Search Results - "WARREN, J"
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Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy
Published in Immunity (Cambridge, Mass.) (24-01-2013)“…Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays pivotal roles in the immune response. Discovered as a T cell growth…”
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Role of thymic stromal lymphopoietin in allergy and beyond
Published in Nature reviews. Immunology (01-01-2023)“…Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell lineages, including dendritic cells, T cells, B cells, neutrophils,…”
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3
Biology and regulation of IL-2: from molecular mechanisms to human therapy
Published in Nature reviews. Immunology (01-10-2018)“…IL-2 was first identified as a growth factor capable of driving the expansion of activated human T cell populations. In the more than 40 years since its…”
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Interleukin-21: a double-edged sword with therapeutic potential
Published in Nature reviews. Drug discovery (01-05-2014)“…Key Points Interleukin-21 (IL-21) is a pleiotropic cytokine with actions on a broad range of lymphoid, myeloid and epithelial cells. These actions include…”
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Controlling the Oxygen Reduction Selectivity of Asymmetric Cobalt Porphyrins by Using Local Electrostatic Interactions
Published in Journal of the American Chemical Society (05-08-2020)“…The development and improvement of electrocatalysts for the 4H+/4e– reduction of O2 to H2O is an ongoing challenge. The addition of ancillary groups (e.g.,…”
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6
Biology of IL‐2 and its therapeutic modulation: Mechanisms and strategies
Published in Journal of leukocyte biology (01-04-2018)“…Cytokines signal through specific cell surface receptors to broadly regulate immune development, differentiation, proliferation, and survival, thereby…”
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Polymerization-Induced Self-Assembly of Block Copolymer Nano-objects via RAFT Aqueous Dispersion Polymerization
Published in Journal of the American Chemical Society (23-07-2014)“…In this Perspective, we discuss the recent development of polymerization-induced self-assembly mediated by reversible addition–fragmentation chain transfer…”
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New insights into the regulation of T cells by γ c family cytokines
Published in Nature reviews. Immunology (01-07-2009)“…Key Points The common cytokine receptor γ-chain (γ c ) family of cytokines consists of interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15 and IL-21, each of which…”
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9
The Fundamental Theorem of Natural Selection: the End of a Story
Published in Evolution (01-05-2024)“…The direction of research in population genetics theory is currently, and correctly, retrospec- tive, that is directed towards the past. What events in the…”
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10
New insights into the regulation of T cells by gamma(c) family cytokines
Published in Nature reviews. Immunology (01-07-2009)“…Common cytokine receptor gamma-chain (gamma(c)) family cytokines have crucial roles in the development, proliferation, survival and differentiation of multiple…”
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11
Deep Learning Methods for Improved Decoding of Linear Codes
Published in IEEE journal of selected topics in signal processing (01-02-2018)“…The problem of low complexity, close to optimal, channel decoding of linear codes with short to moderate block length is considered. It is shown that deep…”
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12
Fast Polar Decoders: Algorithm and Implementation
Published in IEEE journal on selected areas in communications (01-05-2014)“…Polar codes provably achieve the symmetric capacity of a memoryless channel while having an explicit construction. The adoption of polar codes however, has…”
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13
Tricuspid Valve Dysfunction Following Pacemaker or Cardioverter-Defibrillator Implantation
Published in Journal of the American College of Cardiology (09-05-2017)“…Abstract The potential for cardiac implantable electronic device leads to interfere with tricuspid valve (TV) function has gained increasing recognition as…”
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14
Molecular basis of the human ribosomopathy Shwachman-Diamond syndrome
Published in Advances in biological regulation (01-01-2018)“…Mutations that target the ubiquitous process of ribosome assembly paradoxically cause diverse tissue-specific disorders (ribosomopathies) that are often…”
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Interleukin-21: basic biology and implications for cancer and autoimmunity
Published in Annual review of immunology (01-01-2008)“…Interleukin-21 (IL-21), a potent immunomodulatory four-alpha-helical-bundle type I cytokine, is produced by NKT and CD4(+) T cells and has pleiotropic effects…”
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16
Biosynthesis of the modified tetrapyrroles—the pigments of life
Published in The Journal of biological chemistry (15-05-2020)“…Modified tetrapyrroles are large macrocyclic compounds, consisting of diverse conjugation and metal chelation systems and imparting an array of colors to the…”
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Strategies to therapeutically modulate cytokine action
Published in Nature reviews. Drug discovery (01-10-2023)“…Cytokines are secreted or membrane-presented molecules that mediate broad cellular functions, including development, differentiation, growth and survival…”
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Improved Bit-Flipping Algorithm for Successive Cancellation Decoding of Polar Codes
Published in IEEE transactions on communications (01-01-2019)“…The interest in polar codes has been increasing significantly since their adoption for use in the 5 th generation wireless systems standard. Successive…”
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Aromatherapy, botanicals, and essential oils in acne
Published in Clinics in dermatology (01-05-2018)“…AbstractComplementary and alternative medicine approaches are popular among some patient segments due to the perception that they are “natural” and thus are…”
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The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications
Published in Immunity (Cambridge, Mass.) (16-04-2019)“…The common cytokine receptor γ chain, γc, is a component of the receptors for interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene…”
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