Search Results - "WARGIN, W"

A phase 1 ascending dose study of a subcutaneously administered factor IXa inhibitor and its active control agent by VAVALLE, J. P., RUSCONI, C. P., ZELENKOFSKE, S., WARGIN, W. A., ALEXANDER, J. H., BECKER, R. C.

“…Background:  The REG2 anticoagulation system consists of pegnivacogin, a subcutaneously administered aptamer factor IXa inhibitor, and its intravenous control…”
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The effect of the REG2 Anticoagulation System on thrombin generation kinetics: a pharmacodynamic and pharmacokinetic first-in-human study by Vavalle, J. P., Rusconi, C. P., Zelenkofske, S., Wargin, W. A., Ortel, T. L., Alexander, J. H., Povsic, T. J., Becker, R. C.

“…The REG2 Anticoagulation System consists of pegnivacogin, a subcutaneously administered aptamer factor IXa inhibitor, and its intravenous active control agent,…”
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Dose Selection for a Direct and Selective Factor IXa Inhibitor and its Complementary Reversal Agent: Translating Pharmacokinetic and Pharmacodynamic Properties of the REG1 System to Clinical Trial Design by Povsic, T. J., Cohen, M. G., Chan, M. Y., Zelenkofske, S. L., Wargin, W. A., Harrington, R. A., Alexander, J. H., Rusconi, C. P., Becker, R. C.

“…We performed detailed pharmacokinetic and pharmacodynamic modeling of REG1, an anticoagulation system composed of the direct factor IXa (FIXa) inhibitor…”
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Importance of the Organ-Independent Elimination of Cisatracurium by Kisor, David F., Schmith, Virginia D., Wargin, William A., Lien, Cynthia A., Ornstein, Eugene, Cook, D. Ryan

“…Cisatracurium, one of 10 isomers of atracurium, undergoes pH and temperature-dependent Hofmann elimination in plasma and tissues. The clearance of…”
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PHASE 1 STUDY EVALUATING THE PHARMACOKINETICS, BIOAVAILABILITY, SAFETY, AND TOLERABILITY OF INTRANASALLY ADMINISTERED EPINEPHRINE POWDER by Francoeur, B., Wargin, W., Taubenheim, B., Lyman, S.

“…Epinephrine is the treatment of choice for patients at risk of anaphylaxis due to severe allergies. Intranasal (IN) epinephrine powder has been developed as an…”
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Bidirectional interaction of valproate and lamotrigine in healthy subjects by Anderson, G D, Yau, M K, Gidal, B E, Harris, S J, Levy, R H, Lai, A A, Wolf, K B, Wargin, W A, Dren, A T

“…To evaluate the steady-state pharmacokinetics of lamotrigine and valproate at three dosing levels of lamotrigine in normal volunteers receiving steady-state…”
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Pharmacokinetics of RheothRx injection in healthy male volunteers by Jewell, R C, Khor, S P, Kisor, D F, LaCroix, K A, Wargin, W A

“…The objectives of this study were to evaluate the safety and tolerability of RheothRx (poloxamer 188) injection administered as an intravenous (i.v.) infusion…”
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The pharmacokinetics and pharmacodynamics of the stereoisomers of mivacurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia by Lien, C A, Schmith, V D, Embree, P B, Belmont, M R, Wargin, W A, Savarese, J J

“…Mivacurium consists of a mixture of three stereoisomers: cis-trans (34-40%), trans-trans (52-60%), and cis-cis (4-8%). These isomers differ in potency (the…”
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The clinical pharmacokinetics of vinorelbine (Navelbine) by Wargin, W A, Lucas, V S

“…Vinorelbine (Navelbine; Burroughs Wellcome Co, Research Triangle Park, NC; Pierre Fabre Médicament, Paris, France) is a semisynthetic vinca alkaloid agent that…”
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Pharmacokinetics and safety of lamotrigine (Lamictal) in patients with epilepsy by Ramsay, R E, Pellock, J M, Garnett, W R, Sanchez, R M, Valakas, A M, Wargin, W A, Lai, A A, Hubbell, J, Chern, W H, Allsup, T

“…In a double-blind parallel study, patients with epilepsy on stable regimen of antiepileptic drugs (AEDs) were given lamotrigine (8 pts) or placebo (3 pts)…”
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Pharmacokinetic, bioavailability, and feasibility study of oral vinorelbine in patients with solid tumors by Rowinsky, E K, Noe, D A, Trump, D L, Winer, E P, Lucas, V S, Wargin, W A, Hohneker, J A, Lubejko, B, Sartorius, S E, Ettinger, D S

“…The feasibility of administering vinorelbine (Navelbine, Burroughs Wellcome Co, Research Triangle Park, NC), a semisynthetic vinca alkaloid with broad…”
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Pharmacokinetics of methylphenidate in man, rat and monkey by Wargin, W, Patrick, K, Kilts, C, Gualtieri, C T, Ellington, K, Mueller, R A, Kraemer, G, Breese, G R

“…The pharmacokinetics and bioavailability of methylphenidate (MPH) and a metabolite, ritalinic acid (RA), were studied in normal adults, children with…”
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Pharmacokinetics and Pharmacodynamics of Doxacurium in Young and Elderly Patients During Isoflurane Anesthesia by Dresner, David L., Basta, Salvatore J., Ali, Hassan H., Schwartz, Ann F., Embree, Patricia B., Wargin, William A., Lai, Allen A., Brady, Karen A., Savarese, John J.

“…Preliminary disposition studies of the investigational, long-acting muscle relaxant doxacurium chloride (Nuromax) have demonstrated dual elimination by renal…”
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THE PHARMACOKINETICS OF 1954U89, 1, 3-DIAMINO-7-(1-ETHYLPROPYL)-8-METHYL-7H-PYRROLO-(3, 2-f  )QUINAZOLINE, IN DOGS AND RATS AFTER INTRAVENOUS AND ORAL ADMINISTRATION by STUDENBERG, S. D., WOOLLEY, J. L., DEANGELIS, D. V., WARGIN, W. A.

“…1954U89, 1, 3‐diamino‐7‐(1‐ethylpropyl)‐8‐methyl‐7H‐pyrrolo‐(3, 2‐f  )quinazoline, is a potent, lipid‐soluble inhibitor of dihydrofolate reductase. The…”
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Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy by Povsic, Thomas J., Wargin, William A., Alexander, John H., Krasnow, Joshua, Krolick, Merill, Cohen, Mauricio G., Mehran, Roxana, Buller, Christopher E., Bode, Christoph, Zelenkofske, Steven L., Rusconi, Christopher P., Becker, Richard C.

“…Aims Establishing factor IX inhibition in patients with acute coronary syndrome/non-ST-elevation myocardial infarction (ACS/NSTEMI), a setting characterized by…”
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Pharmacokinetics of oral and transdermal triprolidine by Miles, M V, Balasubramanian, R, Pittman, A W, Grossman, S H, Pappa, K A, Smith, M F, Wargin, W A, Findlay, J W, Poust, R I, Frosolono, M F

“…In this open, nonrandomized, three-way crossover study, six healthy male volunteers received single doses of triprolidine (TPL) hydrochloride syrup orally (2.5…”
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Separation and quantitation of theophylline and paraxanthine by reversed-phase liquid chromatography by Farrish, H H, Wargin, W A

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Antipyrine kinetics following partial blood exchange with Fluosol-DA in the rat by Shrewsbury, R P, White, S G, Pollack, G M, Wargin, W A

“…The effects of partial blood exchange with Fluosol-DA on hepatic microsomal oxidative metabolism have been studied in the rat. Antipyrine clearance (Cl) was…”
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Crisnatol mesylate : phase I dose escalation by extending infusion duration by POPLIN, E. A, CHABOT, G. G, TUTTLE, R. L, WARGIN, W. A, BAKER, L. H

“…Crisnatol mesylate is a rationally designed cytotoxic arylmethylamino-propanediol with broad spectrum cytotoxic activity. A phase I study with an…”
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The effects of food and divided dosing on the bioavailability of oral vinorelbine by Rowinsky, E K, Lucas, V S, Hsieh, A L, Wargin, W A, Hohneker, J A, Lubejko, B, Sartorius, S E, Donehower, R C

“…The effects of food and divided dosing on the bioavailability of a liquid-filled gelatin capsule formulation of vinorelbine (Navelbine), a semisynthetic vinca…”
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