Search Results - "WANG, Jiou"

G-Quadruplexes as pathogenic drivers in neurodegenerative disorders by Wang, Ernest, Thombre, Ravi, Shah, Yajas, Latanich, Rachel, Wang, Jiou

“…Abstract G-quadruplexes (G4s), higher-order DNA and RNA secondary structures featuring guanine-rich nucleic acid sequences with various conformations, are…”
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Autophagy as a common pathway in amyotrophic lateral sclerosis by Nguyen, Dao K.H., Thombre, Ravi, Wang, Jiou

“…•Many ALS-causing genetic factors share a common link to autophagy.•Diverse mechanisms in ALS impair or overactivate autophagy.•Autophagic activation or…”
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Fast genetic mapping using insertion-deletion polymorphisms in Caenorhabditis elegans by Hwang, Ho-Yon, Wang, Jiou

“…Genetic mapping is used in forward genetics to narrow the list of candidate mutations and genes corresponding to the mutant phenotype of interest. Even with…”
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Effect of recombination on genetic diversity of Caenorhabditis elegans by Hwang, Ho-Yon, Wang, Jiou

“…Greater molecular divergence and genetic diversity are present in regions of high recombination in many species. Studies describing the correlation between…”
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The C9orf72 repeat expansion disrupts nucleocytoplasmic transport by Zhang, Ke, Donnelly, Christopher J., Haeusler, Aaron R., Grima, Jonathan C., Machamer, James B., Steinwald, Peter, Daley, Elizabeth L., Miller, Sean J., Cunningham, Kathleen M., Vidensky, Svetlana, Gupta, Saksham, Thomas, Michael A., Hong, Ingie, Chiu, Shu-Ling, Huganir, Richard L., Ostrow, Lyle W., Matunis, Michael J., Wang, Jiou, Sattler, Rita, Lloyd, Thomas E., Rothstein, Jeffrey D.

“…The hexanucleotide repeat expansion (HRE) GGGGCC (G 4 C 2 ) in C9orf72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal…”
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Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling by Ugolino, Janet, Ji, Yon Ju, Conchina, Karen, Chu, Justin, Nirujogi, Raja Sekhar, Pandey, Akhilesh, Brady, Nathan R, Hamacher-Brady, Anne, Wang, Jiou

“…The most common cause of the neurodegenerative diseases amyotrophic lateral sclerosis and frontotemporal dementia is a hexanucleotide repeat expansion in…”
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C9orf72/ALFA-1 controls TFEB/HLH-30-dependent metabolism through dynamic regulation of Rag GTPases by Ji, Yon Ju, Ugolino, Janet, Zhang, Tao, Lu, Jiayin, Kim, Dohoon, Wang, Jiou

“…Nutrient utilization and energy metabolism are critical for the maintenance of cellular homeostasis. A mutation in the C9orf72 gene has been linked to the most…”
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Intracellular energy controls dynamics of stress-induced ribonucleoprotein granules by Wang, Tao, Tian, Xibin, Kim, Han Byeol, Jang, Yura, Huang, Zhiyuan, Na, Chan Hyun, Wang, Jiou

“…Energy metabolism and membraneless organelles have been implicated in human diseases including neurodegeneration. How energy deficiency regulates…”
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Ubiquilin 2 modulates ALS/FTD-linked FUS–RNA complex dynamics and stress granule formation by Alexander, Elizabeth J., Niaki, Amirhossein Ghanbari, Zhang, Tao, Sarkar, Jaya, Liu, Yang, Nirujogi, Raja Sekhar, Pandey, Akhilesh, Myong, Sua, Wang, Jiou

“…The ubiquitin-like protein ubiquilin 2 (UBQLN2) has been genetically and pathologically linked to the neurodegenerative diseases amyotrophic lateral sclerosis…”
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G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 architectural lncRNA by Simko, Eric A J, Liu, Honghe, Zhang, Tao, Velasquez, Adan, Teli, Shraddha, Haeusler, Aaron R, Wang, Jiou

“…Abstract The long non-coding RNA NEAT1 serves as a scaffold for the assembly of paraspeckles, membraneless nuclear organelles involved in gene regulation…”
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RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention by Donnelly, Christopher J., Zhang, Ping-Wu, Pham, Jacqueline T., Haeusler, Aaron R., Mistry, Nipun A., Vidensky, Svetlana, Daley, Elizabeth L., Poth, Erin M., Hoover, Benjamin, Fines, Daniel M., Maragakis, Nicholas, Tienari, Pentti J., Petrucelli, Leonard, Traynor, Bryan J., Wang, Jiou, Rigo, Frank, Bennett, C. Frank, Blackshaw, Seth, Sattler, Rita, Rothstein, Jeffrey D.

“…A hexanucleotide GGGGCC repeat expansion in the noncoding region of the C9ORF72 gene is the most common genetic abnormality in familial and sporadic…”
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RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response by Zhang, Tao, Baldie, Gerard, Periz, Goran, Wang, Jiou

“…Protein homeostasis is critical for cell survival and functions during stress and is regulated at both RNA and protein levels. However, how the cell integrates…”
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DBT is a metabolic switch for maintenance of proteostasis under proteasomal impairment by Hwang, Ran-Der, Lu, YuNing, Tang, Qing, Periz, Goran, Park, Giho, Li, Xiangning, Xiang, Qiwang, Liu, Yang, Zhang, Tao, Wang, Jiou

“…Proteotoxic stress impairs cellular homeostasis and underlies the pathogenesis of many neurodegenerative diseases, including amyotrophic lateral sclerosis…”
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A C9orf72-CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress by Liu, Yang, Wang, Tao, Ji, Yon Ju, Johnson, Kenji, Liu, Honghe, Johnson, Kaitlin, Bailey, Scott, Suk, Yongwon, Lu, Yu-Ning, Liu, Mingming, Wang, Jiou

“…Cells undergo metabolic adaptation during environmental changes by using evolutionarily conserved stress response programs. This metabolic homeostasis is…”
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MARK2 phosphorylates eIF2α in response to proteotoxic stress by Lu, Yu-Ning, Kavianpour, Sarah, Zhang, Tao, Zhang, Xumei, Nguyen, Dao, Thombre, Ravi, He, Lu, Wang, Jiou

“…The regulation of protein synthesis is essential for maintaining cellular homeostasis, especially during stress responses, and its dysregulation could underlie…”
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A Helicase Unwinds Hexanucleotide Repeat RNA G‑Quadruplexes and Facilitates Repeat-Associated Non-AUG Translation by Liu, Honghe, Lu, Yu-Ning, Paul, Tapas, Periz, Goran, Banco, Michael T, Ferré-D’Amaré, Adrian R, Rothstein, Jeffrey D, Hayes, Lindsey R, Myong, Sua, Wang, Jiou

“…The expansion of a hexanucleotide repeat GGGGCC (G4C2) in the C9orf72 gene is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal…”
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Heterochronic Phenotype Analysis of Hypodermal Seam Cells in Caenorhabditis elegans by Ji, Yon Ju, Wang, Jiou

“…Heterochrony refers to changes in the timing of developmental events, and it is precisely regulated in the organisms by the heterochronic genes such as and …”
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Systemic deregulation of autophagy upon loss of ALS- and FTD-linked C9orf72 by Ji, Yon Ju, Ugolino, Janet, Brady, Nathan Ryan, Hamacher-Brady, Anne, Wang, Jiou

“…A genetic mutation in the C9orf72 gene causes the most common forms of neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal…”
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TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling by TAO ZHANG, MULLANE, Patrick C, PERIZ, Goran, WANG, Jiou

“…TAR DNA-binding protein 43 (TDP-43) plays a key role in the neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar…”
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Protocol to identify DNA-binding proteins recognizing nucleotide repeat dsDNAs by Huang, Zhiyuan, Zhou, Yixin, Liu, Yang, Wang, Jiou

“…DNA-binding proteins perform diverse functions, including regulating cellular growth and orchestrating chromatin architecture. Here, we present a protocol to…”
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