Search Results - "WARFEL, Noel"

PIM kinase (and Akt) biology and signaling in tumors by Warfel, Noel A, Kraft, Andrew S

“…The initiation and progression of human cancer is frequently linked to the uncontrolled activation of survival kinases. Two such pro-survival kinases that are…”
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Strange Bedfellows: Nuclear Factor, Erythroid 2-Like 2 (Nrf2) and Hypoxia-Inducible Factor 1 (HIF-1) in Tumor Hypoxia by Toth, Rachel K, Warfel, Noel A

“…The importance of the tumor microenvironment for cancer progression and therapeutic resistance is an emerging focus of cancer biology. Hypoxia, or low oxygen,…”
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Defining the mechanisms underlying cyclin dependent kinase control of HIF-1α by Warfel, Noel A

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p21WAF1 and tumourigenesis: 20 years after by Warfel, Noel A, El-Deiry, Wafik S

“…PURPOSE OF REVIEWThis review provides an overview of the structure, regulation and physiological functions of p21, the product of the cyclin-dependent kinase…”
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Targeting PIM Kinases to Overcome Therapeutic Resistance in Cancer by Toth, Rachel K, Warfel, Noel A

“…Cancer progression and the onset of therapeutic resistance are often the results of uncontrolled activation of survival kinases. The proviral integration for…”
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Targeting CDK4/6 to oppose hypoxia-mediated therapeutic resistance by Warfel, Noel A.

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PIM kinases alter mitochondrial dynamics and chemosensitivity in lung cancer by Chauhan, Shailender S., Toth, Rachel K., Jensen, Corbin C., Casillas, Andrea L., Kashatus, David F., Warfel, Noel A.

“…Resistance to chemotherapy represents a major obstacle to the successful treatment of non-small-cell lung cancer (NSCLC). The goal of this study was to…”
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Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase (PHLPP): A New Player in Cell Signaling by Warfel, Noel A., Newton, Alexandra C.

“…Precise balance between phosphorylation, catalyzed by protein kinases, and dephosphorylation, catalyzed by protein phosphatases, is essential for cellular…”
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PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species by Warfel, Noel A, Sainz, Alva G, Song, Jin H, Kraft, Andrew S

“…Intratumoral hypoxia is a significant obstacle to the successful treatment of solid tumors, and it is highly correlated with metastasis, therapeutic…”
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Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53 by Zhang, Shengliang, Zhou, Lanlan, Hong, Bo, van den Heuvel, A Pieter J, Prabhu, Varun V, Warfel, Noel A, Kline, Christina Leah B, Dicker, David T, Kopelovich, Levy, El-Deiry, Wafik S

“…The tumor-suppressor p53 prevents cancer development via initiating cell-cycle arrest, cell death, repair, or antiangiogenesis processes. Over 50% of human…”
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Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents by Casillas, Andrea L, Toth, Rachel K, Sainz, Alva G, Singh, Neha, Desai, Ankit A, Kraft, Andrew S, Warfel, Noel A

“…Patients develop resistance to antiangiogenic drugs, secondary to changes in the tumor microenvironment, including hypoxia. PIM kinases are prosurvival kinases…”
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Targeting PIM Kinases to Improve the Efficacy of Immunotherapy by Clements, Amber N, Warfel, Noel A

“…The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases is a family of serine/threonine kinases that regulates numerous signaling…”
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CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth by Warfel, Noel A, Dolloff, Nathan G, Dicker, David T, Malysz, Jozef, El-Deiry, Wafik S.

“…Hypoxia-inducible factor 1 (HIF-1) is a major mediator of tumor physiology, and its activation is correlated with tumor progression, metastasis, and…”
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Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors by Casillas, Andrea L., Chauhan, Shailender S., Toth, Rachel K., Sainz, Alva G., Clements, Amber N., Jensen, Corbin C., Langlais, Paul R., Miranti, Cindy K., Cress, Anne E., Warfel, Noel A.

“…Angiogenesis is essential for the sustained growth of solid tumors. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of angiogenesis and constitutive…”
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PIM1 drives lipid droplet accumulation to promote proliferation and survival in prostate cancer by Chauhan, Shailender S., Casillas, Andrea L., Vizzerra, Andres D., Liou, Hope, Clements, Amber N., Flores, Caitlyn E., Prevost, Christopher T., Kashatus, David F., Snider, Ashley J., Snider, Justin M., Warfel, Noel A.

“…Lipid droplets (LDs) are dynamic organelles with a neutral lipid core surrounded by a phospholipid monolayer. Solid tumors exhibit LD accumulation, and it is…”
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Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase by Song, Jin H, Singh, Neha, Luevano, Libia A, Padi, Sathish K R, Okumura, Koichi, Olive, Virginie, Black, Stephen M, Warfel, Noel A, Goodrich, David W, Kraft, Andrew S

“…Cancer resistance to PI3K inhibitor therapy can be in part mediated by increases in the PIM1 kinase. However, the exact mechanism by which PIM kinase promotes…”
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Digital image analysis using video microscopy of human-derived prostate cancer vs normal prostate organoids to assess migratory behavior on extracellular matrix proteins by Marr, Kendra D, Ignatenko, Natalia A, Warfel, Noel A, Batai, Ken, Cress, Anne E, Pollock, Grant R, Wong, Ava C, Lee, Benjamin R

“…The advent of perpetuating living organoids derived from patient tissue is a promising avenue for cancer research but is limited by difficulties with precise…”
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Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28 by Toth, Rachel K, Solomon, Regina, Warfel, Noel A

“…Proviral integration sites for Moloney murine leukemia virus (PIM) kinases are upregulated at the protein level in response to hypoxia and have multiple…”
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PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion by Jensen, Corbin C, Clements, Amber N, Liou, Hope, Ball, Lauren E, Bethard, Jennifer R, Langlais, Paul R, Toth, Rachel K, Chauhan, Shailender S, Casillas, Andrea L, Daulat, Sohail R, Kraft, Andrew S, Cress, Anne E, Miranti, Cindy K, Mouneimne, Ghassan, Rogers, Greg C, Warfel, Noel A

“…Distinguishing key factors that drive the switch from indolent to invasive disease will make a significant impact on guiding the treatment of prostate cancer…”
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Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo by GILLS, Joell J, LOPICCOLO, Jaclyn, HOLLANDER, M. Christine, KAWABATA, Shigeru, TSOKOS, Maria, FIGG, William D, STEEG, Patricia S, DENNIS, Phillip A, TSURUTANI, Junji, SHOEMAKER, Robert H, BEST, Carolyn J. M, ABU-ASAB, Mones S, BOROJERDI, Jennifer, WARFEL, Noel A, GARDNER, Erin R, DANISH, Matthew

“…Purpose: The development of new cancer drugs is slow and costly. HIV protease inhibitors are Food and Drug Administration approved for HIV patients. Because…”
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