Search Results - "WAN, W. Brad"

The Medicinal Chemistry of Therapeutic Oligonucleotides by Wan, W. Brad, Seth, Punit P

“…Oligonucleotide-based therapeutics have made rapid progress in the clinic for treatment of a variety of disease indications. Unmodified oligonucleotides are…”
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Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides by Anderson, Brooke A, Freestone, Graeme C, Low, Audrey, De-Hoyos, Cheryl L, III, William J Drury, Østergaard, Michael E, Migawa, Michael T, Fazio, Michael, Wan, W Brad, Berdeja, Andres, Scandalis, Eli, Burel, Sebastien A, Vickers, Timothy A, Crooke, Stanley T, Swayze, Eric E, Liang, Xuehai, Seth, Punit P

“…Abstract The PS modification enhances the nuclease stability and protein binding properties of gapmer antisense oligonucleotides (ASOs) and is one of very few…”
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Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins by Migawa, Michael T, Shen, Wen, Wan, W Brad, Vasquez, Guillermo, Oestergaard, Michael E, Low, Audrey, De Hoyos, Cheryl L, Gupta, Ruchi, Murray, Susan, Tanowitz, Michael, Bell, Melanie, Nichols, Joshua G, Gaus, Hans, Liang, Xue-Hai, Swayze, Eric E, Crooke, Stanley T, Seth, Punit P

“…Phosphorothioate-modified antisense oligonucleotides (PS-ASOs) interact with a host of plasma, cell-surface and intracellular proteins which govern their…”
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Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides by Østergaard, Michael E, De Hoyos, Cheryl L, Wan, W Brad, Shen, Wen, Low, Audrey, Berdeja, Andres, Vasquez, Guillermo, Murray, Susan, Migawa, Michael T, Liang, Xue-Hai, Swayze, Eric E, Crooke, Stanley T, Seth, Punit P

“…Therapeutic oligonucleotides are often modified using the phosphorothioate (PS) backbone modification which enhances stability from nuclease mediated…”
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Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics by Finicle, Brendan T, Eckenstein, Kazumi H, Revenko, Alexey S, Anderson, Brooke A, Wan, W Brad, McCracken, Alison N, Gil, Daniel, Fruman, David A, Hanessian, Stephen, Seth, Punit P, Edinger, Aimee L

“…Inefficient endosomal escape remains the primary barrier to the broad application of oligonucleotide therapeutics. Liver uptake after systemic administration…”
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Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages by Wan, W Brad, Migawa, Michael T, Vasquez, Guillermo, Murray, Heather M, Nichols, Josh G, Gaus, Hans, Berdeja, Andres, Lee, Sam, Hart, Christopher E, Lima, Walt F, Swayze, Eric E, Seth, Punit P

“…Bicyclic oxazaphospholidine monomers were used to prepare a series of phosphorothioate (PS)-modified gapmer antisense oligonucleotides (ASOs) with control of…”
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Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs by Vasquez, Guillermo, Freestone, Graeme C, Wan, W Brad, Low, Audrey, De Hoyos, Cheryl Li, Yu, Jinghua, Prakash, Thazha P, Ǿstergaard, Michael E, Liang, Xue-hai, Crooke, Stanley T, Swayze, Eric E, Migawa, Michael T, Seth, Punit P

“…Abstract We recently showed that site-specific incorporation of 2′-modifications or neutral linkages in the oligo-deoxynucleotide gap region of toxic…”
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Comprehensive Structure–Activity Relationship of Triantennary N‑Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes by Prakash, Thazha P, Yu, Jinghua, Migawa, Michael T, Kinberger, Garth A, Wan, W. Brad, Østergaard, Michael E, Carty, Recaldo L, Vasquez, Guillermo, Low, Audrey, Chappell, Alfred, Schmidt, Karsten, Aghajan, Mariam, Crosby, Jeff, Murray, Heather M, Booten, Sheri L, Hsiao, Jill, Soriano, Armand, Machemer, Todd, Cauntay, Patrick, Burel, Sebastien A, Murray, Susan F, Gaus, Hans, Graham, Mark J, Swayze, Eric E, Seth, Punit P

“…The comprehensive structure–activity relationships of triantennary GalNAc conjugated ASOs for enhancing potency via ASGR mediated delivery to hepatocytes is…”
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Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides by Østergaard, Michael E, Yu, Jinghua, Kinberger, Garth A, Wan, W. Brad, Migawa, Michael T, Vasquez, Guillermo, Schmidt, Karsten, Gaus, Hans J, Murray, Heather M, Low, Audrey, Swayze, Eric E, Prakash, Thazha P, Seth, Punit P

“…Conjugation of triantennary N-acetyl galactosamine (GalNAc) to oligonucleotide therapeutics results in marked improvement in potency for reducing gene targets…”
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Solid-phase synthesis of 5′-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry by Prakash, Thazha P., Brad Wan, W., Low, Audrey, Yu, Jinghua, Chappell, Alfred E., Gaus, Hans, Kinberger, Garth A., Østergaard, Michael E., Migawa, Michael T., Swayze, Eric E., Seth, Punit P.

“…[Display omitted] A convenient solid-phase synthetic method was developed for assembling a triantennary N-acetylgalactosamine (GalNAc) cluster on the 5′-end of…”
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A convenient synthesis of 5′-triantennary N-acetyl-galactosamine clusters based on nitromethanetrispropionic acid by Migawa, Michael T., Prakash, Thazha P., Vasquez, Guillermo, Wan, W. Brad, Yu, Jinghua, Kinberger, Garth A., Østergaard, Michael E., Swayze, Eric E., Seth, Punit P.

“…[Display omitted] A convenient method for the synthesis of several triantennary GalNAc clusters based on a nitromethanetrispropionic acid core was developed…”
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Effect of diastereoisomeric composition on the chromatographic retention of phosphorothioated oligonucleotides using three different liquid chromatography systems by Roussis, Stilianos G., Wan, W. Brad, Rentel, Claus

“…•Stereo-enriched PS oligonucleotides analyzed by RP-SAX, IP-RP and MICC.•Linear relationships between tR and the numbers of linkages by RP-SAX and IP-RP.•Broad…”
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Oral Treatment of Cowpox and Vaccinia Virus Infections in Mice with Ether Lipid Esters of Cidofovir by Quenelle, Debra C, Collins, Deborah J, Wan, W Brad, Beadle, James R, Hostetler, Karl Y, Kern, Earl R

“…AUTHOR'S CORRECTION ( vol. 48 , p. 1919 ) Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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Comparative Activities of Lipid Esters of Cidofovir and Cyclic Cidofovir against Replication of Herpesviruses In Vitro by WILLIAMS-AZIZ, Stephanie L, HARTLINE, Caroll B, HARDEN, Emma A, DAILY, Shannon L, PRICHARD, Mark N, KUSHNER, Nicole L, BEADLE, James R, WAN, W. Brad, HOSTETLER, Karl Y, KERN, Earl R

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Oral Activity of Ether Lipid Ester Prodrugs of Cidofovir against Experimental Human Cytomegalovirus Infection by Bidanset, Deborah J., Beadle, James R., Wan, W. Brad, Hostetler, Karl Y., Kern, Earl R.

“…Infection with human cytomegalovirus (HCMV) can cause serious complications in bone-marrow and solidorgan transplant recipients, and current therapies are not…”
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Oral Treatment of Murine Cytomegalovirus Infections with Ether Lipid Esters of Cidofovir by KERN, Earl R, COLLINS, Deborah J, WAN, W. Brad, BEADLE, James R, HOSTETLER, Karl Y, QUENELLE, Debra C

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Endosomal Escape of Antisense Oligonucleotides Internalized by Stabilin Receptors Is Regulated by Rab5C and EEA1 During Endosomal Maturation by Miller, Colton M, Wan, W Brad, Seth, Punit P, Harris, Edward N

“…Second-generation (Gen 2) Antisense oligonucleotides (ASOs) show increased nuclease stability and affinity for their RNA targets, which has translated to…”
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Effect of oral treatment with ( S)-HPMPA, HDP-( S)-HPMPA or ODE-( S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models by Quenelle, Debra C., Collins, Deborah J., Pettway, Latisha R., Hartline, Caroll B., Beadle, James R., Wan, W. Brad, Hostetler, Karl Y., Kern, Earl R.

“…We utilized BALB/c mice infected with murine CMV (MCMV) or severe combined immunodeficient (SCID) mice implanted with human fetal tissue and infected with HCMV…”
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Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney by Ciesla, Stephanie L, Trahan, Julissa, Wan, W.Brad, Beadle, James R, Aldern, Kathy A, Painter, George R, Hostetler, Karl Y

“…Smallpox was eradicated by vaccination in the 1970s. However, concerns have arisen about the potential use of variola virus as a biological weapon. Most of the…”
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Synthesis and Spectroscopic Studies of Expanded Planar Dehydrotribenzo[n]annulenes Containing One or Two Isolated Alkene Units by Wan, W. Brad, Chiechi, Ryan C., Weakley, Timothy J. R., Haley, Michael M.

“…Dehydrobenzoannulene derivatives 5−7 containing isolated alkene linkages were synthesized by combining an in‐situ Pd/Cu‐mediated cross‐coupling with an…”
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