Search Results - "WARSHAW, D. M"

Molecular Mechanics of Cardiac Myosin-Binding Protein C in Native Thick Filaments by Previs, M. J., Previs, S. Beck, Gulick, J., Robbins, J., Warshaw, D. M.

“…The heart's pumping capacity results from highly regulated interactions of actomyosin molecular motors. Mutations in the gene for a potential regulator of…”
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Effect of low pH on single skeletal muscle myosin mechanics and kinetics by Debold, E P, Beck, S E, Warshaw, D M

“…Acidosis (low pH) is the oldest putative agent of muscular fatigue, but the molecular mechanism underlying its depressive effect on muscular performance…”
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Modeling myosin Va liposome transport through actin filament networks reveals a percolation threshold that modulates transport properties by Walcott, S, Warshaw, D M

“…Myosin Va (myoVa) motors transport membrane-bound cargo through three-dimensional, intracellular actin filament networks. We developed a coarse-grained, in…”
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Single-Molecule Mechanics of R403Q Cardiac Myosin Isolated From the Mouse Model of Familial Hypertrophic Cardiomyopathy by Tyska, M J, Hayes, E, Giewat, M, Seidman, C E, Seidman, J G, Warshaw, D M

“…ABSTRACTFamilial hypertrophic cardiomyopathy (FHC) is an inherited cardiac disease that can result in sudden death in the absence of any overt symptoms. Many…”
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Two Heads of Myosin Are Better Than One for Generating Force and Motion by Tyska, M. J., Dupuis, D. E., Guilford, W. H., Patlak, J. B., Waller, G. S., Trybus, K. M., Warshaw, D. M., Lowey, S.

“…Several classes of the myosin superfamily are distinguished by their "double-headed" structure, where each head is a molecular motor capable of hydrolyzing ATP…”
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Smooth and skeletal muscle myosin both exhibit low duty cycles at zero load in vitro by HARRIS, D. E, WARSHAW, D. M

“…Smooth muscle's stress equals that of skeletal muscle with less myosin. Thus, under isometric conditions, smooth muscle myosin may spend a greater fraction of…”
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Stereoselective Actions of Thiadiazinones on Canine Cardiac Myocytes and Myofilaments by Solaro, R John, Gambassi, Giovanni, Warshaw, David M, Keller, Michael R, Spurgeon, Harold A, Beier, Norbert, Lakatta, Edward G

“…Thiadiazinones are cardiotonic agents that have potent, direct, and stereoselective actions on the myofilament response to Ca in intact myocardium. Their…”
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Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay by Debold, Edward P, Schmitt, J P, Patlak, J B, Beck, S E, Moore, J R, Seidman, J G, Seidman, C, Warshaw, D M

“…Point mutations in cardiac myosin, the heart's molecular motor, produce distinct clinical phenotypes: hypertrophic (HCM) and dilated (DCM) cardiomyopathy. Do…”
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Smooth Muscle Myosin Cross-Bridge Interactions Modulate Actin Filament Sliding Velocity in vitro by Warshaw, David M., Desrosiers, Janet M., Work, Steven S., Trybus, Kathleen M.

“…Although it is generally believed that phosphorylation of the regulatory light chain of myosin is required before smooth muscle can develop force, it is not…”
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Smooth, cardiac and skeletal muscle myosin force and motion generation assessed by cross-bridge mechanical interactions in vitro by Harris, D E, Work, S S, Wright, R K, Alpert, N R, Warshaw, D M

“…Differences in the mechanical properties of mammalian smooth, skeletal, and cardiac muscle have led to the proposal that the myosin isozymes expressed by these…”
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Actin filament mechanics in the laser trap by Dupuis, D E, Guilford, W H, Wu, J, Warshaw, D M

“…Numerous biological processes, including muscular contraction, depend upon the mechanical properties of actin filaments. One such property is resistance to…”
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The Essential Light Chain is Required for Full Force Production by Skeletal Muscle Myosin by VanBuren, Peter, Waller, Guillermina S., Harris, David E., Trybus, Kathleen M., Warshaw, David M., Lowey, Susan

“…Myosin, a molecular motor that is responsible for muscle contraction, is composed of two heavy chains each with two light chains. The crystal structure of…”
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Enhanced Force Generation by Smooth Muscle Myosin in vitro by VanBuren, Peter, Work, Steven S., Warshaw, David M.

“…To determine whether the apparent enhanced force-generating capabilities of smooth muscle relative to skeletal muscle are inherent to the myosin cross-bridge,…”
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In Vivo Analysis of an Essential Myosin Light Chain Mutation Linked to Familial Hypertrophic Cardiomyopathy by Sanbe, Atsushi, Nelson, David, Gulick, James, Setser, Elizabeth, Osinska, Hanna, Wang, Xuejun, Hewett, Timothy E, Klevitsky, Raisa, Hayes, Eric, Warshaw, David M, Robbins, Jeffrey

“…Mutations in cardiac motor protein genes are associated with familial hypertrophic cardiomyopathy. Mutations in both the regulatory (Glu22Lys) and essential…”
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The effects of smooth muscle caldesmon on actin filament motility by HAEBERLE, J. R, TRYBUS, K. M, HEMRIC, M. E, WARSHAW, D. M

“…The movement of reconstituted thin filaments over an immobilized surface of thiophosphorylated smooth muscle myosin was examined using an in vitro motility…”
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Length vs. active force relationship in single isolated smooth muscle cells by Harris, D E, Warshaw, D M

“…The length vs. active force relationship (L-F) may provide information about changes in smooth muscle contractile protein interactions as muscle length…”
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Computer-assisted tracking of actin filament motility by Work, S S, Warshaw, D M

“…In vitro motility assays, in which fluorescently labeled actin filaments are propelled by myosin molecules adhered to a glass coverslip, require that actin…”
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Effects of MgATP, MgADP, and Pi on actin movement by smooth muscle myosin by WARSHAW, D. M, DESROSIERS, J. M, WORK, S. S, TRYBUS, K. M

“…To test the idea that the in vitro motility assay is a simplified model system for muscle contraction, the MgATP-dependent movement of actin filaments by…”
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Actomyosin interaction modulates resting length of unstimulated cardiac ventricular cells by Sollott, S J, Ziman, B D, Warshaw, D M, Spurgeon, H A, Lakatta, E G

“…We sought to determine whether resting or diastolic cardiac myocyte length during low stimulation rates is regulated by myofilament interaction. Cytosolic Ca2+…”
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Maximal Actomyosin ATPase Activity and In Vitro Myosin Motility Are Unaltered in Human Mitral Regurgitation Heart Failure by Nguyen, The-Tin T, Hayes, Eric, Mulieri, Louis A, Leavitt, Bruce J, ter Keurs, Henk E.D.J, Alpert, Norman R, Warshaw, David M

“…Myofibrillar but not actomyosin ATPase is depressed in failing myocardium from patients with dilated cardiomyopathy. Since there is a similar depression of…”
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