Search Results - "WARD, Peter A"

Oxidative stress: acute and progressive lung injury by Ward, Peter A.

“…Oxidative stress in lung often occurs in humans during acute lung injury (ALI) and in the acute respiratory distress syndrome. The lung inflammatory response…”
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Modulation of inflammation by interleukin-27 by Bosmann, Markus, Ward, Peter A.

“…Review on how IL‐27 balances inflammation during infectious and autoimmune diseases. A growing body of evidence suggests an essential role of the heterodimeric…”
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Therapeutic targeting of acute lung injury and acute respiratory distress syndrome by Standiford, Theodore J, Ward, Peter A

“…There is no Food and Drug Administration-approved treatment for acute respiratory distress syndrome (ARDS), in spite of the relatively large number of patients…”
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Obesity and type 2 diabetes mellitus drive immune dysfunction, infection development, and sepsis mortality by Frydrych, Lynn M., Bian, Guowu, O'Lone, David E., Ward, Peter A., Delano, Matthew J.

“…Obesity and type 2 diabetes mellitus (T2D) are global pandemics. Worldwide, the prevalence of obesity has nearly tripled since 1975 and the prevalence of T2D…”
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New approaches to the study of sepsis by Ward, Peter A.

“…Models of sepsis have been instructive in understanding the sequence of events in animals and, to an extent, in humans with sepsis. Events developing early in…”
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Role of C3, C5 and anaphylatoxin receptors in acute lung injury and in sepsis by Bosmann, Markus, Ward, Peter A

“…The complement system plays a major role in innate immune defenses against infectious agents, but exaggerated activation of complement can lead to severe…”
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Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome by Zhang, Yong, Li, Xiru, Grailer, Jamison J., Wang, Na, Wang, Mingming, Yao, Jianfei, Zhong, Rui, Gao, George F., Ward, Peter A., Tan, Dun-Xian, Li, Xiangdong

“…Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are clinically severe respiratory disorders, and there are currently no Food and Drug…”
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Critical role for the NLRP3 inflammasome during acute lung injury by Grailer, Jamison J, Canning, Bethany A, Kalbitz, Miriam, Haggadone, Mikel D, Dhond, Rasika M, Andjelkovic, Anuska V, Zetoune, Firas S, Ward, Peter A

“…The inflammasome is a key factor in innate immunity and senses soluble pathogen and danger-associated molecular patterns as well as biological crystals (urate,…”
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The Harmful Role of C5a on Innate Immunity in Sepsis by Ward, Peter A.

“…There is accumulating evidence in humans and in experimental sepsis that robust activation of the complement system occurs along with development of defects in…”
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The disconnect between animal models of sepsis and human sepsis by Rittirsch, Daniel, Hoesel, L. Marco, Ward, Peter A.

“…Frequently used experimental models of sepsis include cecal ligation and puncture, ascending colon stent peritonitis, and the i.p. or i.v. injection of…”
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Extracellular histones are essential effectors of C5aR‐ and C5L2‐mediated tissue damage and inflammation in acute lung injury by Bosmann, Markus, Grailer, Jamison J., Ruemmler, Robert, Russkamp, Norman F., Zetoune, Firas S., Sarma, J. Vidya, Standiford, Theodore J., Ward, Peter A.

“…We investigated how complement activation promotes tissue injury and organ dysfunction during acute inflammation. Three models of acute lung injury (ALI)…”
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Complement‐induced activation of the cardiac NLRP3 inflammasome in sepsis by Kalbitz, Miriam, Fattahi, Fatemeh, Grailer, Jamison J., Jajou, Lawrence, Malan, Elizabeth A., Zetoune, Firas S., Huber‐Lang, Markus, Russell, Mark W., Ward, Peter A.

“…ABSTRACT Cardiac dysfunction develops during sepsis in humans and rodents. In the model of polymicrobial sepsis induced by cecal ligation and puncture (CLP),…”
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Role of oxidants in lung injury during sepsis by Guo, Ren-Feng, Ward, Peter A

“…The role of oxidative stress has been well appreciated in the development of sepsis-induced acute lung injury (ALI). Oxidative stress in sepsis-induced ALI is…”
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Role of C5a in inflammatory responses by Guo, Ren-Feng, Ward, Peter A

“…The complement system not only represents an effective innate immune mechanism of host defense to eradicate microbial pathogens, but it is also widely involved…”
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Diabetes and Sepsis: Risk, Recurrence, and Ruination by Frydrych, Lynn M, Fattahi, Fatemeh, He, Katherine, Ward, Peter A, Delano, Matthew J

“…Sepsis develops when an infection surpasses local tissue containment. A series of dysregulated physiological responses are generated, leading to organ…”
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Role of extracellular histones in the cardiomyopathy of sepsis by Kalbitz, Miriam, Grailer, Jamison J., Fattahi, Fatemeh, Jajou, Lawrence, Herron, Todd J., Campbell, Katherine F., Zetoune, Firas S., Bosmann, Markus, Sarma, J. Vidya, Huber‐Lang, Markus, Gebhard, Florian, Loaiza, Randall, Valdivia, Hector H., Jalife, José, Russell, Mark W., Ward, Peter A.

“…ABSTRACT The purpose of this study was to define the relationship in polymicrobial sepsis (in adult male C57BL/6 mice) between heart dysfunction and the…”
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The Impact of Extracellular Histones and Absence of Toll-like Receptors on Cardiac Functional and Electrical Disturbances in Mouse Hearts by Loaiza, Randall, Fattahi, Fatemeh, Kalbitz, Miriam, Grailer, Jamison J, Russell, Mark W, Jalife, Jose, Valdivia, Hector H, Zetoune, Firas S, Ward, Peter A

“…In polymicrobial sepsis, the extracellular histones, mainly released from activated neutrophils, significantly contribute to cardiac dysfunction (septic…”
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Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality by Sun, Yaping, Varambally, Sooryanarayana, Maher, Christopher A., Cao, Qi, Chockley, Peter, Toubai, Tomomi, Malter, Chelsea, Nieves, Evelyn, Tawara, Isao, Wang, Yongqing, Ward, Peter A., Chinnaiyan, Arul, Reddy, Pavan

“…While miRNAs are increasingly linked to various immune responses, whether they can be targeted for regulating in vivo inflammatory processes such as…”
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Inhibition of junctional adhesion molecule-A/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia/reperfusion injury by Sladojevic, Nikola, Stamatovic, Svetlana M, Keep, Richard F, Grailer, Jamison J, Sarma, J. Vidya, Ward, Peter A, Andjelkovic, Anuska V

“…Abstract Proinflammatory mediators trigger intensive postischemic inflammatory remodeling of the blood–brain barrier (BBB) including extensive brain…”
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Role of Complement and Histones in Sepsis by Zetoune, Firas S, Ward, Peter A

“…The wide use of the mouse model of polymicrobial sepsis has provided important evidence for events occurring in infectious sepsis involving septic mice and…”
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