Search Results - "WARE, Carol"

Concise Review: Lessons from Naïve Human Pluripotent Cells by Ware, Carol B.

“…The naïve state of pluripotency is actively being explored by a number of labs. There is some controversy in the field as to the true identity of naïve human…”
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Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells by Grow, Edward J., Flynn, Ryan A., Chavez, Shawn L., Bayless, Nicholas L., Wossidlo, Mark, Wesche, Daniel J., Martin, Lance, Ware, Carol B., Blish, Catherine A., Chang, Howard Y., Reijo Pera, Renee A., Wysocka, Joanna

“…The human endogenous retrovirus HERVK is normally silenced, but here the surprising discovery is made that in early human embryo development it is expressed,…”
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Capturing cell type-specific chromatin compartment patterns by applying topic modeling to single-cell Hi-C data by Kim, Hyeon-Jin, Yardimci, Galip Gürkan, Bonora, Giancarlo, Ramani, Vijay, Liu, Jie, Qiu, Ruolan, Lee, Choli, Hesson, Jennifer, Ware, Carol B, Shendure, Jay, Duan, Zhijun, Noble, William Stafford

“…Single-cell Hi-C (scHi-C) interrogates genome-wide chromatin interaction in individual cells, allowing us to gain insights into 3D genome organization…”
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The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition by Sperber, Henrik, Mathieu, Julie, Wang, Yuliang, Ferreccio, Amy, Hesson, Jennifer, Xu, Zhuojin, Fischer, Karin A., Devi, Arikketh, Detraux, Damien, Gu, Haiwei, Battle, Stephanie L., Showalter, Megan, Valensisi, Cristina, Bielas, Jason H., Ericson, Nolan G., Margaretha, Lilyana, Robitaille, Aaron M., Margineantu, Daciana, Fiehn, Oliver, Hockenbery, David, Blau, C. Anthony, Raftery, Daniel, Margolin, Adam A., Hawkins, R. David, Moon, Randall T., Ware, Carol B., Ruohola-Baker, Hannele

“…For nearly a century developmental biologists have recognized that cells from embryos can differ in their potential to differentiate into distinct cell types…”
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Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene by Snider, Lauren, Geng, Linda N, Lemmers, Richard J L F, Kyba, Michael, Ware, Carol B, Nelson, Angelique M, Tawil, Rabi, Filippova, Galina N, van der Maarel, Silvère M, Tapscott, Stephen J, Miller, Daniel G

“…Each unit of the D4Z4 macrosatellite repeat contains a retrotransposed gene encoding the DUX4 double-homeobox transcription factor. Facioscapulohumeral…”
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Derivation of naïve human embryonic stem cells by Ware, Carol B., Nelson, Angelique M., Mecham, Brigham, Hesson, Jennifer, Zhou, Wenyu, Jonlin, Erica C., Jimenez-Caliani, Antonio J., Deng, Xinxian, Cavanaugh, Christopher, Cook, Savannah, Tesar, Paul J., Okada, Jeffrey, Margaretha, Lilyana, Sperber, Henrik, Choi, Michael, Balu, C. Anthony, Treuting, Piper M., Hawkins, R. David, Cirulli, Vincenzo, Ruohola-Baker, Hannele

“…The naïve pluripotent state has been shown in mice to lead to broad and more robust developmental potential relative to primed mouse epiblast cells. The human…”
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Fine-scale chromatin interaction maps reveal the cis-regulatory landscape of human lincRNA genes by Ma, Wenxiu, Ay, Ferhat, Lee, Choli, Gulsoy, Gunhan, Deng, Xinxian, Cook, Savannah, Hesson, Jennifer, Cavanaugh, Christopher, Ware, Carol B, Krumm, Anton, Shendure, Jay, Blau, Carl Anthony, Disteche, Christine M, Noble, William S, Duan, Zhijun

“…Targeted DNase Hi-C uses DNase I instead of restriction enzymes for chromatin fragmentation and improves the resolution of chromatin interaction maps…”
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Metabolic Control over mTOR-Dependent Diapause-like State by Hussein, Abdiasis M., Wang, Yuliang, Mathieu, Julie, Margaretha, Lilyana, Song, Chaozhong, Jones, Daniel C., Cavanaugh, Christopher, Miklas, Jason W., Mahen, Elisabeth, Showalter, Megan R., Ruzzo, Walter L., Fiehn, Oliver, Ware, Carol B., Blau, C. Anthony, Ruohola-Baker, Hannele

“…Regulation of embryonic diapause, dormancy that interrupts the tight connection between developmental stage and time, is still poorly understood. Here, we…”
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Efficient Generation of Retinal Progenitor Cells from Human Embryonic Stem Cells by Lamba, Deepak A., Karl, Mike O., Ware, Carol B., Reh, Thomas A.

“…The retina is subject to degenerative conditions, leading to blindness. Although retinal regeneration is robust in lower vertebrates, regeneration does not…”
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Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response by Nussbaum, Jeannette, Minami, Elina, Laflamme, Michael A., Virag, Jitka A. I., Ware, Carol B., Masino, Amanda, Muskheli, Veronica, Pabon, Lil, Reinecke, Hans, Murry, Charles E.

“…ABSTRACT Embryonic stem (ES) cells are promising for cardiac repair’ but directing their differentiation toward cardiomyocytes remains challenging. We…”
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HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells by MATHIEU, Julie, ZHAN ZHANG, TEWARI, Muneesh, LIU, Alvin, VESSELLA, Robert, ROSTOMILY, Robert, BORN, Donald, HORWITZ, Marshall, WARE, Carol, BLAU, C. Anthony, CLEARY, MicheleA, RICH, Jeremy N, WENYU ZHOU, RUOHOLA-BAKER, Hannele, WANG, Amy J, HEDDLESTON, John M, PINNA, Claudia M. A, HUBAUD, Alexis, STADLER, Bradford, CHOI, Michael, BAR, Merav

“…Low oxygen levels have been shown to promote self-renewal in many stem cells. In tumors, hypoxia is associated with aggressive disease course and poor clinical…”
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Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling by Wang, Linlin, Schulz, Thomas C., Sherrer, Eric S., Dauphin, Derek S., Shin, Soojung, Nelson, Angelique M., Ware, Carol B., Zhan, Mei, Song, Chao-Zhong, Chen, Xiaoji, Brimble, Sandii N., McLean, Amanda, Galeano, Maria J., Uhl, Elizabeth W., D'Amour, Kevin A., Chesnut, Jonathan D., Rao, Mahendra S., Blau, C. Anthony, Robins, Allan J.

“…Despite progress in developing defined conditions for human embryonic stem cell (hESC) cultures, little is known about the cell-surface receptors that are…”
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MicroRNA Discovery and Profiling in Human Embryonic Stem Cells by Deep Sequencing of Small RNA Libraries by Bar, Merav, Wyman, Stacia K., Fritz, Brian R., Qi, Junlin, Garg, Kavita S., Parkin, Rachael K., Kroh, Evan M., Bendoraite, Ausra, Mitchell, Patrick S., Nelson, Angelique M., Ruzzo, Walter L., Ware, Carol, Radich, Jerald P., Gentleman, Robert, Ruohola‐Baker, Hannele, Tewari, Muneesh

“…We used massively parallel pyrosequencing to discover and characterize microRNAs (miRNAs) expressed in human embryonic stem cells (hESC). Sequencing of small…”
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Naive embryonic stem cells: the future of stem cell research? by Ware, Carol B

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Histone Deacetylase Inhibition Elicits an Evolutionarily Conserved Self-Renewal Program in Embryonic Stem Cells by Ware, Carol B., Wang, Linlin, Mecham, Brigham H., Shen, Lanlan, Nelson, Angelique M., Bar, Merav, Lamba, Deepak A., Dauphin, Derek S., Buckingham, Brian, Askari, Bardia, Lim, Raymond, Tewari, Muneesh, Gartler, Stanley M., Issa, Jean-Pierre, Pavlidis, Paul, Duan, Zhijun, Blau, C. Anthony

“…Recent evidence indicates that mouse and human embryonic stem cells (ESCs) are fixed at different developmental stages, with the former positioned earlier. We…”
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The GIPC1‐Akt1 Pathway Is Required for the Specification of the Eye Field in Mouse Embryonic Stem Cells by La Torre, Anna, Hoshino, Akina, Cavanaugh, Christopher, Ware, Carol B., Reh, Thomas A.

“…During early patterning of the neural plate, a single region of the embryonic forebrain, the eye field, becomes competent for eye development. The hallmark of…”
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Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells by Choi, Minseung, Genereux, Diane P, Goodson, Jamie, Al-Azzawi, Haneen, Allain, Shannon Q, Simon, Noah, Palasek, Stan, Ware, Carol B, Cavanaugh, Chris, Miller, Daniel G, Johnson, Winslow C, Sinclair, Kevin D, Stöger, Reinhard, Laird, Charles D

“…In storing and transmitting epigenetic information, organisms must balance the need to maintain information about past conditions with the capacity to respond…”
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Using DNase Hi-C techniques to map global and local three-dimensional genome architecture at high resolution by Ma, Wenxiu, Ay, Ferhat, Lee, Choli, Gulsoy, Gunhan, Deng, Xinxian, Cook, Savannah, Hesson, Jennifer, Cavanaugh, Christopher, Ware, Carol B., Krumm, Anton, Shendure, Jay, Blau, C. Anthony, Disteche, Christine M., Noble, William S., Duan, ZhiJun

“…•DNase Hi-C is based on random chromatin fragmentation by DNase I digestion.•Targeted DNase Hi-C is a method for mapping fine-scale chromatin architecture.•The…”
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Enhancer Chromatin and 3D Genome Architecture Changes from Naive to Primed Human Embryonic Stem Cell States by Battle, Stephanie L., Doni Jayavelu, Naresh, Azad, Robert N., Hesson, Jennifer, Ahmed, Faria N., Overbey, Eliah G., Zoller, Joseph A., Mathieu, Julie, Ruohola-Baker, Hannele, Ware, Carol B., Hawkins, R. David

“…During mammalian embryogenesis, changes in morphology and gene expression are concurrent with epigenomic reprogramming. Using human embryonic stem cells…”
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Engineering of Human Pluripotent Stem Cells by AAV-mediated Gene Targeting by Khan, Iram F, Hirata, Roli K, Wang, Pei-Rong, Li, Yi, Kho, Jordan, Nelson, Angel, Huo, Yunwen, Zavaljevski, Maja, Ware, Carol, Russell, David W

“…Precise genetic manipulation of human pluripotent stem cells will be required to realize their scientific and therapeutic potential. Here, we show that…”
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