Search Results - "WARDLAW, Sharon L"

Hypothalamic proopiomelanocortin processing and the regulation of energy balance by Wardlaw, Sharon L.

“…Hypothalamic proopiomelanocortin (POMC) neurons play a key role in regulating energy balance and neuroendocrine function. Much attention has been focused on…”
Get full text

FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake by Ren, Hongxia, Orozco, Ian J., Su, Ya, Suyama, Shigetomo, Gutiérrez-Juárez, Roger, Horvath, Tamas L., Wardlaw, Sharon L., Plum, Leona, Arancio, Ottavio, Accili, Domenico

“…Hypothalamic neurons expressing Agouti-related peptide (AgRP) are critical for initiating food intake, but druggable biochemical pathways that control this…”
Get full text

Differentiation of hypothalamic-like neurons from human pluripotent stem cells by Wang, Liheng, Meece, Kana, Williams, Damian J, Lo, Kinyui Alice, Zimmer, Matthew, Heinrich, Garrett, Martin Carli, Jayne, Leduc, Charles A, Sun, Lei, Zeltser, Lori M, Freeby, Matthew, Goland, Robin, Tsang, Stephen H, Wardlaw, Sharon L, Egli, Dieter, Leibel, Rudolph L

“…The hypothalamus is the central regulator of systemic energy homeostasis, and its dysfunction can result in extreme body weight alterations. Insights into the…”
Get full text

Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold by Lam, Daniel D, de Souza, Flavio S J, Nasif, Sofia, Yamashita, Miho, López-Leal, Rodrigo, Otero-Corchon, Veronica, Meece, Kana, Sampath, Harini, Mercer, Aaron J, Wardlaw, Sharon L, Rubinstein, Marcelo, Low, Malcolm J

“…Cell-specific expression of many genes is conveyed by multiple enhancers, with each individual enhancer controlling a particular expression domain. In…”
Get full text

Plasma Agouti-Related Protein and Cortisol Levels in Cushing Disease: Evidence for the Regulation of Agouti-Related Protein by Glucocorticoids in Humans by Page-Wilson, Gabrielle, Peters, Jane B, Panigrahi, Sunil K, Jacobs, Thomas P, Korner, Judith, Otten, Marc, Bruce, Jeffrey N, Wardlaw, Sharon L

“…Glucocorticoids regulate energy balance, in part by stimulating the orexigenic neuropeptide agouti-related protein (AgRP). AgRP neurons express glucocorticoid…”
Get full text

Clinical Utility of Plasma POMC and AgRP Measurements in the Differential Diagnosis of ACTH-Dependent Cushing's Syndrome by Page-Wilson, Gabrielle, Freda, Pamela U, Jacobs, Thomas P, Khandji, Alexander G, Bruce, Jeffrey N, Foo, Sandra T, Meece, Kana, White, Anne, Wardlaw, Sharon L

“…Context: Distinguishing between pituitary [Cushing's disease (CD)] and ectopic causes [ectopic ACTH syndrome (EAS)] of ACTH-dependent Cushing's syndrome can be…”
Get full text

Preserved Energy Balance in Mice Lacking FoxO1 in Neurons of Nkx2.1 Lineage Reveals Functional Heterogeneity of FoxO1 Signaling Within the Hypothalamus by HEINRICH, Garrett, MEECE, Kana, WARDLAW, Sharon L, ACCILI, Domenico

“…Transcription factor forkhead box O1 (FoxO1) regulates energy expenditure (EE), food intake, and hepatic glucose production. These activities have been mapped…”
Get full text

PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons by Wang, Liheng, Sui, Lina, Panigrahi, Sunil K., Meece, Kana, Xin, Yurong, Kim, Jinrang, Gromada, Jesper, Doege, Claudia A., Wardlaw, Sharon L., Egli, Dieter, Leibel, Rudolph L.

“…We recently developed a technique for generating hypothalamic neurons from human pluripotent stem cells. Here, as proof of principle, we examine the use of…”
Get full text

Effects of AgRP inhibition on energy balance and metabolism in rodent models by Dutia, Roxanne, Kim, Andrea J, Modes, Matthew, Rothlein, Robert, Shen, Jane M, Tian, Ye Edward, Ihbais, Jumana, Victory, Sam F, Valcarce, Carmen, Wardlaw, Sharon L

“…Activation of brain melanocortin-4 receptors (MC4-R) by α-melanocyte-stimulating hormone (MSH) or inhibition by agouti-related protein (AgRP) regulates food…”
Get full text

Effects of adrenalectomy on AGRP, POMC, NPY and CART gene expression in the basal hypothalamus of fed and fasted rats by Savontaus, Eriika, Conwell, Irene M, Wardlaw, Sharon L

“…Glucocorticoids regulate body energy balance through both peripheral and central mechanisms. In order to understand the central mechanisms that mediate these…”
Get full text

Effects of Opioid Antagonism on Cerebrospinal Fluid Melanocortin Peptides and Cortisol Levels in Humans by Gordon, Rebecca J, Panigrahi, Sunil K, Meece, Kana, Atalayer, Deniz, Smiley, Richard, Wardlaw, Sharon L

“…Hypothalamic proopiomelanocortin (POMC) is processed to -melanocyte-stimulating hormone, which interacts with the melanocortin antagonist agouti-related…”
Get full text

Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet by Lee, Michelle, Kim, Andrea, Chua, Jr, Streamson C, Obici, Silvana, Wardlaw, Sharon L

“…To determine whether long-term melanocortinergic activation can attenuate the metabolic effects of a high fat diet, mice overexpressing an NH(2)-terminal POMC…”
Get more information

Effects of fasting, leptin, and insulin on AGRP and POMC peptide release in the hypothalamus by Breen, Tracy L., Conwell, Irene M., Wardlaw, Sharon L.

“…Agouti-related protein (AGRP) and proopiomelanocortin (POMC) have opposing effects on melanocortin receptor (MC-R) signaling and energy balance, and are…”
Get full text

Central Infusion of Agouti-Related Peptide Suppresses Pulsatile Luteinizing Hormone Release in the Ovariectomized Rhesus Monkey by Vulliémoz, Nicolas R, Xiao, Ennian, Xia-Zhang, Linna, Wardlaw, Sharon L, Ferin, Michel

“…Agouti-related peptide (AGRP), an endogenous melanocortin receptor antagonist, is a powerful orexigenic peptide when infused centrally. AGRP and neuropeptide Y…”
Get full text

Serum Ghrelin Levels in Acromegaly: Effects of Surgical and Long-Acting Octreotide Therapy by Freda, Pamela U., Reyes, Carlos M., Conwell, Irene M., Sundeen, Robert E., Wardlaw, Sharon L.

“…The orexigenic peptide, ghrelin, is regulated by acute and chronic nutritional state. Although exogenously administered ghrelin stimulates pituitary GH…”
Get full text

Pitfall in the Diagnosis of Diabetes Insipidus and Pregnancy by Wardlaw, Sharon L., Khandji, Alexander G., Fleischer, Jessica B., Sum, Melissa

“…Diabetes insipidus (DI) during pregnancy and the perinatal period is an uncommon medical problem characterized by polyuria and excessive thirst. Diagnosis of…”
Get full text

Defining Predictors of Weight Loss Response to Lorcaserin by Sideri Gugger, Aristea, Dimino, Cara, Panigrahi, Sunil K, Mayer, Laurel, Smiley, Richard M, Korner, Judith, Wardlaw, Sharon L

“…Abstract Context Individual responses to weight loss (WL) medications vary widely and prediction of response remains elusive. Objective We investigated…”
Get full text

β-Endorphin Antagonizes the Effects of α-MSH on Food Intake and Body Weight by Dutia, Roxanne, Meece, Kana, Dighe, Shveta, Kim, Andrea J, Wardlaw, Sharon L

“…Proopiomelanocortin (POMC) is posttranslationally processed to several peptides including α-MSH, a primary regulator of energy balance that inhibits food…”
Get full text

α-Melanocyte-stimulating hormone alleviates pathological cardiac remodeling via melanocortin 5 receptor by Suominen, Anni, Saldo Rubio, Guillem, Ruohonen, Saku, Szabó, Zoltán, Pohjolainen, Lotta, Ghimire, Bishwa, Ruohonen, Suvi T, Saukkonen, Karla, Ijas, Jani, Skarp, Sini, Kaikkonen, Leena, Cai, Minying, Wardlaw, Sharon L, Ruskoaho, Heikki, Talman, Virpi, Savontaus, Eriika, Kerkelä, Risto, Rinne, Petteri

“…α-Melanocyte-stimulating hormone (α-MSH) regulates diverse physiological functions by activating melanocortin receptors (MC-R). However, the role of α-MSH and…”
Get full text

Approach to the Treatment of a Patient with an Aggressive Pituitary Tumor by Lin, Andrew L, Donoghue, Mark T A, Wardlaw, Sharon L, Yang, T Jonathan, Bodei, Lisa, Tabar, Viviane, Geer, Eliza B

“…Abstract A small subset of pituitary adenomas grows despite maximal treatment with standard therapies; namely, surgery and radiotherapy. These aggressive…”
Get full text