Search Results - "WARDLE, R. L"

Modelling asthma in macaques: longitudinal changes in cellular and molecular markers by AYANOGLU, G, DESAI, B, WARDLE, R. L, FICK, R. B, GREIN, J, DE WAAL MALEFYT, R, MATTSON, J, MCCLANAHAN, T, OLMSTEAD, S, REECE, S. P, VAN SCOTT, M. R

“…The aim of the present study was to determine whether systemic sensitisation and chronic aeroallergen challenge in macaques replicate the classical and…”
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Activation of Myosin Light Chain Phosphatase in Intact Arterial Smooth Muscle During Nitric Oxide-induced Relaxation by Etter, Elaine F., Eto, Masumi, Wardle, Robert L., Brautigan, David L., Murphy, Richard A.

“…We investigated whether myosin light chain phosphatase activity changes during nitric oxide-induced relaxation of contracted intact carotid media and how…”
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Effect of a regional increase in alveolar pressure on pulmonary blood flow by Olson, L E, Wardle, R L

“…We examined whether wedging a catheter (0.5 cm OD) into a subsegmental airway in dog (n = 6) or pig lungs (n = 5) and increasing pressure in the distal lung…”
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Heterologous desensitization of smooth muscle to K+ depolarization: retarded stimulus-[Ca2+]i coupling by Wardle, R L, Strauss, J D, Rembold, C M, Murphy, R A

“…To understand the phenomenon of postreceptor heterologous desensitization, we exposed porcine carotid media to 40 mM KCl physiological saline solution both…”
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Pleural pressure as a function of body position in rabbits by Olson, L E, Wardle, R L

“…Pleural pressure was measured at end expiration in spontaneously breathing anesthetized rabbits. A liquid-filled capsule was implanted into a rib to measure…”
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Effect of temperature upon carbon dioxide stores in the snake Coluber constrictor and the turtle Chrysemys scripta by Stinner, J N, Wardle, R L

“…The effect of temperature upon respiratory exchange ratio (R) was measured in snakes (Coluber constrictor) and turtles (Chrysemys scripta). Increasing body…”
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C36 NOVEL MECHANISMS OF ALLERGIC AIRWAY INFLAMMATION IN ANIMAL MODELS: Epsi-Gam Attenuates Aeroallergen-Induced Early Phase Bronchoconstriction And Late Phase Inflammation In House Dust Mite-Sensitive non-Human Primates by Wardle, R L, Gowdy, K M, Chandler, J H, Reece, S W, Sperinde, G, Von Loehneysen, K, Holley, K B, Reid, A F, Sigal, N, Van Scott, M R

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Pleural pressure measured with a rib capsule in anesthetized pneumonectomized rabbits by Olson, L E, Wardle, R L

“…Pleural pressure was measured at end expiration in anesthetized rabbits using a rib capsule placed in the right fifth rib. Three groups of rabbits were studied…”
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Minor role of a Ca2+-depleted sarcoplasmic reticulum in heterologous desensitization of smooth muscle to K by Wardle, R L, Murphy, R A

“…Exposure of porcine carotid artery smooth muscle (PCASM) to histamine was followed by a large reduction in the rate of force generation in response to 40 mM…”
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C32 ASTHMA: PRE-CLINICAL STUDIES: Vaccine Attenuates Aeroallergen-Induced Early And Late Phase Responses In House Dust Mite Sensitive Non-Human Primates by Wardle, R L, Chandler, J H, Wang, X, Putnam, B D, Pichler, J, Gaier, S, Olmstead, S G, Reece, S P, Katwa, L C, Mudde, G C, Van Scott, M R

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Cooperative attachment of cross bridges predicts regulation of smooth muscle force by myosin phosphorylation by Rembold, Christopher M, Wardle, Robert L, Wingard, Christopher J, Batts, Timothy W, Etter, Elaine F, Murphy, Richard A

“…Serine 19 phosphorylation of the myosin regulatory light chain (MRLC) appears to be the primary determinant of smooth muscle force development. The…”
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Ca2+-desensitizing hypoxic vasorelaxation: pivotal role for the myosin binding subunit of myosin phosphatase (MYPT1) in porcine coronary artery by Wardle, Robert L., Gu, Min, Ishida, Yukisato, Paul, Richard J.

“…Acute hypoxia dilates most systemic arteries leading to increased tissue perfusion. We showed that at high stimulus conditions, porcine coronary artery was…”
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Use of Respiratory Inductance Plethysmography to Monitor Changes in Lung Compliance and Resistance in Allergic Asthma by Wang, X, Olmstead, S, Reece, S, Wardle, R.L, Van Scott, M.R

“…Methods House dust mite (HDM)-sensitive macaques were anesthetized, and simultaneous measurements of Cdyn, RL, RIP parameters were made during challenged with…”
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Signal Transduction in Smooth Muscle: Selected Contribution: HSP20 phosphorylation in nitroglycerin- and forskolin-induced sustained reductions in swine carotid media tone by Rembold, Christopher M, O'Connor, Matthew, Clarkson, Michael, Wardle, Robert L, Murphy, Richard A

“…1  Cardiovascular Division, Department of Internal Medicine, and 2  Department of Molecular Physiology and Biological Physics, University of Virginia Health…”
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Selected contribution: HSP20 phosphorylation in nitroglycerin- and forskolin-induced sustained reductions in swine carotid media tone by Rembold, C M, O'Connor, M, Clarkson, M, Wardle, R L, Murphy, R A

“…Cyclic nucleotide-induced relaxation of maximally activated arterial smooth muscle has two phases. 1) The initial relaxation transient is typically…”
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Ca2+-independent hypoxic vasorelaxation in porcine coronary artery by Gu, Min, Thorne, George D., Wardle, Robert L., Ishida, Yukisato, Paul, Richard J.

“…To demonstrate a Ca 2+ -independent component of hypoxic vasorelaxation and to investigate its mechanism, we utilized permeabilized porcine coronary arteries,…”
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