Search Results - "WARD, T. H"

Biomarker method validation in anticancer drug development by Cummings, J, Ward, T H, Greystoke, A, Ranson, M, Dive, C

“…Over recent years the role of biomarkers in anticancer drug development has expanded across a spectrum of applications ranging from research tool during early…”
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Biomarkers of apoptosis by Ward, T H, Cummings, J, Dean, E, Greystoke, A, Hou, J M, Backen, A, Ranson, M, Dive, C

“…Within the era of molecularly targeted anticancer agents, it has become increasingly important to provide proof of mechanism as early on as possible in the…”
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Noninvasive fluorescence imaging of small animals by ZELMER, A., WARD, T.H.

“…Summary Noninvasive in vivo fluorescence imaging of small animals as a method in preclinical research has developed considerably in recent years, and is used…”
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Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors by Pires, IM, Ward, TH, Dive, C

“…Background and purpose:  Checkpoint kinase 2 (CHK2) is activated by DNA damage and can contribute to p53 stabilization, modulating growth arrest and/or…”
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Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP by CUMMINGS, J, WARD, T. H, LACASSE, E, LEFEBVRE, C, ST-JEAN, M, DURKIN, J, RANSON, M, DIVE, C

“…The inhibitor of apoptosis protein, XIAP, is frequently overexpressed in chemoresistant human tumours. An antisense oligonucleotide (AEG 35156/GEM 640) that…”
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Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1 by Danson, S.J., Johnson, P., Ward, T.H., Dawson, M., Denneny, O., Dickinson, G., Aarons, L., Watson, A., Jowle, D., Cummings, J., Robson, L., Halbert, G., Dive, C., Ranson, M.

“…This trial describes a first-in-man evaluation of RH1, a novel bioreductive drug activated by DT-diaphorase (DTD), an enzyme overexpressed in many tumours. A…”
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DT-diaphorase: a target for new anticancer drugs by Danson, S, Ward, T.H, Butler, J, Ranson, M

“…DT-diaphorase (DTD) is an obligate two-electron reductase which bioactivates chemotherapeutic quinones. DTD levels are elevated in a number of tumour types,…”
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‘Fit-for-purpose’ validation of SearchLight multiplex ELISAs of angiogenesis for clinical trial use by Backen, A.C., Cummings, J., Mitchell, C., Jayson, G., Ward, T.H., Dive, C.

“…Validated assays of circulating biomarkers of angiogenesis to predict and determine the efficacy of vascular-targeted anticancer drugs would facilitate…”
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Validation of an ELISA for the determination of rituximab pharmacokinetics in clinical trials subjects by Hampson, G., Ward, T.H., Cummings, J., Bayne, M., Tutt, A.L., Cragg, M.S., Dive, C., Illidge, T.M.

“…Rituximab is a chimeric anti-CD20 monoclonal antibody that has revolutionised the treatment of many B-cell malignancies, and is now increasingly being used in…”
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Hypoxia in head and neck cancer by ISA, A. Y, WARD, T. H, WEST, C. M. L, SLEVIN, N. J, HOMER, J. J

“…A high level of hypoxia in solid tumours is an adverse prognostic factor for the poor outcome of cancer patients following treatment. This review describes the…”
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Validation of the comet-X assay as a pharmacodynamic assay for measuring DNA cross-linking produced by the novel anticancer agent RH1 during a phase I clinical trial by DANSON, S, RANSON, M, DENNENY, O, CUMMINGS, J, WARD, T. H

“…RH1 is a novel anticancer agent with potent DNA-cross linking activity. RH1 has the potential to be activated within tumors over expressing NQO1, giving…”
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Dynamics of proteins in Golgi membranes: comparisons between mammalian and plant cells highlighted by photobleaching techniques by Ward, T H, Brandizzi, F

“…In less than a decade the green fluorescent protein (GFP) has become one of the most popular tools for cell biologists for the study of dynamic processes in…”
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Ethanol-induced free radicals and hepatic DNA strand breaks are prevented in vivo by antioxidants: effects of acute and chronic ethanol exposure by Navasumrit, Panidz, Ward, Timothy H., Dodd, Nicholas J.F., O'Connor, Peter J.

“…Ethanol was given to male Wistar rats as an acute dose (5 g/kg) or continuously at 5% (w/v) in a liquid diet to provide 36% of the caloric requirement. Free…”
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Fern spore extracts can damage DNA by SIMAN, S. E, POVEY, A. C, WARD, T. H, MARGISON, G. P, SHEFFIELD, E

“…The carcinogenicity of the vegetative tissues of bracken fern (Pteridium) has long been established. More recently, the carcinogenic effects of the spores of…”
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DNA Damage and Repair in Gorlin Syndrome and Normal Fibroblasts After Aminolevulinic Acid Photodynamic Therapy: A Comet Assay Study by Haylett, A. K., Ward, T. H., Moore, J. V.

“…Using normal, untransformed, human fibroblasts, the effectiveness of aminolevulinic (ALA)-mediated photodynamic therapy (PDT) was investigated in terms of both…”
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Influence of extracellular pH on the cytotoxicity and DNA damage of a series of indolequinone compounds by Phillips, R M, Ward, T H

“…The existence of an acidic extracellular pH (pHe) within solid tumours is regarded as a potential target for drug development. The indolequinone EO9 has a…”
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Quantitative multiplexed quantum dot immunohistochemistry by Sweeney, E., Ward, T.H., Gray, N., Womack, C., Jayson, G., Hughes, A., Dive, C., Byers, R.

“…Quantum dots are photostable fluorescent semiconductor nanocrystals possessing wide excitation and bright narrow, symmetrical, emission spectra. These…”
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A retrospective case note review of deceased recipients of vCJD-implicated blood transfusions by Gillies, M., Chohan, G., Llewelyn, C. A., MacKenzie, J., Ward, H. J. T., Hewitt, P. E., Will, R. G.

“…Background  To date, four instances of probable transfusion–transmission of variant Creutzfeldt–Jakob disease (vCJD) infection have been described, and…”
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Electrochemical Monitoring of Anticancer Compounds on the Human Ovarian Carcinoma Cell Line A2780 and Its Adriamycin- and Cisplatin-Resistant Variants by Woolley, D.E., Tetlow, L.C., Adlam, D.J., Gearey, D., Eden, R.D., Ward, T.H., Allen, T.D.

“…A novel electrochemical technique which detects and monitors real-time changes in cell behavior in vitro has been used to examine the effects of recognized…”
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Maintenance of Golgi Structure and Function Depends on the Integrity of ER Export by Ward, Theresa H., Polishchuk, Roman S., Caplan, Steve, Hirschberg, Koret, Lippincott-Schwartz, Jennifer

“…The Golgi apparatus comprises an enormous array of components that generate its unique architecture and function within cells. Here, we use quantitative…”
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