Search Results - "WANAKA, K."

Plasmin inhibitor reduces T-cell lymphoid tumor growth by suppressing matrix metalloproteinase-9-dependent CD11b F4 80 myeloid cell recruitment by Ishihara, M, Nishida, C, Tashiro, Y, Gritli, I, Rosenkvist, J, Koizumi, M, Okaji, Y, Yamamoto, R, Yagita, H, Okumura, K, Nishikori, M, Wanaka, K, Tsuda, Y, Okada, Y, Nakauchi, H, Heissig, B, Hattori, K

“…Activation of the fibrinolytic system during lymphoma progression is a well-documented clinical phenomenon. But the mechanism by which the fibrinolytic system…”
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Re‐exposure to heparin in uremic patients requiring hemodialysis with heparin‐induced thrombocytopenia by WANAKA, K., MATSUO, T., MATSUO, M., KANEKO, C., MIYASHITA, K., ASADA, R., MATSUSHIMA, H., NAKAJIMA, Y.

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Heparin re‐exposure after heparin‐induced thrombocytopenia in a chronic hemodialysis patient by Matsuo, T., Matuo, M., Wanaka, K., Sakai, R.

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Structure-inhibitory activity relationship of plasmin and plasma kallikrein inhibitors by Tsuda, Y, Tada, M, Wanaka, K, Okamoto, U, Hijikata-Okunomiya, A, Okamoto, S, Okad, Y

“…Based on the structure of Tra-Tyr(O-Pic)-octylamide, a portion of the octylamine was replaced with moieties bearing hydrophobic, basic or acidic groups…”
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Binding Diversity of a Noncovalent-Type Low-Molecular-Weight Serine Protease Inhibitor and Function of a Catalytic Water Molecule: X-Ray Crystal Structure of PKSI-527-Inhibited Trypsin by Tomoo, Koji, Satoh, Kazuhiro, Tsuda, Yuko, Wanaka, Keiko, Okamoto, Shosuke, Hijikata-Okunomiya, Akiko, Okada, Yoshio, Ishida, Toshimasa

“…PKSI-527 is a noncovalent-type low-molecular-weight inhibitor. The X-ray crystal structure of the trypsin-PKSI-527 complex revealed a binding mode (Form II)…”
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Effects of Argatroban on Thrombin-Induced Events in Cultured Vascular Smooth Muscle Cells by Hijikata-Okunomiya, A, Nakaya, Y, Inoue, N, Takahashi, A, Taniguchi, T, Wanaka, K, Tsuda, Y, Okada, Y, Ishikawa, Y

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Design of Noncovalent Trypsin Inhibitor Based on the X-Ray Crystal Structure of the Complex by Nakamura, M., Tomoo, K., Ishida, T., Taguchi, H., Tsuda, Y., Okada, Y., Okunomiya, A., Wanaka, K., Okamoto, S.

“…The inhibitory mechanism of trans-4-aminomethylcyclohexanecarbonyl-L-phenylalanine-4-carboxymethylanilide (1), a noncovalent serine protease inhibitor…”
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Effect of a highly selective plasma-kallikrein synthetic inhibitor on contact activation relating to kinin generation, coagulation and fibrinolysis by Wanaka, K, Okamoto, S, Bohgaki, M, Hijikata-Okunomiya, A, Naito, T, Okada, Y

“…A highly selective inhibitor of plasma-kallikrein (PK), N-(trans-4-aminomethylcyclohexylcarbonyl)-L-phenylalanine 4-carboxymethyl-anilide hydrochloride, was…”
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In vitro and in vivo properties of synthetic inhibitors of thrombin: recent advances by Okamoto, S, Wanaka, K, Hijikata-Okunomiya, A

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Plasmin inhibitor reduces T-cell lymphoid tumor growth by suppressing matrix metalloproteinase-9-dependent CD11b super(+)/F4/80 super(+) myeloid cell recruitment by Ishihara, M, Nishida, C, Tashiro, Y, Gritli, I, Rosenkvist, J, Koizumi, M, Okaji, Y, Yamamoto, R, Yagita, H, Okumura, K, Nishikori, M, Wanaka, K, Tsuda, Y, Okada, Y, Nakauchi, H, Heissig, B, Hattori, K

“…Activation of the fibrinolytic system during lymphoma progression is a well-documented clinical phenomenon. But the mechanism by which the fibrinolytic system…”
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Plasmin inhibitor reduces T-cell lymphoid tumor growth by suppressing matrix metalloproteinase-9-dependent [CD11b.sup.+]/[F4/80.sup.+] myeloid cell recruitment by Ishihara, M, Nishida, C, Tashiro, Y, Gritli, I, Rosenkvist, J, Koizumi, M, Okaji, Y, Yamamoto, R, Yagita, H, Okumura, K, Nishikori, M, Wanaka, K, Tsuda, Y, Okada, Y, Nakauchi, H, Heissig, B, Hattori, K

“…Activation of the fibrinolytic system during lymphoma progression is a well-documented clinical phenomenon. But the mechanism by which the fibrinolytic system…”
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Effects of a highly selective plasma kallikrein inhibitor on collagen-induced arthritis in mice by Fujimori, Y, Nakamura, T, Shimizu, K, Yamamuro, T, Wanaka, K, Okamoto, S, Katsuura, Y

“…A study was conducted to evaluate the effects of a new, highly selective plasma kallikrein inhibitor, PKSI-527, on collagen-induced arthritis (CIA) in mice…”
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Highly selective synthetic inhibitors with regard to plasma-kallikrein activities by Okamoto, S, Okamoto, U, Wanaka, K, Hijikata-Okunomiya, A, Bohgaki, M, Naito, T, Horie, N, Okada, Y

“…The synthetic inhibitors of plasma kallikrein (PK) were found, which are called PKSI-1007, PKSI-0180 and PKSI-0527 in our laboratories. (1) The inhibitors…”
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Enzyme-controlling medicines: introduction by Okamoto, S, Hijikata-Okunomiya, A, Wanaka, K, Okada, Y, Okamoto, U

“…A short history of the research work of S. Okamoto and co-workers, for the previous 50 years, is briefly described. In the 1950s, when the physiologic role of…”
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Heparin re-exposure after heparin-induced thrombocytopenia in a chronic hemodialysis patient: Correspondence by Matsuo, T., Matuo, M., Wanaka, K., Sakai, R.

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Development of Potent and Selective Plasmin and Plasma Kallikrein Inhibitors and Studies on the Structure-Activity Relationship by OKADA, Yoshio, TSUDA, Yuko, TADA, Mayako, WANAKA, Keiko, OKAMOTO, Utako, HIJIKATA-OKUNOMIYA, Akiko, OKAMOTO, Shosuke

“…Based on structure-activity relationship studies, we designed and synthesized plasmin (PL) and plasma Kallikrein (PK) inhibitors…”
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A novel plasmin-inhibitor inhibits the growth of human tumor xenografts and decreases metastasis number by Szende, Béla, Okada, Yoshio, Tsuda, Yuko, Horvath, Aniko, Bökönyi, Gyöngyi, Okamoto, Shosuke, Wanaka, Keiko, Kéri, György

“…The novel plasmin inhibitor YO-2, which also exerts an apoptosis-inducing effect on various human tumor cell cultures, was examined regarding its tumor growth…”
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Development of plasmin and plasma kallikrein selective inhibitors and their effect on M1 (melanoma) and ht29 cell lines by Okada, Yoshio, Tsuda, Yuko, Wanaka, Keiko, Tada, Mayako, Okamoto, Utako, Okamoto, Shosuke, Hijikata-Okunomiya, Akiko, Bokonyi, Gyorgyi, Szende, Bela, Keri, Gyorgy

“…trans-4-Aminomethylcyclohexanecarbonyl-Tyr( O-Pic)-octylamide (YO-2) inhibited plasmin (PL) selectively, while…”
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Development of plasma kallikrein selective inhibitors by Okada, Yoshio, Tsuda, Yuko, Tada, Mayako, Wanaka, Keiko, Hijikata-Okunomiya, Akiko, Okamoto, Utako, Okamoto, Shosuke

“…During the course of the development of active center‐directed plasmin inhibitors, it was found that…”
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Effects of a highly selective synthetic inhibitor of plasma kallikrein on disseminated intravascular coagulation in rats by Katsuura, Yasuhiro, Okamoto, Shosuke, Ohno, Norio, Wanaka, Keiko

“…We found a new, highly selective plasma kallikrein inhibitor, trans-4-aminomethyl-cyclohexanecarbonylphenylalanine 4-carboxymethylanilide hydrochloride, called…”
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