Search Results - "WANGHAI ZHANG"

Human Carboxylesterase 2 Is Commonly Expressed in Tumor Tissue and Is Correlated with Activation of Irinotecan by GUANG XU, WANGHAI ZHANG, MA, Margaret K, MCLEOD, Howard L

“…The prodrug irinotecan is an active agent for the treatment of advanced colorectal cancer and a number of other solid tumors. Irinotecan is converted in vivo…”
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Pharmacogenomic profiling of the PI3K/PTEN-AKT-mTOR pathway in common human tumors by Xu, Guang, Zhang, Wanghai, Bertram, Paula, Zheng, Xiao Feng, McLeod, Howard

“…The protein synthetic machinery is activated by a variety of genetic alterations during tumor progression and represents an attractive target for cancer…”
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Therapeutic Synergy Between Irinotecan and 5-Fluorouracil against Human Tumor Xenografts by Azrak, Rami G, Cao, Shousong, Slocum, Harry K, Tóth, Károly, Durrani, Farukh A, Yin, Ming-biao, Pendyala, Lakshmi, Zhang, Wanghai, McLeod, Howard L, Rustum, Youcef M

“…Purpose: Although the combination of irinotecan and 5-Fluorouracil is clinically active, it is associated with significant toxicity and resistance. Studies…”
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MAGED2 : A novel p53-dissociator by PAPAGEORGIO, Chris, BRACHMANN, Rainer, JUE ZENG, CULVERHOUSE, Robert, WANGHAI ZHANG, MCLEOD, Howard

“…The tumor suppressor protein p53 is a transcription factor that is frequently mutated in human cancers. In response to DNA damage, unmutated or wild-type (wt)…”
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Copy-number analysis of topoisomerase and thymidylate synthase genes in frozen and FFPE DNAs of colorectal cancers by Yu, Jinsheng, Miller, Ryan, Zhang, Wanghai, Sharma, Mala, Holtschlag, Vicky, Watson, Mark A, McLeod, Howard L

“…Archived formalin-fixed, paraffin-embedded specimens represent an important resource for pharmacogenomic analysis in retrospective clinical studies but the…”
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DNA Repair Pathway Profiling and Microsatellite Instability in Colorectal Cancer by Yu, Jinsheng, Mallon, Mary A, Zhang, Wanghai, Freimuth, Robert R, Marsh, Sharon, Watson, Mark A, Goodfellow, Paul J, McLeod, Howard L

“…Background: The ability to maintain DNA integrity is a critical cellular function. DNA repair is conducted by distinct pathways of genes, many of which are…”
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Differential expression of the AP-1 transcription factor family members in human colorectal epithelial and neuroendocrine neoplasms by WANGHAI ZHANG, HART, John, MCLEOD, Howard L, WANG, Hanlin L

“…We immunohistochemically examined 75 human colorectal neoplasms (adenoma, 27; adenocarcinoma, 24; neuroendocrine carcinoma, 24) for the expression of activator…”
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A mouse model for developing treatment for secondary liver tumors by Cai, Shi-Rong, Garbow, Joel R, Culverhouse, Robert, Church, Robert D, Zhang, Wanghai, Shannon, William D, McLeod, Howard L

“…Metastatic colorectal cancer is the second most common cause of cancer mortality. The liver is a common site of metastasis and only a minority of patients with…”
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Altered Expression of TFF-1 and CES-2 in Barrett's Esophagus and Associated Adenocarcinomas by Fox, Charles A., Sapinoso, Lisa M., Zhang, Hong, Zhang, Wanghai, McLeod, Howard L., Petroni, Gina R., Mullick, Tarun, Moskaluk, Christopher A., Frierson, Henry F., Hampton, Garret M., Powell, Steven M.

“…Identification of biomarkers to recognize individuals with Barrett's esophagus (BE) predisposed to develop malignancy is currently a pressing issue. We…”
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Comprehensive Evaluation of Carboxylesterase-2 Expression in Normal Human Tissues Using Tissue Array Analysis by Zhang, Wanghai, Xu, Guang, McLeod, Howard L.

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In Situ Telomeric Repeat Amplification Protocol (TRAP) Detecting Telomerase Activity in Human Hepatocellular Carcinoma by Lu, Jian-Ping, Zhu, Shineng, Song, Baoping, Mao, Jianqun, Lu, Shilun, Su, Yinhao, Zhang, Wanghai

“…In situ telomeric repeat amplification protocol (TRAP) assay was used to show the telomerase activity on the cryostat section of hepatocellular carcinoma (HCC)…”
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Image-based evaluation of the molecular events underlying HC11 mammary epithelial cell differentiation by Shan, Liang, Zhang, Renshu, Zhang, Wanghai, Lee, Edward, Sridhar, Rajagopalan, Snyderwine, Elizabeth G., Wang, Paul C.

“…We have developed an image-based technique for signal pathway analysis, target validation, and compound screening related to mammary epithelial cell…”
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Comprehensive evaluation of carboxylesterase-2 expression in normal human tissues using tissue array analysis by Zhang, Wanghai, Xu, Guang, McLeod, Howard L

“…Carboxylesterases play an important role in the hydrolytic biotransformation of a number of structurally diverse endogenous compounds and medications. Several…”
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Analysis of variation in mouse TPMT genotype, expression and activity by WATTERS, James W, WANGHAI ZHANG, MEUCCI, Melissa A, WEIYING HOU, MA, Margaret K, MCLEOD, Howard L

“…Although the mouse has great potential for pharmacogenomic discovery, little is known about variation in drug response or genetic variation in…”
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Altered Expression of TFF-1 and CES-2 in Barrett's Esophagus and Associated Adenocarcinomas1 by Fox, Charles A, Sapinoso, Lisa M, Zhang, Hong, Zhang, Wanghai, McLeod, Howard L, Petroni, Gina R, Mullick, Tarun, Moskaluk, Christopher A, Frierson, Henry F, Hampton, Garret M, Powell, Steven M

“…Identification of biomarkers to recognize individuals with Barrett's esophagus (BE) predisposed to develop malignancy is currently a pressing issue. We…”
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