Search Results - "WARRELL, R."

Therapeutic Targeting of Transcription in Acute Promyelocytic Leukemia by Use of an Inhibitor of Histone Deacetylase by WARRELL, R. P, HE, L.-Z, RICHON, V, CALLEJA, E, PANDOLFI, P. P

“…Background: Acetylation of DNA-associated histones is linked to activation of gene transcription, whereas histone deacetylation is associated with…”
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Complete Remission after Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide by Soignet, Steven L, Maslak, Peter, Wang, Zhu-Gang, Jhanwar, Suresh, Calleja, Elizabeth, Dardashti, Laura J, Corso, Diane, DeBlasio, Anthony, Gabrilove, Janice, Scheinberg, David A, Pandolfi, Pier Paolo, Warrell, Raymond P

“…Acute promyelocytic leukemia (APL) represents 10 to 15 percent of the cases of acute myeloid leukemia in adults. This disease is characterized by a specific…”
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Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia by He, L Z, Tolentino, T, Grayson, P, Zhong, S, Warrell, Jr, R P, Rifkind, R A, Marks, P A, Richon, V M, Pandolfi, P P

“…Acute promyelocytic leukemia (APL) is associated with chromosomal translocations, invariably involving the retinoic acid receptor alpha (RAR alpha) gene fused…”
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United States Multicenter Study of Arsenic Trioxide in Relapsed Acute Promyelocytic Leukemia by SOIGNET, Steven L, FRANKEL, Stanley R, SIEVERS, Eric L, COUTRE, Steven, DAHLBERG, Steve, ELLISON, Ralph, WARRELL, Raymond P, DOUER, Dan, TALLMAN, Martin S, KANTARJIAN, Hagop, CALLEJA, Elizabeth, STONE, Richard M, KALAYCIO, Matt, SCHEINBERG, David A, STEINHERZ, Peter

“…To determine the safety and efficacy of arsenic trioxide (ATO) in patients with relapsed acute promyelocytic leukemia (APL). Forty patients experiencing first…”
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Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML by Kakizuka, A, Miller, Jr, W H, Umesono, K, Warrell, Jr, R P, Frankel, S R, Murty, V V, Dmitrovsky, E, Evans, R M

“…A unique mRNA produced in leukemic cells from a t(15;17) acute promyelocytic leukemia (APL) patient encodes a fusion protein between the retinoic acid receptor…”
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Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis by Roboz, Gail J., Dias, Sergio, Lam, George, Lane, William J., Soignet, Steven L., Warrell, Raymond P., Rafii, Shahin

“…Arsenic trioxide (As2O3) has recently been used successfully in the treatment of acute promyelocytic leukemia and has been shown to induce partial…”
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Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome by MASLAK, P, CHANEL, S, CAMACHO, L. H, SOIGNET, S, PANDOLFI, P. P, GUERNAH, I, WARRELL, R, NIMER, S

“…Epigenetic mechanisms underlying tumorigenesis have recently received much attention as potential therapeutic targets of human cancer. We designed a pilot…”
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Initial clinical trial of a selective retinoid X receptor ligand, LGD1069 by Miller, V A, Benedetti, F M, Rigas, J R, Verret, A L, Pfister, D G, Straus, D, Kris, M G, Crisp, M, Heyman, R, Loewen, G R, Truglia, J A, Warrell, Jr, R P

“…The retinoid response is mediated by nuclear receptors, including retinoic acid receptors (RARs) and retinoid "X" receptors (RXRs). All-trans retinoic acid…”
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Acute Promyelocytic Leukemia by Warrell, Raymond P, de The, Hugues, Wang, Zhen-Yi, Degos, Laurent

“…Discoveries in cancer research are rarely so exceptional that they both cause immediate changes in the treatment of patients and dramatically advance our…”
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Leukocytosis and the Retinoic Acid Syndrome in Patients With Acute Promyelocytic Leukemia Treated With Arsenic Trioxide by CAMACHO, L. H, SOIGNET, S. L, CHANEL, S, HO, R, HELLER, G, SCHEINBERG, D. A, ELLISON, R, WARRELL, R. P

“…Arsenic trioxide, like all-trans-retinoic acid (RA), induces differentiation of acute promyelocytic leukemia (APL) cells in vivo. Treatment of APL patients…”
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Acute promyelocytic leukemia cell line AP-1060 established as a cytokine-dependent culture from a patient clinically resistant to all-trans retinoic acid and arsenic trioxide by SUN, Y, KIM, S. H, GALLAGHER, R. E, ZHOU, D.-C, DING, W, PAIETTA, E, GUIDEZ, F, ZELENT, A, RAMESH, K. H, CANNIZZARO, L, WARRELL, R. P

“…AP-1060 is a newly established acute promyelocytic leukemia (APL) cell line from a multiple-relapse patient clinically resistant to both all-trans retinoic…”
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Early Mortality and the Retinoic Acid Syndrome in Acute Promyelocytic Leukemia: Impact of Leukocytosis, Low-Dose Chemotherapy, PMN/RAR-α Isoform, and CD13 Expression in Patients Treated With All-Trans Retinoic Acid by Vahdat, Linda, Maslak, Peter, Miller, Wilson H., Eardley, Anna, Heller, Glenn, Scheinberg, David A., Warrell, Raymond P.

“…All-trans retinoic acid (RA) has proven a major advance in the treatment of acute promyelocytic leukemia (APL). However, the proper management of patients who…”
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Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations : implications for relapse and retinoid resistance in patients with acute promyelocytic leukemia by MUINDI, J, FRANKEL, S. R, MILLER, W. H, JAKUBOWSKI, A, SCHEINBERG, D. A, YOUNG, C. W, DMITROVSKY, E, WARRELL, R. P

“…Although all-trans retinoic acid (RA) induces complete remission in a high proportion of patients with acute promyelocytic leukemia (APL), all groups have…”
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All-trans retinoic acid for acute promyelocytic leukemia : results of the New York Study by FRANKEL, S. R, EARDLEY, A, HELLER, G, BERMAN, E, MILLER, W. H, DMITROVSKY, E, WARRELL, R. P

“…To evaluate the safety and efficacy of all-trans retinoic acid to induce complete remission and to examine its effects on duration of remission and survival in…”
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Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid) by Warrell, Raymond P, Frankel, Stanley R, Miller, Wilson H, Scheinberg, David A, Itri, Loretta M, Hittelman, Walter N, Vyas, Rohini, Andreeff, Michael, Tafuri, Agostino, Jakubowski, Ann, Gabrilove, Janice, Gordon, Michael S, Dmitrovsky, Ethan

“…ACUTE promyelocytic leukemia makes up approximately 15 percent of the adult acute nonlymphoblastic leukemias. 1 The disease is associated with a specific…”
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Retinoid resistance in acute promyelocytic leukemia: new mechanisms, strategies, and implications [editorial; comment] by Warrell, RP Jr

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Prognostic significance of minimal residual disease detection and PML/RAR-α isoform type: long-term follow-up in acute promyelocytic leukemia by Jurcic, Joseph G., Nimer, Stephen D., Scheinberg, David A., DeBlasio, Tony, Warrell, Raymond P., Miller, Wilson H.

“…The t(15;17) translocation in acute promyelocytic leukemia (APL) yields a PML/RAR-α fusion messenger RNA species that can be detected by reverse…”
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Reverse Transcription Polymerase Chain Reaction for the Rearranged Retinoic Acid Receptor α Clarifies Diagnosis and Detects Minimal Residual Disease in Acute Promyelocytic Leukemia by Miller, Wilson H., Kakizuka, Akira, Frankel, Stanley R., Warrell, Raymond P., DeBlasio, Anthony, Levine, Kristi, Evans, Ronald M., Dmitrovsky, Ethan

“…The characteristic t(15;17) of acute promyelocytic leukemia (APL) fuses the retinoic acid receptor α (RAR-α) gene on chromosome 17 to a gene on chromosome 15…”
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The "retinoic acid syndrome" in acute promyelocytic leukemia by Frankel, S R, Eardley, A, Lauwers, G, Weiss, M, Warrell, Jr, R P

“…To describe a novel complication of therapy with all-trans retinoic acid in patients with acute promyelocytic leukemia. Case series. Comprehensive cancer…”
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Gallium nitrate for the treatment of bone metastases by Warrell, Raymond P.

“…Gallium nitrate was originally developed as an antineoplastic agent; however, further studies have revealed that this drug has extremely potent effects on…”
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