, Rory, Dedoussis, George, Farrall, Martin, Franks, Paul W, Groop, Leif, Hall, Alistair S, Hamsten, Anders, Hengstenberg, Christian, Hovingh, G. Kees, Ingelsson, Erik, Kathiresan, Sekar, Kee, Frank, König, Inke R, Kooner, Jaspal, Lehtimäki, Terho, März, Winifred, McPherson, Ruth, Metspalu, Andres, Nieminen, Markku S, O'Donnell, Christopher J, Palmer, Colin N.A, Peters, Annette, Perola, Markus, Reilly, Muredach P, Ripatti, Samuli, Roberts, Robert, Salomaa, Veikko, Shah, Svati H, Schreiber, Stefan, Siegbahn, Agneta, Thorsteinsdottir, Unnur, Veronesi, Giovani, Wareham, Nicholas, Willer, Cristen J, Zalloua, Pierre A, Erdmann, Jeanette, Deloukas, Panos, Watkins, Hugh, Schunkert, Heribert, Danesh, John, Thompson, John R, Samani, Nilesh J

“…In this study, there was a relative increase of 13.5% in the risk of coronary artery disease for each 1-SD decrease in genetically determined adult height…”
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The EWAS Catalog: a database of epigenome-wide association studies by Battram, Thomas, Yousefi, Paul, Crawford, Gemma, Prince, Claire, Sheikhali Babaei, Mahsa, Sharp, Gemma, Hatcher, Charlie, Vega-Salas, María Jesús, Khodabakhsh, Sahar, Whitehurst, Oliver, Langdon, Ryan, Mahoney, Luke, Elliott, Hannah R, Mancano, Giulia, Lee, Matthew A, Watkins, Sarah H, Lay, Abigail C, Hemani, Gibran, Gaunt, Tom R, Relton, Caroline L, Staley, James R, Suderman, Matthew

“…Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures and DNA methylation measured at thousands or millions of CpG…”
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Ancestry, ethnicity, and race: explaining inequalities in cardiometabolic disease by Eastwood, Sophie V., Hemani, Gibran, Watkins, Sarah H., Scally, Aylwyn, Davey Smith, George, Chaturvedi, Nishi

“…•Use of the terms ‘ethnicity,’ ‘race,’ and ‘ancestry’ to distinguish populations must recognize their distinct definitions and how these definitions associate…”
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Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data by Wensley, Frances, Gao, Pei, Burgess, Stephen, Kaptoge, Stephen, Di Angelantonio, Emanuele, Shah, Tina, Engert, James C, Clarke, Robert, Davey-Smith, George, Nordestgaard, Børge G, Saleheen, Danish, Samani, Nilesh J, Sandhu, Manjinder, Anand, Sonia, Pepys, Mark B, Smeeth, Liam, Whittaker, John, Casas, Juan Pablo, Thompson, Simon G, Hingorani, Aroon D, Danesh, John

“…Objective To use genetic variants as unconfounded proxies of C reactive protein concentration to study its causal role in coronary heart disease.Design…”
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Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins by Jessop, Catherine E, Watkins, Rachel H, Simmons, Jennifer J, Tasab, Mohammed, Bulleid, Neil J

“…At least 17 members of the protein disulphide isomerase (PDI) family of oxidoreductases are present in the endoplasmic reticulum (ER) of mammalian cells. They…”
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Assessment of a causal relationship between body mass index and atopic dermatitis by Budu-Aggrey, Ashley, Watkins, Sarah H., Brumpton, Ben, Løset, Mari, Tyrrell, Jess, Modalsli, Ellen H., Vie, Gunnhild Åberge, Palmer, Tom, Fritsche, Lars G., Nielsen, Jonas Bille, Romundstad, Pål Richard, Davey Smith, George, Åsvold, Bjørn Olav, Paternoster, Lavinia, Brown, Sara J.

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Optimal delineation of single C-tactile and C-nociceptive afferents in humans by latency slowing by Watkins, Roger H, Wessberg, Johan, Backlund Wasling, Helena, Dunham, James P, Olausson, Håkan, Johnson, Richard D, Ackerley, Rochelle

“…C-mechanoreceptors in humans comprise a population of unmyelinated afferents exhibiting a wide range of mechanical sensitivities. C-mechanoreceptors are…”
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Novel insights into diminished cardiac reserve in non-obstructive hypertrophic cardiomyopathy from four-dimensional flow cardiac magnetic resonance component analysis by Ashkir, Z, Johnson, S, Lewandowski, A J, Hess, A, Wicks, E, Mahmod, M, Myerson, S, Ebbers, T, Watkins, H, Neubauer, S, Carlhäll, C J, Raman, B

“…Abstract Aims Hypertrophic cardiomyopathy (HCM) is characterized by hypercontractility and diastolic dysfunction, which alter blood flow haemodynamics and are…”
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Disrupted Pulmonary Vasculature and Decreased Vascular Endothelial Growth Factor, Flt-1, and TIE-2 in Human Infants Dying with Bronchopulmonary Dysplasia by BHATT, ABHAY J, PRYHUBER, GLORIA S, HUYCK, HEIDIE, WATKINS, RICHARD H, METLAY, LEON A, MANISCALCO, WILLIAM M

“…An abnormal pulmonary vasculature may be an important component of bronchopulmonary dysplasia (BPD). We examined human infant lung for the endothelial cell…”
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DNA testing for hypertrophic cardiomyopathy: a cost-effectiveness model by Wordsworth, Sarah, Leal, José, Blair, Edward, Legood, Rosa, Thomson, Kate, Seller, Anneke, Taylor, Jenny, Watkins, Hugh

“…Aims To explore the cost-effectiveness of alternative methods of screening family members for hypertrophic cardiomyopathy (HCM), the most common monogenic…”
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Receptor activity‐modifying protein‐dependent effects of mutations in the calcitonin receptor‐like receptor: implications for adrenomedullin and calcitonin gene‐related peptide pharmacology by Watkins, H A, Walker, C S, Ly, K N, Bailey, R J, Barwell, J, Poyner, D R, Hay, D L

“…Background and Purpose Receptor activity‐modifying proteins (RAMPs) define the pharmacology of the calcitonin receptor‐like receptor (CLR). The interactions of…”
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Receptor activity‐modifying protein‐dependent impairment of calcitonin receptor splice variant Δ(1–47)hCT(a) function by Qi, T, Dong, M, Watkins, HA, Wootten, D, Miller, LJ, Hay, DL

“…Background and Purpose Alternative splicing expands proteome diversity to GPCRs. Distinct receptor variants have been identified for a secretin family GPCR,…”
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Fathers' preconception smoking and offspring DNA methylation by Kitaba, Negusse Tadesse, Knudsen, Gerd Toril Mørkve, Johannessen, Ane, Rezwan, Faisal I, Malinovschi, Andrei, Oudin, Anna, Benediktsdottir, Bryndis, Martino, David, González, Francisco Javier Callejas, Gómez, Leopoldo Palacios, Holm, Mathias, Jõgi, Nils Oskar, Dharmage, Shyamali C, Skulstad, Svein Magne, Watkins, Sarah H, Suderman, Matthew, Gómez-Real, Francisco, Schlünssen, Vivi, Svanes, Cecilie, Holloway, John W

“…Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ…”
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Impact of lipoprotein(a) levels and apolipoprotein(a) isoform size on risk of coronary heart disease by Hopewell, J. C., Seedorf, U., Farrall, M., Parish, S., Kyriakou, T., Goel, A., Hamsten, A., Collins, R., Watkins, H., Clarke, R.

“…Objectives Observational and genetic studies have shown that lipoprotein(a) [Lp(a)] levels and apolipoprotein(a) [apo(a)] isoform size are both associated with…”
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Substrate Specificity of the Oxidoreductase ERp57 Is Determined Primarily by Its Interaction with Calnexin and Calreticulin by Jessop, Catherine E., Tavender, Timothy J., Watkins, Rachel H., Chambers, Joseph E., Bulleid, Neil J.

“…The formation of disulfides within proteins entering the secretory pathway is catalyzed by the protein disulfide isomerase family of endoplasmic reticulum…”
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Identification of key residues involved in adrenomedullin binding to the AM1 receptor by Watkins, HA, Au, M, Bobby, R, Archbold, JK, Abdul‐Manan, N, Moore, JM, Middleditch, MJ, Williams, GM, Brimble, MA, Dingley, AJ, Hay, DL

“…Background and Purpose Adrenomedullin (AM) is a peptide hormone whose receptors are members of the class B GPCR family. They comprise a heteromer between the…”
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Oxidation of the yeast mitochondrial thioredoxin promotes cell death by Greetham, Darren, Kritsiligkou, Paraskevi, Watkins, Rachel H, Carter, Zorana, Parkin, Jill, Grant, Chris M

“…Yeast, like other eukaryotes, contains a complete mitochondrial thioredoxin system comprising a thioredoxin (Trx3) and a thioredoxin reductase (Trr2)…”
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Angiogenic factors and alveolar vasculature: development and alterations by injury in very premature baboons by Maniscalco, William M, Watkins, Richard H, Pryhuber, Gloria S, Bhatt, Abhay, Shea, Colleen, Huyck, Heidie

“…Proper formation of the pulmonary microvasculature is essential for normal lung development and gas exchange. Lung microvascular development may be disrupted…”
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The genetics of hypertrophic cardiomyopathy: Teare redux by Watkins, H, Ashrafian, H, McKenna, W J

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