Search Results - "WATANABE, Hidenori"
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1
Forelimb movements evoked by optogenetic stimulation of the macaque motor cortex
Published in Nature communications (26-06-2020)“…Optogenetics has become an indispensable tool for investigating brain functions. Although non-human primates are particularly useful models for understanding…”
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2
Transcriptional regulators involved in responses to volatile organic compounds in plants
Published in The Journal of biological chemistry (15-02-2019)“…Field studies have shown that plants growing next to herbivore-infested plants acquire higher resistance to herbivore damage. This increased resistance is…”
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3
Asymmetric synthesis of trans-p-menth-3-ene-1,2,8-triol, the monoterpene isolated from herbal plants
Published in Bioscience, biotechnology, and biochemistry (02-01-2020)“…The monoterpene, trans-p-menth-3-ene-1,2,8-triol, is a naturally occurring alcohol isolated from several herbal plants. In the present work, the asymmetric…”
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4
Identification of a pheromone that increases anxiety in rats
Published in Proceedings of the National Academy of Sciences - PNAS (30-12-2014)“…Chemical communication plays an important role in the social lives of various mammalian species. Some of these chemicals are called pheromones. Rats release a…”
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5
NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein
Published in Molecular and cellular biology (28-04-2020)“…Proteasomes are essential protease complexes that maintain cellular homeostasis, and aberrant proteasomal activity supports cancer development. The regulatory…”
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6
First total synthesis of glabramycin B and revision of its relative configuration
Published in Tetrahedron (08-06-2017)“…Structural revision of glabramycin B, which is an antibacterial 10-membered lactone isolated from a fermentation broth of Neosartorya glabra, was achieved by…”
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7
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
Published in Nature chemical biology (01-09-2007)“…The removal of intervening sequences from transcripts is catalyzed by the spliceosome, a multicomponent complex that assembles on the newly synthesized…”
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8
Asymmetric Formal Synthesis of Azadirachtin
Published in Angewandte Chemie International Edition (01-12-2015)“…An asymmetric formal synthesis of azadirachtin, a potent insect antifeedant, was accomplished in 30 steps to Ley’s synthetic intermediate (longest linear…”
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9
Enantioselective Total Synthesis of (+)-Anthecularin
Published in Organic letters (06-07-2018)“…An enantioselective total synthesis of (+)-anthecularin, an antiplasmodial and antitrypanosomal sesquiterpene lactone, has been achieved in 3.9% overall yield…”
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10
Unified synthesis and assessment of tumor cell migration inhibitory activity of optically active UTKO1, originally designed moverastin analog
Published in Bioscience, biotechnology, and biochemistry (07-01-2021)“…UTKO1 is a synthetic analog of a natural tumor cell migration inhibitor, moverastin, isolated from microbial extracts of Aspergillus sp. 7720. UTKO1 was…”
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11
Stereoselective synthesis of (±)-urechitol A employing [4+3] cycloaddition
Published in Tetrahedron (03-11-2016)“…Urechitol A was synthesized as a racemate employing a [4+3] cycloaddition reaction and a methanol assisted intramolecular epoxide opening as key steps for…”
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12
Transcriptional regulators involved in responses to volatile organic compounds in plants
Published in The FASEB journal (01-05-2021)“…It has been reported since the 1980s that plants neighboring to herbivore‐infested plants in field acquire higher levels of resistance to damages. The current…”
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13
Synthesis and bioactivity of 4-methylthio-3-butenylisothiocyanate and raphanusanin, phototropism-regulating substances of radish hypocotyls
Published in Tetrahedron letters (11-05-2021)“…[Display omitted] •Total syntheses of 4-methylthio-3-butenylisothiocyanate and raphanusanin.•MTBI and raphanusanin are phototropism-regulating substances of…”
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14
An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor
Published in Nature chemical biology (01-03-2013)“…A natural aliphatic alcohol ligand of the mouse orphan odorant receptor Olfr288 from the male preputial gland is regulated by testosterone and affects…”
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15
Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF
Published in Cancer science (01-11-2010)“…Spliceostatin A (SSA) is a methylated derivative of an antitumor natural product FR901464, which specifically binds and inhibits the SF3b spliceosome…”
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16
First enantioselective synthesis of exiguamide, a nitrogen-containing spirocyclic sesquiterpene isolated from the marine sponge Geodia exigua
Published in Tetrahedron (01-02-2019)“…(+)-Exiguamide is a nitrogen-containing spirocyclic sesquiterpene isolated from the marine sponge Geodia exigua. This study aims to report the first synthesis…”
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17
A suicide enzyme catalyzes multiple reactions for biotin biosynthesis in cyanobacteria
Published in Nature chemical biology (01-04-2020)“…In biotin biosynthesis, the conversion of pimeloyl intermediates to biotin is catalyzed by a universal set of four enzymes: BioF, BioA, BioD and BioB. We found…”
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18
Biosynthesis of γ-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces
Published in Proceedings of the National Academy of Sciences - PNAS (13-02-2007)“…A factor (2-isocapryloyl-3R-hydroxymethyl-γ-butyrolactone) is a representative of the γ-butyrolactone autoregulators that trigger secondary metabolism and…”
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19
Synthesis and revision of the relative configuration of glabramycin B
Published in Tetrahedron letters (04-11-2015)“…[Display omitted] The stereostructure of glabramycin B, which is an antibacterial 10-membered lactone fused with 4-oxygenated cyclohexanone, was presumed on…”
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20
First enantioselective synthesis of salinipostin A, a marine cyclic enol-phosphotriester isolated from Salinispora sp
Published in Tetrahedron letters (08-08-2019)“…[Display omitted] •First asymmetric synthesis of salinipostin A was achieved.•Salinipostin A is a cyclic enol-phosphotriester isolated from a marine-derived…”
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