Search Results - "WASOWSKI, C"

Flavonoids and the Central Nervous System: from Forgotten Factors to Potent Anxiolytic Compounds by PALADINI, A. C., MARDER, M., VIOLA, H., WOLFMAN, C., WASOWSKI, C., MEDINA, J. H.

“…The list of activities of plant flavonoids did not include effects on the central nervous system (CNS) up to 1990, when our laboratory described the existence…”
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The anxiolytic-like effects of Aloysia polystachya (Griseb.) Moldenke (Verbenaceae) in mice by Hellión-Ibarrola, M.C., Ibarrola, D.A., Montalbetti, Y., Kennedy, M.L., Heinichen, O., Campuzano, M., Tortoriello, J., Fernández, S., Wasowski, C., Marder, M., De Lima, T.C.M., Mora, S.

“…The aim of the present work is to demonstrate the putative sedative and anxiolytic-like effects of a hydro-ethanolic extract obtained from the aerial parts of…”
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Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects by Viola, H, Wasowski, C, Levi de Stein, M, Wolfman, C, Silveira, R, Dajas, F, Medina, J H, Paladini, A C

“…The dried flower heads of Matricaria recutita L. (Asteraceae) are used in folk medicine to prepare a spasmolytic and sedative tea. Our fractionation of the…”
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Neuroactive flavonoids: new ligands for the Benzodiazepine receptors by Medina, J.H., Viola, H., Wolfman, C., Marder, M., Wasowski, C., Calvo, D., Paladini, A.C.

“…Flavonoids isolated from plants used as tranquilizers in folkloric medicine have a selective affinity, for central benzodiazepine receptors (BDZ-Rs) and some…”
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Isolation of pharmacologically active benzodiazepine receptor ligands from Tilia tomentosa (Tiliaceae) by Viola, H, Wolfman, C, Levi de Stein, M, Wasowski, C, Peña, C, Medina, J H, Paladini, A C

“…Tilia species are traditional medicinal plants widely used in Latin America as sedatives and tranquilizers. For this purpose, the infusion of their…”
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Cirsiliol and caffeic acid ethyl ester, isolated from Salvia guaranitica, are competitive ligands for the central benzodiazepine receptors by Marder, M., Viola, H., Wasowski, C., Wolfman, C., Waterman, P.G., Medina, J.H., Paladini, A.C.

“…Ligands for the central benzodiazepine receptors have been detected in the crude ethanolic extract of Salvia guaranitica. The compounds responsible for the…”
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6-Chloro-3′-nitroflavone is a Potent Ligand for the Benzodiazepine Binding Site of the GABA A Receptor Devoid of Intrinsic Activity by Viola, H, Wolfman, C, Marder, M, Goutman, J.D, Bianchin, M, Wasowski, C, Calvo, D.J, Izquierdo, I, Paladini, A.C, Medina, J.H

“…6-Chloro-3′-nitroflavone integrates a list of nearly 70 flavone derivatives synthesized in our laboratories. The effects of 6-chloro-3′-nitroflavone on the…”
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Sedative and hypnotic properties of Salvia guaranitica St. Hil. and of its active principle, Cirsiliol by Viola, H., Wasowski, C., Marder, M., Wolfman, C., Paladini, A.C., Medina, J.H.

“…Salvia guaranitica St. Hil. is a traditional medicinal plant used in Latin America as sedative. We have recently demonstrated the presence of cirsiliol in its…”
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Pharmacological Characterization of 6-Bromo-3′-nitroflavone, a Synthetic Flavonoid with High Affinity for the Benzodiazepine Receptors by Wolfman, C., Viola, H., Marder, M., Ardenghi, P., Wasowski, C., Schröder, N., Izquierdo, I., Rúveda, E., Paladini, A., Medina, J.H.

“…6-Bromo-3′-nitroflavone is a synthetic flavone derivative that selectively recognizes benzodiazepine receptors and has potent anxiolytic-like effects. Here, we…”
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Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis by Fernández, Sebastián, Wasowski, Cristina, Paladini, Alejandro C, Marder, Mariel

“…We have recently reported the presence of the anxiolytic flavone 6-methylapigenin (MA) and of the sedative and sleep-enhancing flavanone glycoside 2S (−)…”
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6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS by Marder, Mariel, Viola, Haydeé, Wasowski, Cristina, Fernández, Sebastián, Medina, Jorge H, Paladini, Alejandro C

“…Valerian is an ancient tranquillizing drug obtained from the underground organs of several Valeriana species. Its active principles were assumed to be…”
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K+-montmorillonite: its electric double layer extension and point of zero charge by diffusion potential by Tschapek, M., Wasowski, C., Falasca, S.

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Synergistic interaction between hesperidin, a natural flavonoid, and diazepam by Fernández, Sebastián P., Wasowski, Cristina, Paladini, Alejandro C., Marder, Mariel

“…It has been recently reported the presence in Valeriana of the flavone 6-methylapigenin and the flavanone glycoside hesperidin. The apigenin derivative is a…”
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In vivo formation of benzodiazepine-like molecules in mammalian brain by Medina, J H, Levi de Stein, M, Wolfman, C, Wasowski, C, De Blas, A, Paladini, A C

“…The possible cerebral formation of benzodiazepine (BDZ)-like molecules was evaluated in rats bilaterally microinjected into either the lateral ventricles (ICV)…”
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Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice by Martínez, M. Cecilia, Fernandez, Sebastian P., Loscalzo, Leonardo M., Wasowski, Cristina, Paladini, Alejandro C., Marder, Mariel, Medina, Jorge H., Viola, Haydée

“…The aim of this work was to evaluate if the intraperitoneal administration of the natural compound hesperidin, in a sedative dose, and neo-hesperidin, a…”
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Production of benzodiazepine-like compounds in bovine rumen by Medina, J H, Danelon, J L, Wasowski, C, Levi de Stein, M, Paladini, A C

“…The presence of benzodiazepine-like molecules was detected radioimmunologically in bovine rumen contents and in incubates of ruminal contents with homogenates…”
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Benzodiazepines in the brain. Their origin and possible biological roles by Medina, J H, Peña, C, Piva, M, Wolfman, C, de Stein, M L, Wasowski, C, Da Cunha, C, Izquierdo, I, Paladini, A C

“…Great progress has been made in the last 5 yr in demonstrating the presence of benzodiazepines (BDZs) in mammalian tissues, in beginning studies on the origin…”
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Flavonoids as GABAA receptor ligands: the whole story? by Wasowski, Cristina, Marder, Mariel

“…Benzodiazepines are the most widely prescribed class of psychoactive drugs in current therapeutic use, despite the important unwanted side effects that they…”
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Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(A) receptors, from Valeriana wallichii by Wasowski, Cristina, Marder, Mariel, Viola, Haydeé, Medina, Jorge Horacio, Paladini, Alejandro Constantino

“…Using the guidance by a competitive assay for the benzodiazepine binding site in the GABA(A) receptor, active compounds were isolated from the rhizomes and…”
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The hydration of a zwitterion, glycine, as a function of pH by Tschapek, M, Wasowski, C

“…1. The hydration numbers of glycine (concentrations 1--3 M), as a function of concentration, were determined by surface tension measurements, using octan-1-ol…”
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