Search Results - "WAREHAM, NICHOLAS J"

Large Scale Population Assessment of Physical Activity Using Wrist Worn Accelerometers: The UK Biobank Study by Doherty, Aiden, Jackson, Dan, Hammerla, Nils, Plötz, Thomas, Olivier, Patrick, Granat, Malcolm H, White, Tom, van Hees, Vincent T, Trenell, Michael I, Owen, Christoper G, Preece, Stephen J, Gillions, Rob, Sheard, Simon, Peakman, Tim, Brage, Soren, Wareham, Nicholas J

“…Physical activity has not been objectively measured in prospective cohorts with sufficiently large numbers to reliably detect associations with multiple health…”
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Estimation of Physical Activity Energy Expenditure during Free-Living from Wrist Accelerometry in UK Adults by White, Tom, Westgate, Kate, Wareham, Nicholas J, Brage, Soren

“…Wrist-worn accelerometers are emerging as the most common instrument for measuring physical activity in large-scale epidemiological studies, though little is…”
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Plasma metabolites to profile pathways in noncommunicable disease multimorbidity by Pietzner, Maik, Stewart, Isobel D., Raffler, Johannes, Khaw, Kay-Tee, Michelotti, Gregory A., Kastenmüller, Gabi, Wareham, Nicholas J., Langenberg, Claudia

“…Multimorbidity, the simultaneous presence of multiple chronic conditions, is an increasing global health problem and research into its determinants is of high…”
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Plasma protein patterns as comprehensive indicators of health by Williams, Stephen A., Kivimaki, Mika, Langenberg, Claudia, Hingorani, Aroon D., Casas, J. P., Bouchard, Claude, Jonasson, Christian, Sarzynski, Mark A., Shipley, Martin J., Alexander, Leigh, Ash, Jessica, Bauer, Tim, Chadwick, Jessica, Datta, Gargi, DeLisle, Robert Kirk, Hagar, Yolanda, Hinterberg, Michael, Ostroff, Rachel, Weiss, Sophie, Ganz, Peter, Wareham, Nicholas J.

“…Proteins are effector molecules that mediate the functions of genes 1 , 2 and modulate comorbidities 3 – 10 , behaviors and drug treatments 11 . They represent…”
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Mapping the proteo-genomic convergence of human diseases by Pietzner, Maik, Wheeler, Eleanor, Carrasco-Zanini, Julia, Cortes, Adrian, Koprulu, Mine, Wörheide, Maria A, Oerton, Erin, Cook, James, Stewart, Isobel D, Kerrison, Nicola D, Luan, Jian'an, Raffler, Johannes, Arnold, Matthias, Arlt, Wiebke, O'Rahilly, Stephen, Kastenmüller, Gabi, Gamazon, Eric R, Hingorani, Aroon D, Scott, Robert A, Wareham, Nicholas J, Langenberg, Claudia

“…Characterization of the genetic regulation of proteins is essential for understanding disease etiology and developing therapies. We identified 10,674 genetic…”
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Using natural experimental studies to guide public health action: turning the evidence-based medicine paradigm on its head by Ogilvie, David, Adams, Jean, Bauman, Adrian, Gregg, Edward W., Panter, Jenna, Siegel, Karen R., Wareham, Nicholas J., White, Martin

“…Despite smaller effect sizes, interventions delivered at population level to prevent non-communicable diseases generally have greater reach, impact and equity…”
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Using human genetics to understand the disease impacts of testosterone in men and women by Ruth, Katherine S, Day, Felix R, Tyrrell, Jessica, Thompson, Deborah J, Wood, Andrew R, Mahajan, Anubha, Beaumont, Robin N, Wittemans, Laura, Martin, Susan, Busch, Alexander S., Erzurumluoglu, A. Mesut, Hollis, Benjamin, O’Mara, Tracy A., McCarthy, Mark I, Langenberg, Claudia, Easton, Douglas F, Wareham, Nicholas J, Burgess, Stephen, Murray, Anna, Ong, Ken K, Frayling, Timothy M, Perry, John R. B.

“…Testosterone supplementation is commonly used for its effects on sexual function, bone health and body composition, yet its effects on disease outcomes are…”
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GDF15 mediates the effects of metformin on body weight and energy balance by Coll, Anthony P., Chen, Michael, Taskar, Pranali, Rimmington, Debra, Patel, Satish, Tadross, John A., Cimino, Irene, Yang, Ming, Welsh, Paul, Virtue, Samuel, Goldspink, Deborah A., Miedzybrodzka, Emily L., Konopka, Adam R., Esponda, Raul Ruiz, Huang, Jeffrey T.-J., Tung, Y. C. Loraine, Rodriguez-Cuenca, Sergio, Tomaz, Rute A., Harding, Heather P., Melvin, Audrey, Yeo, Giles S. H., Preiss, David, Vidal-Puig, Antonio, Vallier, Ludovic, Nair, K. Sreekumaran, Wareham, Nicholas J., Ron, David, Gribble, Fiona M., Reimann, Frank, Sattar, Naveed, Savage, David B., Allan, Bernard B., O’Rahilly, Stephen

“…Metformin, the world’s most prescribed anti-diabetic drug, is also effective in preventing type 2 diabetes in people at high risk 1 , 2 . More than 60% of this…”
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Synergistic insights into human health from aptamer- and antibody-based proteomic profiling by Pietzner, Maik, Wheeler, Eleanor, Carrasco-Zanini, Julia, Kerrison, Nicola D., Oerton, Erin, Koprulu, Mine, Luan, Jian’an, Hingorani, Aroon D., Williams, Steve A., Wareham, Nicholas J., Langenberg, Claudia

“…Affinity-based proteomics has enabled scalable quantification of thousands of protein targets in blood enhancing biomarker discovery, understanding of disease…”
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Dietary Diversity, Diet Cost, and Incidence of Type 2 Diabetes in the United Kingdom: A Prospective Cohort Study by Conklin, Annalijn I, Monsivais, Pablo, Khaw, Kay-Tee, Wareham, Nicholas J, Forouhi, Nita G

“…Diet is a key modifiable risk factor for multiple chronic conditions, including type 2 diabetes (T2D). Consuming a range of foods from the five major food…”
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Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity by Lotta, Luca A., Mokrosiński, Jacek, Mendes de Oliveira, Edson, Li, Chen, Sharp, Stephen J., Luan, Jian’an, Brouwers, Bas, Ayinampudi, Vikram, Bowker, Nicholas, Kerrison, Nicola, Kaimakis, Vasileios, Hoult, Diana, Stewart, Isobel D., Wheeler, Eleanor, Day, Felix R., Perry, John R.B., Langenberg, Claudia, Wareham, Nicholas J., Farooqi, I. Sadaf

“…The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor whose disruption causes obesity. We functionally characterized 61 MC4R variants identified…”
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The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two-sample mendelian randomization study by Perry, Benjamin I, Burgess, Stephen, Jones, Hannah J, Zammit, Stan, Upthegrove, Rachel, Mason, Amy M, Day, Felix R, Langenberg, Claudia, Wareham, Nicholas J, Jones, Peter B, Khandaker, Golam M

“…Insulin resistance predisposes to cardiometabolic disorders, which are commonly comorbid with schizophrenia and are key contributors to the significant excess…”
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A cross-platform approach identifies genetic regulators of human metabolism and health by Lotta, Luca A., Pietzner, Maik, Stewart, Isobel D., Wittemans, Laura B. L., Li, Chen, Bonelli, Roberto, Raffler, Johannes, Biggs, Emma K., Oliver-Williams, Clare, Auyeung, Victoria P. W., Luan, Jian’an, Wheeler, Eleanor, Paige, Ellie, Surendran, Praveen, Michelotti, Gregory A., Scott, Robert A., Burgess, Stephen, Zuber, Verena, Sanderson, Eleanor, Koulman, Albert, Imamura, Fumiaki, Forouhi, Nita G., Khaw, Kay-Tee, Griffin, Julian L., Wood, Angela M., Kastenmüller, Gabi, Danesh, John, Butterworth, Adam S., Gribble, Fiona M., Reimann, Frank, Bahlo, Melanie, Fauman, Eric, Wareham, Nicholas J., Langenberg, Claudia

“…In cross-platform analyses of 174 metabolites, we identify 499 associations ( P  < 4.9 × 10 −10 ) characterized by pleiotropy, allelic heterogeneity, large and…”
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Genetic architecture of host proteins involved in SARS-CoV-2 infection by Pietzner, Maik, Wheeler, Eleanor, Carrasco-Zanini, Julia, Raffler, Johannes, Kerrison, Nicola D., Oerton, Erin, Auyeung, Victoria P. W., Luan, Jian’an, Finan, Chris, Casas, Juan P., Ostroff, Rachel, Williams, Steve A., Kastenmüller, Gabi, Ralser, Markus, Gamazon, Eric R., Wareham, Nicholas J., Hingorani, Aroon D., Langenberg, Claudia

“…Understanding the genetic architecture of host proteins interacting with SARS-CoV-2 or mediating the maladaptive host response to COVID-19 can help to identify…”
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Assessment of physical activity in youth by Corder, Kirsten, Ekelund, Ulf, Steele, Rebekah M, Wareham, Nicholas J, Brage, Soren

“…Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom Submitted 29 January 2008 ; accepted in final form 17…”
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Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson’s Disease by Hertel, Johannes, Harms, Amy C., Heinken, Almut, Baldini, Federico, Thinnes, Cyrille C., Glaab, Enrico, Vasco, Daniel A., Pietzner, Maik, Stewart, Isobel D., Wareham, Nicholas J., Langenberg, Claudia, Trenkwalder, Claudia, Krüger, Rejko, Hankemeier, Thomas, Fleming, Ronan M.T., Mollenhauer, Brit, Thiele, Ines

“…Parkinson’s disease (PD) exhibits systemic effects on the human metabolism, with emerging roles for the gut microbiome. Here, we integrate longitudinal…”
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Changes in household, transport and recreational physical activity and television viewing time across the transition to retirement: longitudinal evidence from the EPIC-Norfolk cohort by Barnett, Inka, van Sluijs, Esther, Ogilvie, David, Wareham, Nicholas J

“…Background Retirement is associated with an increase in recreational physical activity but its impact on other domains of activity (at home, for transport) and…”
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Estimation of Free-Living Energy Expenditure by Heart Rate and Movement Sensing: A Doubly-Labelled Water Study by Brage, Søren, Westgate, Kate, Franks, Paul W, Stegle, Oliver, Wright, Antony, Ekelund, Ulf, Wareham, Nicholas J

“…Accurate assessment of energy expenditure (EE) is important for the study of energy balance and metabolic disorders. Combined heart rate (HR) and acceleration…”
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Variability in the heritability of body mass index: a systematic review and meta-regression by Elks, Cathy E, den Hoed, Marcel, Zhao, Jing Hua, Sharp, Stephen J, Wareham, Nicholas J, Loos, Ruth J F, Ong, Ken K

“…Evidence for a major role of genetic factors in the determination of body mass index (BMI) comes from studies of related individuals. Despite consistent…”
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Causal associations between cardiorespiratory fitness and type 2 diabetes by Cai, Lina, Gonzales, Tomas, Wheeler, Eleanor, Kerrison, Nicola D., Day, Felix R., Langenberg, Claudia, Perry, John R. B., Brage, Soren, Wareham, Nicholas J.

“…Higher cardiorespiratory fitness is associated with lower risk of type 2 diabetes. However, the causality of this relationship and the biological mechanisms…”
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