Search Results - "WARDEN, D"
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GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease
Published in Cell stem cell (02-08-2018)“…Alexander disease (AxD) is a leukodystrophy that primarily affects astrocytes and is caused by mutations in the astrocytic filament gene GFAP. While astrocytes…”
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Glioma IL13Rα2 is associated with mesenchymal signature gene expression and poor patient prognosis
Published in PloS one (18-10-2013)“…A major challenge for successful immunotherapy against glioma is the identification and characterization of validated targets. We have taken a bioinformatics…”
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Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche
Published in Nature communications (10-10-2016)“…Microenvironment cues received by haematopoietic stem cells (HSC) are important in regulating the choice between self-renewal and differentiation. On the basis…”
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L1CAM is an independent predictor of poor survival in endometrial cancer — An analysis of The Cancer Genome Atlas (TCGA)
Published in Gynecologic oncology (01-05-2016)“…Abstract Background L1-cell adhesion molecule (L1CAM) was previously reported to carry a poor prognosis in Stage I, low-risk endometrial cancer (EC). We…”
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Genomic analyses of germline and somatic variation in high-grade serous ovarian cancer
Published in Journal of ovarian research (17-07-2023)“…High-grade serous ovarian cancers (HGSCs) display a high degree of complex genetic alterations. In this study, we identified germline and somatic genetic…”
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Correction: HPV genotyping by L1 amplicon sequencing of archived invasive cervical cancer samples: a pilot study
Published in Infectious agents and cancer (19-06-2024)Get full text
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The histone demethylase jumonji coordinates cellular senescence including secretion of neural stem cell-attracting cytokines
Published in Molecular cancer research (01-04-2015)“…Jumonji domain-containing protein 3 (JMJD3/KDM6B) demethylates lysine 27 on histone H3 (H3K27me3), a repressive epigenetic mark controlling chromatin…”
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A Human Embryonic Stem Cell Model of Aβ-Dependent Chronic Progressive Neurodegeneration
Published in Frontiers in neuroscience (20-09-2019)“…We describe construction and phenotypic analysis of a human embryonic stem cell model of progressive Abeta-dependent neurodegeneration (ND) with potential…”
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Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer’s disease
Published in Journal of medical genetics (01-04-2004)“…Background: There is evidence that iron may play a role in the pathology of Alzheimer’s disease (AD). There may be genetic factors that contribute to iron…”
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Does early-onset chronic or recurrent major depression impact outcomes with antidepressant medications? A CO-MED trial report
Published in Psychological medicine (01-05-2013)“…Prior studies have suggested that major depressive disorder (MDD) with pre-adult onset represents a distinct subtype with greater symptom severity and higher…”
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HPV genotyping by L1 amplicon sequencing of archived invasive cervical cancer samples: a pilot study
Published in Infectious agents and cancer (09-08-2022)“…Human papillomavirus (HPV) is the primary cause of invasive cervical cancer (ICC). The prevalence of various HPV genotypes, ranging from oncogenically low- to…”
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MONITORING OF SYPHILIS IN BLOOD DONATIONS: CORRELATIONS WITH NOTIFIED CASES IN BRAZIL
Published in Hematology, Transfusion and Cell Therapy (01-10-2024)“…Background: Syphilis is a public health problem with traditional surveillance limited to clinical monitoring data; asymptomatic and low-risk populations rarely…”
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SOCIODEMOGRAPHIC FACTORS ASSOCIATED WITH ACTIVE SYPHILIS AMONG BRAZILIAN BLOOD DONORS
Published in Hematology, Transfusion and Cell Therapy (01-10-2024)“…Background: A concerning increase in syphilis has been observed worldwide. Traditional surveillance is limited by the scarce routine testing of asymptomatic…”
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Is prior course of illness relevant to acute or longer-term outcomes in depressed out-patients? A STARD report
Published in Psychological medicine (01-06-2012)“…Major depressive disorder (MDD) is commonly chronic and/or recurrent. We aimed to determine whether a chronic and/or recurrent course of MDD is associated with…”
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Detailed comparison of two popular variant calling packages for exome and targeted exon studies
Published in PeerJ (San Francisco, CA) (30-09-2014)“…The Genome Analysis Toolkit (GATK) is commonly used for variant calling of single nucleotide polymorphisms (SNPs) and small insertions and deletions (indels)…”
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Effects of rivastigmine on cognitive function in patients with traumatic brain injury
Published in Neurology (12-09-2006)“…To compare the efficacy and safety of rivastigmine (3 to 6 mg/day) vs placebo over 12 weeks in patients with traumatic brain injury and persistent cognitive…”
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Persistent prolongation of simple reaction time in sports concussion
Published in Neurology (14-08-2001)“…A baseline computerized cognitive assessment was completed by 483 military cadets before their initial school year. Fourteen cadets concussed during physical…”
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Global expression of molecular transporters in the human vaginal tract: implications for HIV chemoprophylaxis
Published in PloS one (15-10-2013)“…Pre-exposure chemoprophylaxis (PrECP) using antiretroviral agents is a promising strategy for the prevention of sexual HIV transmission in women. Molecular…”
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Principles and practices for treatment of cutaneous wounds with cultured skin substitutes
Published in The American journal of surgery (01-04-2002)“…Background: Skin substitutes prepared from cultured skin cells and biopolymers may reduce requirements for donor skin autograft, and have been shown to be…”
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