Search Results - "WARD, Robyn L"

The evidence for functional non-CpG methylation in mammalian cells by Patil, Vibha, Ward, Robyn L, Hesson, Luke B

“…In mammalian genomes, the methylation of cytosine residues within CpG dinucleotides is crucial to normal development and cell differentiation. However,…”
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Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution by Dewhurst, Sally M, McGranahan, Nicholas, Burrell, Rebecca A, Rowan, Andrew J, Grönroos, Eva, Endesfelder, David, Joshi, Tejal, Mouradov, Dmitri, Gibbs, Peter, Ward, Robyn L, Hawkins, Nicholas J, Szallasi, Zoltan, Sieber, Oliver M, Swanton, Charles

“…The contribution of whole-genome doubling to chromosomal instability (CIN) and tumor evolution is unclear. We use long-term culture of isogenic tetraploid…”
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Oncomicrobial Community Profiling Identifies Clinicomolecular and Prognostic Subtypes of Colorectal Cancer by Mouradov, Dmitri, Greenfield, Paul, Li, Shan, In, Eun-Jung, Storey, Claire, Sakthianandeswaren, Anuratha, Georgeson, Peter, Buchanan, Daniel D., Ward, Robyn L., Hawkins, Nicholas J., Skinner, Iain, Jones, Ian T., Gibbs, Peter, Ma, Chenkai, Liew, Yi Jin, Fung, Kim Y.C., Sieber, Oliver M.

“…Dysbiosis of gut microbiota is linked to the development of colorectal cancer (CRC). However, microbiota-based stratification of CRC tissue and how this…”
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What are the attitudes of health professionals regarding patient reported outcome measures (PROMs) in oncology practice? A mixed-method synthesis of the qualitative evidence by Nic Giolla Easpaig, Bróna, Tran, Yvonne, Bierbaum, Mia, Arnolda, Gaston, Delaney, Geoff P, Liauw, Winston, Ward, Robyn L, Olver, Ian, Currow, David, Girgis, Afaf, Durcinoska, Ivana, Braithwaite, Jeffrey

“…The adoption of Patient Reported Outcome Measures (PROMs) in cancer care has been widely advocated, but little is known about the evidence for the…”
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Population-Based Molecular Screening for Lynch Syndrome: Implications for Personalized Medicine by WARD, Robyn L, HICKS, Sian, HAWKINS, Nicholas J

“…Molecular screening techniques are available to identify hereditary Lynch syndrome in people with newly diagnosed colorectal cancer (CRC). We aimed to…”
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Dominantly Inherited Constitutional Epigenetic Silencing of MLH1 in a Cancer-Affected Family Is Linked to a Single Nucleotide Variant within the 5′UTR by Hitchins, Megan P., Rapkins, Robert W., Kwok, Chau-To, Srivastava, Sameer, Wong, Justin J.L., Khachigian, Levon M., Polly, Patsie, Goldblatt, Jack, Ward, Robyn L.

“…Constitutional epimutations of tumor suppressor genes manifest as promoter methylation and transcriptional silencing of a single allele in normal somatic…”
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The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis by Ford, Caroline E., Qian Ma, Sean Si, Quadir, Ashfaque, Ward, Robyn L.

“…The Wnt signaling pathway is involved in the development and progression of many human cancers, yet attempts to target the pathway therapeutically have been…”
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Challenges in valuing and paying for combination regimens in oncology: reporting the perspectives of a multi-stakeholder, international workshop by Latimer, Nicholas R, Pollard, Daniel, Towse, Adrian, Henshall, Chris, Sansom, Lloyd, Ward, Robyn L, Bruce, Andrew, Deakin, Carla

“…It is increasingly common for two or more treatments for cancer to be combined as a single regimen. Determining value and appropriate payment for such regimens…”
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Facilitating a culture of responsible and effective sharing of cancer genome data by Siu, Lillian L, Lawler, Mark, Haussler, David, Knoppers, Bartha Maria, Lewin, Jeremy, Vis, Daniel J, Liao, Rachel G, Andre, Fabrice, Banks, Ian, Barrett, J Carl, Caldas, Carlos, Camargo, Anamaria Aranha, Fitzgerald, Rebecca C, Mao, Mao, Mattison, John E, Pao, William, Sellers, William R, Sullivan, Patrick, Teh, Bin Tean, Ward, Robyn L, ZenKlusen, Jean Claude, Sawyers, Charles L, Voest, Emile E

“…Rapid and affordable tumor molecular profiling has led to an explosion of clinical and genomic data poised to enhance the diagnosis, prognostication and…”
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The Wnt gatekeeper SFRP4 modulates EMT, cell migration and downstream Wnt signalling in serous ovarian cancer cells by Ford, Caroline E, Jary, Eve, Ma, Sean Si Qian, Nixdorf, Sheri, Heinzelmann-Schwarz, Viola A, Ward, Robyn L

“…Aberrant Wnt signalling is implicated in numerous human cancers, and understanding the effects of modulation of pathway members may lead to the development of…”
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PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer by Day, Fiona L, Jorissen, Robert N, Lipton, Lara, Mouradov, Dmitri, Sakthianandeswaren, Anuratha, Christie, Michael, Li, Shan, Tsui, Cary, Tie, Jeannie, Desai, Jayesh, Xu, Zheng-Zhou, Molloy, Peter, Whitehall, Vicki, Leggett, Barbara A, Jones, Ian T, McLaughlin, Stephen, Ward, Robyn L, Hawkins, Nicholas J, Ruszkiewicz, Andrew R, Moore, James, Busam, Dana, Zhao, Qi, Strausberg, Robert L, Gibbs, Peter, Sieber, Oliver M

“…PIK3CA and PTEN mutations are prevalent in colorectal cancer and potential markers of response to mitogen-activated protein/extracellular signal-regulated…”
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Colon and rectal cancer treatment patterns and their associations with clinical, sociodemographic and lifestyle characteristics: analysis of the Australian 45 and Up Study cohort by Yap, Sarsha, He, Emily, Egger, Sam, Goldsbury, David E, Lew, Jie-Bin, Ngo, Preston J, Worthington, Joachim, Rillstone, Hannah, Zalcberg, John R, Cuff, Jeff, Ward, Robyn L, Canfell, Karen, Feletto, Eleonora, Steinberg, Julia

“…Colorectal cancer is the third most diagnosed cancer globally and the second leading cause of cancer death. We examined colon and rectal cancer treatment…”
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Identification of constitutional MLH1 epimutations and promoter variants in colorectal cancer patients from the Colon Cancer Family Registry by Ward, Robyn L., Dobbins, Timothy, Lindor, Noralane M., Rapkins, Robert W., Hitchins, Megan P.

“…Purpose: Constitutional MLH1 epimutations manifest as promoter methylation and silencing of the affected allele in normal tissues, predisposing to Lynch…”
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Diagnostic and health service pathways to diagnosis of cancer-registry notified cancer of unknown primary site (CUP) by Schaffer, Andrea L, Pearson, Sallie-Anne, Perez-Concha, Oscar, Dobbins, Timothy, Ward, Robyn L, van Leeuwen, Marina T, Rhee, Joel J, Laaksonen, Maarit A, Craigen, Glynis, Vajdic, Claire M

“…Cancer of unknown primary (CUP) is a late-stage malignancy with poor prognosis, but we know little about what diagnostic tests and procedures people with CUP…”
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Epimutations and cancer predisposition: importance and mechanisms by Hesson, Luke B, Hitchins, Megan P, Ward, Robyn L

“…Germline sequence mutations in tumour suppressor genes can cause cancer predisposition syndromes. More recently, epimutations have also been proposed to cause…”
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The complexities, coordination, culture and capacities that characterise the delivery of oncology services in the common areas of ambulatory settings by Nic Giolla Easpaig, Bróna, Tran, Yvonne, Winata, Teresa, Lamprell, Klay, Fajardo Pulido, Diana, Arnolda, Gaston, Delaney, Geoff P, Liauw, Winston, Smith, Kylie, Avery, Sandra, Rigg, Kim, Westbrook, Johanna, Olver, Ian, Currow, David, Karnon, Jonathan, Ward, Robyn L, Braithwaite, Jeffrey

“…Relatively little is understood about real-world provision of oncology care in ambulatory outpatient clinics (OPCs). This study aimed to: 1) develop an…”
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Response rate or time to progression as predictors of survival in trials of metastatic colorectal cancer or non-small-cell lung cancer: a meta-analysis by Johnson, Kent R, Ringland, Clare, Stokes, Barrie J, Anthony, Danielle M, Freemantle, Nick, Irs, Alar, Hill, Suzanne R, Ward, Robyn L

“…The duration and cost of cancer clinical trials could be reduced if a surrogate endpoint were used in place of survival. We did a meta-analysis to assess the…”
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PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells by Chandrakanthan, Vashe, Yeola, Avani, Kwan, Jair C., Oliver, Rema A., Qiao, Qiao, Kang, Young Chan, Zarzour, Peter, Beck, Dominik, Boelen, Lies, Unnikrishnan, Ashwin, Villanueva, Jeanette E., Nunez, Andrea C., Knezevic, Kathy, Palu, Cintia, Nasrallah, Rabab, Carnell, Michael, Macmillan, Alex, Whan, Renee, Yu, Yan, Hardy, Philip, Grey, Shane T., Gladbach, Amadeus, Delerue, Fabien, Ittner, Lars, Mobbs, Ralph, Walkley, Carl R., Purton, Louise E., Ward, Robyn L., Wong, Jason W. H., Hesson, Luke B., Walsh, William, Pimanda, John E.

“…Current approaches in tissue engineering are geared toward generating tissue-specific stem cells. Given the complexity and heterogeneity of tissues, this…”
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Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer by Jorissen, Robert N, Christie, Michael, Mouradov, Dmitri, Sakthianandeswaren, Anuratha, Li, Shan, Love, Christopher, Xu, Zheng-Zhou, Molloy, Peter L, Jones, Ian T, McLaughlin, Stephen, Ward, Robyn L, Hawkins, Nicholas J, Ruszkiewicz, Andrew R, Moore, James, Burgess, Antony W, Busam, Dana, Zhao, Qi, Strausberg, Robert L, Lipton, Lara, Desai, Jayesh, Gibbs, Peter, Sieber, Oliver M

“…Background: APC mutations ( APC -mt) occur in ∼70% of colorectal cancers (CRCs), but their relationship to prognosis is unclear. Methods: APC prognostic value…”
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Cohesin Rad21 mediates loss of heterozygosity and is upregulated via Wnt promoting transcriptional dysregulation in gastrointestinal tumors by Xu, Huiling, Yan, Yuqian, Deb, Siddhartha, Rangasamy, Danny, Germann, Markus, Malaterre, Jordane, Eder, Noreen C, Ward, Robyn L, Hawkins, Nicholas J, Tothill, Richard W, Chen, Long, Mortensen, Neil J, Fox, Stephen B, McKay, Michael J, Ramsay, Robert G

“…Loss of heterozygosity (LOH) of the adenomatous polyposis coli (APC) gene triggers a series of molecular events leading to intestinal adenomagenesis…”
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