Search Results - "WATAYA, Yusuke"

Anticancer Strategy Targeting Cell Death Regulators: Switching the Mechanism of Anticancer Floxuridine-Induced Cell Death from Necrosis to Apoptosis by Sato, Akira, Hiramoto, Akiko, Kim, Hye-Sook, Wataya, Yusuke

“…Cell death can be broadly characterized as either necrosis or apoptosis, depending on the morphological and biochemical features of the cell itself. We have…”
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Adenosine kinase is a key determinant for the anti‐HCV activity of ribavirin by Mori, Kyoko, Hiraoka, Osamu, Ikeda, Masanori, Ariumi, Yasuo, Hiramoto, Akiko, Wataya, Yusuke, Kato, Nobuyuki

“…Ribavirin (RBV) is often used in conjunction with interferon‐based therapy for patients with chronic hepatitis C. There is a drastic difference in the…”
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MicroRNA-351 Regulates Two-Types of Cell Death, Necrosis and Apoptosis, Induced by 5-fluoro-2'-deoxyuridine by Sato, Akira, Omi, Takuya, Yamamoto, Akihiro, Satake, Akito, Hiramoto, Akiko, Masutani, Mitsuko, Tanuma, Sei-ichi, Wataya, Yusuke, Kim, Hye-Sook

“…Cell-death can be necrosis and apoptosis. We are investigating the mechanisms regulating the cell death that occurs on treatment of mouse cancer cell-line FM3A…”
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Direct interaction analysis of microRNA-351-5p and nuclear scaffold lamin B1 mRNA by the cell-free in vitro mRNA/miRNA binding evaluation system by Sato, Akira, Ogino, Yoko, Shimotsuma, Akira, Hiramoto, Akiko, Kim, Hye-Sook, Wataya, Yusuke

“…We previously demonstrated that miR-351-5p regulates nuclear scaffold lamin B1 expression and mediates the anticancer floxuridine-induced necrosis shift to…”
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Role of the uridine/cytidine kinase 2 mutation in cellular sensitiveness toward 3'-ethynylcytidine treatment of human cancer cells by Sato, Akira, Takano, Takeshi, Hiramoto, Akiko, Naito, Tomoharu, Matsuda, Akira, Fukushima, Masakazu, Wataya, Yusuke, Kim, Hye-Sook

“…A nucleosidic medicine, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine [3'-ethynylcytidine (ECyd)], is a potent inhibitor of RNA polymerase I and shows…”
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Andirolides H–P from the flower of andiroba (Carapa guianensis, Meliaceae) by Tanaka, Yuji, Sakamoto, Asami, Inoue, Takanobu, Yamada, Takeshi, Kikuchi, Takashi, Kajimoto, Tetsuya, Muraoka, Osamu, Sato, Akira, Wataya, Yusuke, Kim, Hye-Sook, Tanaka, Reiko

“…Three new gedunins, an andirobin, three mexicanolides, and two phragmalin-type limonoids named andirolides H (1), I (2), J (3), K (4), L (5), M (6), N (7), O…”
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Role of activating transcription factor 3 protein ATF3 in necrosis and apoptosis induced by 5‐fluoro‐2′‐deoxyuridine by Sato, Akira, Nakama, Kentaro, Watanabe, Hiroki, Satake, Akito, Yamamoto, Akihiro, Omi, Takuya, Hiramoto, Akiko, Masutani, Mitsuko, Wataya, Yusuke, Kim, Hye‐Sook

“…Necrosis and apoptosis are the two major forms of cell death. We have studied the mechanisms that regulate the cell death observed during treatment of mouse…”
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Intracellular microRNA expression patterns influence cell death fates for both necrosis and apoptosis by Sato, Akira, Yamamoto, Akihiro, Shimotsuma, Akira, Ogino, Yoko, Funayama, Naoki, Takahashi, Yui, Hiramoto, Akiko, Wataya, Yusuke, Kim, Hye‐Sook

“…We reveal that intracellular miRNA expression patterns are dramatically altered in necrosis and apoptosis using a floxuridine (FUdR)‐induced mouse mammary…”
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Stage specific activity of synthetic antimalarial endoperoxides, N-89 and N-251, against Plasmodium falciparum by Morita, Masayuki, Koyama, Takahiko, Sanai, Hitomi, Sato, Akira, Hiramoto, Akiko, Masuyama, Araki, Nojima, Masatomo, Wataya, Yusuke, Kim, Hye-Sook

“…Abstract We have reported that two endoperoxides, N-89 and N-251, synthesized in 2001, possess potent antimalarial activities. Aiming at their eventual use for…”
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Protein Expression Profiles of Necrosis and Apoptosis Induced by 5-Fluoro-2′-deoxyuridine in Mouse Cancer Cells by Sato, Akira, Satake, Akito, Hiramoto, Akiko, Wataya, Yusuke, Kim, Hye-Sook

“…We have investigated the molecular mechanisms regulating the necrosis and apoptosis that occur on treatment of mouse mammary tumor FM3A cells with…”
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New preclinical antimalarial drugs potently inhibit hepatitis C virus genotype 1b RNA replication by Ueda, Youki, Takeda, Midori, Mori, Kyoko, Dansako, Hiromichi, Wakita, Takaji, Kim, Hye-Sook, Sato, Akira, Wataya, Yusuke, Ikeda, Masanori, Kato, Nobuyuki

“…Persistent hepatitis C virus (HCV) infection causes chronic liver diseases and is a global health problem. Although new triple therapy (pegylated-interferon,…”
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Correction: New Preclinical Antimalarial Drugs Potently Inhibit Hepatitis C Virus Genotype 1b RNA Replication by Ueda, Youki, Takeda, Midori, Mori, Kyoko, Dansako, Hiromichi, Wakita, Takaji, Kim, Hye-Sook, Sato, Akira, Wataya, Yusuke, Ikeda, Masanori, Kato, Nobuyuki

“…[This corrects the article on p. e72519 in vol. 8.]…”
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Antimalarial activity of endoperoxide compound 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol by Sato, Akira, Hiramoto, Akiko, Morita, Masayuki, Matsumoto, Masahiro, Komich, Yuka, Nakase, Yukari, Tanigawa, Natsuki, Hiraoka, Osamu, Hiramoto, Kazuyuki, Hayatsu, Hikoya, Higaki, Kazutaka, Kawai, Satoru, Masuyama, Araki, Nojima, Masatomo, Wataya, Yusuke, Kim, Hye-Sook

“…Abstract Plasmodium falciparum , the major causative parasite for the disease, has acquired resistance to most of the antimalarial drugs used today, presenting…”
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Antimalarial activity of 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) and its carboxylic acid derivatives by Sato, Akira, Kawai, Satoru, Hiramoto, Akiko, Morita, Masayuki, Tanigawa, Natsuki, Nakase, Yukari, Komichi, Yuka, Matsumoto, Masahiro, Hiraoka, Osamu, Hiramoto, Kazuyuki, Tokuhara, Hidekazu, Masuyama, Araki, Nojima, Masatomo, Higaki, Kazutaka, Hayatsu, Hikoya, Wataya, Yusuke, Kim, Hye-Sook

“…Abstract Malaria is one of the world's deadliest diseases and is becoming an increasingly serious problem as malaria parasites develop resistance to most of…”
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In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine by Tran, Quan Le, Tezuka, Yasuhiro, Ueda, Jun-ya, Nguyen, Nhan Trung, Maruyama, Yukiko, Begum, Khurshida, Kim, Hye-Sook, Wataya, Yusuke, Tran, Qui Kim, Kadota, Shigetoshi

“…Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by…”
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Synthesis and Evaluation of β-Carbolinium Cations as New Antimalarial Agents Based on π-Delocalized Lipophilic Cation (DLC) Hypothesis by Takasu, Kiyosei, Shimogama, Tsubasa, Saiin, Chalerm, Kim, Hye-Sook, Wataya, Yusuke, Brun, Reto, Ihara, Masataka

“…Several β-carbolines including naturally occurring substances and their corresponding cationic derivatives were synthesized and evaluated for antimalarial…”
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Gene expression profiles of necrosis and apoptosis induced by 5-fluoro-2′-deoxyuridine by Sato, Akira, Hiramoto, Akiko, Uchikubo, Yusuke, Miyazaki, Eriko, Satake, Akito, Naito, Tomoharu, Hiraoka, Osamu, Miyake, Tsuyoshi, Kim, Hye-Sook, Wataya, Yusuke

“…5-Fluoro-2′-deoxyuridine (FUdR), a potent anticancer agent, exerts its effects by inhibiting thymidylate synthase, an essential machinery for DNA synthesis in…”
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Synthesis and Antimalarial Activity of Novel Medium-Sized 1,2,4,5-Tetraoxacycloalkanes by Kim, Hye-Sook, Nagai, Yukiko, Ono, Kanako, Begum, Khurshida, Wataya, Yusuke, Hamada, Yoshiaki, Tsuchiya, Kaoru, Masuyama, Araki, Nojima, Masatomo, McCullough, Kevin J

“…CsOH- or Ag2O-mediated cycloalkylation of (alkylidene)bisperoxides 3 and 1,n-dihaloalkanes (n = 3−8) provided the corresponding medium-sized…”
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Schistosomicidal and antifecundity effects of oral treatment of synthetic endoperoxide N-89 by Taniguchi, Toshie, Kumagai, Takashi, Shimogawara, Rieko, Ichinose, Shizuko, Hiramoto, Akiko, Sato, Akira, Morita, Masayuki, Nojima, Masatomo, Kim, Hye-Sook, Wataya, Yusuke, Ohta, Nobuo

“…Abstract 1,2,6,7-Tetraoxaspiro[7.11]nonadecane (N-89) is a chemically synthesized compound with good efficacy against malaria parasites. We observed strong…”
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Antimalarial Activity of Lavandulyl Flavanones Isolated from the Roots of Sophora flavescens by Kim, Youn Chul, Kim, Hye-Sook, Wataya, Yusuke, Sohn, Dong Hwan, Kang, Tai Hyun, Kim, Myung Soo, Kim, Yong Man, Lee, Geon-Mok, Chang, Jong-Duk, Park, Hyun

“…Four lavandulyl flavanones, (2S)-2′-methoxykurarinone (1), sophoraflavanone G (2), leachianone A (3), and (−)-kurarinone (4), which are isolated from the roots…”
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